Strategy Development to Support LGB Individuality in the Workplace

Lesbian, gay, and bisexual (LGB) individuals are challenged daily regarding the lack of emotional supportfrom employers in acknowledging cultural differences. The LGB population is at high risk for heterosexistdiscrimination despite new employment laws that protect individuals from termination based on sexualorientation. Previously completed research indicated that LGB employees who felt supported emotionallyin the workplace showed a higher rate of future employee recruitment, increased productivity, quickadjustment periods for new employees, decreased stress, and were committed to their agency. Thepurpose of this research study was to develop strategies to help the LGB population feel supported in theworkplace. The strategies were identified from anonymous surveys completed by employees in thedevelopmental disability support field. The study participants are members of the Advancing StrongLeadership program for North Carolina Developmental Disability (DD) Professionals. Participants sharedtheir personal perceptions of how supportive their agency is for the LGB population. The results showedthat 86.36% of the survey participants felt a change could be made to their agency to help increasesupport and acceptance for LGB employees. There were 16.6% of the employees that identified as LGB from public and non-profit agencies. The results suggest strategies for improving agency climate for LGB workers.

Data Gaps in Evidence-Based Research on Small Water Enterprises in Developing Countries

This paper assess the literature on small water enterprises -- water delivery operations that predominantly provide water at the community level. A research agenda is recommended to advance knowledge on effective SWE service

The effects of light pruning, irrigation and improved soil management on wine quality of the Vitis vinifera cv. Riesling

A number of yield improving viticultural practices were assessed in terms of their effect on wine quality. These were improved soil management, lighter pruning/higher trellis, irrigation and a control. In the first year a yield increase of 1.6 t /ha for the irrigation treatment had no significant effect on wine quality. A procedure is presented to assess judges for reliability, discrimination, variability and stability as part of analysis of the sensory results. Four judges were able to consistently identify lot differences

A Manifesto for project management research

Project management research has evolved over the past five decades and is now a mature disciplinary field investigating phenomena of interest to academics, practitioners and policymakers. Studies of projects and project management practices are theoretically rich and scientifically rigorous. They are practically relevant and impactful when addressing the pursuit of operational, tactical and strategic advancements in the world of organisations. We want to broaden the conversation between project management scholars and other scholars from cognate disciplines, particularly business and management, in a true scholarship of integration and cross-fertilisation. This Manifesto invites the latter scholars to join efforts providing a foundation for further creative, theoretical and empirical contributions, including but not limited to tackling grand challenges such as climate change, pandemics, and global poverty. To this end, we identify five theses: Projects are often ‘agents of change’ and hence fundamental to driving the innovation and change required to tackle grand challenges. Much project management research leverages and challenges theories across disciplines, including business, organisation and management studies, contributing to developing new theories, including those specific to projects and temporary organisations. ‘Projects’ are useful units of analysis, project management research is ideal for scientific cross-fertilisation and project management scholars welcome academics from other communities to engage in fruitful conversations. As in many other fields of knowledge, the project management research community embraces diversity, welcoming researchers of different genders and various scientific and social backgrounds. Historically rooted in ‘problem-solving’ and normative studies, project management research has become open to interpretative and emancipatory research, providing opportunities for other business, management and organisational scholars to advance their knowledge communities

Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

<p>Abstract</p> <p>Background</p> <p>Testicular germ cell tumors (TGCTs) respond well to cisplatin-based chemotherapy and show a low incidence of acquired resistance compared to most somatic tumors. The reasons for these specific characteristics are not known in detail but seem to be multifactorial. We have studied gene expression profiles of testicular and colon cancer derived cell lines treated with cisplatin. The main goal of this study was to identify novel gene expression profiles with their functional categories and the biochemical pathways that are associated with TGCT cells' response to cisplatin.</p> <p>Results</p> <p>Genes that were differentially expressed between the TGCT cell lines vs the (somatic) HCT116 cell line, after cisplatin treatment, were identified using the significance analysis of microarrays (SAM) method. The response of TGCT cells was strikingly different from that of HCT116, and we identified 1794 genes that were differentially expressed. Functional classification of these genes showed that they participate in a variety of different and widely distributed functional categories and biochemical pathways. Database mining showed significant association of genes (n = 41) induced by cisplatin in our study, and genes previously reported to by expressed in differentiated TGCT cells. We identified 37 p53-responsive genes that were altered after cisplatin exposure. We also identified 40 target genes for two microRNAs, hsa-mir-372 and 373 that may interfere with p53 signaling in TGCTs. The tumor suppressor genes <it>NEO1 </it>and <it>LATS2</it>, and the estrogen receptor gene <it>ESR1</it>, all have binding sites for p53 and hsa-mir-372/373. <it>NEO1 </it>and <it>LATS2 </it>were down-regulated in TGCT cells following cisplatin exposure, while <it>ESR1 </it>was up-regulated in TGCT cells. Cisplatin-induced genes associated with terminal growth arrest through senescence were identified, indicating associations which were not previously described for TGCT cells.</p> <p>Conclusion</p> <p>By linking our gene expression data to publicly available databases and literature, we provide a global pattern of cisplatin induced cellular response that is specific for testicular cancer cell lines. We have identified cisplatin-responsive functional classes and pathways, such as the angiogenesis, Wnt, integrin, and cadherin signaling pathways. The identification of differentially expressed genes in this study may contribute to a better understanding of the unusual sensitivity of TGCT to some DNA-damaging agents.</p

Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.

The mechanisms and sites of action of organochlorine (DDT-types and chlorinated alicyclics) and synthetic pyrethroid insecticides are presented with discussion of symptoms, physiological effects, and selectivity. The structural requirements for toxicity are assessed, and structure-activity relationships are considered for each subclass. Lipophilicity is important for all the groups because it facilitates delivery of these neurotoxicants to the site of action in the nerve. Steric factors including molecular volume, shape, and isomeric configuration greatly influence toxicity. Electronic parameters also have been demonstrated to affect biological activity in some of the groups of insecticides, e.g., Hammett's sigma and Taft's sigma * as indicators of electronegativity. New synthetic pyrethroids continue to be developed, with varied structures and different physicochemical and biological properties

Interrelationships Between the Kinetics of VLDL Subspecies and HDL Catabolism in Abdominal Obesity: A Multicenter Tracer Kinetic Study

Context: Low plasma high-density lipoprotein (HDL) cholesterol is a major abnormality in abdominal obesity. This relates due to accelerated HDL catabolism, but the underlying mechanism requires further elucidation. The relationships between HDL catabolism and other variables that may be modified in abdominal obesity, such as very low-density lipoprotein (VLDL) subspecies (VLDL1, VLDL2) kinetics, liver fat, or visceral adiposity, remain to be investigated. Objectives: Our aim was to study the associations between HDL apolipoprotein (apo)-A-I fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and estimates of liver and visceral and sc fat. Design: We carried out a multicenter in vivo kinetic study using stable isotopes (deuterated leucine and glycerol) in 62 individuals with abdominal obesity. Results: In a multivariate analysis, among the morphological and biological parameters that may predict apoA-I FCR, liver fat (beta = .400, P = .003), and VLDL1-apoB (beta = .307, P = .020) were independently associated with apoA-I FCR. In a multivariate analysis, among the kinetic parameters, VLDL1-triglycerides (TGs) indirect FCR (beta = .357, P = .001), VLDL1-TG production rate (beta = 0.213, P = .048), and apoA-II FCR (beta = .667, P < .0001) were independently associated with apoA-I FCR. After adjustment for VLDL1-TG production rate, liver fat was no more correlated with apoA-I FCR. No association between apoA-I FCR and visceral fat was observed. Conclusions: We show that VLDL1 is an important independent determinant of apoA-I FCR and more precisely that apoA-I FCR is independently associated with both catabolism and the production of VLDL1-TG. In addition, we show an association between liver fat and apoA-I FCR that is mostly mediated by VLDL1-TG production. These data indicate that, in abdominal obesity, dysfunctional VLDL1 metabolism is an important modulator of HDL apoA-I catabolism

Dipolar versus multipolar dynamos: the influence of the background density stratification

Context: dynamo action in giant planets and rapidly rotating stars leads to a broad variety of magnetic field geometries including small scale multipolar and large scale dipole-dominated topologies. Previous dynamo models suggest that solutions become multipolar once inertia becomes influential. Being tailored for terrestrial planets, most of these models neglected the background density stratification. Aims: we investigate the influence of the density stratification on convection-driven dynamo models. Methods: three-dimensional nonlinear simulations of rapidly rotating spherical shells are employed using the anelastic approximation to incorporate density stratification. A systematic parametric study for various density stratifications and Rayleigh numbers allows to explore the dependence of the magnetic field topology on these parameters. Results: anelastic dynamo models tend to produce a broad range of magnetic field geometries that fall on two distinct branches with either strong dipole-dominated or weak multipolar fields. As long as inertia is weak, both branches can coexist but the dipolar branch vanishes once inertia becomes influential. The dipolar branch also vanishes for stronger density stratifications. The reason is the concentration of the convective columns in a narrow region close to the outer boundary equator, a configuration that favors non-axisymmetric solutions. In multipolar solutions, zonal flows can become significant and participate in the toroidal field generation. Parker dynamo waves may then play an important role close to onset of dynamo action leading to a cyclic magnetic field behavior. Conclusion: Our simulations also suggest that the fact that late M dwarfs have dipolar or multipolar magnetic fields can be explained in two ways. They may differ either by the relative influence of inertia or fall into the regime where both types of solutions coexist.Comment: 13 pages, 13 figures, 2 tables, accepted for publication in A&

A Vision for Ice Giant Exploration

From Voyager to a Vision for 2050: NASA and ESA have just completed a study of candidate missionsto Uranus and Neptune, the so-called ice giant planets. It is a Pre-Decadal Survey Study, meant to inform the next Planetary Science Decadal Survey about opportunities for missions launching in the 2020's and early 2030's. There have been no space flight missions to the ice giants since the Voyager 2 flybys of Uranus in 1986 and Neptune in 1989. This paper presents some conclusions of that study (hereafter referred to as The Study), and how the results feed into a vision for where planetary science can be in 2050. Reaching that vision will require investments in technology andground-based science in the 2020's, flight during the 2030's along with continued technological development of both ground- and space-based capabilities, and data analysis and additional flights in the 2040's. We first discuss why exploring the ice giants is important. We then summarize the science objectives identified by The Study, and our vision of the science goals for 2050. We then review some of the technologies needed to make this vision a reality