MULTIDISCIPLINARY INVESTIGATION ON EARLY-MID HOLOCENE WILD CEREALS FOUND AT TAKARKORI (CENTRAL SAHARA)

Plant macroremains from rock shelters of central Sahara give information about the environmental conditions during the Holocene, and the adaptive strategies of human groups living in the area. Takarkori was excavated by the Italian-Libyan Archaeological Mission in the Acacus and Messak (directed by S. di Lernia, Sapienza University of Rome) and its chronology ranges from ca. 10,200 to ca. 4,600 cal yr BP (Cremaschi et al. 2014)

Multidisciplinary analysis of Early \u2013 Mid Holocene wild cereal remains from central Sahara (SW Libya).

.Pollen and plant macroremains from rock shelters of central Sahara give information about environmental conditions during the Holocene, and adaptive strategies of human groups living in the area. Wild cereals were long-time exploited and are prevalent among plants selected and transported to these sites. Spikelets and grains of Panicoideae are the most abundant plant remains found at Takarkori, a rock shelter in the Tadrart Acacus Mts. (SW Libya). They have been studied by means of morphological and molecular (ancient DNA) analyses. The excavation by the Italian-Libyan Archaeological Mission in the Acacus and Messak (Sapienza University of Rome and Libyan Department of Archaeology) exposed a surface of 140 m2. The deposit includes stone structures, fireplaces, plant accumulations and a burial area. The site (dated 10,200-4,600 cal yr BP) was occupied throughout Early and Middle Holocene, a pivotal period for human development as include the transition from hunter-gatherer subsistence to food production. Peculiarity of the sequences is the surprising preservation of organic matter. Systematic morphobiometrical analysis was carried out on 1,450 spikelets of Panicum, Echinochloa and Sorghum selected on the basis of their different cultural contexts. The records showed uniform size in each genus. aDNA was extracted testing different protocols and then was studied by the DNA barcoding technique using four chloroplast markers. Bioinformatic analysis of the results allowed to inspect the phylogenetic relationships between the archaeobotanical records and the modern species of African wild cereals

Outcome following a short period of adalimumab dose escalation as rescue therapy in psoriatic patients

Background: Advances in biologic treatments have led to a new therapeutic frontier for moderate-to-severe psoriasis. Nevertheless, the efficacy of anti-TNFα decreases with time, requiring adjustments to maintain valuable Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) responses. Objectives: To evaluate the efficacy and safety of adalimumab dose escalation (40 mg, subcutaneous, once a week for 24 weeks) in psoriatic adult patients with secondary loss of response (PASI ≥50 to ≤75 or PASI≥75 and DLQI ≥5). Materials and Methods: A multicentre, observational study involving different Italian third-level referral centres for psoriasis enrolled a total of 64 adult patients with moderate-to-severe psoriasis who were treated with adalimumab and experienced a secondary loss of response. Primary end-points were PASI< 75 or PASI ≥50 to ≤ 75 with DLQI ≤ 5, and the secondary end-point was the ability to maintain a therapeutic response, resuming adalimumab every other week. Results: At Week 16 and Week 24, 29/64 (45.3%) and 35/64 (54.6%) responded based on PASI, and mean DLQI was 4.9 and 4.09, respectively. At Week 36 and Week 48, 45.3% and 28.1% patients achieved the second end-point, respectively. No adverse events were recorded except for one patient with recurrent tonsillitis. Conclusion: Adalimumab escalation could be considered in cases with loss of response before switching to alternative biologic therapy

Safety of occasional ingestion of gluten in patients with celiac disease: a real-life study

Background Gluten-free diet (GFD) decreases the quality of life of celiac disease (CD) patients, who frequently ask to occasionally ingest gluten-containing food. We evaluated CD patients reporting voluntary and occasional transgressions to their GFD. Methods From October 2017 to September 2018, the patients reporting occasional and voluntary gluten ingestion (GFD-noncompliant) were prospectively enrolled. These patients underwent clinical examination, blood tests, duodenal biopsy, capsule enteroscopy (CE), and a validated food-frequency questionnaire (FFQ) assessing the frequency and quantity of gluten intake. Mortality was calculated and compared to the general population. A group of patients on strict GFD (GFD-adherent) acted as controls. Results One thousand three hundred seventy-eight CD patients were evaluated during the study period. One hundred nine (8%) reported occasional (weekly or monthly) voluntary ingestion of gluten. The mean gluten intake was 185.2 +/- 336.9 g/year, and the duration of their incorrect GFD was 8.6 +/- 6.9 years. Among the noncompliant patients, 57% did not present any histological alteration; furthermore, the Marsh score profile was not different between compliant and noncompliant patients. Seventy percent did not present any alteration at CE. Seventy-five percent of patients reported no gastrointestinal symptoms after gluten ingestion. Twenty-three percent of patients in the GFD-noncompliant group presented positive tTG-IgA. No association was found between gluten intake, clinical symptoms, and biomarkers. Mortality was not different between the groups and the general population. Conclusions Our results are that in a real-life scenario, a group of CD patients on long-term gluten intake showed no significant clinical symptoms or small bowel damage, thus suggesting that a degree of tolerance towards gluten consumption can be reached

Efficacy of Multisensory Technology in Post-Stroke Cognitive Rehabilitation: A Systematic Review

Post-stroke, in addition to sensorimotor signs and symptoms, could lead to cognitive deficits. Theories of embodiment stress the role of sensorimotor system and multisensory integration in sustaining high-order cognitive domains. Despite conventional post-stroke cognitive rehabilitation being effective, innovative technologies could overcome some limitations of standard interventions and exploit bodily information during cognitive rehabilitation. This systematic review aims to investigate whether ‘multisensory technologies’ compared to usual care treatment can be a viable alternative for cognitive rehabilitation. By applying PRISMA guidelines, we extracted data and assessed the bias of 10 studies that met the required criteria. We found that multisensory technologies were at least comparable to standard treatment but particularly effective for attention, spatial cognition, global cognition, and memory. Multisensory technologies consisted principally of virtual reality alone or combined with a motion tracking system. Multisensory technologies without motion tracking were more effective than standard procedures, whereas those with motion tracking showed balanced results for the two treatments. Limitations of the included studies regarded the population (e.g., no study on acute stroke), assessment (e.g., lack of multimodal/multisensory pre-post evaluation), and methodology (e.g., sample size, blinding bias). Recent advancements in technological development and metaverse open new opportunities to design embodied rehabilitative programs

Timing and pace of dairying inception and animal husbandry practices across Holocene North Africa

The timing and extent of the adoption and exploitation of domesticates and their secondary products, across Holocene North Africa, has long been the subject of debate. The three distinct areas within the region, Mediterranean north Africa, the Nile Valley and the Sahara, each with extremely diverse environments and ecologies, demonstrate differing trajectories to pastoralism. Here, we address this question using a combination of faunal evidence and organic residue analyses of c. 300 archaeological vessels from sites in Algeria, Libya and Sudan. This synthesis of new and published data provides a broad regional and chronological perspective on the scale and intensity of domestic animal exploitation and the inception of dairying practices in Holocene North Africa. Following the introduction of domesticated animals into the region our results confirm a hiatus of around one thousand years before the adoption of a full pastoral economy, which appears first in the Libyan Sahara, at c. 5200 BCE, subsequently appearing at c. 4600 BCE in the Nile Valley and at 4400–3900 BCE in Mediterranean north Africa

Earthing the Anthropos? From ‘socializing the Anthropocene’ to geologizing the social

Responding to claims of Anthropocene geoscience that humans are now geological agents, social scientists are calling for renewed attention to the social, cultural, political and historical differentiation of the Anthropos. But does this leave critical social thought’s own key concepts and categories unperturbed by the Anthropocene provocation to think through dynamic earth processes? Can we ‘socialize the Anthropocene’ without also opening ‘the social’ to climate, geology and earth system change? Revisiting the earth science behind the Anthropocene thesis and drawing on social research that is using climatology and earth systems thinking to help understand socio-historical change, this article explores some of the possibilities for ‘geologizing’ social thought. While critical social thought’s attention to justice and exclusion remains vital, it suggests that responding to Anthropocene conditions also calls for a kind of ‘geo-social’ thinking that relates human diversity and social difference to the potentiality and multiplicity of the earth itself

TOpic: rare and special cases, the real "Strange cases"

Introduction: The bladder hernia represents approximately 1-3% of all inguinal hernias, where patients aged more than 50 years have a higher incidence (10%). Many factors contribute to the development of a bladder hernia, including the presence of a urinary outlet obstruction causing chronic bladder distention, the loss of bladder tone, pericystitis, the perivesical bladder fat protrusion and the obesity

La lezione dei maestri. Conversazioni sul lavoro sociale ed educativo

Questo volume nasce dalla volontà di riflettere sulle radici motivazionali del lavoro sociale ed educativo, ripercorrendo, per ognuno degli autori coinvolti, i maestri quali ispiratori di metodi e modelli. A parlare sono sociologi, pedagogisti, assistenti sociali, antropologi, educatori che invitano al confronto con la figura che fa da riferimento al loro lavoro quotidiano. Non solo un lascito del pensiero, ma un invito a continuare ad affrontare le asperità dell’incontro con l’altro, a rispondere alle tante domande lasciate inevase

Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: SUPREME study

Background: Understanding genetic variations is important in predicting treatment response and forms the basis for identifying new pharmacogenetic and pharmacogenomic targets for psoriasis treatment. There are limited data on the efficacy of secukinumab in relation to genetic markers. Objectives: To evaluate the efficacy and safety of secukinumab 300 mg in HLA-Cw6-positive (Cw6-POS) and HLA-Cw6-negative (Cw6-NEG) patients with moderate-to-severe chronic plaque-type psoriasis. Methods: SUPREME was a 24-week, phase IIIb study with an extension period up to 72 weeks. Primary end point was Psoriasis Area Severity Index (PASI) 90 response rate after 16 weeks. Results: In total, 434 patients were recruited: 185 (42\ub76%) were Cw6-POS and 246 (56\ub77%) were Cw6-NEG (three not assessed). Mean \ub1 SD age was 45\ub72 \ub1 13\ub72 years (Cw6-POS 42\ub77 \ub1 13\ub71; Cw6-NEG 47\ub72 \ub1 12\ub79). The baseline PASI score was comparable between the cohorts [Cw6-POS 20\ub77 \ub1 8\ub799; Cw6-NEG 21\ub75 \ub1 9\ub799 (P = 0\ub7777)]. At week 16, PASI 90 was achieved in 80\ub74% of Cw6-POS and 79\ub77% of Cw6-NEG patients (difference 0\ub776; 95% confidence interval 127\ub704 to 8\ub723). No differences in absolute PASI at week 16 (Cw6-POS 1\ub736 \ub1 3\ub758; Cw6-NEG 1\ub718 \ub1 2\ub729) were observed. The overall safety profile of secukinumab was consistent with that previously reported. No statistically significant difference was detected in the rate of treatment-emergent adverse events [Cw6-POS 42\ub77%; Cw6-NEG 49\ub76% (P = 0\ub7295)]. A high PASI 90 response was achieved with secukinumab with a fast reduction in absolute PASI. Conclusions: Determination of HLA-Cw6 status for secukinumab therapy is unnecessary, as it is highly effective regardless of HLA-Cw6 status