The LAUE project for broadband gamma-ray focusing lenses

We present the LAUE project devoted to develop an advanced technology for building a high focal length Laue lens for soft gamma--ray astronomy (80-600 keV). The final goal is to develop a focusing optics that can improve the current sensitivity in the above energy band by 2 orders of magnitude.Comment: 7 pages, 6 figures, presented at the SPIE conference on "Optics for EUV, X-ray, and Gamma-ray Astronomy". To be published in the Proceedings of SPIE, vol.8147, 201

Development status of the LAUE project

We present the status of LAUE, a project supported by the Italian Space Agency (ASI), and devoted to develop Laue lenses with long focal length (up to 100 meters), for hard X--/soft gamma--ray astronomy (80-600 keV). Thanks to their focusing capability, the design goal is to improve the sensitivity of the current instrumention in the above energy band by 2 orders of magnitude, down to a few times $10^{-8}$ photons/(cm$^2$ s keV).Comment: 9 pages, 9 figures, presented at the Space Telescopes and Instrumentation Symposium in Amsterdam, 2012: Ultraviolet to Gamma Ray Conference. Published in the Proceedings of the SPIE, Volume 8443, id. 84430B-84430B-9 (2012

The PRIMA fringe sensor unit

The Fringe Sensor Unit (FSU) is the central element of the Phase Referenced Imaging and Micro-arcsecond Astrometry (PRIMA) dual-feed facility and provides fringe sensing for all observation modes, comprising off-axis fringe tracking, phase referenced imaging, and high-accuracy narrow-angle astrometry. It is installed at the Very Large Telescope Interferometer (VLTI) and successfully servoed the fringe tracking loop during the initial commissioning phase. Unique among interferometric beam combiners, the FSU uses spatial phase modulation in bulk optics to retrieve real-time estimates of fringe phase after spatial filtering. A R=20 spectrometer across the K-band makes the retrieval of the group delay signal possible. The FSU was integrated and aligned at the VLTI in summer 2008. It yields phase and group delay measurements at sampling rates up to 2 kHz, which are used to drive the fringe tracking control loop. During the first commissioning runs, the FSU was used to track the fringes of stars with K-band magnitudes as faint as m_K=9.0, using two VLTI Auxiliary Telescopes (AT) and baselines of up to 96 m. Fringe tracking using two Very Large Telescope (VLT) Unit Telescopes (UT) was demonstrated. During initial commissioning and combining stellar light with two ATs, the FSU showed its ability to improve the VLTI sensitivity in K-band by more than one magnitude towards fainter objects, which is of fundamental importance to achieve the scientific objectives of PRIMA.Comment: 19 pages, 23 figures. minor changes and language editing. this version equals the published articl

Genetic diversity of hepatitis B virus (HBV) in Madagascar

Hepatitis B virus (HBV) is a DNA virus belonging to Hepadnaviridae family. Chronic infection with HBV is one major risk factor of hepatic disease. In Madagascar, former studies classified the country as part of high endemic area, as HBV prevalence can reach 23% in general population. However, this prevalence differs largely between urban and rural areas and is estimated to be respectively 5% and 26%. The aims of the present study were to describe the genetic diversity of HBV strains from different regions of Madagascar, and to describe the viral gene flow throughout the country by using phylogenetic analysis. This is the first large-scale molecular and phylogenetic study analyzing HBV sequences from 28 different Malagasy areas, never sampled in the past. In this study, the most prevalent genotype/sub-genotypes was E. Migration analysis showed a gene flow from zone 3 (rural) to zone 2 (suburban) and a greater gene flow from the middle part of Madagascar to the north than to the south. It is important to study the HBV infections in Madagascar and to monitor the potential spread of this viral strain inside this country

The Brera Multi-scale Wavelet Chandra Survey. I. Serendipitous source catalogue

We present the BMW-Chandra source catalogue drawn from essentially all Chandra ACIS-I pointed observations with an exposure time in excess of 10ks public as of March 2003 (136 observations). Using the wavelet detection algorithm developed by Lazzati et al. (1999) and Campana et al. (1999), which can characterise both point-like and extended sources, we identified 21325 sources. Among them, 16758 are serendipitous, i.e. not associated with the targets of the pointings, and do not require a non-automated analysis. This makes our catalogue the largest compilation of Chandra sources to date. The 0.5--10 keV absorption corrected fluxes of these sources range from ~3E-16 to 9E-12 erg cm^-2 s^-1 with a median of 7E-15 erg cm^-2 s^-1. The catalogue consists of count rates and relative errors in three energy bands (total, 0.5-7keV; soft, 0.5-2keV; and hard, 2-7keV), and source positions relative to the highest signal-to-noise detection among the three bands. The wavelet algorithm also provides an estimate of the extension of the source. We include information drawn from the headers of the original files, as well, and extracted source counts in four additional energy bands, SB1 (0.5-1keV), SB2 (1-2keV), HB1 (2-4keV), and HB2 (4-7keV). We computed the sky coverage for the full catalogue and for a subset at high Galactic latitude (|b|> 20deg). The complete catalogue provides a sky coverage in the soft band (0.5-2keV, S/N =3) of ~8 deg^2 at a limiting flux of 1E-13 erg cm^-2 s^-1, and ~2 deg^2 at a limiting flux of ~1E-15 erg cm^-2 s^-1.Comment: Accepted by A&A, Higher res. Figs 4 and 5 at http://www.ifc.inaf.it/~romano/BMC/Docs/aapaper/9601f4.eps http://www.ifc.inaf.it/~romano/BMC/Docs/aapaper/9601f5.eps, Catalog Web pages: http://www.brera.inaf.it/BMC/bmc_home.html http://www.ifc.inaf.it/~romano/BMC/bmc_home.html (Mirror

Scientific prospects in soft gamma-ray astronomy enabled by the LAUE project

This paper summarizes the development of a successful project, LAUE, supported by the Italian Space Agency (ASI) and devoted to the development of long focal length (up to 100 m) Laue lenses for hard X--/soft gamma--ray astronomy (80-600 keV). The apparatus is ready and the assembling of a prototype lens petal is ongoing. The great achievement of this project is the use of bent crystals. From measurements obtained on single crystals and from simulations, we have estimated the expected Point Spread Function and thus the sensitivity of a lens made of petals. The expected sensitivity is a few $\times10^{-8}$ photons cm$^{-2}$ s$^{-1}$ keV$^{-1}$. We discuss a number of open astrophysical questions that can settled with such an instrument aboard a free-flying satellite.Comment: 17 pages, 18 figures, published in Proceedings of the SPIE, Volume 8861, id. 886106 17 pp. (2013

The Dependency of the Cepheid Period-Luminosity Relation on Chemical Composition

The dependency of the Cepheid Period-Luminosity Relation on chemical composition at different wavelengths is assessed via direct detailed abundance analysis of Galactic and Magellanic Cepheids, as derived from high resolution, high signal-to-noise spectra. Our measurements span one order of magnitude in iron content and allow to rule out at the ~ 9 sigma level the universality of the Period-Luminosity Relation in the V band, with metal rich stars being fainter than metal poor ones by ~0.3 mag. The dependency is less pronounced in the K band. Its magnitude and statistical significance decisively depend on detailed distance measurements to individual stars, as inferred via the Infrared Surface Brightness Method.Comment: 3 pages, 2 figures, to be published in "Stellar Pulsation: Challenges for Theory and Observation" (31 May - 5 June, Santa Fe, New Mexico). Minor typos fixed in v

A wide angle view of the Sagittarius dwarf Spheroidal Galaxy. I: VIMOS photometry and radial velocities across Sgr dSph major and minor axis

The Sagittarius dwarf Spheroidal Galaxy (Sgr dSph) provides us with a unique possibility of studying a dwarf galaxy merging event while still in progress. Due to its low distance (25 kpc), the main body of Sgr dSph covers a vast area in the sky (roughly 15 x 7 degrees). Available photometric and spectroscopic studies have concentrated either on the central part of the galaxy or on the stellar stream, but the overwhelming majority of the galaxy body has never been probed. The aim of the present study is twofold. On the one hand, to produce color magnitude diagrams across the extension of Sgr dSph to study its stellar populations, searching for age and/or composition gradients (or lack thereof). On the other hand, to derive spectroscopic low-resolution radial velocities for a subsample of stars to determine membership to Sgr dSph for the purpose of high resolution spectroscopic follow-up. We used VIMOS-VLT to produce V and I photometry and spectroscopy on 7 fields across the Sgr dSph minor and major axis, plus 3 more centered on the associated globular clusters Terzan 7, Terzan 8 and Arp 2. A last field has been centered on M 54, lying in the center of Sgr dSph. We present photometry for 320,000 stars across the main body of Sgr dSph, one of the richest, and safely the most wide-angle sampling ever produced for this fundamental object. We also provide robust memberships for more than one hundred stars, whose high resolution spectroscopic analysis will be the object of forthcoming papers. Sgr dSph appears remarkably uniform among the observed fields. We confirm the presence of a main Sgr dSph population characterized roughly by the same metallicity of 47 Tuc, but we also found the presence of multiple populations on the peripheral fields of the galaxy, with a metallicity spanning from [Fe/H]=-2.3 to a nearly solar value.Comment: 10 pages, 12 figures, accepted for publication in A&

High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja

Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. During a humanitarian health campaign conducted in Ambanja, a rural city in the northern part of Madagascar, we identified 42 adult subjects with diabetes and compared their features to 24 randomly enrolled healthy controls. 42.9% (n = 18) of diabetic subjects showed HbA1c values ≥ 9.0%. Unexpectedly, waist circumference and BMI were similar in people with diabetes and controls. Different from the healthy controls, diabetic subjects showed a low prevalence of obesity (5.7% versus 30%, p = 0.02). Accordingly, we found a high prevalence of autoimmune diabetes as 12% of people with diabetes showed positivity for the autoantibody against glutamic acid decarboxylase. Diabetic subjects with positive autoantibody had higher HbA1c values (11.3 ± 4.1% versus 8.3 ± 2.6%, p = 0.03) compared to diabetic subjects with negative autoantibody. In conclusion, here we describe the presence of diabetes and its features in a rural area of Northern Madagascar, documenting poor glycaemic control and a high prevalence of autoimmune diabetes. These data highlight that the diabetes epidemic involves every corner of the world possibly with different patterns and features