Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Efeito do estádio de desenvolvimento do fruto sobre a qualidade da semente do cultivar Patrícia de videira Effect of the fruit development stage on the quality of 'Patricia' grape seeds

Durante a maturação do fruto do cultivar Patrícia de videira, podem-se identificar três diferentes estádios de desenvolvimento, com base, principalmente, na coloração do fruto. Neste trabalho, coletaram-se sementes de cada estádio, armazenando-as por diferentes períodos, sendo a qualidade examinada após a colheita e no armazenamento, visando detectar o ponto de menor índice de dormência e máxima germinação. O estádio de maturação do fruto afetou-lhes a viabilidade: as sementes dos frutos maduros sempre apresentaram os maiores valores de viabilidade, ao contrário daquelas de frutos imaturos. Durante o armazenamento, houve diminuição da viabilidade nos três tipos de sementes testados, sendo as de frutos imaturos as mais afetadas. Em sementes de frutos maduros, ocorreu redução da dormência durante o armazenamento. Antes e depois do armazenamento, as sementes dos frutos maduros e meio maduros emergiram mais rápido e houve desenvolvimento de maior número de plântulas, com maior peso de matéria seca, comparativamente às sementes do fruto imaturo. A máxima germinação e vigor da semente são alcançados em sua maturidade fisiológica, aspecto esse a ser considerado antes da colheita, para que se obtenham sementes de alta qualidade.<br>During the maturation of the fruits of 'Patricia' grape (Vitis hybrid), three different development stages can be identified based mainly on the fruit color. Seeds in each of these stages were harvested and stored for different periods of time. Seed quality was analysed before and after storage in order to detect the maximum capacity of germination and the minimum dormancy level. Seed viability was affected by the fruit maturation stage: high-seed viability was obtained from seeds of mature fruits and low-viability from seeds of immature fruits. During storage a reduction of viability was found for all types of analysed seeds; the ones taken from immature fruits were the most affected. A reduction in the dormancy level occurred in seeds taken from mature fruits during storage. Seeds taken from mature and partially mature fruits emerged sooner and developed into a larger number of plantlets with higher dry weight when compared to those from immature fruits independently of being or not stored. In conclusion, in order to obtain high quality grape seeds, with maximun seed viability, it is necessary to wait for the physiological maturity of the fruits before harvesting. This stage can be identified based on the fruit color

Produção e vigor da videira 'Niágara Rosada' relacionados com o porta-enxerto Yield and plant vigor of 'Niágara Rosada' grape vine related to the rootstock

Avaliou-se a produção e o vigor da videira 'Niágara Rosada' sobre os porta-enxertos 'IAC 313', 'IAC 766', 'Kober 5BB', 'Traviú'(106-8 Mgt) e 'Schwarzmann', no período de 1990 a 1998, em Taubaté,SP. As maiores produções médias foram obtidas quando se utilizaram os porta enxertos 'IAC 313' e 'IAC 766', totalizando 2,69 kg/planta e 2,59 kg/planta, respectivamente. As produções alcançadas com os porta-enxertos 'Kober5BB' e 'Schwarzmann' foram, em média, 110% menores que os anteriores, enquanto o 'Traviú' apresentou comportamento intermediário. Os porta-enxertos 'IAC 313' e 'IAC 766' também induziram maior vigor à copa, representado pela maior massa de ramos podados e maior diâmetro das plantas. Para a formação de um vinhedo com 'Niágara Rosada', recomenda-se, para a região, os porta-enxertos 'IAC 313', 'IAC 766' ou 'Traviú'.<br>The yield and plant vigor of 'Niágara Rosada' grafted on the 'IAC 313', 'IAC 766', 'Kober 5BB', 'Traviú' (106-8 Mgt) and 'Schwarzmann' rootstocks were evaluated from 1990 to 1998, in Taubaté,SP, Brazil. The highest average yields were obtained on the 'IAC 313' and 'IAC 766' rootstocks, reaching 2.69 kg/plant and 2.59 kg/plant, respectively. Yields on 'Kober 5BB' and 'Schwarzmann' were 110% smaller than on the previous ones, while 'Traviú' showed intermediary behavior. 'IAC 313' and 'IAC 766' also induced higher vigor in the vine, represented by higher mass of pruned branches and higher diameter of plant. 'Niágara Rosada' cultivation in the region is recommended on the 'IAC 313', 'IAC 766' or 'Traviú' rootstocks

Suplementação de novilhos nelore em pastejo de Brachiaria brizantha com diferentes níveis e fontes de concentrado Supplementation of Nellore grazing steers with different sources and concentrate levels

O objetivo deste trabalho foi avaliar o ganho médio diário (GMD) de novilhos em pastejo de B.brizantha cv. Marandu, suplementados com três tipos de suplementos, no período de julho a dezembro, em dois níveis de fornecimento. Foram utilizados 54 novilhos Nelore (nove por tratamento) com idade aproximada de 20 meses e peso vivo inicial de 370 kg. Os suplementos utilizados foram: suplemento rico em amido (AMI), rico em óleo (OLE) e suplemento composto de amido+óleo (A+O). Os suplementos foram fornecidos em níveis de 0,7 e 1,4% do peso vivo. A disponibilidade de lâminas verdes do capim-braquiária foi de 5,12 kg de MS/100 kg de PV. Os suplementos e níveis influenciaram o ganho médio diário (GMD). Nos dois níveis de fornecimento, o suplemento A+O promoveu o melhor desempenho. No menor nível de fornecimento (0,7% PV), os suplementos com AMI e OLE não diferiram entre si, mas ambos diferiram do suplemento A+O. Para este nível de fornecimento, o GMD foi 0,46; 0,44 e 0,57 kg para os tratamentos AMI, OLE e A+O, respectivamente. Resultados semelhantes foram observados no nível de fornecimento de 1,4% do PV. Neste caso, o suplemento A+O foi superior ao AMI e OLE, que não diferiram entre si. O GMD foi 0,58 kg para AMI, 0,61 kg para OLE e 0,72 kg para A+O. A suplementação com concentrados compostos pela mistura de alimentos ricos em amido (milho) e óleo (caroço de algodão) proporcionou melhor desempenho dos animais em comparação aos suplementados separadamente com as respectivas fontes, independentemente do nível de suplementação. O maior nível de suplementação (1,4% do PV) apresentou eficiência econômica inferior, quando comparada à do menor nível (0,7% do PV).<br>This work was carried out to study the daily average gain (DAG) of steers grazing Brachiaria brizantha cv. Marandu, supplemented, from July to December, with two levels of three different supplements. Fifty-four Nellore steers (9 for each treatment) aged approximately 20 months and initial average live weight of 370 kg were used. The experimental treatments were: AMI - supplement rich in starch (based on corn), OLE - supplement rich in fat (based on whole cottonseed) and A+O - supplement combination (based on mixture of AMI and OLE). All supplements were offered in .7 and 1.4% of liveweight (LW). The green blade availability was 5.12 kg DM/100 kg LW. Treatments and levels influenced DAG. In both levels of supplementation, the combination of feeds promoted higher performance. The lowest level (.7% LW) AMI and OLE was not different, and both were different from A+O. DAG was .44, .46, and .57 kg for AMI, OLE and A+O respectively. Similar results were registered on the higher level (1.4% LW) of supplementation. In this level A+O showed better performance than AMI and OLE that was not different. DAG was .58 kg for AMI, .61 kg for OLE and .72 kg for A+O. The supplementation with concentrates composed by the mixture of rich feeds in starch (corn) and oil (cotton seed) provided higher performance of the animals, that when supplemented separately with the respective sources, independently of the supplementation level. The higher supplementation level (1.4% of LW) showed lower economical efficiency, when compared to the smallest level (.7% PV)

The ninth data release of the Sloan Digital Sky Survey : first spectroscopic data from the SDSS-III Baryon Oscillation Spectroscopic Survey

The Sloan Digital Sky Survey III (SDSS-III) presents the first spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS). This ninth data release (DR9) of the SDSS project includes 535,995 new galaxy spectra (median z ∼ 0.52), 102,100 new quasar spectra (median z ∼ 2.32), and 90,897 new stellar spectra, along with the data presented in previous data releases. These spectra were obtained with the new BOSS spectrograph and were taken between 2009 December and 2011 July. In addition, the stellar parameters pipeline, which determines radial velocities, surface temperatures, surface gravities, and metallicities of stars, has been updated and refined with improvements in temperature estimates for stars with Teff −0.5. DR9 includes new stellar parameters for all stars presented in DR8, including stars from SDSS-I and II, as well as those observed as part of the SEGUE-2. The astrometry error introduced in the DR8 imaging catalogs has been corrected in the DR9 data products. The next data release for SDSS-III will be in Summer 2013, which will present the first data from the APOGEE along with another year of data from BOSS, followed by the final SDSS-III data release in 2014 December