Magneto-transport properties of thin superconducting strips in the framework of Time Dependent Ginzburg Landau model

2010 - 2011This dissertation is addressed to summarize my experimental/phenomenological research activities conducted at the laboratories of Physics Department, University of Salerno. The experimental work consisted in the fabrication of mesoscopic superconducting devices made using Electron Beam Lithography (EBL) on Niobium thin films obtained by magnetron RF sputtering deposition. Among the devices fabricated with success are worthy of attention thin strips (25 nm) of Niobium with a regular array of antidots in deep submicron scale (15 nm diameter holes spaced 50 nm) on which studies were performed about the matching of Abrikosov vortices lattice at high magnetic fields. Other devices successfully produced have been superconducting strips with lateral dimensions of the order of microns, but with variable thickness on the nanometer scale. On this type of devices we have conducted a study of magneto‐transport properties at cryogenic (liquid helium) and deep cryogenic (300 mK) temperatures in a magnetic field both parallel and perpendicular to the substrate. The most interesting result was that these devices may exhibit a behavior of superconducting diode. In parallel to experimental activities were carried out investigations aimed at the theoretical and computational description/interpretation of the phenomena observed experimentally in the framework of Time‐Dependent Ginzburg‐Landau (TDGL) model of superconductivity. The direct numerical integration of the TDGL as well as its specialization to magneto‐transport properties of superconducting strips in finite and unconventional geometry had not tradition at the Department of Physics, and we gave an original contribution to this research line. Results acquired in this activity that are worth mentioning are the interpretation of the asymmetry and bistability in a Abrikosov diode based on superconductor/ferromagnet strips, the interpretation of matching properties in strips with square arrays of antidots in the nanometer scale, the behavior of superconducting cylindrical shells in the presence of a magnetic field applied parallel and perpendicular to the axis, including the dynamics of a single Abrikosov vortex trapped in these shells, and finally the magneto‐transport properties of superconducting strips with variable section at the nanoscale. [edited by author]X n.s

Reduced statistical fluctuations of the position of an object partitioning in two its environment

Through hard‐disk simulations and theoretical considerations on the movement of an object that partitions a microtubule filled with small particles, we find that the vibrations typical of thermal equilibrium are reached after a time that increases exponentially with the number of particles involved. The result is a mechanism capable of breaching, on accessible time scales, the ergodic constraints in nano‐scale systems

Two-dimensional Stellar Evolution Code Including Arbitrary Magnetic Fields. I. Mathematical Techniques and Test Cases

A high-precision two-dimensional stellar evolution code has been developed for studying solar variability due to structural changes produced by varying internal magnetic fields of arbitrary configurations. Specifically, we are interested in modeling the effects of a dynamo-type field on the detailed internal structure and on the global parameters of the Sun. The high precision is required to model both very small solar changes (of the order of 10-4) and short timescales (of the order of 1 yr). It is accomplished by using the mass coordinate to replace the radial coordinate, by using fixed and adjustable time steps, a realistic stellar atmosphere, and element diffusion, and by adjusting the grid points. We have also built into the code the potential to subsequently include rotation and turbulence. The current code has been tested for several cases, including its ability to reproduce the one-dimensional results

A modification of the leaf-nets method for sampling benthic invertebrates in spring habitats

The full ecological potential of spring habitats remains relatively unexplored mostly because of the lack of standardized sampling procedures and difficulties to collect representative biological samples, especially in small-sized springs. Recent studies on sampling methodologies in spring habitats indicated that a modified Surber net with a reduced frame area, reliably describes the structure and composition of spring communities. This method, however, is very invasive and may severely impact the spring, especially when a large number of samples is required. The paper presents a new quantitative method (leaf-nets) for sampling crenic invertebrates which combines a rather high efficiency with negligible impacts on spring habitat structure and biota. The effectiveness of the new methodology was tested in a medium-size rheocrene spring in Central Apennine, where spring assemblages were sampled in parallel with a modified Surber net and with the new method. Taxa richness and density were higher in the Surber net, while no between-method differences were recorded for the number of insect taxa and Simpson diversity. Furthermore, the overall functional organization of Surber net and leaf-nets assemblages was very similar. The new method sampled only 25% of the individuals cumulatively collected, but 75% of the total richness, with a good representation of the structure and the functional organization of spring assemblages. In comparison with the Surber net, the negligible loss of information of the new method is highly compensated by its minor invasivity, lower impacts on spring microhabitats and invertebrate populations and by its higher versatility. Leaf-nets could also be used to assess leaf-detritus breakdown in springs, thus allowing a better ecological characterization of these ecosystems. </p

Observational evidence of intensified nocturnal urban heat island during heatwaves in European cities

A heatwave (HW) is a large-scale meteorological event characterised by persistent and extremely high-temperature condition. At the local scale, the urban heat island (UHI) is another thermal-related phenomenon defined as an urban area warmer than its surrounding regions due to different surfaces’ capabilities to absorb and store heat. However, the assessment about the effect produced on UHI by HW events is not homogeneous. Indeed, regarding the capability of HWs to influence the urban-rural temperature difference, several studies report different conclusions describing both an exacerbation and a reduction of UHI during HW events. In this context, the present study analyses in situ long records of temperature measurements (20 years) to provide observational shreds of evidence of UHI modification under HW conditions. We examine data from the European Climate Assessment &amp; Dataset and World Meteorological Organization computing the UHI index (UHII) to quantify the UHI effect intensity in 37 European cities during the last 20 summers. The results show an UHII intensification for 28 of the 32 cities affected by positive UHI during extremely high temperatures at night, while substantial variations are not observed during the daytime. The time evolution of UHI during a HW highlights that a more significant and persistent urban-rural temperature gradient explains the UHI intensification. Finally, the relationship between the large and local-scale temperature phenomena reveals that continental high-temperature periods are often associated with prominent temperature differences between small-scale urban and rural environments, assessing the impact of large-scale features on thermal stress at the local scale

Effects of Propionyl-L-Carnitine on Ischemia–Reperfusion Injury in Hamster Cheek Pouch Microcirculation

Background and purpose Propionyl-l-carnitine (pLc) exerts protective effects in different experimental models of ischemia–reperfusion (I/R). The aim of the present study was to assess the effects of intravenously and topically applied pLc on microvascular permeability increase induced by I/R in the hamster cheek pouch preparation. Methods The hamster cheek pouch microcirculation was visualized by fluorescence microscopy. Microvascular permeability, leukocyte adhesion to venular walls, perfused capillary length, and capillary red blood cell velocity (VRBC) were evaluated by computer-assisted methods. E-selectin expression was assessed by in vitro analysis. Lipid peroxidation and reactive oxygen species (ROS) formation were determined by thiobarbituric acid-reactive substances (TBARS) and 2′-7′-dichlorofluorescein (DCF), respectively. Results In control animals, I/R caused a significant increase in permeability and in the leukocyte adhesion in venules. Capillary perfusion and VRBC decreased. TBARS levels and DCF fluorescence significantly increased compared with baseline. Intravenously infused pLc dose-dependently prevented leakage and leukocyte adhesion, preserved capillary perfusion, and induced vasodilation at the end of reperfusion, while ROS concentration decreased. Inhibition of nitric oxide synthase prior to pLc caused vasoconstriction and partially blunted the pLc-induced protective effects; inhibition of the endothelium-derived hyperpolarizing factor (EDHF) abolished pLc effects. Topical application of pLc on cheek pouch membrane produced the same effects as observed with intravenous administration. pLc decreased the E-selectin expression. Conclusions pLc prevents microvascular changes induced by I/R injury. The reduction of permeability increase could be mainly due to EDHF release induce vasodilatation together with NO. The reduction of E-selectin expression prevents leukocyte adhesion and permeability increase

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates

The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development. NC destabilizes nucleic acid structures and promotes the formation of annealed substrates for HIV-1 reverse transcription elongation. Short helical nucleic acid segments bordered by bulges and loops, such as the Trans-Activation Response element (TAR) of HIV-1 and its complementary sequence (cTAR), are nucleation elements for helix destabilization by NC and also preferred recognition sites for threading intercalators. Inspired by these observations, we have recently demonstrated that 2,6-disubstituted peptidylanthraquinone-conjugates inhibit the chaperone activities of recombinant NC in vitro, and that inhibition correlates with the stabilization of TAR and cTAR stem-loop structures. We describe here enhanced NC inhibitory activity by novel conjugates that exhibit longer peptidyl chains ending with a conserved Nterminal lysine. Their efficient inhibition of TAR/cTAR annealing mediated by NC originates from the combination of at least three different mechanisms, namely, their stabilizing effects on nucleic acids dynamics by threading intercalation, their ability to target TAR RNA substrate leading to a direct competition with the protein for the same binding sites on TAR, and, finally, their effective binding to the NC protein. Our results suggest that these molecules may represent the stepping-stone for the future development of NC-inhibitors capable of targeting the protein itself and its recognition site in RNA