Measurements of total alkalinity and inorganic dissolved carbon in the Atlantic Ocean and adjacent Southern Ocean between 2008 and 2010

Water column dissolved inorganic carbon and total alkalinity were measured during five hydrographic sections in the Atlantic Ocean and Drake Passage. The work was funded through the Strategic Funding Initiative of the UK's Oceans2025 programme, which ran from 2007 to 2012. The aims of this programme were to establish the regional budgets of natural and anthropogenic carbon in the North Atlantic, the South Atlantic, and the Atlantic sector of the Southern Ocean, as well as the rates of change of these budgets. This paper describes in detail the dissolved inorganic carbon and total alkalinity data collected along east–west sections at 47° N to 60° N, 24.5° N, and 24° S in the Atlantic and across two Drake Passage sections. Other hydrographic and biogeochemical parameters were measured during these sections, and relevant standard operating procedures are mentioned here. Over 95% of dissolved inorganic carbon and total alkalinity samples taken during the 24.5° N, 24° S, and the Drake Passage sections were analysed onboard and subjected to a first-level quality control addressing technical and analytical issues. Samples taken along 47° N to 60° N were analysed and subjected to quality control back in the laboratory. Complete post-cruise second-level quality control was performed using cross-over analysis with historical data in the vicinity of measurements, and data were submitted to the CLIVAR and Carbon Hydrographic Data Office (CCHDO), the Carbon Dioxide Information Analysis Center (CDIAC) and and will be included in the Global Ocean Data Analyses Project, version 2 (GLODAP 2), the upcoming update of Key et al. (2004)

Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy

Funding Tenovus Scotland. Grant number G13/10.Peer reviewedPublisher PD

Do binaries in clusters form in the same way as in the field?

We examine the dynamical destruction of binary systems in star clusters of different densities. We find that at high densities (10^4 - 10^5 Msun pc^-3) almost all binaries with separations > 10^3 AU are destroyed after a few crossing times. At low densities (order(10^2) Msun pc^-3) many binaries with separations > 10^3 AU are destroyed, and no binaries with separations > 10^4 AU survive after a few crossing times. Therefore the binary separations in clusters can be used as a tracer of the dynamical age and past density of a cluster. We argue that the central region of the Orion Nebula Cluster was around 100 times denser in the past with a half-mass radius of only 0.1 - 0.2 pc as (a) it is expanding, (b) it has very few binaries with separations > 10^3 AU, and (c) it is well-mixed and therefore dynamically old. We also examine the origin of the field binary population. Binaries with separations < 10^2 AU are not significantly modified in any cluster, therefore at these separations the field reflects the sum of all star formation. Binaries with separations in the range 10^2 - 10^4 AU are progressively more and more heavily affected by dynamical disruption in increasingly dense clusters. If most star formation is clustered, these binaries must be over-produced relative to the field. Finally, no binary with a separation > 10^4 AU can survive in any cluster and so must be produced by isolated star formation, but only if all isolated star formation produces extremely wide binaries.Comment: 12 pages, 6 figures, accepted for publication in MNRA

Disruption of a Proto-Planetary Disk by the Black Hole at the Milky Way Centre

Recently, an ionized cloud of gas was discovered plunging toward the supermassive black hole, SgrA*, at the centre of the Milky Way. The cloud is being tidally disrupted along its path to closest approach at ~3100 Schwarzschild radii from the black hole. Here, we show that the observed properties of this cloud of gas can naturally be produced by a proto-planetary disk surrounding a low-mass star, which was scattered from the observed ring of young stars orbiting SgrA*. As the young star approaches the black hole, its disk experiences both photo-evaporation and tidal disruption, producing a cloud. Our model implies that planets form in the Galactic centre, and that tidal debris from proto-planetary disks can flag low mass stars which are otherwise too faint to be detected.Comment: Accepted to Nature Communications; new Figure 4b provides predicted Br-gamma emission as a function of tim

Nutritional adequacy of a cows’ milk exclusion diet in infancy

BACKGROUND: Infants with suspected cows’ milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of this study was to assess the nutritional adequacy of a cows’ milk exclusion diet in a group of UK infants over a period of 6 months. METHODS: Participants in this study are a subgroup of the Prevalence of Infant Food Allergy study, a prospective food allergy birth cohort study from the South of England. Each infant consuming a milk free diet, following advice from a specialist allergy dietitian, was matched to two control infants who were consuming an unrestricted diet, forming a nested matched case–control study. Detailed food diaries completed prospectively for 1 week per month over a 5 month period, were coded and analysed according to a standard protocol. RESULTS: The diets of 39 infants (13 milk-free and 26 controls) were assessed. Mean age at diet commencement was 14 weeks. Two of the eleven infants started on an extensively hydrolysed formula did not tolerate it and required an amino acid formula for symptom resolution. All infants had mean intakes in excess of the estimated average requirement for energy and the recommended nutrient intake (RNI) for protein, calcium, iron, selenium, zinc, vitamins A, C and E. Vitamin D intake was in excess of the RNI at all time-points, except at 44 weeks of age. Across the study period, selenium intake was higher for infants consuming a milk free diet whilst vitamin C intake was higher for infants consuming an unrestricted diet. Differences were found between the two groups for protein, calcium, iron and vitamin E intakes at differing time points. CONCLUSION: This study demonstrated that although infants consuming a milk-free diet have a nutritional intake that is significantly different to matched controls who are eating an unrestricted diet, this difference is not constant and it is not seen for all nutrients. Further research in infants without dietetic input is needed to explore the nutritional implications of unsupervised cows’ milk exclusion diets

Critical values for Lawshe's content validity ratio: revisiting the original methods of calculation

YesThe content validity ratio originally proposed by Lawshe is widely used to quantify content validity and yet methods used to calculate the original critical values were never reported. Methods for original calculation of critical values are suggested along with tables of exact binomial probabilities

Blood ties: ABO is a trans-species polymorphism in primates

The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date. Whether this recurrence of A and B antigens is the result of an ancient polymorphism maintained across species or due to numerous, more recent instances of convergent evolution has been debated for decades, with a current consensus in support of convergent evolution. We show instead that genetic variation data in humans and gibbons as well as in Old World Monkeys are inconsistent with a model of convergent evolution and support the hypothesis of an ancient, multi-allelic polymorphism of which some alleles are shared by descent among species. These results demonstrate that the ABO polymorphism is a trans-species polymorphism among distantly related species and has remained under balancing selection for tens of millions of years, to date, the only such example in Hominoids and Old World Monkeys outside of the Major Histocompatibility Complex.Comment: 45 pages, 4 Figures, 4 Supplementary Figures, 5 Supplementary Table

Planets around evolved intermediate-mass stars. I. Two substellar companions in the open clusters NGC 2423 and NGC 4349

Context. Many efforts are being made to characterize extrasolar planetary systems and unveil the fundamental mechanisms of planet formation. An important aspect of the problem, which remains largely unknown, is to understand how the planet formation process depends on the mass of the parent star. In particular, as most planets discovered to date orbit a solar-mass primary, little is known about planet formation around more massive stars. Aims. To investigate this point, we present first results from a radial velocity planet search around red giants in the clump of intermediate-age open clusters. We choose clusters harbouring red giants with masses between 1.5 and 4 M_sun, using the well-known cluster parameters to accurately determine the stellar masses. We are therefore exploring a poorly-known domain of primary masses, which will bring new insights into the properties of extrasolar planetary systems. Methods. We are following a sample of about 115 red giants with the Coralie and HARPS spectrographs to obtain high-precision radial velocity (RV) measurements and detect giant planets around these stars. We use bisector and activity index diagnostics to distinguish between planetary-induced RV variations and stellar photospheric jitter. Results. We present the discoveries of a giant planet and a brown dwarf in the open clusters NGC 2423 and NGC 4349, orbiting the 2.4 M_sun-star NGC2423 No3 (TYC 5409-2156-1) and the 3.9 M_sun-star NGC4349 No127 (TYC 8975-2606-1). These low-mass companions have orbital periods of 714 and 678 days and minimum masses of 10.6 and 19.8 M_jup, respectively. Combined with the other known planetary systems, these detections indicate that the frequency of massive planets is higher around intermediate-mass stars, and therefore probably scales with the mass of the protoplanetary disk.Comment: 9 pages, 11 figures, accepted for publication in A&

Methodological Challenges of Researching Positive Action Measures

This paper highlights some ofthe methodological challenges which have arisen in collecting data for an international study on positive action measures. It will describe strategies employed to encourage participation in the study from as wide a range of organisations and individuals using a mixed method approach. The paper will also discuss the methodological and sensitive issues related to this type of research in organisations and strategies adopted by the research team to ameliorate any problems that have arisen whilst maintaining trustworthiness and rigour in the study