4,510 research outputs found
Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training.
Predicting treatment outcomes in psychiatric populations remains a challenge, but is increasingly important in the pursuit of personalized medicine. Patients with schizophrenia have deficits in cognition, and targeted cognitive training (TCT) of auditory processing and working memory has been shown to improve some of these impairments; but little is known about the baseline patient characteristics predictive of cognitive improvement. Here we use a model selection and regression approach called least absolute shrinkage and selection operator (LASSO) to examine predictors of cognitive improvement in response to TCT for patients with recent onset schizophrenia. Forty-three individuals with recent onset schizophrenia randomized to undergo TCT were assessed at baseline on measures of cognition, symptoms, functioning, illness duration, and demographic variables. We carried out 10-fold cross-validation of LASSO for model selection and regression. We followed up on these results using linear models for statistical inference. No individual variable was found to correlate with improvement in global cognition using a Pearson correlation approach, and a linear model including all variables was also found not to be significant. However, the LASSO model identified baseline global cognition, education, and gender in a model predictive of improvement on global cognition following TCT. These findings offer guidelines for personalized approaches to cognitive training for patients with schizophrenia
Quadratic reheating
The reheating process for the inflationary scenario is investigated
phenomenologically. The decay of the oscillating massive inflaton field into
light bosons is modeled after an out of equilibrium mixture of interacting
fluids within the framework of irreversible thermodynamics. Self-consistent,
analytic results for the evolution of the main macroscopic magnitudes like
temperature and particle number densities are obtained. The models for linear
and quadratic decay rates are investigated in the quasiperfect regime. The
linear model is shown to reheat very slowly while the quadratic one is shown to
yield explosive particle and entropy production. The maximum reheating
temperature is reached much faster and its magnitude is comparable with the
inflaton mass.Comment: 21 pages, LaTeX 2.09, 4 figures. To be published in International
Journal of Modern Physics
Long term outcomes of simple clinical risk stratification in management of differentiated thyroid cancer
WL Craig was supported by a Cameron Research Fellowship, NHS Grampian. The University of Aberdeen Health Services Research Unit is supported by a core grant from the Chief Scientist Office of the Scottish Government Health and Social Care Directorate. There are no declared conflicts of interest.Peer reviewedPostprin
RAT J0455+1305: A rare hybrid pulsating subdwarf B star
We present results on the second-faintest pulsating subdwarf B (sdB) star
known, RAT J0455+1305, derived from photometric data obtained in 2009. It shows
both short and long periods oscillations, theoretically assigned as pressure
and gravity modes. We identify six short-period frequencies (with one being a
combination) and six long-period frequencies. This star is the fourth hybrid
sdB star discovered so far which makes it of special interest as each type of
mode probes a different part of the star. This star is similar to the sdB
hybrid pulsator Balloon 090100001 in that it exhibits short-period mode
groupings, which can be used to identify pulsation parameters and constrain
theoretical models.Comment: published in MNRA
Feedback from massive stars at low metallicities : MUSE observations of N44 and N180 in the Large Magellanic Cloud
Accepted for publication in MNRAS, 27 pages, 21 figuresWe present MUSE integral field data of two HII region complexes in the Large Magellanic Cloud (LMC), N44 and N180. Both regions consist of a main superbubble and a number of smaller, more compact HII regions that formed on the edge of the superbubble. For a total of 11 HII regions, we systematically analyse the radiative and mechanical feedback from the massive O-type stars on the surrounding gas. We exploit the integral field property of the data and the coverage of the HeII5412 line to identify and classify the feedback-driving massive stars, and from the estimated spectral types and luminosity classes we determine the stellar radiative output in terms of the ionising photon flux . We characterise the HII regions in terms of their sizes, morphologies, ionisation structure, luminosity and kinematics, and derive oxygen abundances via emission line ratios. We analyse the role of different stellar feedback mechanisms for each region by measuring the direct radiation pressure, the pressure of the ionised gas, and the pressure of the shock-heated winds. We find that stellar winds and ionised gas are the main drivers of HII region expansion in our sample, while the direct radiation pressure is up to three orders of magnitude lower than the other terms. We relate the total pressure to the star formation rate per unit area, , for each region and find that stellar feedback has a negative effect on star formation, and sets an upper limit to as a function of increasing pressure.Peer reviewe
The Ratio of Ortho- to Para-H2 in Photodissociation Regions
We discuss the ratio of ortho- to para-H2 in photodissociation regions
(PDRs). We draw attention to an apparent confusion in the literature between
the ortho-to-para ratio of molecules in FUV-pumped vibrationally excited
states, and the H2 ortho-to-para abundance ratio. These ratios are not the same
because the process of FUV-pumping of fluorescent H2 emission in PDRs occurs
via optically thick absorption lines. Thus, gas with an equilibrium ratio of
ortho- to para-H2 equal to 3 will yield FUV-pumped vibrationally excited
ortho-to-para ratios smaller than 3, because the ortho-H2 pumping rates are
preferentially reduced by optical depth effects. Indeed, if the ortho and para
pumping lines are on the ``square root'' part of the curve-of-growth, then the
expected ratio of ortho and para vibrational line strengths is the square root
of 3, ~ 1.7, close to the typically observed value. Thus, contrary to what has
sometimes been stated in the literature, most previous measurements of the
ratio of ortho- to para-H2 in vibrationally excited states are entirely
consistent with a total ortho-to-para ratio of 3, the equilibrium value for
temperatures greater than 200 K. We present an analysis and several detailed
models which illustrate the relationship between the total ratios of ortho- to
para-H2 and the vibrationally excited ortho-to-para ratios in PDRs. Recent
Infrared Space Observatory (ISO) measurements of pure rotational and
vibrational H2 emissions from the PDR in the star-forming region S140 provide
strong observational support for our conclusions.Comment: 23 pages (including 5 figures), LaTeX, uses aaspp4.sty, accepted for
publication in Ap
Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance.
Since 2015 in the United States (US), the US Neisseria meningitidis urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males. Its 'parent' strain caused numerous outbreaks of invasive meningococcal disease among men who have sex with men in Europe and North America. We highlight the arrival and dissemination of US_NmUC in the United Kingdom and the emergence of multiple antibiotic resistance. Surveillance systems should be developed that include anogenital meningococci
N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe
Near-Infrared Spectroscopy of Molecular Filaments in the Reflection Nebula NGC 7023
We present near-infrared spectroscopy of fluorescent molecular hydrogen (H_2)
emission from molecular filaments in the reflection nebula NGC 7023. We derive
the relative column densities of H_2 rotational-vibrational states from the
measured line emission and compare these results with several model
photodissociation regions covering a range of densities, incident UV-fields,
and excitation mechanisms. Our best-fit models for one filament suggest, but do
not require, either a combination of different densities, suggesting clumps of
10^6 cm^{-3} in a 10^4 - 10^5 cm^{-3} filament, or a combination of fluorescent
excitation and thermally-excited gas, perhaps due to a shock from a bipolar
outflow. We derive densities and UV fields for these molecular filaments that
are in agreement with previous determinations.Comment: ApJ accepted, 26 pages including 5 embedded figures, uses AASTEX.
Also available at http://www-astronomy.mps.ohio-state.edu/~martini/pubs.htm
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