Phytohemagglutinin-Induced Mitotic Index in Blood Lymphocytes: A Potential Biomarker for Breast Cancer Risk

Background Cell proliferation is associated with the pathogenesis of cancer because it provides opportunities for accumulating genetic mutations. However, biomarkers of cell proliferation in response to environmental stimuli have not been adequately explored for breast cancer risk. Methods In a case-control study of 200 breast cancer patients and 360 healthy controls, we investigated the association between phytohemagglutinin (PHA)-induced mitotic index in blood lymphocyte and breast cancer risk. Results Having high mitotic index (>3.19%) was associated with an increased risk of breast cancer, with adjusted odds ratios (95% confidence interval) of 1.54 (1.03–2.30) and 2.03 (1.18–3.57) for all women and post-menopausal women, respectively. Mitotic index was correlated with some reproductive factors and body mass index in controls. Conclusions Our data suggest increased PHA-induced mitotic index in blood lymphocytes is associated with an increased breast cancer risk and that this association may be modulated by reproductive and other hormones

Are they ‘worth their weight in gold’? Sport for older adults: benefits and barriers of their participation for sporting organisations

The ageing global population has led to an increased focus on health for older adults. However, older adults have not been a specific priority for some sporting organisations (SOs). Thus, there is an emerging opportunity for this age group to be considered within international sport policy. The aim of this study was to understand the benefits and barriers that SOs encounter when engaging older adults. Eight focus group interviews (n = 49) were held with representatives of Australian national sporting organisations (NSOs), and older adults who were either sport club or non-sport club members. The socioecological model domains, interpersonal, organisational and policy, were used as a framework for thematic analysis, and organisational capacity building concepts were utilised to explain the findings. Common perceived benefits included interpersonal benefits (intergenerational opportunities and role models) and organisational benefits (volunteering, financial contributions and maximised facility usage) for engaging older adults. Common perceived barriers included interpersonal barriers (competing priorities and perceived societal expectations), organisational barriers (lack of appropriate playing opportunities, lack of facility access and lack of club capacity) and policy barriers (strategic organisational focus on children and elite sport and risk management). Whilst participation in sport is not common for older adults, their involvement can be invaluable for sport clubs. It is not anticipated that any policy focus on older adults will significantly increase active participation for this age group. However, any increase in older adults’ sport participation either through actively playing, supporting family and friends and/or volunteering will contribute to the positive health of individuals, sport clubs and the community.Peer reviewedFinal Accepted Versio

Quark mixing from softly broken symmetries

Quark flavor mixing may originate in the soft breaking of horizontal symmetries. Those symmetries, which in the simplest case are three family U(1) groups, are obeyed only by the dimension-4 Yukawa couplings and lead, when unbroken, to the absence of mixing. Their breaking may arise from the dimension-3 mass terms of SU(2)-singlet vector-like quarks. Those gauge-singlet mass terms break the horizontal symmetries at a scale much higher than the Fermi scale, yet softly, leading to quark mixing while the quark masses remain unsuppressed.Comment: 9 pages, plain Latex, no figure

Certain subclasses of multivalent functions defined by new multiplier transformations

In the present paper the new multiplier transformations \mathrm{{\mathcal{J}% }}_{p}^{\delta }(\lambda ,\mu ,l) (\delta ,l\geq 0,\;\lambda \geq \mu \geq 0;\;p\in \mathrm{% }%\mathbb{N} )} of multivalent functions is defined. Making use of the operator $\mathrm{{\mathcal{J}}}_{p}^{\delta }(\lambda ,\mu ,l),$ two new subclasses $\mathcal{P}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$ and $\widetilde{\mathcal{P}}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$\textbf{\ }of multivalent analytic functions are introduced and investigated in the open unit disk. Some interesting relations and characteristics such as inclusion relationships, neighborhoods, partial sums, some applications of fractional calculus and quasi-convolution properties of functions belonging to each of these subclasses $\mathcal{P}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$ and $\widetilde{\mathcal{P}}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$ are investigated. Relevant connections of the definitions and results presented in this paper with those obtained in several earlier works on the subject are also pointed out

Chromomagnetic Dipole Moment of the Top Quark Revisited

We study the complete one-loop contributions to the chromagnetic dipole moment $\Delta\kappa$ of the top quark in the Standard Model, two Higgs doublet models, topcolor assited technicolor models (TC2), 331 models and extended models with a single extra dimension. We find that the SM predicts $\Delta\kappa = - 0.056$ and that the predictions of the other models are also consitent with the constraints imposed on $\Delta\kappa$ by low-energy precision measurements.Comment: 20 pages, 5 figures, Updat

GOODS-ALMA: Optically dark ALMA galaxies shed light on a cluster in formation at z = 3.5

Thanks to its outstanding angular resolution, the Atacama Large Millimeter/submillimeter Array (ALMA) has recently unambiguously identified a population of optically dark galaxies with redshifts greater than z = 3, which play an important role in the cosmic star formation in massive galaxies. In this paper we study the properties of the six optically dark galaxies detected in the 69 arcmin2 GOODS-ALMA 1.1 mm continuum survey. While none of them are listed in the deepest H-band based CANDELS catalog in the GOODS-South field down to H = 28.16 AB, we were able to de-blend two of them from their bright neighbor and measure an H-band flux for them. We present the spectroscopic scan follow-up of five of the six sources with ALMA band 4. All are detected in the 2 mm continuum with signal-to-noise ratios higher than eight. One emission line is detected in AGS4 (νobs = 151.44 GHz with an S/N = 8.58) and AGS17 (νobs = 154.78 GHz with an S/N = 10.23), which we interpret in both cases as being due to the CO(6–5) line at zspecAGS4 = 3.556 and zspecAGS17 = 3.467, respectively. These redshifts match both the probability distribution of the photometric redshifts derived from the UV to near-infrared spectral energy distributions (SEDs) and the far-infrared SEDs for typical dust temperatures of galaxies at these redshifts. We present evidence that nearly 70% (4/6 of galaxies) of the optically dark galaxies belong to the same overdensity of galaxies at z ∼ 3.5. overdensity The most massive one, AGS24 (M⋆ = 1011.32−0.19+0.02 M⊙), is the most massive galaxy without an active galactic nucleus at z > 3 in the GOODS-ALMA field. It falls in the very center of the peak of the galaxy surface density, which suggests that the surrounding overdensity is a proto-cluster in the process of virialization and that AGS24 is the candidate progenitor of the future brightest cluster galaxy

Direct Measurement of the Pseudoscalar Decay Constant fD+

The absolute branching fraction of $D^+ \to \mu^+ \nu$ has been directly measured by an analysis of a data sample of about 33 ${\rm pb^{-1}}$ collected around $\sqrt{s}=3.773$ GeV with the BES-II at the BEPC. At these energies, $D^-$ meson is produced in pair as $e^+e^-\to D^{+} D^{-}$. A total of $5321 \pm 149 \pm 160$ $D^-$ mesons are reconstructed from this data set. In the recoil side of the tagged $D^-$ mesons, $2.67\pm1.74$ purely leptonic decay events of $D^+ \to \mu^+ \nu$ are observed. This yields a branching fraction of $BF(D^+ \to \mu^+ \nu_{\mu}) = (0.122^{+0.111}_{-0.053}\pm 0.010)$, and a corresponding pseudoscalar decay constant $f_{D^+}=(371^{+129}_{-119}\pm 25)$ MeV.Comment: 7 pages, 8 figures, Submitted to Physics Letters B in October, 200

GOODS-ALMA: The slow downfall of star formation in z = 2–3 massive galaxies

We investigate the properties of a sample of 35 galaxies, detected with the Atacama Large Millimeter/Submillimeter Array (ALMA) at 1.1 mm in the GOODS-ALMA field (area of 69 arcmin2, resolution = 0.60″, rms ≃ 0.18 mJy beam−1). Using the ultraviolet-to-radio deep multiwavelength coverage of the GOODS–South field, we fit the spectral energy distributions of these galaxies to derive their key physical properties. The galaxies detected by ALMA are among the most massive at z = 2−4 (M⋆, med = 8.5 × 1010 M⊙) and they are either starburst or located in the upper part of the galaxy star-forming main sequence. A significant portion of our galaxy population (∼40%), located at z ∼ 2.5 − 3, exhibits abnormally low gas fractions. The sizes of these galaxies, measured with ALMA, are compatible with the trend between the rest-frame 5000 Å size and stellar mass observed for z ∼ 2 elliptical galaxies, suggesting that they are building compact bulges. We show that there is a strong link between star formation surface density (at 1.1 mm) and gas depletion time: The more compact a galaxy’s star-forming region is, the shorter its lifetime will be (without gas replenishment). The identified compact sources associated with relatively short depletion timescales (∼100 Myr) are the ideal candidates to be the progenitors of compact elliptical galaxies at z ∼ 2

GOODS-ALMA: Using IRAC and VLA to probe fainter millimeter galaxies

In this paper, we extend the source detection in the GOODS-ALMA field (69 arcmin2, 1σ ≃ 0.18 mJy beam−1) to deeper levels than presented in our previous work. Using positional information at 3.6 and 4.5 μm (from Spitzer-IRAC) as well as the Very Large Array (VLA) at 3 GHz, we explore the presence of galaxies detected at 1.1 mm with ALMA below our original blind detection limit of 4.8-σ, at which the number of spurious sources starts to dominate over that of real sources. In order to ensure the most reliable counterpart association possible, we have investigated the astrometry differences between different instruments in the GOODS–South field. In addition to a global offset between the Atacama Large Millimeter/submillimeter Array (ALMA) and the Hubble Space Telescope (HST) already discussed in previous studies, we have highlighted a local offset between ALMA and the HST that was artificially introduced in the process of building the mosaic of the GOODS–South image. We created a distortion map that can be used to correct for these astrometric issues. In this Supplementary Catalog, we find a total of 16 galaxies, including two galaxies with no counterpart in HST images (also known as optically dark galaxies), down to a 5σ limiting depth of H = 28.2 AB (HST/WFC3 F160W). This brings the total sample of GOODS-ALMA 1.1 mm sources to 35 galaxies. Galaxies in the new sample cover a wider dynamic range in redshift (z = 0.65−4.73), are on average twice as large (1.3 vs 0.65 kpc), and have lower stellar masses (M⋆SC = 7.6 × 1010 M⊙ vs M⋆MC = 1.2 × 1011 M⊙). Although exhibiting larger physical sizes, these galaxies still have far-infrared sizes that are significantly more compact than inferred from their optical emission

SARS-CoV-2 wastewater surveillance for public health action

Wastewater surveillance for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has garnered extensive public attention during the coronavirus disease pandemic as a proposed complement to existing disease surveillance systems. Over the past year, methods for detection and quantifi cation of SARS-CoV-2 viral RNA in untreated sewage have advanced, and concentrations in wastewater have been shown to correlate with trends in reported cases. Despite the promise of wastewater surveillance, for these measurements to translate into useful public health tools, bridging the communication and knowledge gaps between researchers and public health responders is needed. We describe the key uses, barriers, and applicability of SARS-CoV-2 wastewater surveillance for supporting public health decisions and actions, including establishing ethics consideration for monitoring. Although wastewater surveillance to assess community infections is not a new idea, the coronavirus disease pandemic might be the initiating event to make this emerging public health tool a sustainable nationwide surveillance system, provided that these barriers are addressed