108 research outputs found
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression
The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders. Toll-like receptors (TLR) are master regulators of innate immune function and involved in the activation of inflammatory responses in the brain. TLR3 agonist poly I:C exerts anti-inflammatory effect and prevents cell injury in the brain. The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-α, IFN-γ, IL-4, TGF-β1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAα, GABAAβ as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats. Poly I:C significantly attenuated CSD-induced production of TNF-α and IFN-γ in the brain as well as TNF-α and IL-4 in the spleen. Poly I:C did not affect enhancement of splenic lymphocyte proliferation after CSD. Administration of poly I:C increased expression of GABAAα, GABAAβ as well as Hsp70 and decreased expression of GAD65 in the entorhinal cortex compared to CSD-treated tissues. In addition, poly I:C significantly prevented production of CSD-induced dark neurons. The data indicate neuroprotective and anti-inflammatory effects of TLR3 activation on CSD-induced neuroinflammation. Targeting TLR3 may provide a novel strategy for developing new treatments for CSD-related neurological disorders. © 2014, Springer Science+Business Media New York
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression
The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders. Toll-like receptors (TLR) are master regulators of innate immune function and involved in the activation of inflammatory responses in the brain. TLR3 agonist poly I:C exerts anti-inflammatory effect and prevents cell injury in the brain. The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-α, IFN-γ, IL-4, TGF-β1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAα, GABAAβ as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats. Poly I:C significantly attenuated CSD-induced production of TNF-α and IFN-γ in the brain as well as TNF-α and IL-4 in the spleen. Poly I:C did not affect enhancement of splenic lymphocyte proliferation after CSD. Administration of poly I:C increased expression of GABAAα, GABAAβ as well as Hsp70 and decreased expression of GAD65 in the entorhinal cortex compared to CSD-treated tissues. In addition, poly I:C significantly prevented production of CSD-induced dark neurons. The data indicate neuroprotective and anti-inflammatory effects of TLR3 activation on CSD-induced neuroinflammation. Targeting TLR3 may provide a novel strategy for developing new treatments for CSD-related neurological disorders. © 2014, Springer Science+Business Media New York
VLT, GROND and Danish telescope observations of transits in the TRAPPIST-1 system
Funding: UGJ acknowledges funding from the Novo Nordisk Foundation Interdisciplinary Synergy Programme grant no. NNF19OC0057374 and from the European Union H2020-MSCA-ITN-2019 under Grant no. 860470 (CHAMELEON). NP’s work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the research grants UIDB/04434/2020 and UIDP/04434/2020. PLP was partly funded by Programa de Iniciación en Investigación-Universidad de Antofagasta, INI-17-03.TRAPPIST-1 is an ultra-cool dwarf that hosts seven known transiting planets. We present photometry of the system obtained using three telescopes at ESO La Silla (the Danish 1.54-m telescope and the 2.2-m MPI telescope) and Paranal (Unit Telescope 1 of the Very Large Telescope). We obtained 18 light curves from the Danish telescope, eight from the 2.2-m and four from the VLT. From these we measure 25 times of mid-transit for four of the planets (b, c, f, g). These light curves and times of mid-transit will be useful in determining the masses and radii of the planets, which show variations in their transit times due to gravitational interactions.PostprintPeer reviewe
OGLE-2017-BLG-0329L: A Microlensing Binary Characterized with Dramatically Enhanced Precision Using Data from Space-based Observations
Mass measurements of gravitational microlenses require one to determine the microlens parallax π E, but precise π E measurement, in many cases, is hampered due to the subtlety of the microlens-parallax signal combined with the difficulty of distinguishing the signal from those induced by other higher-order effects. In this work, we present the analysis of the binary-lens event OGLE-2017-BLG-0329, for which π E is measured with a dramatically improved precision using additional data from space-based Spitzer observations. We find that while the parallax model based on the ground-based data cannot be distinguished from a zero-π E model at the 2σ level, the addition of the Spitzer data enables us to identify two classes of solutions, each composed of a pair of solutions according to the well-known ecliptic degeneracy. It is found that the space-based data reduce the measurement uncertainties of the north and east components of the microlens-parallax vector π E by factors ~18 and ~4, respectively. With the measured microlens parallax combined with the angular Einstein radius measured from the resolved caustic crossings, we find that the lens is composed of a binary with component masses of either (M1, M2) ~ (1.1, 0.8) M⊙ or ~(0.4, 0.3) M⊙ according to the two solution classes. The first solution is significantly favored but the second cannot be securely ruled out based on the microlensing data alone. However, the degeneracy can be resolved from adaptive optics observations taken ~10 years after the event
Gaia21blx : Complete resolution of a binary microlensing event in the Galactic disk
This work has made use of the IAC-STAR Synthetic CMD computation code. IAC-STAR is supported and maintained by the IT department of the Instituto de Astrofísica de Canarias. EB gratefully acknowledges support from NASA grant 80NSSC19K0291. This research has made use of the NASA Exoplanet Archive, which is operated by the California Institute of Technology, under contract with the National Aeronautics and Space Administration under the Exoplanet Exploration Program. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium) and the Photometric Science Alerts Team (http://gsaweb.ast.cam.ac.uk/alerts). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This work makes use of observations from the Las Cumbres Observatory global telescope network. YT acknowledges the support of DFG priority program SPP 1992 “Exploring the Diversity of Extrasolar Planets” (TS 356/3-1). RFJ acknowledges support for this project provided by ANID’s Millennium Science Initiative through grant ICN12_009, awarded to the Millennium Institute of Astrophysics (MAS), and by ANID’s Basal project FB210003. This work is supported by Polish MNiSW grant DIR/WK/2018/12 and European Union’s Horizon 2020 research and innovation program under grant agreement no. 101004719 (OPTICON-RadioNet Pilot, ORP). We also acknowledge support by the italian PRIN 2022J4H55R – Detection of Earth-like ExoPlanets, CUP D53D23002590006. N.P.’s work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the research grants UIDB/04434/2020 and UIDP/04434/2020. We acknowledge support from the Novo Nordisk Foundation Interdisciplinary Synergy Program grant no. NNF19OC0057374.Context. Gravitational microlensing is a method that is used to discover planet-hosting systems at distances of several kiloparsec in the Galactic disk and bulge. We present the analysis of a microlensing event reported by the Gaia photometric alert team that might have a bright lens. Aims. In order to infer the mass and distance to the lensing system, the parallax measurement at the position of Gaia21blx was used. In this particular case, the source and the lens have comparable magnitudes and we cannot attribute the parallax measured by Gaia to the lens or source alone. Methods. Since the blending flux is important, we assumed that the Gaia parallax is the flux-weighted average of the parallaxes of the lens and source. Combining this assumption with the information from the microlensing models and the finite source effects we were able to resolve all degeneracies and thus obtained the mass, distance, luminosities and projected kinematics of the binary lens and the source. Results. According to the best model, the lens is a binary system at kpc from Earth. It is composed of a G star with and a K star with . The source is likely to be an F subgiant star at kpc with a mass of . Both lenses and the source follow the kinematics of the thin-disk population. We also discuss alternative models, that are disfavored by the data or by prior expectations, however.Peer reviewe
Large-scale changes of the cloud coverage in the ε Indi Ba,Bb system
We present the results of 14 nights of I-band photometric monitoring of the nearby brown dwarf binary, ε Indi Ba,Bb. Observations were acquired over 2 months, and total close to 42 hours of coverage at a typically high cadence of 1.4 minutes. At a separation of just 0.7″, we do not resolve the individual components, and so effectively treat the binary as if it were a single object. However, ε Indi Ba (spectral type T1) is the brightest known T-type brown dwarf, and is expected to dominate the photometric signal. We typically find no strong variability associated with the target during each individual night of observing, but see significant changes in mean brightness - by as much as 0.10 magnitudes - over the 2 months of the campaign. This strong variation is apparent on a timescale of at least 2 days. We detect no clear periodic signature, which suggests we may be observing the T1 brown dwarf almost pole-on, and the days-long variability in mean brightness is caused by changes in the large-scale structure of the cloud coverage. Dynamic clouds will very likely produce lightning, and complementary high cadence V-band and Hα images were acquired to search for the emission signatures associated with stochastic ‘strikes’. We report no positive detections for the target in either of these passbands
Transit timing variations in the WASP-4 planetary system*
Abstract Transits in the planetary system WASP-4 were recently found to occur 80 s earlier than expected in observations from the TESS satellite. We present 22 new times of mid-transit that confirm the existence of transit timing variations, and are well fitted by a quadratic ephemeris with period decay dP/dt = −9.2 ± 1.1 ms yr−1. We rule out instrumental issues, stellar activity and the Applegate mechanism as possible causes. The light-time effect is also not favoured due to the non-detection of changes in the systemic velocity. Orbital decay and apsidal precession are plausible but unproven. WASP-4 b is only the third hot Jupiter known to show transit timing variations to high confidence. We discuss a variety of observations of this and other planetary systems that would be useful in improving our understanding of WASP-4 in particular and orbital decay in general
OGLE-2018-BLG-0022: A Nearby M-dwarf Binary
We report observations of the binary microlensing event OGLE-2018-BLG-0022, provided by the Robotic Observations of Microlensing Events (ROME)/Reactive Event Assessment (REA) Survey, which indicate that the lens is a low-mass binary star consisting of M3 (0.375 ± 0.020 M⊙) and M7 (0.098 ± 0.005 M⊙) components. The lens is unusually close, at 0.998 ± 0.047 kpc, compared with the majority of microlensing events, and despite its intrinsically low luminosity, it is likely that adaptive optics observations in the near future will be able to provide an independent confirmation of the lens masses
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Gaia21blx: complete resolution of a binary microlensing event in the Galactic disk
Context. Gravitational microlensing is a method that is used to discover planet-hosting systems at distances of several kiloparsec in the Galactic disk and bulge. We present the analysis of a microlensing event reported by the Gaia photometric alert team that might have a bright lens. Aims. In order to infer the mass and distance to the lensing system, the parallax measurement at the position of Gaia21blx was used. In this particular case, the source and the lens have comparable magnitudes and we cannot attribute the parallax measured by Gaia to the lens or source alone. Methods. Since the blending flux is important, we assumed that the Gaia parallax is the flux-weighted average of the parallaxes of the lens and source. Combining this assumption with the information from the microlensing models and the finite source effects we were able to resolve all degeneracies and thus obtained the mass, distance, luminosities and projected kinematics of the binary lens and the source. Results. According to the best model, the lens is a binary system at 2.18 ± 0.07 kpc from Earth. It is composed of a G star with 0.95 ± 0.17 M ⊙ and a K star with 0.53 ± 0.07 M ⊙. The source is likely to be an F subgiant star at 2.38 ± 1.71 kpc with a mass of 1.10 ± 0.18 M ⊙. Both lenses and the source follow the kinematics of the thin-disk population. We also discuss alternative models, that are disfavored by the data or by prior expectations, however.</p
OGLE-2016-BLG-1190Lb: The First Spitzer Bulge Planet Lies Near the Planet/Brown-dwarf Boundary
We report the discovery of OGLE-2016-BLG-1190Lb, which is likely to be the first Spitzer microlensing planet in the Galactic bulge/bar, an assignation that can be confirmed by two epochs of high-resolution imaging of the combined source–lens baseline object. The planet's mass, M p = 13.4 ± 0.9 M J , places it right at the deuterium-burning limit, i.e., the conventional boundary between "planets" and "brown dwarfs." Its existence raises the question of whether such objects are really "planets" (formed within the disks of their hosts) or "failed stars" (low-mass objects formed by gas fragmentation). This question may ultimately be addressed by comparing disk and bulge/bar planets, which is a goal of the Spitzer microlens program. The host is a G dwarf, M host = 0.89 ± 0.07 M ⊙, and the planet has a semimajor axis a ~ 2.0 au. We use Kepler K2 Campaign 9 microlensing data to break the lens-mass degeneracy that generically impacts parallax solutions from Earth–Spitzer observations alone, which is the first successful application of this approach. The microlensing data, derived primarily from near-continuous, ultradense survey observations from OGLE, MOA, and three KMTNet telescopes, contain more orbital information than for any previous microlensing planet, but not quite enough to accurately specify the full orbit. However, these data do permit the first rigorous test of microlensing orbital-motion measurements, which are typically derived from data taken over <1% of an orbital period
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