Towards a Citizenship of the European Union

International audienceBasing on the various legal and historical experiences of different States, as well as the actual ambitions of European construction, the authors explore some challenges around the construction of an European citizenship.Les auteurs explorent des pistes de construction d'une citoyenneté européenne sur la base des expériences historiques et juridiques nationales, mais aussi en évaluant les ambitions de la construction européenne

High Prevalence of Respiratory Ciliary Dysfunction in Congenital Heart Disease Patients With Heterotaxy

Patients with congenital heart disease (CHD) and heterotaxy show high postsurgical morbidity/mortality, with some developing respiratory complications. Although this finding is often attributed to the CHD, airway clearance and left-right patterning both require motile cilia function. Thus, airway ciliary dysfunction (CD) similar to that of primary ciliary dyskinesia (PCD) may contribute to increased respiratory complications in heterotaxy patients

Temporal properties of human information processing: Tests of discrete versus continuous models,

Cognitive psychologists have characterized the temporal properties of human information processing in terms of discrete and continuous models. Discrete models postulate that component mental processes transmit a finite number of intermittent outputs (quanta) of information over time, whereas continuous models postulate that information is transmitted in a gradual fashion. These postulates may be tested by using an adaptive response-priming procedure and analysis of reaction-time mixture distributions. Three experiments based on this procedure and analysis are reported. The experiments involved varying the temporal interval between the onsets of a prime stimulus and a subsequent test stimulus to which a response had to be made. Reaction time was measured as a function of the duration of the priming interval and the type of prime stimulus. Discrete models predict that manipulations of the priming interval should yield a family of reaction-time mixture distributions formed from a finite number of underlying basis distributions, corresponding to distinct preparatory states. Continuous models make a different prediction. Goodness-of-fit tests between these predictions and the data supported either the discrete or the continuous models, depending on the nature of the stimuli and responses being used. When there were only two alternative responses and the stimulus-response mapping was a compatible one, discrete models with two or three states of preparation fit the results best. For larger response sets with an incompatible stimulus-response mapping, a continuous model fit some of the data better. These results are relevant to the interpretation of reaction-time data in a variety of contexts and to the analysis of speed-accuracy trade-offs in mental processes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25558/1/0000100.pd

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Touch of civilization: comparing American and Russian internal colonization, The

Includes bibliographical references and index.This work compares the process and practice of nineteenth-century American and Russian internal colonization, a form of contiguous, continental expansion, imperialism and colonialism that incorporated indigenous lands and peoples. It provides a critical, comparative examination of internal colonization exercised by the United States and Russia and experienced by two indigenous populations, the Sioux and the Kazakhs. In particular, it examines how and why perceptions of the Sioux and Kazakhs as ostensibly uncivilized peoples, and similarly held American and Russian perceptions of the Northern Plains and the Kazakh Steppe as "uninhabited" regions that ought to be settled, reinforced American and Russian government sedentarization policies and land allotment programs among the Sioux and Kazakhs. In addition, it compares the processes practiced by the two empires and the various forms of Sioux and Kazakh martial, political, social and culture resistance evident throughout the 19th century.The Sioux and the Kazakhs -- Pre-nineteenth-century expansion -- Conquest and martial resistance -- Through the colonial looking-glass -- Internal colonization -- Assimilation and identity