Can remote STI/HIV testing and eClinical Care be compatible with robust public health surveillance?

In this paper we outline the current data capture systems for human immunodeficiency virus (HIV) and sexually transmitted infection (STI) surveillance used by Public Health England (PHE), and how these will be affected by the introduction of novel testing platforms and changing patient pathways. We outline the Chlamydia Online Clinical Care Pathway (COCCP), developed as part of the Electronic Self-Testing for Sexually Transmitted Infections (eSTI(2)) Consortium, which ensures that surveillance data continue to be routinely collected and transmitted to PHE. We conclude that both novel diagnostic testing platforms and established data capture systems must be adaptable to ensure continued robust public health surveillance

Using Remote Sensing and Detection of Early Season Invasives (DESI) to Analyze the Temporal Dynamics of Invasive Cheatgrass (Bromus tectorum)

The invasion of exotic annual grasses during the last century has transformed plant habitats and communities worldwide. Cheatgrass (Bromus tectorum) is a winter annual grass that has invaded over 100 million acres of the western United States (Pellant and Hall, 1994. Pellant, 1996). Cheatgrass quickly utilizes available resources especially after a disturbance to the landscape. A major impact of invasion is the increased frequency in fires (D’Antonio and Vitousek, 1992). As cheatgrass is highly successful at invading open and disturbed landscapes at a rapid pace it increases the frequency and severity of fires in arid landscapes (Brooks, 2005). Cheatgrass’ prolific seed production and flammability allows it to competitively exclude native plant species (Seabloom et al., 2003). The successful life strategy of cheatgrass gives a unique spectral image reflectance that can allow the use of remote sensing platforms to track and locate invasions

Using Hotspot Analysis and Detection of Early Season Invasives (DESI) to analyze the temporal and spatial dynamics of invasive cheatgrass (Bromus tectorum).

The invasion of exotic annual grasses during the last century has transformed plant habitats and communities worldwide. Cheatgrass (Bromus tectorum) is a winter annual grass that has invaded over 100 million acres of the western United States (Pellant and Hall, 1994. Pellant, 1996). Cheatgrass quickly utilizes available resources especially after a disturbance to the landscape. A major impact of invasion is the increased frequency in fires (D’Antonio and Vitousek, 1992). As cheatgrass is highly successful at invading open and disturbed landscapes at a rapid pace it increases the frequency and severity of fires in arid landscapes (Brooks, 2005). Cheatgrass’ prolific seed production and flammability allows it to competitively exclude native plant species (Seabloom et al., 2003). The successful life strategy of cheatgrass gives a unique spectral image reflectance that can allow the use of remote sensing platforms to track and locate invasions

Comparison of deep-ocean finescale shear at two sites along the Mid-Atlantic Ridge

Author Posting. © The Author, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 53 (2006): 207-225, doi:10.1016/j.dsr2.2005.08.021.Four drifting floats were used to measure the magnitude of the vertical derivative of horizontal velocity in waters above the rough bathymetry of the Mid Atlantic Ridge. This derivative is typically the dominant component of the velocity gradient (the shear). Two floats were at the site of the Brazil Basin Tracer Release Experiment (BBTRE) in the South Atlantic, and two were near the site of the Guiana Abyssal Gyre Experiment (GAGE) in the North Atlantic. Floats operated for one year except for one BBTRE float which operated for 100 days. Shear was measured over a vertical span of 9.5 m using drag elements that caused the floats to rotate slowly in response to shear. For each float, the first, second and fourth moments of shear were elevated above levels associated with the Garrett-Munk model internal-wave spectrum. Three of the four floats were tracked as they moved over mountainous terrain, allowing shear intensity to be measured as a function of height above the bottom. A deep BBTRE float showed enhancement of rms shear near the bottom. Floats at both areas provided measurements at 2000 m above the bottom, with differing results: The GAGE site had a lower fourth moment of shear (diapycnal diffusivity proxy) than the BBTRE site. However, application of normalization factors accounting for differences between the sites in bottom roughness, latitude-dependent internal-wave dynamics, and tidal current speeds brings the results into agreement.This work was funded by the National Science Foundation under grants OCE9416014 and OCE9906685

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size

Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood. The authors show mice deficient in FSTL3 develop markedly enlarged testes that are also delayed in their age-related regression. These FSTL3 knockout mice exhibit increased Sertoli cell numbers, allowing for increased spermatogenesis but otherwise showing normal testicular function. The data show that FSTL3 deletion leads to increased AKT signaling and SIRT1 expression in the testis. This demonstrates a cross-talk between TGFβ ligand and AKT signaling and leads to a potential mechanism for increased cellular survival and antiaging. The findings identify crucial roles for FSTL3 in limiting testis organ size and promoting age-related testicular regression

Incentives as connectors : insights into a breastfeeding incentive intervention in a disadvantaged area of North-West England

PMID: 22458841 [PubMed - indexed for MEDLINE] PMCID: PMC3414740 Free PMC ArticlePeer reviewedPublisher PD

A conceptual model of an Arctic sea

Author Posting. © American Geophysical Union, 2012. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 117 (2012): C06010, doi:10.1029/2011JC007652.We propose a conceptual model for an Arctic sea that is driven by river runoff, atmospheric fluxes, sea ice melt/growth, and winds. The model domain is divided into two areas, the interior and boundary regions, that are coupled through Ekman and eddy fluxes of buoyancy. The model is applied to Hudson and James Bays (HJB, a large inland basin in northeastern Canada) for the period 1979–2007. Several yearlong records from instruments moored within HJB show that the model results are consistent with the real system. The model notably reproduces the seasonal migration of the halocline, the baroclinic boundary current, spatial variability of freshwater content, and the fall maximum in freshwater export. The simulations clarify the important differences in the freshwater balance of the western and eastern sides of HJB. The significant role played by the boundary current in the freshwater budget of the system, and its sensitivity to the wind-forcing, are also highlighted by the simulations and new data analyses. We conclude that the model proposed is useful for the interpretation of observed data from Arctic seas and model outputs from more complex coupled/climate models.We thank NSERC and the Canada Research Chairs program for funding. FS acknowledges support from NSF OCE–0927797 and ONR N00014-08-10490.2012-12-2

Forcing of the overturning circulation across a circumpolar channel by internal wave breaking

The hypothesis that the impingement of mesoscale eddy flows on small-scale topography regulates diapycnal mixing and meridional overturning across the deep Southern Ocean is assessed in an idealized model. The model simulates an eddying circumpolar current coupled to a double-celled meridional overturning with properties broadly resembling those of the Southern Ocean circulation and represents lee wave-induced diapycnal mixing using an online formulation grounded on wave radiation theory. The diapycnal mixing generated by the simulated eddy field is found to play a major role in sustaining the lower overturning cell in the model, and to underpin a significant sensitivity of this cell to wind forcing. The vertical structure of lower overturning is set by mesoscale eddies, which propagate the effects of near-bottom diapycnal mixing by displacing isopycnals vertically

Forum: Feminism in German Studies

From Professor Wallach\u27s contribution entitled Jews and Gender : To consider Jews and gender within German Studies is to explore the evolution of German‐Jewish Studies with respect to feminist and gender studies. At times this involves looking beyond German Studies to other scholarship in Jewish gender studies, an interdisciplinary subfield in its own right. Over the past few decades, the focus on gender within German‐Jewish Studies has experienced several shifts in line with broader trends: an initial focus on the history of Jewish women and feminist movements gradually expanded to encompass the study of gender identity, masculinity, and sexuality. Historical and literary scholarly approaches now operate alongside and in dialogue with interdisciplinary scholarship in cultural studies, film and visual studies, performance studies, and other fields. [excerpt