THE PERFORMING ARTS AND PSYCHOLOGICAL WELL-BEING

Although psychotropic drugs have been hailed as, \u27One of the success stories of modern psychiatry\u27 the prescribing of these medicines has not been without commotion, concern and controversy. Moreover, the President of the World Psychiatry Association Professor Dinesh Bhugra and colleagues, after conducting a recent large-scale study (n=25,522) on psychiatric morbidity in the UK, collectively issued the clarion call that, \u27The mental health of the nation was unlikely to be improved by treatment with psychotropic medication alone\u27. The provision of mental healthcare services may likely benefit from a holistic approach that includes a variety of treatment options that prioritizes patient safety and preference. The performing arts is gaining popularity among service users as an adjunctive form of treatment for mental illness. There is a growing body of evidence that provisionally supports the claim that art therapy, \u27Possesses the power to heal psychological wounds\u27. The North American Drama Therapy Association defines drama therapy as, \u27The intentional use of drama and/or theatre processes to achieve therapeutic goals\u27 and that it is \u27active and experiential\u27. This review article discusses and describes the merits of dramatherapy and how this treatment modality can contribute to a patient\u27s recovery from psychological distress

A novel driver emotion recognition system based on deep ensemble classification

Driver emotion classification is an important topic that can raise awareness of driving habits because many drivers are overconfident and unaware of their bad driving habits. Drivers will acquire insight into their poor driving behaviors and be better able to avoid future accidents if their behavior is automatically identified. In this paper, we use different models such as convolutional neural networks, recurrent neural networks, and multi-layer perceptron classification models to construct an ensemble convolutional neural network-based enhanced driver facial expression recognition model. First, the faces of the drivers are discovered using the faster region-based convolutional neural network (R-CNN) model, which can recognize faces in real-time and offline video reliably and effectively. The feature-fusing technique is utilized to integrate the features extracted from three CNN models, and the fused features are then used to train the suggested ensemble classification model. To increase the accuracy and efficiency of face detection, a new convolutional neural network block (InceptionV3) replaces the improved Faster R-CNN feature-learning block. To evaluate the proposed face detection and driver facial expression recognition (DFER) datasets, we achieved an accuracy of 98.01%, 99.53%, 99.27%, 96.81%, and 99.90% on the JAFFE, CK+, FER-2013, AffectNet, and custom-developed datasets, respectively. The custom-developed dataset has been recorded as the best among all under the simulation environment

Genotypic determinants of fluoroquinolone and macrolide resistance in Neisseria gonorrhoeae.

Background:High rates of antimicrobial resistance (AMR) in Neisseria gonorrhoeae hinder effective treatment, but molecular AMR diagnostics may help address the challenge. This study aimed to appraise the literature for resistance-associated genotypic markers linked to fluoroquinolones and macrolides, to identify and review their use in diagnostics. Methods: Medline and EMBASE databases were searched and data pooled to evaluate associations between genotype and phenotypic resistance. The minimum inhibitory concentration (MIC) cut-offs were ≤ 0.06 mg L-1 for non-resistance to ciprofloxacin and ≤ 0.5 mg L-1 for non-resistance to azithromycin. Results: Diagnostic accuracy estimates were limited by data availability and reporting. It was found that: 1) S91 and D95 mutations in the GyrA protein independently predicted ciprofloxacin resistance and, used together, gave 98.6% (95% confidence interval (CI) 98.0-99.0%) sensitivity and 91.4% (95%CI 88.6-93.7%) specificity; 2) the number of 23S rRNA gene alleles with C2611T or A2059G mutations was highly correlated with azithromycin resistance, with mutation in any allele giving a sensitivity and specificity of 66.1% (95%CI 62.1-70.0%) and 98.9% (95%CI 97.5-99.5%) respectively. Estimated negative (NPV) and positive predictive values (PPV) for a 23S rRNA diagnostic were 98.6% (95%CI 96.8-99.4%) and 71.5% (95%CI 68.0-74.8%) respectively; 3) mutation at amino acid position G45 in the MtrR protein independently predicted azithromycin resistance; however, when combined with 23S rRNA, did not improve the PPV or NPV. Conclusions: Viable candidates for markers of resistance detection for incorporation into diagnostics were demonstrated. Such tests may enhance antibiotic stewardship and treatment options

Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature

<p>Abstract</p> <p>Background</p> <p>Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.</p> <p>Methods</p> <p>We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials.</p> <p>Results and discussion</p> <p>Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.</p> <p>Conclusion</p> <p>The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.</p

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation &lt;92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p&lt;0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p&lt;0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

KNOWLEDGE SHARING AND UTILIZATION IN SMEs: WITH SUBSIDIARY IN DEVELOPING COUNTRY

Globalization was the turning point when many large corporations started to begin their operations in foreign countries which provided them with new markets to sell their products as well as new manufacturing facilities. While this trend of internationalization was not new but what was interesting was the speed at which this happened with globalization. The large enterprises were the first to internationalize but later this trend was growing where SME’s have also diversified their operations in foreign countries because of new opportunities available, low cost of labor, and limited growth opportunities in their home countries (Vachini, 2005). While this expansion opens new doors, there are lot of challenges that could firm could face in the host country (Vachani, 1998).  The world economy at present is moving rapidly towards a knowledge-based economy. According to OECD (1996) the term knowledge based economy is the total recognition of the role of knowledge and technology in economic growth. Knowledge is being widely accepted as the most important resource which is an intangible resource, hard to imitate and these makes it a source of competitive advantage for organizations. But, merely recognizing the importance of knowledge is not sufficient to have competitive advantage, Organizations must understand how to best manage this precious resource and it requires great effort in terms of how to create, share and utilize knowledge. If this knowledge is not managed properly it could affect growth, operational efficiency and innovation capacity (De Long &amp; Davenport, 2003).  N/

THE PERFORMING ARTS AND PSYCHOLOGICAL WELL-BEING

Although psychotropic drugs have been hailed as, \u27One of the success stories of modern psychiatry\u27 the prescribing of these medicines has not been without commotion, concern and controversy. Moreover, the President of the World Psychiatry Association Professor Dinesh Bhugra and colleagues, after conducting a recent large-scale study (n=25,522) on psychiatric morbidity in the UK, collectively issued the clarion call that, \u27The mental health of the nation was unlikely to be improved by treatment with psychotropic medication alone\u27. The provision of mental healthcare services may likely benefit from a holistic approach that includes a variety of treatment options that prioritizes patient safety and preference. The performing arts is gaining popularity among service users as an adjunctive form of treatment for mental illness. There is a growing body of evidence that provisionally supports the claim that art therapy, \u27Possesses the power to heal psychological wounds\u27. The North American Drama Therapy Association defines drama therapy as, \u27The intentional use of drama and/or theatre processes to achieve therapeutic goals\u27 and that it is \u27active and experiential\u27. This review article discusses and describes the merits of dramatherapy and how this treatment modality can contribute to a patient\u27s recovery from psychological distress

Integration of Regression Analysis and Monte Carlo Simulation for Probabilistic Energy Policy Guidelines in Pakistan

Forecasting energy demand and supply is the most crucial concern for energy policymakers. However, forecasting may introduce uncertainty in the energy model, and an energy policy based on an uncertain model could be misleading. Without certainty in energy data, investors cannot quantify risk and trade-offs, which are compulsory for investments in energy projects. In this work, the energy policies of Pakistan are taken as a case study, and flaws in its energy policymaking are identified. A novel probabilistic model integrated with curve fitting methods was proposed and was applied to 17 different energy demand and supply variables. Monte Carlo simulation (MCS) was performed to develop probabilistic energy profiles for each year from 2017 to 2050. Results show that the forecasted energy supply of Pakistan in the years 2025 and 2050 would be 70.69 MTOE and 131.65 MTOE, respectively. The probabilistic analysis showed that there is 14% and 6% uncertainty in achieving these targets. The research shows the expected energy consumption of 70.33 MTOE and 189.48 MTOE in 2025 and 2050, respectively, indicating uncertainties of 65% and 31%. Based on the results, eight energy policy guidelines and recommendations are provided for sustainable energy resource management. This study recommends developing a robust and sustainable energy policy for Pakistan with the help of transparent governance