Harm perceptions of e-cigarettes among smokers with and without mental health conditions in England: A cross-sectional population survey

INTRODUCTION: E-cigarettes (ECs) may benefit smokers with mental health conditions who are more likely to smoke, and smoke more heavily, than those without mental health conditions. This could be undermined if harm misperceptions in this group are high as is the case in the general population. This study aimed to assess EC harm perceptions relative to cigarettes as a function of mental health status and a variety of characteristics. METHODS: Data were collected from 6,531 current smokers in 2016/17 in household surveys of representative samples of adults. The associations of mental health status (self-reported mental health condition and past year treatment), smoking and EC use characteristics, and characteristics relating to use of potential information sources with harm perceptions of ECs relative to cigarettes (measured by correct response 'less harmful' vs wrong responses 'more harmful', 'equally harmful', 'don't know') were analysed with logistic regression. RESULTS: A similar proportion of smokers without mental health conditions (61.5%, 95% CI 60.1-62.9) and with mental health conditions (both with [61.3%, 95% CI 58.7-63.8] and without past year treatment [61.5%, 95% CI 58.1-64.7] held inaccurate EC harm perceptions (all P>0.05). Being female, non-white, aged 25-34 compared with 16-24, from lower social grades (C2, D and E), not having post-16 qualifications, no EC experience, a daily smoker, unmotivated to quit <1 month, non-internet user and non-broadsheet reader were all associated with more inaccurate harm perceptions (all P<0.05). CONCLUSIONS: The majority of smokers in England have inaccurate harm perceptions of ECs regardless of mental health status

Experimental validation of a computational screening approach to predict redox potentials for a diverse variety of redox-active organic molecules

Organic redox flow batteries are currently the focus of intense scientific interest because they have the potential to be developed into low-cost, environmentally sustainable solutions to the energy storage problem that stands in the way of widespread uptake of renewable power generation technologies. Because the search space of suitable redox-active electrolytes is large, computational screening is increasingly being employed as a tool to identify promising candidates. It is well known in the computational chemistry literature that redox potentials for organic molecules can be accurately calculated on a class-by-class basis, but the general utility and accuracy of the relatively low-cost quantum chemical methods used in high-throughput screening are currently unclear. In this work, we measure the redox potentials of 24 commonly available but chemically diverse redox-active organic molecules in acetonitrile, carefully controlling experimental errors by using an internal reference (a ferrocene/ferrocenium redox couple), and compare these with redox potentials computed at B3LYP/6−31+G(d,p) using a polarizable continuum model to account for solvation. Unlike previous lar e-scale computational screenin studies this work carefully establishes the accuracy of the computational procedure by benchmarking against experimental results. While previous small-scale computational studies have been carried out on structurally homologous compounds, this work assesses the accuracy of the computational model across a variety of compound classes, without applying class-dependent empirical corrections. We find that redox potential differences for coupled one-electron transfer processes can be computed to within 0.4 V and two-electron redox potential differences can usually be computed to within 0.15 V

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype

Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical HD phenotype without the expected mutation. The objective of this study was to assess the occurrence of diseases such as Huntington’s disease-like 2 (HDL2), spinocerebellar ataxia (SCA) 1, SCA2, SCA3, SCA7, dentatorubral-pallidoluysian atrophy (DRPLA) and choreaacanthocytosis (ChAc) among 29 Brazilian patients with a HD-like phenotype. In the group analyzed, we found 3 patients with HDL2 and 2 patients with ChAc. The diagnosis was not reached in 79.3% of the patients. HDL2 was the main cause of the HD-like phenotype in the group analyzed, and is attributable to the African ancestry of this population. However, the etiology of the disease remains undetermined in the majority of the HD negative patients with HD-like phenotype. Key words: Huntington’s disease, Huntington’s disease-like, chorea-acanthocytosis, Huntington’s disease-like 2

Straight from the source's mouth: Controls on field‐constrained sediment export across the entire active Corinth Rift, central Greece

The volume and grain‐size of sediment supplied from catchments fundamentally control basin stratigraphy. Despite their importance, few studies have constrained sediment budgets and grain‐size exported into an active rift at the basin scale. Here, we used the Corinth Rift as a natural laboratory to quantify the controls on sediment export within an active rift. In the field, we measured the hydraulic geometries, surface grain‐sizes of channel bars and full‐weighted grain‐size distributions of river sediment at the mouths of 47 catchments draining the rift (constituting 83% of the areal extent). Results show that the sediment grain‐size increases westward along the southern coast of the Gulf of Corinth, with the coarse‐fraction grain‐sizes (84th percentile of weighted grain‐size distribution) ranging from approximately 19 to 91 mm. We find that the median and coarse‐fraction of the sieved grain‐size distribution are primarily controlled by bedrock lithology, with late Quaternary uplift rates exerting a secondary control. Our results indicate that grain‐size export is primarily controlled by the input grain‐size within the catchment and subsequent abrasion during fluvial transport, both quantities that are sensitive to catchment lithology. We also demonstrate that the median and coarse‐fraction of the grain‐size distribution are predominantly transported in bedload; however, typical sand‐grade particles are transported as suspended load at bankfull conditions, suggesting disparate source‐to‐sink transit timescales for sand and gravel. Finally, we derive both a full Holocene sediment budget and a grain‐size‐specific bedload discharged into the Gulf of Corinth using the grain‐size measurements and previously published estimates of sediment fluxes and volumes. Results show that the bedload sediment budget is primarily comprised (~79%) of pebble to cobble grade (0.475–16 cm). Our results suggest that the grain‐size of sediment export at the rift scale is particularly sensitive to catchment lithology and fluvial mophodynamics, which complicates our ability to make direct inferences of tectonic and palaeoenvironmental forcing from local stratigraphic characteristics

Mangroves enhance the biomass of coral reef fish communities in the Caribbean

Mangrove forests are one of the world's most threatened tropical ecosystems with global loss exceeding 35% (ref. 1). Juvenile coral reef fish often inhabit mangroves, but the importance of these nurseries to reef fish population dynamics has not been quantified. Indeed, mangroves might be expected to have negligible influence on reef fish communities: juvenile fish can inhabit alternative habitats and fish populations may be regulated by other limiting factors such as larval supply or fishing. Here we show that mangroves are unexpectedly important, serving as an intermediate nursery habitat that may increase the survivorship of young fish. Mangroves in the Caribbean strongly influence the community structure of fish on neighbouring coral reefs. In addition, the biomass of several commercially important species is more than doubled when adult habitat is connected to mangroves. The largest herbivorous fish in the Atlantic, Scarus guacamaia, has a functional dependency on mangroves and has suffered local extinction after mangrove removal. Current rates of mangrove deforestation are likely to have severe deleterious consequences for the ecosystem function, fisheries productivity and resilience of reefs. Conservation efforts should protect connected corridors of mangroves, seagrass beds and coral reefs

The influence of parental smoking and family type on saliva cotinine in UK ethnic minority children: a cross sectional study

Background In the United Kingdom, there has been an increase in cigarette smoking in ethnic minority adults since the 1970s; in some groups levels are now similar to that of White British people. We aimed to examine the determinants of exposure to secondhand smoke in ethnic minority children. We hypothesised that exposure to secondhand smoke in children will vary across ethnic groups, but that the correlates of exposure would be similar to that of Whites. Methods The Determinants of Adolescent Social well-being and Health sample comprises 3468 White United Kingdom and ethnic minority (Black Caribbean, Black African, Indian, Pakistani, Bangladeshi) pupils aged 11-13 yrs. Outcome was saliva cotinine concentration. Explanatory variables collected by self-complete questionnaire included ethnicity, child reported household smoking and socio-economic circumstances. Data were analysed using linear regression models with a random intercept function. Results Ethnic minority children had lower saliva cotinine than Whites, partly explained by less smoking among parents. White and Black Caribbean children had higher cotinine levels if they lived in a household with a maternal smoker only, than with a paternal smoker only. Living in a lone compared to a dual parent household was associated with increased cotinine concentration of 45% (95%CI 5, 99%) in Whites, 27% (95%CI 5,53%) in Black Caribbeans and 21% (95%CI 1, 45%) in Black Africans after adjusting for household smoking status. Material disadvantage was a significant correlate only for White children (40% (95%CI 1, 94%) increase in cotinine in least compared to most advantaged group). Conclusions Ethnic minority children were less exposed to secondhand smoke than Whites, but the variations within groups were similarly patterned. These findings suggest that it is important not to be complacent about low smoking prevalence in some minority groups

Smoking in cars in England: a study of school students in an English city

Background Exposure to secondhand smoke is associated with an increased risk of adverse health effects among children. Although smoking in the home is an established major source of exposure, less is known about rules on smoking in cars. Methods In a survey including a sample of secondary school students in Nottingham (UK) in 2012, participants were asked whether smoking was allowed in the family car, and how often the respondent travelled in a car in which smoking was allowed. Rules on smoking in cars were investigated in relation to socio-demographic variables and whether children had ever smoked themselves using logistic regression. Results Of 4,190 students aged 11–16 who provided data, approximately 12% reported that smoking was allowed in their family car and 35% that they travelled in a car where smoking was allowed at least sometimes. Absence of smoke free rules in the family car was more likely to be reported by children from more disadvantaged families, if parents and friends were smokers and if smoking was allowed in the main home. These factors, and having a sibling who smokes, were also independently associated with an increased risk of travelling in a car in which smoking was allowed at least sometimes. Respondents who were not protected from secondhand smoke in the car were also more likely to have ever smoked (adjusted odds ratio 1.59, 95% CI 1.18-2.14). Conclusions Absence of smoke free rules in a family car and travelling in a car where smoking was allowed was relatively common among secondary school students, was strongly related to social disadvantage and a higher risk of smoking experimentation. Measures to prevent such exposure are therefore indicated

How does the built environment affect teenagers (aged 13–14) physical activity and fitness? A cross-sectional analysis of the ACTIVE Project

Built environments have been cited as important facilitators of activity and research using geographic information systems (GIS) has emerged as a novel approach in exploring environmental determinants. The Active Children Through Individual Vouchers Evaluation Project used GIS to conduct a cross-sectional analysis of how teenager's (aged 13-14) environments impacted on their amount of activity and influences fitness. The ACTIVE Project recruited 270 participants aged 13-14 (year 9) from 7 secondary schools in south Wales, UK. Demographic data and objective measures of accelerometery and fitness were collected from each participant between September and December 2016. Objective data was mapped in a GIS alongside datasets relating to activity provision, active travel routes, public transport stops, main roads and natural resources. This study shows that fitness and physical activity are not correlated. Teenagers who had higher levels of activity also had higher levels of sedentary time/inactivity. Teenagers showed higher amounts of moderate-to-vigorous physical activity if their homes were closer to public transport. However, they were also more active if their schools were further away from public transport and natural resources. Teenagers were fitter if schools were closer to natural resources. Sedentary behaviour, fitness and activity do not cluster in the same teenagers. Policymakers/planning committees need to consider this when designing teenage friendly environments. Access to public transport, active travel, green space and activities that teenagers want, and need could make a significant difference to teenage health

Association between physical activity and metabolic syndrome in middle-aged Japanese: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Although many studies have reported an association between self-reported physical activity and metabolic syndrome (MetS), there is limited information on the optimal level of physical activity required to prevent MetS. This study aimed to determine the association between objectively measured physical activity and MetS in middle-aged Japanese individuals. We also determined the optimal cutoff value for physical activity required to decrease the risk of developing MetS.</p> <p>Methods</p> <p>A total of 179 men and 304 women, aged between 30 and 64 years, participated in this study. Participants were divided into two groups using the Japanese criteria for MetS as those with MetS or pre-MetS, and those without MetS. Participants were considered to be physically active if they achieved a physical activity level of 23 metabolic equivalents (METs) h/week, measured using a triaxial accelerometer. The association between physical activity and MetS was analyzed using logistic regression with the following covariates: sex, age, sedentary time, low intensity activity, calorie intake, smoking, menopause and body mass index. We also evaluated the factors that determined the association between the prevalence of MetS and pre-MetS and the physical activity cutoff value using classification and regression tree (CART) analysis.</p> <p>Results</p> <p>The odds ratio for MetS and pre-MetS was 2.20 for physically inactive participants (< 23 METs h/week), compared with physically active participants (≥ 23 METs h/week). The corresponding odds ratios for men and women were 2.27 (<it>P </it>< 0.01) and 1.95 (not significant), respectively. CART analyses revealed that moderate-vigorous physical activity of > 26.5 METs h/week was sufficient to decrease the prevalence of MetS and pre-MetS in middle-aged Japanese men and women.</p> <p>Conclusions</p> <p>The results of this cross-sectional study indicate that the Exercise and Physical Activity Reference for Health Promotion 2006 is inversely associated with the prevalence of MetS in men. Our results also suggest that moderate physical activity of > 26.5 METs h/week may decrease the risk of developing MetS and pre-MetS in middle-aged Japanese individuals.</p