CO Emission in Low Luminosity, HI Rich Galaxies

We present 12CO 1-0 observations of eleven low luminosity M_B > -18), HI--rich dwarf galaxies. Only the three most metal-rich galaxies, with 12+log(O/H) ~ 8.2, are detected. Very deep CO spectra of six extremely metal-poor systems (12+log(O/H) < 7.5) yield only low upper limits on the CO surface brightness, I_CO < 0.1 K km/s. Three of these six have never before been observed in a CO line, while the others now have much more stringent upper limits. For the very low metallicity galaxy Leo A, we do not confirm a previously reported detection in CO, and the limits are consistent with another recent nondetection. We combine these new observations with data from the literature to form a sample of dwarf galaxies which all have CO observations and measured oxygen abundances. No known galaxies with 12+log(O/H) < 7.9 (Z < 0.1 solar) have been detected in CO. Most of the star-forming galaxies with higher (12+log(O/H) > 8.1) metallicities are detected at similar or higher I_CO surface brightnesses. The data are consistent with a strong dependence of the I_CO/M_H_2 = X_CO conversion factor on ambient metallicity. The strikingly low upper limits on some metal-poor galaxies lead us to predict that the conversion factor is non-linear, increasing sharply below approximately 1/10 of the solar metallicity (12+log(O/H) < 7.9).Comment: 25 pages, 4 figures, 3 tables. Accepted for publication in AJ Tables replaced -- now formated for landscape orientatio

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Intrinsic tumour suppression

Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically