335 research outputs found
Quantum Fields a la Sylvester and Witt
A structural explanation of the coupling constants in the standard model, i.e
the fine structure constant and the Weinberg angle, and of the gauge fixing
contributions is given in terms of symmetries and representation theory. The
coupling constants are normalizations of Lorentz invariantly embedded little
groups (spin and polarization) arising in a harmonic analysis of quantum vector
fields. It is shown that the harmonic analysis of massless fields requires an
extension of the familiar Fourier decomposition, containing also indefinite
unitary nondecomposable time representations. This is illustrated by the
nonprobabilistic contributions in the electromagnetic field.Comment: 18 pages LaTeX file (62 kB), all macros are include
Realizations of Causal Manifolds by Quantum Fields
Quantum mechanical operators and quantum fields are interpreted as
realizations of timespace manifolds. Such causal manifolds are parametrized by
the classes of the positive unitary operations in all complex operations, i.e.
by the homogenous spaces \D(n)=\GL(\C^n_\R)/\U(n) with for mechanics
and for relativistic fields. The rank gives the number of both the
discrete and continuous invariants used in the harmonic analysis, i.e. two
characteristic masses in the relativistic case. 'Canonical' field theories with
the familiar divergencies are inappropriate realizations of the real
4-dimensional causal manifold \D(2). Faithful timespace realizations do not
lead to divergencies. In general they are reducible, but nondecomposable - in
addition to representations with eigenvectors (states, particle) they
incorporate principal vectors without a particle (eigenvector) basis as
exemplified by the Coulomb field.Comment: 36 pages, latex, macros include
Simplicial quantum dynamics
Present-day quantum field theory can be regularized by a decomposition into
quantum simplices. This replaces the infinite-dimensional Hilbert space by a
high-dimensional spinor space and singular canonical Lie groups by regular spin
groups. It radically changes the uncertainty principle for small distances.
Gaugeons, including the gravitational, are represented as bound fermion-pairs,
and space-time curvature as a singular organized limit of quantum
non-commutativity.
Keywords: Quantum logic, quantum set theory, quantum gravity, quantum
topology, simplicial quantization.Comment: 25 pages. 1 table. Conference of the International Association for
Relativistic Dynamics, Taiwan, 201
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzymatically inactive caspase-1 <sup>C284A</sup> , we provide genetic evidence that caspase-1 protease activity is required for canonical IL-1 secretion, pyroptosis, and inflammasome-mediated immunity. In caspase-1-deficient cells, caspase-8 can be activated at the inflammasome. Using mice either lacking the pyroptosis effector gasdermin D (GSDMD) or expressing caspase-1 <sup>C284A</sup> , we found that GSDMD-dependent pyroptosis prevented caspase-8 activation at the inflammasome. In the absence of GSDMD-dependent pyroptosis, the inflammasome engaged a delayed, alternative form of lytic cell death that was accompanied by the release of large amounts of mature IL-1 and contributed to host protection. Features of this cell death modality distinguished it from apoptosis, suggesting it may represent a distinct form of pro-inflammatory regulated necrosis
First Measurement of the Transverse Spin Asymmetries of the Deuteron in Semi-Inclusive Deep Inelastic Scattering
First measurements of the Collins and Sivers asymmetries of charged hadrons
produced in deep-inelastic scattering of muons on a transversely polarized
6-LiD target are presented. The data were taken in 2002 with the COMPASS
spectrometer using the muon beam of the CERN SPS at 160 GeV/c. The Collins
asymmetry turns out to be compatible with zero, as does the measured Sivers
asymmetry within the present statistical errors.Comment: 6 pages, 2 figure
Tectono-stratigraphic response of the Sandino Forearc Basin (N-Costa Rica and W-Nicaragua) to episodes of rough crust and oblique subduction
The southern Central American active margin is a world-class site where past and
present subduction processes have been extensively studied. Tectonic erosion/accretion
and oblique/orthogonal subduction are thought to alternate in space and time
along the Middle American Trench. These processes may cause various responses
in the upper plate, such as uplift/subsidence, deformation, and volcanic arc migration/
shut-off. We present an updated stratigraphic framework of the Late Cretaceous–
Cenozoic Sandino Forearc Basin (SFB) which provides evidence of
sedimentary response to tectonic events. Since its inception, the basin was predominantly
filled with deep-water volcaniclastic deposits. In contrast, shallow-water
deposits appeared episodically in the basin record and are considered as tectonic
event markers. The SFB stretches for about 300 km and varies in thickness from
5 km (southern part) to about 16 km (northern part). The drastic, along-basin, thickness
variation appears to be the result of (1) differential tectonic evolutions and (2)
differential rates of sediment supply. (1) The northern SFB did not experience major
tectonic events. In contrast, the reduced thickness of the southern SFB (5 km) is the
result of at least four uplift phases related to the collision/accretion of bathymetric
reliefs on the incoming plate: (i) the accretion of a buoyant oceanic plateau (Nicoya
Complex) during the middle Campanian; (ii) the collision of an oceanic plateau (?)
during the late Danian–Selandian; (iii) the collision/accretion of seamounts during
the late Eocene–early Oligocene; (iv) the collision of seamounts and ridges during
the Pliocene–Holocene. (2) The northwestward thickening of the SFB may have
been enhanced by high sediment supply in the Fonseca Gulf area which reflects
sourcing from wide, high relief drainage basins. In contrast, sedimentary input has
possibly been lower along the southern SFB, due to the proximity of the narrow,
lowland isthmus of southern Central America. Moreover, two phases of strongly
oblique subduction affected the margin, producing strike-slip faulting in the forearc
basin: (1) prior to the Farallon Plate breakup, an Oligocene transpressional phase
caused deformation and uplift of the basin depocenter, triggering shallowing-upward
of the Nicaraguan Isthmus in the central and northern SFB; (2) a Pleistocene–Holocene transtensional phase drives the NW-directed motion of a forearc sliver
and reactivation of the graben-bounding faults of the late Neogene Nicaraguan
Depression. We discuss arguments in favour of a Pliocene development of the
Nicaraguan Depression and propose that the Nicaraguan Isthmus, which is the
apparent rift shoulder of the depression, represents a structure inherited from the Oligocene
transpressional phase
Gluon polarization in the nucleon from quasi-real photoproduction of high-pT hadron pairs
We present a determination of the gluon polarization Delta G/G in the
nucleon, based on the helicity asymmetry of quasi-real photoproduction events,
Q^2<1(GeV/c)^2, with a pair of large transverse-momentum hadrons in the final
state. The data were obtained by the COMPASS experiment at CERN using a 160 GeV
polarized muon beam scattered on a polarized 6-LiD target. The helicity
asymmetry for the selected events is = 0.002 +- 0.019(stat.) +-
0.003(syst.). From this value, we obtain in a leading-order QCD analysis Delta
G/G=0.024 +- 0.089(stat.) +- 0.057(syst.) at x_g = 0.095 and mu^2 =~ 3
(GeV}/c)^2.Comment: 10 pages, 3 figure
Measurement of the Spin Structure of the Deuteron in the DIS Region
We present a new measurement of the longitudinal spin asymmetry A_1^d and the
spin-dependent structure function g_1^d of the deuteron in the range 1 GeV^2 <
Q^2 < 100 GeV^2 and 0.004< x <0.7. The data were obtained by the COMPASS
experiment at CERN using a 160 GeV polarised muon beam and a large polarised
6-LiD target. The results are in agreement with those from previous experiments
and improve considerably the statistical accuracy in the region 0.004 < x <
0.03.Comment: 10 pages, 6 figures, subm. to PLB, revised: author list, Fig. 4,
details adde
Unraveling the performance of dispersion-corrected functionals for the accurate description of weakly bound natural polyphenols
Long-range non-covalent interactions play a key role in the chemistry of natural polyphenols. We have previously proposed a description of supramolecular polyphenol complexes by the B3P86 density functional coupled with some corrections for dispersion. We couple here the B3P86 functional with the D3 correction for dispersion, assessing systematically the accuracy of the new B3P86-D3 model using for that the well-known S66, HB23, NCCE31, and S12L datasets for non-covalent interactions. Furthermore, the association energies of these complexes were carefully compared to those obtained by other dispersion-corrected functionals, such as B(3)LYP-D3, BP86-D3 or B3P86-NL. Finally, this set of models were also applied to a database composed of seven non-covalent polyphenol complexes of the most interest.FDM acknowledges financial support from the Swedish Research Council (Grant No. 621-2014-4646) and SNIC (Swedish National Infrastructure for Computing) for providing computer resources. The work in Limoges (IB and PT) is supported by the “Conseil Régional du Limousin”. PT gratefully acknowledges the support by the Operational Program Research and Development Fund (project CZ.1.05/2.1.00/03.0058 of the Ministry of Education, Youth and Sports of the Czech Republic). IB gratefully acknowledges financial support from “Association Djerbienne en France”
Inhibition of HCV 3a core gene through Silymarin and its fractions
Hepatitis C is a major health problem affecting 270 million individuals in world including Pakistan. Current treatment regimen, interferon alpha and ribavirin only cure half of patients due to side effects and high cost.
In the present study Silybum marianum (Milk thistle) seeds were collected, extracted and analyzed against HCV 3a core gene by transiently transfecting the liver cells with HCV core plasmid. Our results demonstrated that Silymarin (SM) dose dependently inhibit the expression or function of HCV core gene at a non toxic concentration while the GAPDH remained constant. To identify the active ingredient, SM was fractioned by thin layer chromatography (TLC), column chromatography and HPLC. Purified fractions were tested for HCV core gene and western blotting results showed that two factions of SM (S1 and S2) inhibit HCV 3a core expression or function in liver cells
Our results suggest SM and its fractions (S1 and S2) inhibit HCV core gene of 3a genotype and combination of SM and its fractions with interferon will be a better option to treat HCV infection
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