Los proyectos prácticos de la Cátedra Inditex-UDC de sostenibilidad como experiencia innovadora en el ámbito de la educación para la sostenibilidad

[Resumen] La Cátedra Inditex-UDC de Sostenibilidad nace como un espacio de reflexión -formación, investigación y divulgación- en el ámbito de la sostenibilidad, la responsabilidad e innovación social. El objetivo de esta comunicación es analizar los proyectos prácticos de esta cátedra en colaboración con entidades como metodología de innovación educativa y transferencia de conocimiento, basada en el aprendizaje colaborativo entre seis actores diferentes: la dirección académica, los alumnos, los representantes de las entidades colaboradoras, el tutor metodológico, los antiguos alumnos que mentorizan los proyectos y los miembros del tribunal. Para ello, se hace especial hincapié en los retos que supone su desarrollo, se detallan las acciones de mejora continua adoptadas y se evalúan tanto los resultados de aprendizaje como los resultados de implantación de las recomendaciones de los alumnos en las entidades colaboradoras. Hasta el momento, estos proyectos en colaboración se traducen en un modelo exitoso de aprendizaje para los alumnos, y en transferencia de conocimiento a las entidades colaboradoras, que obtienen ideas y recomendaciones innovadoras para resolver necesidades reales e inmediatas[Abstract] The Inditex-UDC Chair of Sustainability emerged as a space for reflection -training, research and dissemination- in the field of sustainability, responsibility and social innovation. The objective of this communication is to analyze the projects of this chair in collaboration with entities as educational innovation and knowledge transfer methodology, based on the collaborative learning among six different actors: Academic Direction, students, representatives of the collaborating entities, the methodological tutor, alumni who mentor the projects and the members of the Academic Tribunal. Along these lines, the challenges encountered in its development are highlighted, the continuous improvement actions adopted are detailed, and the results of the learning and results of the implementation of recommendations from students on the collaborating entities are evaluated. So far, these collaborative projects translate into a successful learning model for students, and knowledge transfer to collaborating entities, which obtain innovative ideas and recommendations to solve real and immediate need

Criterios programáticos para la innovación docente en ciencias de la empresa: planificación didáctica orientada a la realidad empresarial

[Resumen] Conseguir un aprendizaje efectivo en el campo de las ciencias de la empresa requiere de innovación docente continua y orientada a un triple esfuerzo de integración. En primer lugar, el diseño del plan didáctico de las materias debe integrar contenidos pertenecientes a distintos niveles de análisis. Desplegarlos con eficacia dentro y fuera del aula requiere, en segundo lugar, de una continua transición entre recursos relativos a los fundamentos teórico-conceptuales de las materias y a los problemas prácticos de la empresa en un entorno de cambio acelerado; de modo que los alumnos visibilicen y contextualicen los retos a los que se enfrentan en la realidad, su relevancia y las posibles soluciones. En tercer lugar, es aconsejable combinar una pléyade de metodologías activas que impacten tanto sobre la mejora de sus competencias como de su empleabilidad. El objetivo del presente trabajo es fundamentar metodológicamente el diseño e implementación de un plan didáctico innovador para materias de empresa acorde a los tres criterios programáticos señalados. Se utilizará como caso de estudio el desarrollo del plan didáctico de la materia ‘Distribución Comercial’ (2011-2019), con especial énfasis en su articulación metodológica a través del aprendizaje colaborativo por proyectos. Por último, se valorará la aplicabilidad de esta experiencia innovadora a otras materias del ámbito de las ciencias de la empresa.[Abstract] Achieving effective learning in the field of Business Studies requires continuous teaching innovation aimed at a three-fold integration effort. Firstly, the design of the teaching plan must integrate contents related to multiple levels of analysis. Secondly, deploying them within and outside the classroom requires a continuous transition between resources relative to the theoretical-conceptual contents and to the practical problems posed to businesses by an environment in accelerated change; so that students visualize and contextualize the real challenges being faced, their relevance and the potential solutions. Thirdly, a plethora of active learning methodologies should be combined in order to improve not only students’ competencies but also their employability. In this context, the objective of this paper is to methodologically substantiate the design and implementation of an innovative teaching plan in the field of Business Studies in accordance with the three above-mentioned programmatic criteria. A case study of its development for the 'Retail Management' course (2011-2019) will be presented, with special emphasis on its methodological approach through collaborative project-based learning. Finally, the applicability of this teaching innovation experience for other subjects in the Business Studies field will be assessed

Determinants of success of donation-based crowdfunding through digital platforms : The influence of offline factors

The purpose of this research consist of exploring the extent to which factors traditionally explaining the success of offline fundraising campaigns for social causes may also influence the success of donationbased crowdfunding (DCF) campaigns promoted by social economy organizations (SEO) through digital platforms. Firstly, factors determining the success of offline fundraising campaigns for social causes are identified from previous literature. Secondly, a set of hypotheses linking these determinants to DCF campaigns is proposed. Thirdly, their explanatory capacity is measured through quantitative analysis based on a database of 360 campaigns fostered by small, medium and large-size organizations via Microdonaciones, a donation-based crowdfunding digital platform, for the period between 2012 and 2017. Logistic regression analysis is used to test the hypotheses proposed. Results confirm the high explanatory capacity of determinants related to the geographical scope of the campaign, the volume of potential beneficiaries involved ?in these two cases in unexpected ways-, and the information provided by the promoting organizations. However, factors related to the timing of the campaigns do not influence their success. This research suggests that not only the funding channels and tools but also the nature of the fundraising campaigns themselves have been digitally transformed. Implications of this research may assist SEO in establishing effective relationships with new digital donors in order to achieve sustainable growth.

Directed Pancreatic Acinar Differentiation of Mouse Embryonic Stem Cells via Embryonic Signalling Molecules and Exocrine Transcription Factors

Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unlimited source of tissue for the treatment of chronic diseases and valuable in vitro differentiation models for drug testing. Our aim was to direct differentiation of mouse ESC into pancreatic acinar cells, which play key roles in pancreatitis and pancreatic cancer. To that end, ESC were first differentiated as embryoid bodies and sequentially incubated with activin A, inhibitors of Sonic hedgehog (Shh) and bone morphogenetic protein (BMP) pathways, fibroblast growth factors (FGF) and retinoic acid (RA) in order to achieve a stepwise increase in the expression of mRNA transcripts encoding for endodermal and pancreatic progenitor markers. Subsequent plating in Matrigel® and concomitant modulation of FGF, glucocorticoid, and folllistatin signalling pathways involved in exocrine differentiation resulted in a significant increase of mRNAs encoding secretory enzymes and in the number of cells co-expressing their protein products. Also, pancreatic endocrine marker expression was down-regulated and accompanied by a significant reduction in the number of hormone-expressing cells with a limited presence of hepatic marker expressing-cells. These findings suggest a selective activation of the acinar differentiation program. The newly differentiated cells were able to release α-amylase and this feature was greatly improved by lentiviral-mediated expression of Rbpjl and Ptf1a, two transcription factors involved in the maximal production of digestive enzymes. This study provides a novel method to produce functional pancreatic exocrine cells from ESC. © 2013 Delaspre et al.This work was supported by grants from the Instituto de Salud Carlos III (ISCIII)-FEDER (PI052738 and PI080511 to A.S.; PI100094 and Tercel RD06/0010/ 0025 to B.S.). A.S. was supported by ISCIII and the Health Department of the Generalitat de Catalunya; F.D. was the recipient of a Graduate Fellowship from ISCIII and was also supported by Tercel; M.M. was the recipient of a Graduate Fellowship from the Generalitat de Catalunya.Peer Reviewe

Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistry

INTRODUCTION: One of the most common genetic aberrations associated with breast cancer is the amplification and overexpression of the ERBB2 proto-oncogene located at chromosome 17, bands q12-21. The amplification/overexpression occurs in 25 to 30% of all breast cancers. In breast cancer, aneusomy of chromosome 17, either monosomy or polysomy, is frequently observed by conventional cytogenetics and fluorescence in situ hybridization (FISH). The aim of this study was to discover whether or not numerical aberrations on chromosome 17 have a correlation to the amplification or overexpression of the ERBB2 gene and to analyze their clinical implications in subgroups showing 2+ or 3+ positive scores by immunohistochemistry (IHC). METHODS: We used FISH on a series of 175 formalin-fixed paraffin-embedded breast carcinomas to detect ERBB2 amplification, using a dual-probe system for the simultaneous enumeration of the ERBB2 gene and the centromeric region of chromosome 17, as well as using IHC to detect overexpression. We analyzed clinical and pathological variables in a subgroup of patients with 2+ and 3+ IHC scores (147 patients), to describe any differences in clinicopathological characteristics between polysomic and non-polysomic cases with the use of the χ(2 )test. RESULTS: We found 13% of cases presenting polysomy, and three cases presented monosomy 17 (2%). According to the status of the ERBB2 gene, instances of polysomy 17 were more frequently observed in non-amplified cases than in FISH-amplified cases, suggesting that the mechanism for ERBB2 amplification is independent of polysomy 17. Polysomy 17 was detected in patients with 2+ and 3+ IHC scores. We found that nodal involvement was more frequent in polysomic than in non-polysomic cases (P = 0.046). CONCLUSIONS: The determination of the copy number of chromosome 17 should be incorporated into the assesment of ERBB2 status. It might also be helpful to differentiate a subgroup of breast cancer patients with polysomy of chromosome 17 and overexpression of ERBB2 protein that probably have genetic and clinical differences

Clinical Interest of LMO2 Testing for the Diagnosis of Aggressive Large B-Cell Lymphomas

MYC rearrangements usually confer aggressive biological behavior to large B-cell lymphomas. In this study, we aimed to evaluate the relevance of LMO2 detection to the clinical approach to these tumors. First, the ability of LMO2 loss of expression to recognize the presence of MYC rearrangements was evaluated. A series of 365 samples obtained from 351 patients, including 28 Burkitt lymphoma, 230 diffuse large B-cell lymphoma, 30 high-grade B-cell lymphoma with MYC and BCL2/BCL6 rearrangements, eight high-grade B-cell lymphoma-NOS, 43 transformed diffuse large B-cell lymphoma, and 26 high-grade follicular lymphomas was analyzed. Among the CD10-positive tumors prospectively analyzed in whole tissue sections, LMO2 negative expression obtained values of 88% sensitivity, 94% specificity, and 93% accuracy, proving the utility of LMO2 to screen MYC rearrangements. In addition, survival analyses were performed in a series of 155 patients. As per univariate analyses, the prognosis relevance of LMO2 was as useful as that of the diagnostic categories, MYC rearrangements, and MYC immunohistochemistry. Multivariate models revealed that both LMO2 (hazard ratio 0.51 p = 0.02) and IPI (hazard ratio 1.67 p < 0.005) were independent variables predicting overall survival. Finally, MYC and LMO2 mRNA expression were analyzed in a small group of cases. Taken together, these findings show the interest of LMO2 testing in large B-cell lymphomas

Museología para la innovación social: una experiencia de regeneración territorial en la periferia europea

La museología social emerge como un innovador paradigma de gestión museística cuya misión va más allá de la tradicional preservación y exhibición de las colecciones para convertirse en un factor de dinamización y cohesión social. Desde este nuevo enfoque, un museo se convierte en una institución en permanente interacción no sólo con sus visitantes, sino también con todos los actores de la sociedad civil, entre otros grupos de interés. Un museo social tiene el potencial de contribuir a la regeneración del territorio donde se ubica si comparte responsabilidades con otros actores acerca del diagnóstico de los problemas sociales y coproduce con ellos nuevas soluciones orientadas hacia un desarrollo más sostenible. En este marco conceptual, el presente trabajo contextualiza el caso de los partenariados públicos-no lucrativos tejidos en torno al Museo Provincial de Lugo (Galicia, España) como una experiencia innovadora de inclusión social de los colectivos más vulnerables y de contribución a la regeneración del territorio a nivel local. Palabras clave: innovación social, museología social, sociedad civil, organizaciones del tercer sector, regeneración territorial, partenariados públicos-no lucrativos, inclusión social, colectivos vulnerables. Museology for social innovation: an experience of territorial regeneration in the periphery of Europe Abstract: Social museology emerges as an innovative model for museum management whose mission goes beyond the traditional conservation and exhibition of collections, to become a driver of social dynamism and cohesion. Under this new approach, a museum constantly interacts not only with its visitors, but also with all civil society actors, among other stakeholders. A social museum can potentially contribute to regenerating the territory around it if the responsibilities for diagnosing social problems are shared with other actors and innovative solutions oriented towards a more sustainable development are coproduced with them. Under this conceptual framework, this article contextualizes the case study of the public-non profit part- nerships that have been launched by the Provincial Museum of Lugo (Galicia, Spain), as an innovative ex- perience aimed towards social inclusion of vulnerable segments of population and local regeneration of the territory. Keywords: social innovation, social museology, civil society, third sector organizations, territorial regeneration, public-non profit partnerships, social inclusion, vulnerable segments of population.    

Museology for social innovation: an experience of territorial regeneration in the periphery of Europe

La museología social emerge como un innovador paradigma de gestión museística cuya misión va más allá de la tradicional preservación y exhibición de las colecciones para convertirse en un factor de dinamización y cohesión social. Desde este nuevo enfoque, un museo se convierte en una institución en permanente interacción no sólo con sus visitantes, sino también con todos los actores de la sociedad civil, entre otros grupos de interés. Un museo social tiene el potencial de contribuir a la regeneración del territorio donde se ubica si comparte responsabilidades con otros actores acerca del diagnóstico de los problemas sociales y coproduce con ellos nuevas soluciones orientadas hacia un desarrollo más sostenible. En este marco conceptual, el presente trabajo contextualiza el caso de los partenariados públicos- no lucrativos tejidos en torno al Museo Provincial de Lugo (Galicia, España) como una experiencia innovadora de inclusión social de los colectivos más vulnerables y de contribución a la regeneración del territorio a nivel local.Social museology emerges as an innovative model for museum management whose mission goes beyond the traditional conservation and exhibition of collections, to become a driver of social dynamism and cohesion. Under this new approach, a museum constantly interacts not only with its visitors, but also with all civil society actors, among other stakeholders. A social museum can potentially contribute to regenerating the territory around it if the responsibilities for diagnosing social problems are shared with other actors and innovative solutions oriented towards a more sustainable development are coproduced with them. Under this conceptual framework, this article contextualizes the case study of the public-non profit partnerships that have been launched by the Provincial Museum of Lugo (Galicia, Spain), as an innovative experience aimed towards social inclusion of vulnerable segments of population and local regeneration of the territory

P53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and patient outcome is primarily unstudied. Using CRC patient-derived organoids (PDO)s, we show that sublethal doses of chemotherapy (CT) does not select previously resistant tumor populations but induces a quiescent state specifically to TP53 wildtype (WT) cancer cells, which is linked to the acquisition of a YAP1-dependent fetal phenotype. Cells displaying this phenotype exhibit high tumor-initiating and metastatic activity. Nuclear YAP1 and fetal traits are present in a proportion of tumors at diagnosis and predict poor prognosis in patients carrying TP53 WT CRC tumors. We provide data indicating the higher efficacy of CT together with YAP1 inhibitors for eradication of therapy resistant TP53 WT cancer cells. Together these results identify fetal conversion as a useful biomarker for patient prognosis and therapy prescription. The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic activity and poor prognosis in patients

FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors

Grants PI05/0961 and PI06/1513 from Ministerio de Sanidad y Consumo ISCIII and RTICC 06/0020/1