Backwards by Design Project Assessment Write-Up

In Fall 2012, I taught Phil 355: Aesthetics and the Philosophy of Art. I used this course as an opportunity to test a new pedagogical technique. I will call this pedagogical technique the Incremental Exercises Model (IEM). Below, I will quickly summarize the course and its learning goals. Second, I will explain my previous method of meeting these learning goals. Third, I will explain IEM and how I implemented it in this particular class. Finally, I will provide some concluding observations about the successes and failures of this technique

Assessment Project Write-Up: Phil 112, Ethical Question Activity

I regularly teach Phil 112: Introduction to Moral Issues. This is a 100-level, 3 credit hour course that is intended to introduce students to philosophy in general and the study of ethics in particular. One of the most significant goals I have for the course is getting students to understand how to engage in ethical inquiry. I don’t want them to learn just the content of ethical theories that other people have previously developed; I want them to develop the skills that will permit them to engage in ethical inquiry themselves. The most significant threshold concepts covered in this class are those associated with the skill of inquiring

From High School to College: Teachers and Students Assess the Impact of an Expository Reading and Writing Course on College Readiness

The study aimed to examine teachers’ and students’ views on the impact of the Expository Reading and Writing Course (ERWC) on students’ college readiness and on teaching practices. Literature in the areas of college readiness, critiques of the English curriculum at the secondary level, and a review of research on the effects of ERWC are summarized. The mixed-methods study used a teacher survey, teacher interviews, and student focus groups. Findings showed that teachers reported making numerous changes and improvements in their teaching as a result of attending a professional development program and also reported making changes in other courses. Teachers found that ERWC helped student engagement, motivation, and learning and helped prepare students for college. Students reported learning strategies in the class that they transfer and apply in other classes. Using ERWC materials can strengthen participating teachers’ instruction and participating students’ learning

Arrival of Paleo-Indians to the Southern Cone of South America: New Clues from Mitogenomes

With analyses of entire mitogenomes, studies of Native American mitochondrial DNA (mtDNA) variation have entered the final phase of phylogenetic refinement: the dissection of the founding haplogroups into clades that arose in America during and after human arrival and spread. Ages and geographic distributions of these clades could provide novel clues on the colonization processes of the different regions of the double continent. As for the Southern Cone of South America, this approach has recently allowed the identification of two local clades (D1g and D1j) whose age estimates agree with the dating of the earliest archaeological sites in South America, indicating that Paleo-Indians might have reached that region from Beringia in less than 2000 years. In this study, we sequenced 46 mitogenomes belonging to two additional clades, termed B2i2 (former B2l) and C1b13, which were recently identified on the basis of mtDNA control-region data and whose geographical distributions appear to be restricted to Chile and Argentina. We confirm that their mutational motifs most likely arose in the Southern Cone region. However, the age estimate for B2i2 and C1b13 (11–13,000 years) appears to be younger than those of other local clades. The difference could reflect the different evolutionary origins of the distinct South American-specific sub-haplogroups, with some being already present, at different times and locations, at the very front of the expansion wave in South America, and others originating later in situ, when the tribalization process had already begun. A delayed origin of a few thousand years in one of the locally derived populations, possibly in the central part of Chile, would have limited the geographical and ethnic diffusion of B2i2 and explain the present-day occurrence that appears to be mainly confined to the Tehuelche and Araucanian-speaking grou

Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague–Dawley and Long–Evans rats

Prepulse inhibition (PPI) of startle is a measure of sensorimotor gating that is heritable and deficient in certain psychiatric disorders, including schizophrenia. Sprague–Dawley (SD) rats are more sensitive to PPI disruptive effects of dopamine (DA) agonists at long interstimulus intervals (60–120 ms) and less sensitive to their PPI-enhancing effects at short (10–30 ms), compared with Long–Evans (LE) rats. These heritable strain differences in sensitivity to the PPI disruptive effects of DA agonists must ultimately reflect neural changes "downstream" from forebrain DA receptors. The current study evaluated the effects of the DA agonist, apomorphine (APO), on ventral pallidal (VP) gamma-aminobutyric acid (GABA) and glutamate efflux and PPI in SD and LE rats. PPI was tested in SD and LE rats after vehicle or APO (0.5 mg/kg, subcutaneously (s.c.)) in a within-subject design. In different SD and LE rats, VP dialysate was collected every 10 min for 120 min after vehicle or APO (0.5 mg/kg, s.c.) and analyzed for GABA and glutamate content by capillary electrophoresis (CE) coupled with laser-induced fluorescence (LIF). As predicted, SD rats exhibited greater APO-induced PPI deficits at long intervals and less APO-induced PPI enhancement at short intervals compared to LE rats. APO significantly reduced VP GABA efflux in SD but not in LE rats; glutamate efflux was unaffected in both strains. Heritable strain differences in PPI APO sensitivity in SD vs LE rats parallel, and may be mediated by, strain differences in the VP GABA efflux

An alternative model for the early peopling of Southern South America revealed by analyses of three mitochondrial DNA haplogroups

After several years of research, there is now a consensus that America was populated from Asia through Beringia, probably at the end of the Pleistocene. But many details such as the timing, route(s), and origin of the first settlers remain uncertain. In the last decade genetic evidence has taken on a major role in elucidating the peopling of the Americas. To study the early peopling of South America, we sequenced the control region of mitochondrial DNA from 300 individuals belonging to indigenous populations of Chile and Argentina, and also obtained seven complete mitochondrial DNA sequences. We identified two novel mtDNA monophyletic clades, preliminarily designated B2l and C1b13, which together with the recently described D1g sub-haplogroup have locally high frequencies and are basically restricted to populations from the extreme south of South America. The estimated ages of D1g and B2l, about ∼ 15,000 years BP, together with their similar population dynamics and the high haplotype diversity shown by the networks, suggests that they probably appeared soon after the arrival of the first settlers and agrees with the dating of the earliest archaeological sites in South America (Monte Verde, Chile, 14,500 BP). One further sub-haplogroup, D4h3a5, appears to be restricted to Fuegian-Patagonian populations and reinforces our hypothesis of the continuity of the current Patagonian populations with the initial founders. Our results indicate that the extant native populations inhabiting South Chile and Argentina are a group which had a common origin, and suggest a population break between the extreme south of South America and the more northern part of the continent. Thus the early colonization process was not just an expansion from north to south, but also included movements across the Andes.Instituto Multidisciplinario de Biología Celula

Direct Dates and mtDNA of Late Pleistocene Human Skeletons from South America: A Comment on Chatters et al. (2014)

In a recent paper in the journal Science (2014, Vol. 344, pp. 750–754), J. Chatters et al. present a new early human skeleton from the Yucatan, Mexico, considering it in the context of eight other early “Paleoamerican” individuals—all from North America—that previously yielded ancient genetic evidence and/or direct radiocarbon ages. Despite including the archaeological site of Monte Verde II, Chile, in their discussion, we were alarmed that the authors otherwise ignored the South American record, presenting a map with the southern continent being devoid of PaleoAmerican human remains. We felt it important to remind our colleagues that South America has produced numerous directly dated human skeletal remains that are as old as the ones cited by Chatters et al. for North America, and that several of these have actually yielded mitochondrial (mt) DNA. Significant implications can be derived from this radiocarbon, bioanthropological, and mtDNA dataset, especially considering the antiquity of the earliest human populations and process of peopling of the New World.Facultad de Ciencias Naturales y Muse