3,447 research outputs found
Red wine quality and style: Diversities of composition and adverse influences from free SO2
Relationships between wine colour composition and the overall quality rating were investigated by analyses of 404 young red wines in two varietal classes from three successive vintages. The wines, of Shiraz and Cabernet Sauvignon from 20 viticultural regions of Australia, had been presented for comparative assessment at the Adelaide Wine Shows of 1974-75-76. There was a large variability in all aspects of phenolic content, in wine colour density and tint, in pH, and in levels of total SO2 and free SO2. The latter was the major influence on pigment equilibria, in which there was up to 10-fold variation in the degree of ionisation of anthocyanins (a). Positive quality factors were wine colour density, the parameter a, coloured anthocyanins, total pigments and total phenolics. Negative factors included colour tint, free SO2 and total SO2. There was no correlation with wine pH. Wide variation in winemaking practice concerning the amount and timing of SO2 additions is considered to have been responsible for much of the range in quality within these groups of wines.QualitĂ€t und Nuance von Rotwein: Schwankungen der Zusammensetzung sowie nachteiliger EinfluĂ von freiem SO2 Anhand der Analysen von 404 jungen Rotweinen - zwei Sorten aus drei aufeinanderfolgenden JahrgĂ€ngen - wurden die Beziehungen zwischen den Komponenten der WeinfĂ€rbung und der Gesamtnote der sensorischen QualitĂ€tsprĂŒfung untersucht. Die Weine, Shiraz und Cabernet Sauvignon, waren bei den Adelaide Wine Shows 1974/75/76 zur vergleichenden Beurteilung angestellt worden. SĂ€mtliche Parameter des Phenolgehaltes, die FarbintensitĂ€t und -tönung, der pH-Wert sowie der Gehalt an Gesamt-SO2 und freiem SO2 zeigten eine betrĂ€chtliche VariabilitĂ€t. Das freie SO2 beeinfluĂte das Pigmentgleichgewicht am stĂ€rksten, wobei der Ionisationsgrad der Anthocyane (a) bis zu 10fach schwanken konnte. Positive QualitĂ€tsfaktoren waren: FarbintensitĂ€t, der Parameter a, gefĂ€rbte Anthocyane, Gesamtpigmente sowie Gesamtphenole. Zu den negativen Faktoren gehörten Farbtönung, freies SO2 und Gesamt-SO2. Keinerlei Korrelation bestand zum Wein-pH. Die unterschiedlichen QualitĂ€tsnoten der geprĂŒften Rotweine dĂŒrften zum Gutteil kellertechnisch, durch die betrĂ€chtlichen Schwankungen der zugesetzten SO2 -Mengen und des Behandlungszeitpunktes, bedingt sein
Exciton lifetime and emission polarization dispersion in strongly in-plane asymmetric nanostructures
We present experimental and theoretical investigation of exciton
recombination dynamics and the related polarization of emission in highly
in-plane asymmetric nanostructures. Considering general asymmetry- and
size-driven effects, we illustrate them with a detailed analysis of
InAs/AlGaInAs/InP elongated quantum dots. These offer a widely varied
confinement characteristics tuned by size and geometry that are tailored during
the growth process, which leads to emission in the application-relevant
spectral range of 1.25-1.65 {\mu}m. By exploring the interplay of the very
shallow hole confining potential and widely varying structural asymmetry, we
show that a transition from the strong through intermediate to even weak
confinement regime is possible in nanostructures of this kind. This has a
significant impact on exciton recombination dynamics and the polarization of
emission, which are shown to depend not only on details of the calculated
excitonic states but also on excitation conditions in the photoluminescence
experiments. We estimate the impact of the latter and propose a way to
determine the intrinsic polarization-dependent exciton light-matter coupling
based on kinetic characteristics.Comment: 11 pages, 8 figure
Coherent response of lakes in Ontario, Canada to reductions in sulphur deposition: the effects of climate on sulphate concentrations
International audienceSulphate deposition in south-central Ontario declined between 1976 and 2000 by more than 50%, whereas lake sulphate (SO42?) concentrations decreased by, on average, only half as much. To investigate the factors that controlled this slower than expected response, the temporal patterns in lake SO42? concentrations were compared with patterns in both deposition and climate, since climate has a major influence on the hydrological cycle in this part of the continent. To do this, the temporal coherence in SO42? concentrations between 9 lake basins was estimated using the intraclass correlation from a repeated-measures analysis of variance and two subsets of lakes were found (six in one group, four in the other), each with lakes having synchronous patterns. One subset (4 lakes) included the 3 with the longest water replenishment times (>3.4 yr) which are expected to respond to decreases in SO42? deposition more slowly. However, the average pattern reflecting the temporal changes of each of the two subsets was very similar. The response of both subsets of lakes to the decreasing SO42? deposition over two decades was independent of the degree of acidification or sensitivity to acidification of the lakes. In a determination of which factors best predicted each of those two subsets' SO42? time series, good predictive models were produced by regional/global-scale climate indices, specifically the Southern Oscillation Index (SOI) describing the El Niño Southern Oscillation (ENSO) and the North Atlantic Oscillation Index (NAOI), as well as by SO42? deposition indices. When the predictor variables were combined, models which described the long-term changes in lake SO42? concentration best included the SOI, the NAOI and SO42? deposition. Thus, large-scale climate factors play a major role in determining the response of aquatic systems to changes in SO42? deposition, perhaps through their influence on lake and/or catchment processes that effectively delay recovery. Keywords: Atmospheric deposition, lake recovery, temporal trends, climate, temporal coherenc
Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting
Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs. Different tools and strategies have been developed to reduce inappropriate prescribing; the available measures can be divided into medication assessment tools, and speciïŹc interventions to reduce inappropriate prescribing. Implicit criteria of inappropriate prescribing focus on appropriate dosing, search for drug-drug interactions, and increase adherence. Explicit criteria are consensus-based standards focusing on drugs and diseases and include lists of drugs to avoid in general or lists combining drugs with clinical data. These criteria take into consideration differences between patients, and stand for a medication review, by using a systematic approach. Different types of interventions exist in order to reduce inappropriate prescribing in older patients, such as: educational interventions, computerized decision support systems, pharmacist-based interventions, and geriatric assessment. The effects of these interventions have been studied, sometimes in a multifaceted approach combining different techniques, and all types seem to have positive effects on appropriateness of prescribing. Interdisciplinary teamwork within the integrative pharmaceutical care is important for improving of outcomes and safety of drug therapy. The pharmaceutical care process consists offour steps, which are cyclic for an individual patient. These steps are pharmaceutical anamnesis, medication review, design and follow-up of a pharmaceutical care plan. A standardized approach is necessary for the adequate detection and evaluation of drug-related problems. Furthermore, it is clear that drug therapy should be reviewed in-depth, by having full access to medical records, laboratory values and nursing notes. Although clinical pharmacists perform the pharmaceutical care process to manage the patientâs drug therapy in every day clinical practice, the physician takes the ultimate responsibility for the care of the patient in close collaboration with nurses
Exciton lifetime and emission polarization dispersion in strongly in-plane asymmetric nanostructures
The work was supported by the Grant No. 2011/02/A/ST3/00152 from the Polish National Science Centre (Narodowe Centrum Nauki). K. G. acknowledges support by the Grant No. 2014/12/B/ST3/04603 from the Polish National Science Centre (Narodowe Centrum Nauki). S. H. acknowledges support from the State of Bavaria in Germany.We present experimental and theoretical investigation of exciton recombination dynamics and the related polarization of emission in highly in-plane asymmetric nanostructures. Considering general asymmetry- and size-driven effects, we illustrate them with a detailed analysis of InAs/AlGaInAs/InP elongated quantum dots. These offer a widely varied confinement characteristics tuned by size and geometry that are tailored during the growth process, which leads to emission in the application-relevant spectral range of 1.25-1.65 ÎŒm. By exploring the interplay of the very shallow hole confining potential and widely varying structural asymmetry, we show that a transition from the strong through intermediate to even weak confinement regime is possible in nanostructures of this kind. This has a significant impact on exciton recombination dynamics and the polarization of emission, which are shown to depend not only on details of the calculated excitonic states but also on excitation conditions in the photoluminescence experiments. We estimate the impact of the latter and propose a way to determine the intrinsic polarization-dependent exciton light-matter coupling based on kinetic characteristics.PostprintPeer reviewe
Drawing the Line: How African, Caribbean and White British Women Live Out Psychologically Abusive Experiences
The final, definitive version of this paper has been published in Violence Against Women, 19 (9):1104-32, Sept 2013 by SAGE Publications Ltd, All rights reserved. © The Author(s) 2013.
The online version of this article can be found at: http://vaw.sagepub.com/content/19/9/110
Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold
Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.National Cancer Institute (U.S.) (Grant R01-CA126642
Coalition unionism : exploring how and when coalitions contribute to union renewal in Sydney, Toronto and Chicago
Item does not contain fulltextWe have previously identified eight novel autoantibody targets in the cerebrospinal fluid of multiple sclerosis (MS) patients, including sperm-associated Ag 16 (SPAG16). In the current study, we further investigated the autoantibody response against SPAG16-a protein with unknown function in the CNS-and its expression in MS pathology. Using isoelectric focusing, we detected SPAG16-specific oligoclonal bands in the cerebrospinal fluid of 5 of 23 MS patients (22%). Analysis of the anti-SPAG16 Ab reactivity in the plasma of a total of 531 donors using ELISA demonstrated significantly elevated anti-SPAG16 Ab levels (p = 0.002) in 32 of 153 MS patients (21%) compared with all other control groups with 95% specificity for the disease. To investigate the pathologic relevance of anti-SPAG16 Abs in vivo, anti-SPAG16 Abs were injected in mice with experimental autoimmune encephalomyelitis, resulting in a significant disease exacerbation. Finally, we demonstrated a consistent upregulation of SPAG16 in MS brain and experimental autoimmune encephalomyelitis spinal cord lesions, more specifically in reactive astrocytes. We conclude that SPAG16 is a novel autoantibody target in a subgroup of MS patients and in combination with other diagnostic criteria, elevated levels of anti-SPAG16 Abs could be used as a biomarker for diagnosis. Furthermore, the pathologic relevance of anti-SPAG16 Abs was shown in vivo
Selling sex in unsafe spaces: Sex work risk environments in Phnom Penh, Cambodia
Background The risk environment framework provides a valuable but under-utilised heuristic for understanding environmental vulnerability to HIV and other sexually transmitted infections among female sex workers. Brothels have been shown to be safer than street-based sex work, with higher rates of consistent condom use and lower HIV prevalence. While entertainment venues are also assumed to be safer than street-based sex work, few studies have examined environmental influences on vulnerability to HIV in this context. Methods As part of the Young Women's Health Study, a prospective observational study of young women (15-29 years) engaged in sex work in Phnom Penh, we conducted in-depth interviews (n = 33) to explore vulnerability to HIV/STI and related harms. Interviews were conducted in Khmer by trained interviewers, transcribed and translated into English and analysed for thematic content. Results The intensification of anti-prostitution and anti-trafficking efforts in Cambodia has increased the number of women working in entertainment venues and on the street. Our results confirm that street-based sex work places women at risk of HIV/STI infection and identify significant environmental risks related to entertainment-based sex work, including limited access to condoms and alcohol-related intoxication. Our data also indicate that exposure to violence and interactions with the police are mediated by the settings in which sex is sold. In particular, transacting sex in environments such as guest houses where there is little or no oversight in the form of peer or managerial support or protection, may increase vulnerability to HIV/STI. Conclusions Entertainment venues may also provide a high risk environment for sex work. Our results indicate that strategies designed to address HIV prevention among brothel-based FSWs in Cambodia have not translated well to street and entertainment-based sex work venues in which increasing numbers of women are working. There is an urgent need for targeted interventions, supported by legal and policy reforms, designed to reduce the environmental risks of sex work in these settings. Future research should seek to investigate sex work venues as risk environments, explore the role of different business models in mediating these environments, and identify and quantify exposure to risk in different occupational settings. Keywords: sex work; risk; environment; vulnerability; HIV; STI; young women; entertainment; Cambodi
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