1,821 research outputs found
Venous-right atrial bypass for superior vena cava thrombosis during orthotopic liver transplantation
Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites
A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of insertion. Superior venacavography showed multiple filling defects in the right axillary vein, no filling of the right brachiocephalic and right subclavian vein, and thrombotic occlusion of the internal jugular veins bilaterally. The shunt was removed 11 days after insertion, and there was extensive thrombosis of the venous end of the shunt and the compressible pump chamber. Shunt thrombosis is known to occur but remains a rare complication, with 87% of such obstructions being due to a thrombus at the tip of the venous end of the shunt. Extensive thrombosis of the shunt (as in the present case) is very rare
A009 Importance of tweak-CD163 system in peripheral artery disease
IntroductionCD163 is a macrophage receptor of haptoglogin/ haemoglobin complexes responsible for clearance of hemogloin. It has been recently suggested to be a potential scavenger receptor for TWEAK (Tumor necrosis factor-like weak inducer of apoptosis). TWEAK levels were reported to be decreased in carotid atherosclerosis. Our hypothesis is that decreased circulating TWEAK could be paralleled by an increased presence of CD163-expressing macrophage in atherosclerotic plaques. Since peripheral artery disease (PAD) is an important manifestation of systemic atherosclerosis, we have assessed the levels of circulating TWEAK-CD163 in PAD.Methods and ResultsPatients with PAD (n=184) had lower TWEAK (169.2±8.3vs 211.9±15.4pg/mL; p<0.05) and higher sCD163 (408.1±14.5vs 317.4±8.4ng/mL; p<0.05) plasma concentration than age-matched controls (n=330). After stratification according to the severity of disease, we observed that TWEAK/sCD163 ratio was significantly decreased in those patients with higher degree of disease (0.39±0.06vs 0.66±0.08, p<0.05) relative to the other groups. Analysis of conditioned medium obtained from cultured human atherosclerotic femoral plaque samples (n=38) and healthy aortas (n=14) revealed that higher amount of sCD163 was released by the atherosclerotic tissue, whereas TWEAK presented the opposite trend.ConclusionsOur results suggest that CD163/TWEAK plasma ratio could be a potential biomarker of clinical peripheral artery disease. We can hypothesized that decreased levels of circulating TWEAK observed in atherosclerosis may be the result of a trapping by plaque macrophages through their CD163
Initial Hubble Diagram Results from the Nearby Supernova Factory
The use of Type Ia supernovae as distance indicators led to the discovery of
the accelerating expansion of the universe a decade ago. Now that large second
generation surveys have significantly increased the size and quality of the
high-redshift sample, the cosmological constraints are limited by the currently
available sample of ~50 cosmologically useful nearby supernovae. The Nearby
Supernova Factory addresses this problem by discovering nearby supernovae and
observing their spectrophotometric time development. Our data sample includes
over 2400 spectra from spectral timeseries of 185 supernovae. This talk
presents results from a portion of this sample including a Hubble diagram
(relative distance vs. redshift) and a description of some analyses using this
rich dataset.Comment: Short version of proceedings for ICHEP08, Philadelphia PA, July 2008;
see v1 for full-length versio
The Nearby Supernova Factory
The Nearby Supernova Factory (SNfactory) is an ambitious project to find and
study in detail approximately 300 nearby Type Ia supernovae (SNe~Ia) at
redshifts 0.03<z<0.08. This program will provide an exceptional data set of
well-studied SNe in the nearby smooth Hubble flow that can be used as
calibration for the current and future programs designed to use SNe to measure
the cosmological parameters. The first key ingredient for this program is a
reliable supply of Hubble-flow SNe systematically discovered in unprecedented
numbers using the same techniques as those used in distant SNe searches. In
2002, 35 SNe were found using our test-bed pipeline for automated SN search and
discovery. The pipeline uses images from the asteroid search conducted by the
Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction
techniques and analysis have allowed us to increase our effective SN discovery
rate to ~12 SNe/month in 2003.Comment: 7 pages, 3 figures to be published in New Astronomy Review
The Extinction Properties of and Distance to the Highly Reddened Type Ia Supernova SN 2012cu
Correction of Type Ia Supernova brightnesses for extinction by dust has
proven to be a vexing problem. Here we study the dust foreground to the highly
reddened SN 2012cu, which is projected onto a dust lane in the galaxy NGC 4772.
The analysis is based on multi-epoch, spectrophotometric observations spanning
3,300 - 9,200 {\AA}, obtained by the Nearby Supernova Factory. Phase-matched
comparison of the spectroscopically twinned SN 2012cu and SN 2011fe across 10
epochs results in the best-fit color excess of (E(B-V), RMS) = (1.00, 0.03) and
total-to-selective extinction ratio of (RV , RMS) = (2.95, 0.08) toward SN
2012cu within its host galaxy. We further identify several diffuse interstellar
bands, and compare the 5780 {\AA} band with the dust-to-band ratio for the
Milky Way. Overall, we find the foreground dust-extinction properties for SN
2012cu to be consistent with those of the Milky Way. Furthermore we find no
evidence for significant time variation in any of these extinction tracers. We
also compare the dust extinction curve models of Cardelli et al. (1989),
O'Donnell (1994), and Fitzpatrick (1999), and find the predictions of
Fitzpatrick (1999) fit SN 2012cu the best. Finally, the distance to NGC4772,
the host of SN 2012cu, at a redshift of z = 0.0035, often assigned to the Virgo
Southern Extension, is determined to be 16.61.1 Mpc. We compare this
result with distance measurements in the literature.Comment: 48 pages, 13 figures. Accepted for publication in The Astrophysical
Journal. The spectral time series data presented in this article can be found
at http://snfactory.lbl.gov/snf/data
Improving Cosmological Distance Measurements Using Twin Type Ia Supernovae
We introduce a method for identifying "twin" Type Ia supernovae, and using
them to improve distance measurements. This novel approach to Type Ia supernova
standardization is made possible by spectrophotometric time series observations
from the Nearby Supernova Factory (SNfactory). We begin with a well-measured
set of supernovae, find pairs whose spectra match well across the entire
optical window, and then test whether this leads to a smaller dispersion in
their absolute brightnesses. This analysis is completed in a blinded fashion,
ensuring that decisions made in implementing the method do not inadvertently
bias the result. We find that pairs of supernovae with more closely matched
spectra indeed have reduced brightness dispersion. We are able to standardize
this initial set of SNfactory supernovae to 0.083 +/- 0.012 magnitudes,
implying a dispersion of 0.072 +/- 0.010 magnitudes in the absence of peculiar
velocities. We estimate that with larger numbers of comparison SNe, e.g, using
the final SNfactory spectrophotometric dataset as a reference, this method will
be capable of standardizing high-redshift supernovae to within 0.06-0.07
magnitudes. These results imply that at least 3/4 of the variance in Hubble
residuals in current supernova cosmology analyses is due to previously
unaccounted-for astrophysical differences among the supernovaeComment: 37 pages, 9 figures, 5 tables. Accepted for publication in ApJ. Fixed
typo in arXiv abstrac
Standardizing Type Ia Supernova Absolute Magnitudes Using Gaussian Process Data Regression
We present a novel class of models for Type Ia supernova time-evolving
spectral energy distributions (SED) and absolute magnitudes: they are each
modeled as stochastic functions described by Gaussian processes. The values of
the SED and absolute magnitudes are defined through well-defined regression
prescriptions, so that data directly inform the models. As a proof of concept,
we implement a model for synthetic photometry built from the spectrophotometric
time series from the Nearby Supernova Factory. Absolute magnitudes at peak
brightness are calibrated to 0.13 mag in the -band and to as low as 0.09 mag
in the blueshifted -band, where the dispersion includes
contributions from measurement uncertainties and peculiar velocities. The
methodology can be applied to spectrophotometric time series of supernovae that
span a range of redshifts to simultaneously standardize supernovae together
with fitting cosmological parameters.Comment: 47 pages, 15 figures, accepted for publication by Astrophysical
Journa
Atmospheric extinction properties above Mauna Kea from the Nearby Supernova Factory spectro-photometric data set
We present a new atmospheric extinction curve for Mauna Kea spanning
3200--9700 \AA. It is the most comprehensive to date, being based on some 4285
standard star spectra obtained on 478 nights spread over a period of 7 years
obtained by the Nearby SuperNova Factory using the SuperNova Integral Field
Spectrograph. This mean curve and its dispersion can be used as an aid in
calibrating spectroscopic or imaging data from Mauna Kea, and in estimating the
calibration uncertainty associated with the use of a mean extinction curve. Our
method for decomposing the extinction curve into physical components, and the
ability to determine the chromatic portion of the extinction even on cloudy
nights, is described and verified over the wide range of conditions sampled by
our large dataset. We demonstrate good agreement with atmospheric science data
obtain at nearby Mauna Loa Observatory, and with previously published
measurements of the extinction above Mauna Kea.Comment: 22 pages, 24 figures, 6 table
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