Effects of extended grazing during mid, late or throughout pregnancy, and winter shearing of housed ewes, on ewe and lamb performance

peer-reviewedA flock of March-lambing ewes was used to evaluate the effects of (i) extended (deferred, winter) grazing of pasture during mid, late or throughout pregnancy, and (ii) winter shearing of ewes housed during mid and late pregnancy, on lamb birth weight and subsequent growth to weaning. Ewes (n = 265) were allocated at random to five treatments for the period from 7 December (~ day 47 of pregnancy) to lambing. The treatments were: housed shorn (HS), housed unshorn (HU), grazing throughout (EG), grazing to 20 January followed by housing (EGH), housed to 20 January followed by grazing (HEG). From 1 March to lambing the HEG and EG ewes were dispersed on the paddocks intended for grazing post lambing. All ewes were offered a concentrate supplement during the final 6 weeks of pregnancy. Housed ewes were offered grass silage while ewes on extended grazing were allocated 1.3 kg herbage dry matter per head per day from swards that had been closed for approximately 10 weeks. Ewes plus lambs (except triplet-rearing ewes which were grazed separately) from all treatments were grazed together post lambing, grouped according to lambing date. For treatments HS, HU, EGH, HEG and EG gestation lengths were 147.0, 145.6, 146.3, 146.6 and 146.9 (s.e. 0.34, P < 0.001) days, lamb birth weights were 4.9, 4.3, 4.4, 4.6 and 5.0 (s.e. 0.10, P < 0.001) kg, and lamb weaning weights were 34.6, 32.1, 33.3, 33.8 and 34.9 (s.e. 0.66, P < 0.001) kg, respectively. Extended grazing in mid and late pregnancy resulted in 35% and 65%, respectively, of the increase in lamb birth weight associated with extended grazing throughout. Treatment effects on lamb birth weight were associated with those on weaning weight (P < 0.01, R2 = 0.93). It is concluded that extended grazing or shearing of housed ewes increased lamb birth weight and subsequent weaning weight. The increased lamb birth weight from deferred grazing in mid pregnancy was probably due to improved protein utilisation from the grazed herbage. Meanwhile, the increase

An evaluation of two grassland-based systems of mid-season prime lamb production using prolific ewes of two genotypes

peer-reviewedA 4-year study was undertaken to evaluate the effects of two contrasting management systems [year-round grazing (YRG) and normal seasonal grazing followed by indoor feeding during winter (GWF)] on performance of mid-season lambing ewes. On the GWF system, the annual stocking rate was 14.4 ewes/ha, grass silage was conserved for winter feeding indoors, and the ewes were lambed indoors and were then turned out to pasture. The YRG system was stocked at 10.5 ewes/ha, was grazed during the winter, had outdoor lambing and the animals had access to all the farmlet for summer grazing. The ewes were Belclare and Cheviot × Belclare which were balanced across systems. Mean lambing dates and fertiliser N application rates were 20 and 30 March, and 85 and 92 kg/ha, for the GWF and YRG systems, respectively. Concentrate supplementation during late pregnancy was similar on both systems. For the GWF and YRG systems, litter size, lamb mortality, number of lambs reared, birth weight (kg), weaning weight (kg) and lamb carcass output (kg/ha) were 2.17 and 2.24 (s.e. 0.038), 10.1 and 13.8% (P = 0.05), 1.77 and 1.78 (s.e. 0.042), 4.0 and 4.7 (s.e. 0.05, P < 0.001), 27.9 and 30.8 (s.e. 0.25, P < 0.001) and 469 and 348, respectively. Belclare ewes had a higher litter size (2.34 v 2.07; s.e. 0.038, P < 0.001) and number of lambs reared per ewe joined (1.86 v 1.69; s.e. 0.048, P < 0.01) than the Cheviot × Belclare ewes. There were no significant interactions between system and ewe breed type. It is concluded that the YRG system of prime lamb production was sustainable using prolific ewes but at a reduced stocking rate (−26%) and with greater lamb mortality relative to the GWF system. Ewe genotypes with a mean litter size of up to 2.34 lambs are suitable for both systems. Lamb carcass output of 501 kg/ha was achieved from a primarily grass-based system of mid-season prime lamb production using prolific ewes (Belclare)

Living with early-stage dementia: a review of qualitative studies

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Life story resources in dementia care: a review.

PURPOSE: Life story work has a relatively long tradition in the caring sciences and is recognised as an important component of dementia care and practice. However, to date, there has not been a review of accessible life story resources. The paper aims to discuss these issues. DESIGN/METHODOLOGY/APPROACH: Following a systematic approach to identification and inclusion, 11 life story resources were reviewed to ascertain areas of commonality and divergence between the materials. FINDINGS: The authors were able to group the analysis under eight areas and at the end of this process, it was uncertain if life story work is a formal staff intervention or an informal activity that people with dementia and their families could engage in. Resources also varied in terms of whether the life story information was organised in a chronological way, or with topics of interest/discussion or with a combination of both. Life story evaluation and its impact on the life of the person with dementia is in need of development. PRACTICAL IMPLICATIONS: Across the resources the authors identified four reasons to do life story work which the authors have named as: emotional connections; interactional connections; building new connections and practical care connections. SOCIAL IMPLICATIONS: There was limited guidance aimed at helping people with dementia to develop and compile their own life story. ORIGINALITY/VALUE: This paper provides new insights into the usefulness, future directions and content of life story resources in dementia care. It will be of interest to those in health and social care as well as people living with dementia

Neighbourhoods as relational places for people living with dementia

An increase in the number of people living independently with dementia across the developed world has focused attention on the relevance of neighbourhood context for enabling or facilitating social health and wellbeing. Taking the lived experiences and daily realities of people living with dementia as a starting point, this paper contributes new understanding about the relevance of local places for supporting those living with the condition in the community. The paper outlines findings from a study of the neighbourhood experiences, drawing on new data collected from a creative blend of qualitatively-driven mixed methods with people living in a diverse array of settings across three international settings. The paper details some of the implications of neighbourhoods as sites of social connection for those living with dementia from material from 67 people living with dementia and 62 nominated care-partners. It demonstrates how neighbourhoods are experienced as relational places and considers how people living with dementia contribute to the production of such places through engagement and interactions in ways that may be beneficial to social health. We contend that research has rarely focused on the subjective, experiential and ‘everyday’ social practices that contextualise neighbourhood life for people living with dementia. In doing so, the paper extends empirical and conceptual understanding of the relevance of neighbourhoods as sites of connection, interaction, and social engagement for people living with dementia

Re-thinking and re-positioning ‘being in the moment’ within a continuum of moments : introducing a new conceptual framework for dementia studies

This article draws upon six social research studies completed by members of the Dementia and Ageing Research Team at The University of Manchester and their associated networks over an eight-year period [2011-2019] with the aim of constructing a definition of ‘being in the moment’ and situating it within a continuum of moments that could be used to contextualise and frame the lived experience of dementia. Using the approach formulated by Pound et al.(2005) to synthesising qualitative studies, we identified this continuum of moments as comprising four sequential and inter-linked steps: i) ‘Creating the moment’, defined as the processes and procedures necessary to enable being in the moment to take place. The time necessary for this to occur can range from fleeting to prolonged; ii) ‘Being in the moment’, which refers to the multi-sensory processes involved in a personal or relational interaction and embodied engagement. Being in the moment can be sustained through creativity and flow; iii) ‘Ending the moment’, defined as when a specific moment is disengaged. This can be triggered by the person(s) involved consciously or subconsciously, or caused by a distraction in the environment or suchlike; and iv) ‘Reliving the moment’, which refers to the opportunity for the experience(s) involved in ‘being in the moment’ to be later remembered and shared, however fragmentary, supported or full the recall

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

Circulating fatty acids (FAs) increase with obesity and can drive mitochondrial damage and inflammation. Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial protein that positively regulates nicotinamide adenine dinucleotide phosphate (NADPH), a key mediator of energy transduction and redox homeostasis. The role that NNT-regulated bioenergetics play in the inflammatory response of immune cells in obesity is untested. Our objective was to determine how free fatty acids (FFAs) regulate inflammation through impacts on mitochondria and redox homeostasis of peripheral blood mononuclear cells (PBMCs). PBMCs from lean subjects were activated with a T cell-specific stimulus in the presence or absence of generally pro-inflammatory palmitate and/or non-inflammatory oleate. Palmitate decreased immune cell expression of NNT, NADPH, and anti-oxidant glutathione, but increased reactive oxygen and proinflammatory Th17 cytokines. Oleate had no effect on these outcomes. Genetic inhibition of NNT recapitulated the effects of palmitate. PBMCs from obese (BMI \u3e30) compared to lean subjects had lower NNT and glutathione expression, and higher Th17 cytokine expression, none of which were changed by exogenous palmitate. Our data identify NNT as a palmitate-regulated rheostat of redox balance that regulates immune cell function in obesity and suggest that dietary or therapeutic strategies aimed at increasing NNT expression may restore redox balance to ameliorate obesity-associated inflammation

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

Circulating fatty acids (FAs) increase with obesity and can drive mitochondrial damage and inflammation. Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial protein that positively regulates nicotinamide adenine dinucleotide phosphate (NADPH), a key mediator of energy transduction and redox homeostasis. The role that NNT-regulated bioenergetics play in the inflammatory response of immune cells in obesity is untested. Our objective was to determine how free fatty acids (FFAs) regulate inflammation through impacts on mitochondria and redox homeostasis of peripheral blood mononuclear cells (PBMCs). PBMCs from lean subjects were activated with a T cell-specific stimulus in the presence or absence of generally pro-inflammatory palmitate and/or non-inflammatory oleate. Palmitate decreased immune cell expression of NNT, NADPH, and anti-oxidant glutathione, but increased reactive oxygen and proinflammatory Th17 cytokines. Oleate had no effect on these outcomes. Genetic inhibition of NNT recapitulated the effects of palmitate. PBMCs from obese (BMI \u3e 30) compared to lean subjects had lower NNT and glutathione expression, and higher Th17 cytokine expression, none of which were changed by exogenous palmitate. Our data identify NNT as a palmitate-regulated rheostat of redox balance that regulates immune cell function in obesity and suggest that dietary or therapeutic strategies aimed at increasing NNT expression may restore redox balance to ameliorate obesity-associated inflammation

Patients' and carers' views on communication and information provision when undergoing assessments in memory services

Objectives: To explore patients' and carers' views on what constitutes high-quality communication and information provision during diagnostic assessment in memory clinic services in three areas of England. Methods: Interviews with 27 people with cognitive impairment (13 with confirmed dementia) and 26 carers (20 matched pairs). Interviews continued until theoretical saturation was reached. Interview transcripts were subject to constant comparative analysis; data interpretation occurred in 'data clinics'. Results: People with memory problems undergoing assessment often have unmet information needs, especially patients with a diagnosis other than Alzheimer's disease and those who do not receive a diagnosis. Patients wish to be kept informed about both the assessment and its outcomes. Some have unrealistic expectations of the process (expecting assessment and diagnosis to be complete in two weeks) and some experience what appear to be long delays (over 12 months) in receiving results. Most appreciated clear and honest communication about any diagnosis. Post-diagnostic groups, organized by local memory services, afford opportunities to learn practical strategies and gain informal peer support. Voluntary organizations may be an essential source of information. Conclusions: Communication and information need improvement for patients undergoing assessment for possible dementia, especially for those considered unlikely to benefit from medication and those with mild cognitive impairment. © The Author(s) 2013