268 research outputs found

    A proposal to enhance job offers to modern languages students

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    A proposal to enhance job offers to Modern Languages students was an idea that was born back on 2012 during our first cycle at ECCI University; the idea was growing up and developing during our years of studies, thanks to conversations with students and businessmen besides with our job experience. We used descriptive research, to identify characteristics of the population (students and degrees) and situation (job offer). Through this job we went deep into opinions, expectations and facts in order to suggest ways to enhance job offers for students and degrees of Modern Languages from ECCI University.INTRODUCTION AND BACKGROUND INFORMATION Title of the Project Background Information RAISING AN ISSUE JUSTIFICATION General objective: Specific objectives: CHAPTER 2 THEORETICAL FRAMEWORK State of Art Theoretical Framework CHAPTER 3 METHODOLOGY CHAPTER 4 DATA ANALYSIS CHAPTER 5 CONCLUSIONS RECOMMENDATIONS REFERENCES WEBGRAPHY LIST OF ILLUSTRATIONPregradoProfesional en Lenguas ModernasLenguas Moderna

    Application of Nucleic Acid Aptamers to Viral Detection and Inhibition

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    Nucleic acid aptamers are small oligonucleotides that specifically bind to other molecules through noncovalent interactions that rely on complex tridimensional structural arrangements. Aptamers are generated through the iterative in vitro selection method called SELEX, resulting in specific binding against a wide variety of molecular targets including viruses. Because aptamers are obtained in vitro and can be synthetically produced, they have been envisioned as future diagnostic and therapeutic tools for human diseases including virus-borne pathologies. Aptamers have been isolated against a number of viruses including pandemic influenza virus, human papillomavirus and hepatitis C virus. Although aptamers have proven themselves as extremely sensitive detection tools triggering the development of affordable and highly diagnostic methods, their use as therapeutic moieties has been hampered by biostability, delivery and pharmacodynamical issues. Nevertheless, a new generation of chemically modified aptamers shows promise for the coming of age of protein-targeted noncatalytic oligonucleotides for the therapy of viral disease. The present review focuses on the most successful antiviral aptamers reported and includes a description of some of the novel methods developed for their use as diagnostic and therapeutic tool

    Relationship Between Self-Perceived Health, Vitality, and Posttraumatic Growth in Liver Transplant Recipients

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    Our objective was to analyze the differences in posttraumatic growth in 240 liver transplant recipients based on two factors. First, self-perceived health: better (Group 1 = G1) and worse (Group 2 = G2). Second, vitality: more (Group 3 = G3) and less (Group 4 = G4). The Posttraumatic Growth Inventory, SF-36 Health Survey (Item 2) and SF-12 Health Survey (vitality dimension) were used. Firstly, analyzing main effects recipients with better (G1) compared to worse (G2) self-perceived health, showed greater posttraumatic growth. Interaction effects were found on essential posttraumatic growth domains such as new possibilities (p = 0.040), personal strength (p = 0.027), and appreciation of life (p = 0.014). Statistically significant differences showed that among transplant recipients with worse self-perceived health (G2), those with more vitality had higher levels on abovementioned posttraumatic growth dimensions. However, in transplant recipients with better self-perceived health (G1) respective dimensions were not significantly influenced by the level of vitality. Among the recipients with less vitality (G4), those with better self-perceived health showed higher scores on abovementioned posttraumatic growth dimensions. We conclude that positive self-perceived health might compensate for a lack of vitality as well as a high level of vitality may compensate for negative self-perceived health regarding the development of crucial aspects of posttraumatic growth after liver transplantation.Ministerio de Economía y Competitividad de España PSI2014-51950-

    African swine fever virus assembles a single membrane derived from rupture of the endoplasmic reticulum

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    Collective evidence argues that two members of the nucleocytoplasmic large DNA viruses (NCLDVs) acquire their membrane from open membrane intermediates, postulated to be derived from membrane rupture. We now study membrane acquisition of the NCLDV African swine fever virus. By electron tomography (ET), the virion assembles a single bilayer, derived from open membrane precursors that collect as ribbons in the cytoplasm. Biochemically, lumenal endoplasmic reticulum (ER) proteins are released into the cytosol, arguing that the open intermediates are ruptured ER membranes. ET shows that viral capsid assembles on the convex side of the open viral membrane to shape it into an icosahedron. The viral capsid is composed of tiny spikes with a diameter of ∼5nm, connected to the membrane by a 6nm wide structure displaying thin striations, as observed by several complementary electron microscopy imaging methods. Immature particles display an opening that closes after uptake of the viral genome and core proteins, followed by the formation of the mature virion. Together with our previous data, this study shows a common principle of NCLDVs to build a single internal envelope from open membrane intermediates. Our data now provide biochemical evidence that these open intermediates result from rupture of a cellular membrane, the ER. © 2015 John WileyDeutsche Forschungsgemeinschaft personal grant KR2173 to Jacomine Krijnse Locker. German Andres is supported by the ‘Amarouto Program for senior scientists from the Comunidad Autónoma de Madrid’ and by grants BFU2009-08085 and AGL2013-48998-C2- 2-R from the Spanish Ministerio de Economía y CompetitividadPeer Reviewe

    Laser dosimetry planning tool for colonoscopic tumor resection

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    Gastrointestinal tumoral pathologies are quite common nowadays. Diseases such as gastric antral vascular ectasia (GAVE) or actinic proctitis may require endoscopic surgery. Argon Plasma Coagulated (APC) or radiofrequency are usually employed. However, they present disadvantages, such as the reduced treated area, magnetic resonance incompatibility, or an uncontrolled ablation depth. Optical surgery could avoid these problems and contribute to a better and controlled treatment result, either ablative or coagulative, in a minimally invasive, non-contact and non-ionizing way. The treatment area could also be increased by adequate optical fiber probe design. In this work laser surgery is analyzed for resection of colonic tumors. A Monte Carlo model is employed to study optical propagation, and an optical ablation approach allows the estimation of the resected volume. The ablation approach is based on plasma-induced ablation, particularly taking into account the freeelectron density generated in the tissue by the pulsed optical source. Several wavelengths, radii and malignant tissue types are considered, either healthy, adenomatous or even coagulated tissues. Optimum source parameters as a function of tumor geometry can be estimated for treatment planning.This work has been partially supported by the project MAT2012-38664-C02-01 of the Spanish Ministery of Economy and Competitiveness and by San Cándido Foundation

    Inverse malthusianism and recycling economics: the case of the textile industry

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    The current use of natural resources in the textile industry leads us to introduce a new economic concept called inverse Malthusianism describing a context in which population grows linearly and resource consumption grows exponentially. Inverse Malthusianism implies an exponential increase in environmental impact that recycling may contribute to reduce. Our main goal is to extend the analysis of materials selection under the principle of equimarginality proposed by Jevons. As a first result, we show the particular circumstances under which policies excluding recycled supplies are never optimal. We also aim to overcome the difficulties of reducing environmental aspects to monetary units. To this end, we propose a multicriteria approach to solve the conventional-recycled materials dilemma considering not only economic but also environmental criteria. Then, we allow producers to enrich their decision-making process with relevant information about the environmental impact of materials selection. Although we use examples of the textile industry to illustrate our results, most of the insights in this paper can be extended to other industries

    Aspectos biogeográficos y ecológicos del género Quercus (Fagaceae) en Michoacán, México

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    Background and Aims:Michoacan is a state with high biodiversity. Taxonomic studies estimate that there are 30 to 37 species of oak in the state; however, there is scarce information about their distribution patterns. In this study, the geographic and ecological distribution patterns of the genus, and its two sections, composed of 33 species (1734 records), were analyzed at municipality level; topographic, climatic, edaphic, and ecological data are included.Methods: Indices of richness, rarity and irreplaceability were calculated to obtain the distribution patterns at the municipal level of genus and both sections. Cluster analyses were performed to identify patterns of geographic, ecologic and elevational distribution of the species. It was tested whether any environmental gradient explains the distributional patterns.Key results: The highest specific richness of the Quercus genus is located in the Trans-Mexican Volcanic Belt (TMVB) and Sierra Madre del Sur (SMS), where humid and subhumid temperate environments are prevalent; the highest rareness occurred in the east-northeast of the TMVB. With respect to elevation, section Quercus shows larger distribution ranges than section Lobatae. Based on elevation, the oaks can be classified into low (600-1900 m a.s.l.) and high mountains (2000-3100 m a.s.l.) with a strong turnover of species between 1900-2000 m a.s.l. Five groups of species are identified, based on their environmental similarity, which coincide with physiographic regions.Conclusions: The municipal richness of oaks is correlated with topographic and aridity heterogeneity at the generic level, mainly in the Lobatae section. Considering that greater environmental heterogeneity corresponds to a greater diversity of species, it is recommended to increase the sampling effort in municipalities that have greater environmental heterogeneity. Intensive fieldwork in the SMS is suggested. There are still unresolved taxonomic problems that should be studied in detail.Antecedentes y Objetivos: Michoacán es un estado de alta biodiversidad. Estudios taxonómicos estiman que existen de 30 a 37 especies de encinos en el estado; sin embargo, es incipiente la información sobre sus patrones de distribución. En este estudio, se analizaron los patrones de distribución geográfica y ecológica del género, y de sus dos secciones, compuesto por 33 especies (1734 registros), a nivel municipal; se incluye información topográfica, climática, edáfica y ecológica.Métodos: Se calcularon índices de riqueza, rareza e irremplazabilidad para obtener los patrones de distribución municipal del género y de ambas secciones. Se realizaron análisis de agrupamiento para identificar patrones de distribución geográfica, ecológica y altitudinal. Se probó si algún gradiente ambiental explica los patrones de distribución.Resultados clave: En la Faja Volcánica Transmexicana (FVTM) y en la Sierra Madre del Sur (SMS) se localiza la mayor riqueza específica del género Quercus, donde predominan climas templados húmedos a subhúmedos; el centro de mayor rareza estatal se encuentra en el este-noreste de la FVTM. En relación con la altitud, las especies de la sección Quercus tienen amplios intervalos de distribución en comparación con las de la sección Lobatae. La composición de encinos difiere en áreas de baja (600-1900 m s.n.m.) y alta montaña (2000-3100 m s.n.m.) con un recambio importante de especies entre 1900-2000 m s.n.m. Se identifican cinco grupos de especies, con base en su similitud ambiental, que coinciden con regiones fisiográficas.Conclusiones: La riqueza municipal de encinos está correlacionada de manera positiva con la heterogeneidad topográfica y de aridez, principalmente en la sección Lobatae. Considerando que a mayor heterogeneidad ambiental corresponde mayor riqueza de especies, se recomienda aumentar el esfuerzo de muestreo en municipios que tienen una amplia heterogeneidad ambiental. Se sugiere, además, un intenso trabajo de campo en la SMS. Aún hay problemas taxonómicos que deberían ser estudiados detalladamente

    Analysis of radiation parameters to control the effects of Nd: YAG laser surgery on gastric malignancies

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    Endoscopic laser surgery provides an advantageous alternative to Argon Plasma Coagulation, endoscopic tweezers or electro-ablation in gastroenterology that facilitates a selective ablation of stomach tumors with an additional hemostatic effect in the surrounding tissue. This coagulation effect can also be employed for the treatment of gastric ulcers. It is mandatory to control the laser parameters regardless of the desired effect, either cancerous tissue ablation or coagulation to prevent ulcerous bleeding, in order to avoid stomach wall perforation or an insufficient therapeutic outcome. Dosimetric models constitute an attractive tool to determine the proper light dose in order to offer a customized therapy planning that optimizes the treatment results. In this work, a model for Nd:YAG laser surgery is applied to predict both the coagulation zone in gastric ulcers and the removal in adenocarcinomas under different laser setups. Results show clear differences in the effective zone of the gastric malignancy affected by both coagulation and ablation. Therefore the current model could be employed in the clinical practice to plan the optimal laser beam parameters to treat a certain type of pathologic stomach tissue with variable morphology and without risk of perforation or undertreated parts.This work has been partially supported by the project MAT2012-38664-C02-01 of the Spanish Ministery of Economy and Competitiveness

    Murine typhus in Mexico City: report of an imported case

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    Murine typhus is endemic in several countries. We herein report an imported case of murine typhus caused by Rickettsia typhi in Mexico City. This is the first report of a case after almost 20 years since the last report. The species was confirmed by DNA sequencing and phylogenetic reconstruction

    Motivadores de ingreso y permanencia en un grupo de excombatientes de las Fuerzas Armadas Revolucionarias de Colombia (FARC)

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    El presente estudio identificó en nueve excombatientes de las Fuerzas Armadas Revolucionarias de Colombia (FARC), los motivadores de ingreso y la percepción actual de estos, a través de una metodología cualitativa, con un diseño fenomenológico y por medio de entrevistas semiestructuradas. Se analizaron los datos mediante el establecimiento de categorías : la influencia de las redes de apoyo, la ideología política, las motivaciones socio económicas, la curiosidad y la venganza. En lo que respecta a las percepciones actuales de esos motivadores, se encontró que, en la mayoría de los casos, los excombatientes consideran que sus razones fueron las adecuadas, y que fue la apropiación de la ideología política lo que favoreció su permanencia en las filas. Se identificó una categoría emergente sobre el Acuerdo de paz y reincorporación. Finalmente se determinó que en el ingreso al grupo armado se encuentra que no existen categorías puras en tanto se relacionan entre ellas.The purpose of this study was to identify the motives of 9 ex combatants of the Revolutionary Army Forces of Colombia (Farc), regarding the reasons to join the group and the present perception of this motives. Through a qualitative methodology with a phenomenological design and using semi structured interviews. The data was analyzed by establishing categories: the influence of support network, political ideology, socio economics motivation, curiosity and vengeance. Regarding to the actual perceptions of this motives, it was found that in most cases, the ex combatants considerate that their reasons were adequate, and that the political ideology favors the permanency in the group. Also an emerging category about the peace process and reincorporation was identified. Finally, it was determined that there are no pure categories but they all are connected between them.Psicólogo (a)Pregrad
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