La resignificación del jardín hospitalario en la dinámica territorial de Buenos Aires

El Hospital Muñiz presta su servicio público de salud a miles de pacientes en la Ciudad Autónoma de Buenos Aires desde hace más de un siglo. La institución esta conformada por un sistema de pabellones y áreas verdes a modo de jardines que la caracteriza y confiere al conjunto rasgos distintivos en el ámbito urbano. En la actualidad, estos espacios carecen de acciones que los valoricen, poniendo en evidencia contrastes entre los actores sociales que vivencian el lugar y la puja de intereses a escala local y global. En tal sentido, en el marco de una experiencia pedagógica con alumnos de la carrera de Licenciatura en Planificación y Diseño del Paisaje de la Universidad de Buenos Aires en el año 2012, nos proponemos, a través de explorar fuentes bibliográficas de las ciencias sociales y los resultados de encuestas a la comunidad hospitalaria respecto a las áreas verdes mencionadas; analizar la intervención higienista en el proceso de producción del jardín hospitalario en el contexto urbano, examinar las prácticas sociales vigentes en el jardín del Muñiz y exponer algunas consideraciones relacionadas con su gestión, que contemplen su resignificación en la organización territorial.The Muñiz Hospital lends its public health service to thousands of patients in the Autonomous City of Buenos Aires for over a century. The institution is comprised of a system of flags and green areas as a garden that characterizes and gives the distinctive features set in urban environments. At present, these areas lack shares recover them, putting in evidence contrasts between social actors who experience the place and bid interests locally and globally. In this regard, within the framework of an educational experience with students of the Bachelor of Landscape Planning and Design of the University of Buenos Aires in 2012, we intend to explore through literature sources in the social sciences and survey results to the hospital community on the above green areas; analyze the hygienist intervention in the production process of the hospital garden in the urban context, examine the existing social practices in the garden of Muñiz and present some considerations related to management, addressing its signification in the territorial organization.Eje 2: Forma y estructura urbana, organización del territorio, orientación del crecimiento.Facultad de Arquitectura y Urbanism

La resignificación del jardín hospitalario en la dinámica territorial de Buenos Aires

El Hospital Muñiz presta su servicio público de salud a miles de pacientes en la Ciudad Autónoma de Buenos Aires desde hace más de un siglo. La institución esta conformada por un sistema de pabellones y áreas verdes a modo de jardines que la caracteriza y confiere al conjunto rasgos distintivos en el ámbito urbano. En la actualidad, estos espacios carecen de acciones que los valoricen, poniendo en evidencia contrastes entre los actores sociales que vivencian el lugar y la puja de intereses a escala local y global. En tal sentido, en el marco de una experiencia pedagógica con alumnos de la carrera de Licenciatura en Planificación y Diseño del Paisaje de la Universidad de Buenos Aires en el año 2012, nos proponemos, a través de explorar fuentes bibliográficas de las ciencias sociales y los resultados de encuestas a la comunidad hospitalaria respecto a las áreas verdes mencionadas; analizar la intervención higienista en el proceso de producción del jardín hospitalario en el contexto urbano, examinar las prácticas sociales vigentes en el jardín del Muñiz y exponer algunas consideraciones relacionadas con su gestión, que contemplen su resignificación en la organización territorial.The Muñiz Hospital lends its public health service to thousands of patients in the Autonomous City of Buenos Aires for over a century. The institution is comprised of a system of flags and green areas as a garden that characterizes and gives the distinctive features set in urban environments. At present, these areas lack shares recover them, putting in evidence contrasts between social actors who experience the place and bid interests locally and globally. In this regard, within the framework of an educational experience with students of the Bachelor of Landscape Planning and Design of the University of Buenos Aires in 2012, we intend to explore through literature sources in the social sciences and survey results to the hospital community on the above green areas; analyze the hygienist intervention in the production process of the hospital garden in the urban context, examine the existing social practices in the garden of Muñiz and present some considerations related to management, addressing its signification in the territorial organization.Eje 2: Forma y estructura urbana, organización del territorio, orientación del crecimiento.Facultad de Arquitectura y Urbanism

La resignificación del jardín hospitalario en la dinámica territorial de Buenos Aires

El Hospital Muñiz presta su servicio público de salud a miles de pacientes en la Ciudad Autónoma de Buenos Aires desde hace más de un siglo. La institución esta conformada por un sistema de pabellones y áreas verdes a modo de jardines que la caracteriza y confiere al conjunto rasgos distintivos en el ámbito urbano. En la actualidad, estos espacios carecen de acciones que los valoricen, poniendo en evidencia contrastes entre los actores sociales que vivencian el lugar y la puja de intereses a escala local y global. En tal sentido, en el marco de una experiencia pedagógica con alumnos de la carrera de Licenciatura en Planificación y Diseño del Paisaje de la Universidad de Buenos Aires en el año 2012, nos proponemos, a través de explorar fuentes bibliográficas de las ciencias sociales y los resultados de encuestas a la comunidad hospitalaria respecto a las áreas verdes mencionadas; analizar la intervención higienista en el proceso de producción del jardín hospitalario en el contexto urbano, examinar las prácticas sociales vigentes en el jardín del Muñiz y exponer algunas consideraciones relacionadas con su gestión, que contemplen su resignificación en la organización territorial.The Muñiz Hospital lends its public health service to thousands of patients in the Autonomous City of Buenos Aires for over a century. The institution is comprised of a system of flags and green areas as a garden that characterizes and gives the distinctive features set in urban environments. At present, these areas lack shares recover them, putting in evidence contrasts between social actors who experience the place and bid interests locally and globally. In this regard, within the framework of an educational experience with students of the Bachelor of Landscape Planning and Design of the University of Buenos Aires in 2012, we intend to explore through literature sources in the social sciences and survey results to the hospital community on the above green areas; analyze the hygienist intervention in the production process of the hospital garden in the urban context, examine the existing social practices in the garden of Muñiz and present some considerations related to management, addressing its signification in the territorial organization.Eje 2: Forma y estructura urbana, organización del territorio, orientación del crecimiento.Facultad de Arquitectura y Urbanism

Differentiation of Effector/Memory Vδ2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites

Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and mount both immediate effector functions and memory responses after microbial infection. However, how Vδ2 T cells mediate different facets of a memory response remains unknown. Here, we show that the expression of CD45RA and CD27 antigens defines four subsets of human Vδ2 T cells with distinctive compartmentalization routes. Naive CD45RA+CD27+ and memory CD45RA−CD27+ cells express lymph node homing receptors, abound in lymph nodes, and lack immediate effector functions. Conversely, memory CD45RA−CD27− and terminally differentiated CD45RA+CD27− cells, which express receptors for homing to inflamed tissues, are poorly represented in the lymph nodes while abounding at sites of inflammation, and display immediate effector functions. These observations and additional in vitro experiments indicate a lineage differentiation pattern for human Vδ2 T cells that generates naive cells circulating in lymph nodes, effector/memory cells patrolling the blood, and terminally differentiated effector cells residing in inflamed tissues

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection

D6 is a decoy and scavenger receptor for inflammatory CC chemokines. D6-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis. The death of D6−/− mice was associated with a dramatic local and systemic inflammatory response with levels of M. tuberculosis colony-forming units similar to control D6-proficient mice. D6-deficient mice showed an increased numbers of mononuclear cells (macrophages, dendritic cells, and CD4 and CD8 T lymphocytes) infiltrating inflamed tissues and lymph nodes, as well as abnormal increased concentrations of CC chemokines (CCL2, CCL3, CCL4, and CCL5) and proinflammatory cytokines (tumor necrosis factor α, interleukin 1β, and interferon γ) in bronchoalveolar lavage and serum. High levels of inflammatory cytokines in D6−/− infected mice were associated with liver and kidney damage, resulting in both liver and renal failure. Blocking inflammatory CC chemokines with a cocktail of antibodies reversed the inflammatory phenotype of D6−/− mice but led to less controlled growth of M. tuberculosis. Thus, the D6 decoy receptor plays a key role in setting the balance between antimicrobial resistance, immune activation, and inflammation in M. tuberculosis infection

Tuning inflammation in tuberculosis: the role of decoy receptors

Decoy receptors are "silent scavengers" of CC chemokines and cytokines, which play a key role in damping inflammation and tissue damage. In this review we discuss on recent findings demonstrating that these receptors set the balance between antimicrobial resistance, immune activation and inflammatory response in Mycobacterium tuberculosis infection

Terrestrial species adapted to sea dispersal: Differences in propagule dispersal of two Caribbean mangroves

A central goal of comparative phylogeography is to understand how species‐specific traits interact with geomorphological history to govern the geographic distribution of genetic variation within species. One key biotic trait with an immense impact on the spatial patterns of intraspecific genetic differentiation is dispersal. Here, we quantify how species‐specific traits directly related to dispersal affect genetic variation in terrestrial organisms with adaptations for dispersal by sea, not land—the mangroves of the Caribbean. We investigate the phylogeography of white mangroves (Laguncularia racemosa, Combretaceae) and red mangroves (Rhizophora mangle, Rhizophoraceae) using chloroplast genomes and nuclear markers (thousands of RAD‐Seq loci) from individuals throughout the Caribbean. Both coastal tree species have viviparous propagules that can float in salt water for months, meaning they are capable of dispersing long distances. Spatially explicit tests of the role of ocean currents on patterning genetic diversity revealed that ocean currents act as a mechanism for facilitating dispersal, but other means of moving genetic material are also important. We measured pollen‐ vs. propagule‐mediated gene flow and discovered that in white mangroves, seeds were more important for promoting genetic connectivity between populations, but in red mangroves, the opposite was true: pollen contributed more. This result challenges our concept of the importance of both proximity to ocean currents for moving mangrove seeds and the extent of long‐distance pollen dispersal. This study also highlights the importance of spatially explicit quantification of both abiotic (ocean currents) and biotic (dispersal) factors contributing to gene flow to understand fully the phylogeographic histories of species.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146564/1/mec14894-sup-0003-FigS3.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146564/2/mec14894-sup-0001-FigS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146564/3/mec14894_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146564/4/mec14894.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146564/5/mec14894-sup-0002-FigS2.pd

Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

CD8 T-cells contribute to control of Mycobacterium tuberculosis infection, but little is known about the quality of the CD8 T-cell response in subjects with latent infection and in patients with active tuberculosis disease. CD8 T-cells recognizing epitopes from 6 different proteins of Mycobacterium tuberculosis were detected by tetramer staining. Intracellular cytokines staining for specific production of IFN-γ and IL-2 was performed, complemented by phenotyping of memory markers on antigen-specific CD8 T-cells. The ex-vivo frequencies of tetramer-specific CD8 T-cells in tuberculous patients before therapy were lower than in subjects with latent infection, but increased at four months after therapy to comparable percentages detected in subjects with latent infection. The majority of CD8 T-cells from subjects with latent infection expressed a terminally-differentiated phenotype (CD45RA+CCR7−). In contrast, tuberculous patients had only 35% of antigen-specific CD8 T-cells expressing this phenotype, while containing higher proportions of cells with an effector memory- and a central memory-like phenotype, and which did not change significantly after therapy. CD8 T-cells from subjects with latent infection showed a codominance of IL-2+/IFN-γ+ and IL-2−/IFN-γ+ T-cell populations; interestingly, only the IL-2+/IFN-γ+ population was reduced or absent in tuberculous patients, highly suggestive of a restricted functional profile of Mycobacterium tuberculosis-specific CD8 T-cells during active disease. These results suggest distinct Mycobacterium tuberculosis specific CD8 T-cell phenotypic and functional signatures between subjects which control infection (subjects with latent infection) and those who do not (patients with active disease)

Energy Resolution Performance of the CMS Electromagnetic Calorimeter

The energy resolution performance of the CMS lead tungstate crystal electromagnetic calorimeter is presented. Measurements were made with an electron beam using a fully equipped supermodule of the calorimeter barrel. Results are given both for electrons incident on the centre of crystals and for electrons distributed uniformly over the calorimeter surface. The electron energy is reconstructed in matrices of 3 times 3 or 5 times 5 crystals centred on the crystal containing the maximum energy. Corrections for variations in the shower containment are applied in the case of uniform incidence. The resolution measured is consistent with the design goals