2,764 research outputs found
A tĂ©cnica ao serviço da arte – Uma análise ao filme La HaĂne (1995) de Mathieu Kassovitz
Em O Ódio (1995), Mathieu Kassovitz traça um retrato de um subúrbio parisiense
em “estado de sĂtio”. Fá-lo com recurso a um guiĂŁo sĂłlido e uma componente narrativa
elaborada mas, porventura, o que mais salta Ă vista Ă© um filme / uma histĂłria muito forte
que, em conjunto com uma estética peculiar, faz com que, ao falar do filme, recordemos
imagens / planos especĂficos. Pedindo Ă sociologia bases para um enquadramento
genérico do plot, tentaremos entender de que forma as técnicas audiovisuais empregues
por Kassovitz e a sua equipa resultam num retrato sĂłlido e consistente em termos de
ilustração e caracterização da realidade suburbana, dos seus intervenientes e da forma
como estes se enquadram na sociedade
Unidade Técnico Funcional – Prestação de serviços : Formação Profissional de 2011 a junho de 2015.
Unidade Técnico Funcional – Prestação de serviços : Formação Profissional de 2011 a junho de 2015.info:eu-repo/semantics/publishedVersio
Desfile de Moda : potencialidades das actividades multidisciplinares
A realização de um Desfile de Moda é, tal como refere Dillon (2012) uma atividade que exige um esforço muito elevado da equipa que o produz e absorve muito tempo e comporta elevados custos. Se, por um lado, se trata de uma perfeita simbiose entre diversas áreas que trabalham, em conjunto, para um mesmo fim, por outro lado, exige a garantia de sucesso que advém da relação entre todas as partes intervenientes, o que só se consegue com um relacionamento eficaz na equipa.
A complexidade que um Desfile pode implicar na sua organização, quando resulta numa atividade de grande sucesso, representa retorno e identifica-se com enormes potencialidades para todas as partes envolvidas, desde a entidade que o realiza (designer, marca, instituição ou outra) ao pĂşblico que assiste e participa e absorve todo um vasto conjunto de sensações que lhe sĂŁo proporcionadas em diversos nĂveis, visual, estĂ©tico, audiovisual, multimĂ©dia, som/mĂşsica, espaço, etc.info:eu-repo/semantics/publishedVersio
Health-related quality of life impact of a triple combination of olmesartan medoxomil, amlodipine besylate and hydrochlorotiazide in subjects with hypertension
Background
A post-hoc analysis was performed on the data from a 54 weeks phase III study (ClinicalTrials.gov identifier: NCT00923091) to measure changes in the health-related quality of life (HRQoL) of 2,690 patients aged ≥18 with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide (OLM/AML/HCTZ), using the MINICHAL and EQ-5D instruments.
Methods
Descriptive statistics were used to assess blood pressure and HRQoL scores over the study period. Analysis of covariance (ANCOVA) was used to identify those factors that could possibly have influenced HRQoL. Linear regression was used to assess the relationship between changes in blood pressure and HRQoL scores.
Results
Patients’ baseline MINICHAL mood and somatic domains scores were 5.5 and 2.6. Over the study period HRQoL improved as both MINICHAL scores decreased by 31-33%. Patients’ baseline EQ-5D index and VAS scores were 0.9 and 73.4 respectively, increasing by 6% and 12% over the study period. Patients’ QALY gain over the 54 weeks study period was estimated to be 0.029 QALYs. The ANCOVA showed that changes in patients’ HRQoL was likely to have been influenced by patients’ achievement of blood pressure control, the amount of concomitant medication and patients’ last used dosage strength of antihypertensive. Linear regression showed that blood pressure improvement may have been associated with improved HRQoL.
Conclusions
This study showed that OLM/AML/HCTZ reduced blood pressure and significantly increased blood pressure control whilst improving patients’ HRQoL. Achieving blood pressure control, amount of concomitant medication and dosage strength of antihypertensive impacted on patients’ HRQoL
The Problem of Large Leptonic Mixing
Unlike in the quark sector where simple permutation symmetries can
generate the general features of quark masses and mixings, we find it
impossible (under conditions of hierarchy for the charged leptons and without
considering the see-saw mechanism or a more elaborate extension of the SM) to
guarantee large leptonic mixing angles with any general symmetry or
transformation of only known particles. If such symmetries exist, they must be
realized in more extended scenarios.Comment: RevTeX, 4 pages, no figure
Removal of Carbofuran from Drinking Water Using Natural Rutile
Water bodies contaminated with pesticides is a major constrain faced by every agriculturebased country. Providing safe potable drinking water to public has proved to be a challenge insuch situations. Rutile is found in enormous concentrations in the Pulmoddai beach sanddeposit, and is exported as raw material since 1968, without utilising the deposit for any otherpurpose.There were number of reports published regarding the photocatalytic effect of rutile and useof pure titanium dioxide to remove pesticides globally, but according to the availableliterature, no studies on the potential effect of natural rutile sand in Sri Lanka has beencarried out for water purification facility. Therefore, this is the first record on profitableutilisation of the rutile mineral deposit for development of water treatment technology in SriLanka. The naural rutile sand for the experiment was supplied from the mineral deposit ofPulmoddai, Eastern Province.The photocatalytic activity of natural rutile sand was induced by providing ultra violet (UV)illumination. In vitro laboratory experiments were carried out to assess the photocatalyticability of natural rutile sand on carbofuran. The results revealed the potential photocatalyticdegradation of carbofuran by natural rutile sand. The carbofuran removal efficiency ofnatural rutile was compared with pure titanium dioxide (TiO2). The results showed thatremoval rates of carbofuran by natural rutile sand with UV illumination was 72%, whereaspure granular/powder TiO2 showed 74% and 76% of degradation of carbofuran respectively.When carbofuran was exposed to only UV light treatment, 33% of carbofuran reduction wasdetected.Based on the results obtained, a filter model was designed using natural rutile sand andevaluated the potential use of natural rutile sand to remove carbofuran. The filter modelshowed that there were 46%, 50%, 61%, 65% and 71% removal of carbofuran at 60, 120,180, 240 and 300 minutes respectively, for a water circulation rate of 500l /h.The study showed that there is an enormous potential of utilising natural rutile sand toremove hazardous pesticides from water and the result will help to improve a water filter infuture as well.Keywords: Carbofuran, Photocatalysis, Rutile, Water purificatio
Identifying and prioritising services in European terrestrial and freshwater ecosystems
Ecosystems are multifunctional and provide humanity with a broad array of vital services. Effective management of services requires an improved evidence base, identifying the role of ecosystems in delivering multiple services, which can assist policy-makers in maintaining them. Here, information from the literature and scientific experts was used to systematically document the importance of services and identify trends in their use and status over time for the main terrestrial and freshwater ecosystems in Europe. The results from this review show that intensively managed ecosystems contribute mostly to vital provisioning services (e.g. agro-ecosystems provide food via crops and livestock, and forests provide wood), while semi-natural ecosystems (e.g. grasslands and mountains) are key contributors of genetic resources and cultural services (e.g. aesthetic values and sense of place). The most recent European trends in human use of services show increases in demand for crops from agro-ecosystems, timber from forests, water flow regulation from rivers, wetlands and mountains, and recreation and ecotourism in most ecosystems, but decreases in livestock production, freshwater capture fisheries, wild foods and virtually all services associated with ecosystems which have considerably decreased in area (e.g. semi-natural grasslands). The condition of the majority of services show either a degraded or mixed status across Europe with the exception of recent enhancements in timber production in forests and mountains, freshwater provision, water/erosion/natural hazard regulation and recreation/ecotourism in mountains, and climate regulation in forests. Key gaps in knowledge were evident for certain services across all ecosystems, including the provision of biochemicals and natural medicines, genetic resources and the regulating services of seed dispersal, pest/disease regulation and invasion resistance
Field Evaluation Of Safety During Gestation And Horizontal Spread Of A Recombinant Differential Bovine Herpesvirus 1 (bohv-1) Vaccine
Bovine herpesvirus type 1 (BoHV-1) is recognized as a major cause of respiratory, reproductive disease and abortion in cattle. Vaccination is widely applied to minimize losses induced by BoHV-1 infections; however, vaccination of dams during pregnancy with modified live virus (MLV) vaccines has been occasionally associated to abortions. We have previously reported the development of a BoHV-1 recombinant virus, constructed with basis on a Brazilian BoHV-1 (Franco et al. 2002a) from which the gene coding for glycoprotein E (gE) was deleted (gE-) by genetic manipulation. Such recombinant has been previously evaluated in its potential as a differential vaccine (gE-vaccine) that allows differentiation between vaccinated and infected animals. Here, in the first part of the present study, the safety of the gE-vaccine during pregnancy was evaluated by the intramuscular inoculation of 107.4 tissue culture 50% infective doses (TCID50) of the virus into 22 pregnant dams (14 BoHV-1 seronegative; 8 seropositive), at different stages of gestation. Other 15 pregnant dams were kept as non-vaccinated controls. No abortions, stillbirths or fetal abnormalities were seen after vaccination. Seroconversion was observed in both groups of previously seronegative vaccinated animals. In the second part of the study, the potential of the gE-vaccine virus to spread among beef cattle under field conditions was examined. Four heifers were inoculated intranasally with a larger amount (107.6TCID50) of the gE-vaccine (to increase chances of transmission) and mixed with other sixteen animals at the same age and body condition, in the same grazing area, at a population density equal to the average cattle farming density within the region (one cattle head per 10,000 m2), for 180 days. All animals were monitored daily for clinical signs. Serum samples were collected on days 0, 30, 60 and 180 post-vaccination. Seroconversion was observed only in vaccinated heifers. These results indicate that, under the conditions of the present study, the gE-vaccine virus did not cause any noticeable harmful effect on pregnant dams and on its offspring and did not spread horizontally among cattle.2515458Belknap, E.B., Walters, L.M., Kelling, C., Ayers, V.K., Norris, J., McMillend, J., Hayhowe, C., Collins, J.K., Immunogenicity and protective efficacy of a gE, gG and US2 gene-deleted bovine herpesvirus-1 (BHV-1) vaccine (1999) Vaccine, 17, pp. 2297-2305Bouma, A., De Jong, M.C.M., Kimman, T.G., Transmission of pseudorabies virus within pig populations is independent of the size of the population (1995) Prev. Vet. Med., 23, pp. 163-172Casal, J., Planasdemunt, L., Varo, J.A., MartĂn, M., The use of different vaccination schedules for sows to protect piglets against Aujeszky's disease (2004) Vet. Med. B, 51, pp. 8-11D'Arce, R.C.F., Almeida, R.S., Silva, T.C., Franco, A.C., Spilki, F., Roehe, P.M., Arns, C.W., Restriction endonuclease and monoclonal antibody characterization of Brazilian isolates of bovine herpesviruses types 1 and 5 (2002) Vet. Microbiol., 88, pp. 315-324Ellis, J.A., Hassard, L.E., Cortese, V.S., Morley, P.S., Effects of perinatal vaccination on humoral and cellular immune responses in dams and young calves (1996) J. Am. Vet. Med. Assoc., 208, pp. 393-400Flores, E.F., Donis, R.O., Isolation of a mutant MDBK cell line resistant to bovine viral diarrhea virus infection due to a block in viral entry (1995) Virology, 208, pp. 565-575Flores, E.F., Osorio, F.A., Zanella, E.L., Kit, S., Kit, M., Efficacy of a deletion mutant bovine herpesvirus-1 (BHV-1) vaccine that allows serologic differentiation of vaccinated from naturally infected animals (1993) J. Vet. Diagn. Invest., 5, pp. 534-540Franco, A.C., Rijsewijk, F.A.M., Flores, E.F., Weiblen, R., Roehe, P.M., Construction and characterization of a glycoprotein E deletion of bovine herpesvirus type 1.2 strain isolated in Brazil (2002) Braz. J. Microbiol., 33, pp. 274-278Franco, A.C., Spilki, F.R., Esteves, P.A., Lima, M., Weiblen, R., Flores, E.F., Rijsewijk, F.A.M., Roehe, P.M., A Brazilian glycoprotein E-negative bovine herpesvirus type 1.2a (BHV-1.2a) mutant is attenuated for cattle and induces protection against wild-type virus challenge (2002) Pesq. Vet. Bras., 22, pp. 135-140Hage, J.J., Schukken, Y.H., Barkema, H.W., Benedictus, G., Rijsewijk, F.A.M., Wentink, G.H., Population dynamics of bovine herpesvirus infection a dairy herd (1996) Vet. Microbiol., 53, pp. 169-180Guy, J.S., Potgieter, L.N., Bovine herpesvirus-1 infection of cattle: Kinetics of antibody formation after intranasal exposure and abortion induced by the virus (1985) Am. J. Vet. Res., 46, pp. 893-898Kaashoek, M., (1995) Marker Vaccines Against Bovine Herpesvirus 1 Infections, 155p. , Ph.D. Thesis, Utrecht University, NetherlandsKleiboeker, S.B., Lee, S.M., Jones, C.A., Estes, D.M., Evaluation of shedding of bovine herpesvirus 1, bovine viral diarrhea virus 1, and bovine viral diarrhea virus 2 after vaccination of calves with a multivalent modified-live virus vaccine (2003) J. Am. Vet. Med Assoc., 222, pp. 1399-1403Lomba, F., Vascoboinic, E., Zygraich, N., Immunization of pregnant dams with a temperature-sensitive mutant of the IBR Virus (1976) 6th Int. Congr. Diseases of Cattle, pp. 395-399. , ParisMars, M.H., De Jong, M.C.M., Van Oirschot, J.T., A gE-negative BHV-1 vaccine virus strain cannot perpetuate in cattle populations (2000) Vaccine, 18, pp. 2120-2124McFelly, R.A., Merrit, A.M., Stearly, E.L., Abortion in a dairy herd vaccinated for infectious bovine rhinotracheitis (1964) Vet. Path., 1, pp. 7-17Miller, J.M., Whetstone, C.A., Van Der Maaten, M.J., Abortfacient property of bovine herpesvirus type 1 isolates that represent three subtypes determined by restriction endonuclease analysis of viral DNA (1991) Am. J. Vet. Res., 52, pp. 458-461Miller, J.M., Whetstone, C.A., Bello, L.J., Lawrence, W.C., Whitbeck, J.C., Abortions in heifers inoculated with a thymidine kinase-negative recombinant of bovine herpesvirus 1 (1995) Am. J. Vet. Res., 56, pp. 870-874Mitchell, D., An outbreak of abortion in a dairy herd following inoculation with an intramuscular infectious bovine rhinotracheitis virus (1964) Can. Vet. J., 26, pp. 8-14Odde, K.G., Survival of the neonatal calf. Factors influencing colostral and calf serum immunoglobulin levels (1988) Vet. Clin. North Am. Food Anim. 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Stand., 84, pp. 75-81Turin, L., Russo, S., Poli, G., BHV-1: New molecular approaches to control a common and widespread infection (1999) Mol. Med., 5, pp. 261-284Van Drunen Littel-van Den Hurk, S., Parker, M.D., Massie, B., Van Den Hurk, J.V., Harland, R., Babiuk, L.A., Zamb, T.J., Protection of cattle from BHV-1 infection by immunization with recombinant glycoprotein gIV (1993) Vaccine, 11, pp. 25-35Van Engelenburg, F.A.C., Kaashoek, M.J., Van Oirschot, J.T., Rijsewijk, F.A.M., A glycoprotein E deletion mutant of bovine herpesvirus 1 infects the same limited number of tissues in calves as wild-type virus, but for a shorter period (1995) J. Gen. Virol., 76, pp. 2387-2392Wentink, G.H., Van Oirschot, J.T., Verhoeff, J., Risk of infection with bovine herpes virus 1 (BHV-1): A review (1993) Vet. Quarterly, 15, pp. 30-33Whetstone, C.A., Wheeler, J.G., Reed, D.E., Investigation of possible vaccine-induced epizootics of infectious bovine rhinotracheitis, using restriction endonuclease analysis of viral DNA (1986) Am. J. Vet. Res., 47, pp. 1789-1795Zuckermann, F.A., Husmann, R.J., Schwartz, R., Brandt, J., Mateu De Antonio, E., Martin, S., Interleukin-12 enhances the virus-specific interferon gamma response of pigs to an inactivated pseudorabies virus vaccine (1998) Vet. Immunol. Immunopath., 63, pp. 57-6
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