Current Helicity and Twist as Two Indicators of The Mirror Asymmetry of solar Magnetic Fields

A comparison between the two tracers of magnetic field mirror asymmetry in solar active regions, twist and current helicity, is presented. It is shown that for individual active regions these tracers do not possess visible similarity while averaging by time over the solar cycle, or by latitude, reveals similarities in their behaviour. The main property of the dataset is anti-symmetry over the solar equator. Considering the evolution of helical properties over the solar cycle we find signatures of a possible sign change at the beginning of the cycle, though more systematic observational data are required for a definite confirmation. We discuss the role of both tracers in the context of the solar dynamo theory.Comment: 14 pages, 6 figure

A Statistical Study on Photospheric Magnetic Nonpotentiality of Active Regions and Its Relationship with Flares during Solar Cycles 22-23

A statistical study is carried out on the photospheric magnetic nonpotentiality in solar active regions and its relationship with associated flares. We select 2173 photospheric vector magnetograms from 1106 active regions observed by the Solar Magnetic Field Telescope at Huairou Solar Observing Station, National Astronomical Observatories of China, in the period of 1988-2008, which covers most of the 22nd and 23rd solar cycles. We have computed the mean planar magnetic shear angle (\bar{\Delta\phi}), mean shear angle of the vector magnetic field (\bar{\Delta\psi}), mean absolute vertical current density (\bar{|J_{z}|}), mean absolute current helicity density (\bar{|h_{c}|}), absolute twist parameter (|\alpha_{av}|), mean free magnetic energy density (\bar{\rho_{free}}), effective distance of the longitudinal magnetic field (d_{E}), and modified effective distance (d_{Em}) of each photospheric vector magnetogram. Parameters \bar{|h_{c}|}, \bar{\rho_{free}}, and d_{Em} show higher correlation with the evolution of the solar cycle. The Pearson linear correlation coefficients between these three parameters and the yearly mean sunspot number are all larger than 0.59. Parameters \bar{\Delta\phi}, \bar{\Delta\psi}, \bar{|J_{z}|}, |\alpha_{av}|, and d_{E} show only weak correlations with the solar cycle, though the nonpotentiality and the complexity of active regions are greater in the activity maximum periods than in the minimum periods. All of the eight parameters show positive correlations with the flare productivity of active regions, and the combination of different nonpotentiality parameters may be effective in predicting the flaring probability of active regions.Comment: 20 pages, 5 figures, 4 tables, accepted for publication in Solar Physic

Modelling and Interpreting The Effects of Spatial Resolution on Solar Magnetic Field Maps

Different methods for simulating the effects of spatial resolution on magnetic field maps are compared, including those commonly used for inter-instrument comparisons. The investigation first uses synthetic data, and the results are confirmed with {\it Hinode}/SpectroPolarimeter data. Four methods are examined, one which manipulates the Stokes spectra to simulate spatial-resolution degradation, and three "post-facto" methods where the magnetic field maps are manipulated directly. Throughout, statistical comparisons of the degraded maps with the originals serve to quantify the outcomes. Overall, we find that areas with inferred magnetic fill fractions close to unity may be insensitive to optical spatial resolution; areas of sub-unity fill fractions are very sensitive. Trends with worsening spatial resolution can include increased average field strength, lower total flux, and a field vector oriented closer to the line of sight. Further-derived quantities such as vertical current density show variations even in areas of high average magnetic fill-fraction. In short, unresolved maps fail to represent the distribution of the underlying unresolved fields, and the "post-facto" methods generally do not reproduce the effects of a smaller telescope aperture. It is argued that selecting a method in order to reconcile disparate spatial resolution effects should depend on the goal, as one method may better preserve the field distribution, while another can reproduce spatial resolution degradation. The results presented should help direct future inter-instrument comparisons.Comment: Accepted for publication in Solar Physics. The final publication (including full-resolution figures) will be available at http://www.springerlink.co

Further analysis of the quantum critical point of Ce1−x_{1-x}Lax_{x}Ru2_{2}Si2_{2}

New data on the spin dynamics and the magnetic order of Ce$_{1-x}$La$_{x}$Ru$_{2}$Si$_{2}$ are presented. The importance of the Kondo effect at the quantum critical point of this system is emphasized from the behaviour of the relaxation rate at high temperature and from the variation of the ordered moment with respect to the one of the N\'eel temperature for various $x$.Comment: Contribution for the Festschrift on the occasion of Hilbert von Loehneysen 60 th birthday. To be published as a special issue in the Journal of Low Temperature Physic

Associations of autozygosity with a broad range of human phenotypes

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding

A century of trends in adult human height

Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries

Antisense oligonucleotide development for the treatment of muscular dystrophies

Introduction: Depending upon the chemistry and annealing target, antisense oligonucleotides can be used to modify gene expression through several distinct modes of action. Originally used to down-regulate gene expression through specific induction of RNAse-H cleavage of an mRNA, antisense oligonucleotides can be designed to block initiation of translation, manipulate pre-mRNA processing, silence gene expression or act as antagomirs to sequester miRNAs. Area covered: In this review, we describe currently available antisense oligonucleotide chemistries, briefly summarize mechanisms of action, potential applications to neuromuscular diseases and discuss the most clinically advanced antisense oligonucleotide application to muscular dystrophy, restoration of functional dystrophin expression in Duchenne muscular dystrophy. Expert opinion: Antisense oligonucleotide chemistries that are excellent research tools may not necessarily be appropriate or safe for clinical application. Hypothesis-driven translational research demands that changes in target gene expression at both the RNA and protein levels, after administration of the antisense oligonucleotide, should be readily detectable. In ongoing clinical studies on Duchenne muscular dystrophy, it is only the phosphorodiamidate morpholino oligomer that results in unequivocal increases in muscle dystrophin. It is our opinion that these compounds could present new therapeutic opportunities for a number of otherwise untreatable conditions