Guest-shuttling in a nanosized metallobox

An iridium-conjoined long and narrow metallorectangle was obtained by combining a quinoxalinophenanthrophenazine-connected Janus-di-imidazolylidene ligand and pyrazine. The size and shape of this assembly together with the fused polyaromatic nature of its panels provides it with properties that are uncommon for other metallosupramolecular assemblies. For example, this nanosized ‘slit-like’ metallobox is able show very large binding affinities with planar organic molecules in such a way, that the cavity is asymmetrically occupied by the guest molecule. This unsymmetrical conformation leads to the existence of a large amplitude motion of these guests, which slide between the two sides of the cavity of the host, thus constituting rare examples of molecular shuttles.Funding for open access charge: CRUE-Universitat Jaume

Acinetobacter portensis sp. nov. and Acinetobacter guerrae sp. nov., isolated from raw meat

The taxonomic status of six strains of Acinetobacter obtained from meat samples, collected from supermarkets in Porto, Portugal, was investigated using polyphasic analysis. Partial rpoB sequence similarities lower than 95 % to other Acinetobacter species with validly published names led to the hypothesis that these strains represented novel species. This was confirmed based on comparative multilocus sequence analysis, which included the gyrB, recA and 16S rRNA genes, revealing that these strains represented two coherent lineages that were distinct from each other and from all known species. The names Acinetobacter portensis sp. nov. (comprising four strains) and Acinetobacter guerrae sp. nov. (comprising two strains) are proposed for these novel species. The species status of these two groups was confirmed by low (below 95 %) whole-genome sequence average nucleotide identity values and low (below 70 %) digital DNA–DNA hybridization similarities between the whole-genome sequences of the proposed type strains of each novel species and the representatives of the known Acinetobacter species. Phylogenomic treeing from core genome analysis supported these results. The coherence of each new species lineage was supported by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry differentiation of the species at the protein level, by cellular fatty acid profiles, and by unique and differential combinations of metabolic and physiological properties shared by each novel species. The type strain of A. portensis sp. nov. is AC 877T (=CCUG 68672T=CCM 8789T) and the type strain of A. guerrae sp. nov. is AC 1271T (=CCUG 68674T=CCM 8791T).info:eu-repo/publishedVersio

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

El sentimiento de soledad en personas mayores institucionalizadas y no institucionalizadas. Intervenciones para reducir el sentimiento de soledad.

[spa] Introducción: Las personas mayores son el colectivo más propenso a padecer sentimientos de soledad puesto que son personas que se encuentran en la última etapa de su vida dónde están sujetos a constantes cambios como la pérdida de la pareja, la pérdida de amigos, la jubilación, el deterioro fisiológico y cognitivo o la institucionalización, además de sufrir sentimientos de inadaptación por la evolución de las nuevas generaciones y sobretodo respecto a las nuevas tecnologías. Objetivo: El objetivo de esta revisión bibliográfica es determinar cuáles son las personas mayores que presentan niveles más elevados de soledad, si son las institucionalizadas o las no institucionalizadas. Además, esta investigación también busca analizar cuáles son las intervenciones que existen para reducir este sentimiento de soledad, si son efectivas o no y proponer otras intervenciones que puedan paliar este sentimiento. Metodología: Para dicha revisión, se ha realizado una búsqueda bibliográfica en diferentes bases de datos científicas con los descriptores (DeCS) seleccionados, donde se seleccionaron 20 artículos después de descartar artículos que no cumplían con los criterios de inclusión o con los objetivos. Resultados: Los resultados de esta revisión concluyen que las personas mayores que padecen unos niveles más altos de soledad son aquellas que residen en una institucionalización, debido posiblemente a que éstas poseen un menor grado de autonomía, se encuentran fuera del que siempre ha sido su lugar de residencia, sus familiares y amigos no se encuentran cerca y no poseen relaciones significativas con otros residentes. Existen diversas intervenciones para reducir el sentimiento de soledad, pero es necesario que se investigue más sobre la efectividad de estas, se lleven a la práctica más frecuentemente y que se informe a los pacientes de todos los recursos y servicios de los que disponen. Conclusiones: Es tarea de salud pública concienciar a la población de la existencia de los sentimientos de soledad en las personas mayores para crear una red estable de recursos y un protocolo de detección precoz de los sentimientos de soledad. Las enfermeras tenemos un papel clave en la prevención, promoción e intervención de la salud de las personas mayores.[cat] Introducció: Les persones majors són el col·lectiu més propens a patir sentiments de solitud perquè són persones que es troben en l'última etapa de la seva vida on estan subjectes a constants canvis com la pèrdua de la parella, la pèrdua d'amics, la jubilació, la deterioració fisiològica i cognitiva o la institucionalització, a més de sofrir sentiments d'inadaptació per l'evolució de les noves generacions i sobretot respecte a les noves tecnologies. Objectiu: L'objectiu d'aquesta revisió bibliogràfica és determinar quines són les persones majors que presenten nivells més elevats de solitud, si són les institucionalitzades o les no institucionalitzades. A més, aquesta recerca també cerca analitzar quines són les intervencions que existeixen per a reduir aquest sentiment de solitud, si són efectives o no i proposar altres intervencions que puguin pal·liar aquest sentiment. Metodologia: Per a aquesta revisió, s'ha realitzat una recerca bibliogràfica en diferents bases de dades científiques amb els descriptors (DeCS) seleccionats, on es van seleccionar 20 articles després de descartar articles que no complien amb els criteris d'inclusió o amb els objectius. Resultats: Els resultats d'aquesta revisió conclouen que les persones majors que pateixen uns nivells més alts de solitud són aquelles que resideixen en una institucionalització, degut possiblement al fet que aquestes posseeixen un menor grau d'autonomia, es troben fora del que sempre ha estat el seu lloc de residència, els seus familiars i amics no es troben a prop i no posseeixen relacions significatives amb altres residents. Existeixen diverses intervencions per a reduir el sentiment de solitud, però és necessari que s'investigui més sobre l'efectivitat d'aquestes, es duguin a la pràctica més sovint i que s'informi els pacients de tots els recursos i serveis dels quals disposen. Conclusions: És tasca de salut pública conscienciar a la població de l'existència dels sentiments de solitud en les persones majors per a crear una xarxa estable de recursos i un protocol de detecció precoç dels sentiments de solitud. Les infermeres tenim un paper clau en la prevenció, promoció i intervenció de la salut de les persones majors.[eng] Introduction: Elderly people are the most prone to suffer feelings of solitude because they are people who are in the last stage of their life where they are subject to constant changes such as loss of partners, loss of friends, retirement, physiological and cognitive deterioration or institutionalization, as well as suffering feelings of inadequacy with the evolution of the new generations and especially with regard to new technologies. Objectives: The objective of this bibliographic review is to determine which older people have higher levels of solitude, whether institutionalized or non-institutionalized. In addition, this research also seeks to analyse what interventions exist to reduce this feeling of solitude, whether they are effective or not and to propose other interventions that may alleviate this feeling. Methodology: For this revision, bibliographic research has been carried out in different scientific databases with the selected descriptors (DeCS), where 20 articles were selected after discarding articles that did not meet the inclusion criteria or objectives. Results: The results of this review conclude that older people with higher levels of solitude are those who reside in institutionalizations, possibly because they have a lower degree of autonomy and they are outside what has always been their place of residence and their relatives and friends are not nearby and have no meaningful relations with other residents. There are various methods to reduce the feeling of solitude, but more research is needed to find out the effectiveness of this methods. They are carried out more often and patients are informed of all the resources and services available to them. Conclusions: It is a public health task to make people aware of the existence of feelings of solitude in older people in order to create a stable network of resources and a protocol for early detection of feelings of solitude. Nurses have a key role to play in preventing, promoting and intervening with in the health of elder people

Varón africano de 49 años, SIDA, que acude a URGA por fiebre y convulsiones

Young african male with AIDS and poor compliance of treatment addmited to the hospital with fever, painful adenophaties and seizures. Blood test showed severe immunodepression and the CT scan detected brain lessions. He received broad spectrum antimicrobials with no success, dying during the second week of admission.Varón africano joven, diagnosticado de SIDA, mal cumplimentador, que ingresa en el hospital por fiebre, adenopatías dolorosas y convulsiones. Se detecta severa inmunosupresión y lesiones cerebrales y se trata de forma empírica con antimicrobianos de amplio espectro sin éxito, falleciendo durante la segunda semana de ingreso

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat