4-(Benz­yloxy)phenyl 4-hexa­dec­yloxy-3-meth­oxy­benzoate

In the title compound, C37H50O5, the central benzene ring makes dihedral angles of 39.72 (14) and 64.43 (13)° with the benzyl and 3-meth­oxy­benzoate rings, respectively. The crystal structure is stabilized by inter­molecular C—H⋯π inter­actions involving the central benzene ring and the benzene ring closest to the aliphatic chain

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.Peer reviewe

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes

Measurement of Radon Concentration in Some Dwellings near Kabini River, Karnataka, India

461-466Radon is the daughter product of 226Ra, and is exist in large concentration compared to all other radioactive elements present in the atmosphere and contributes more annual effective dose to human than all other radiation sources. Inhaling radioactive radon mainly causes of lung cancer. The effect of radon exposure prevention measures is initially determined by how successfully and quickly information persuades people to test properties. Usually, this is accomplished through educating locals on the dangers radon poses to their health.The activities of radon, thoron and their progenies were measured in the present study using pinhole dosimeters with alpha sensitive films, LR-115 type-II in 26 dwellings with a variety of flooring materials, including cement, tiles, mud, and granite, in both excellent and bad ventilation conditions along the Kabini river bank. The total yearly effective dose obtained from the study area is varied from 0.81 to 5.26 mSv.y-1, with an average dose value of 2.54 mSv.y-1 and is less than the suggested range ofICRP 2011 and the WHO -2011recommended level