What Produced the Ultraluminous Supernova Remnant in NGC 6946?

The ultraluminous supernova remnant (SNR) in NGC 6946 is the brightest known SNR in X-rays, ~1000 times brighter than Cas A. To probe the nature of this remnant and its progenitor, we have obtained high-dispersion optical echelle spectra. The echelle spectra detect H-alpha, [N II], and [O III] lines, and resolve these lines into a narrow (FWHM ~20--40 km/s) component from un-shocked material and a broad (FWHM ~250 km/s) component from shocked material. Both narrow and broad components have unusually high [N II]/H-alpha ratios, ~1. Using the echelle observation, archival HST images, and archival ROSAT X-ray observations, we conclude that the SNR was produced by a normal supernova, whose progenitor was a massive star, either a WN star or a luminous blue variable. The high luminosity of the remnant is caused by the supernova ejecta expanding into a dense, nitrogen-rich circumstellar nebula created by the progenitor.Comment: 20 pages, 5 figures. To be published in The Astronomical Journal, March 200

Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites

The enzymatic complex 5\u3b1-reductase (5\u3b1-R) and 3\u3b1/3\u3b2-hydroxysteroid oxidoreductase (HSOR) is expressed in the nervous system, where it transforms progesterone (PROG) and testosterone (T) into neuroactive metabolites. These metabolites regulate myelination, brain maturation, neurotransmission, reproductive behavior and the stress response. The expression of 5\u3b1-R and 3\u3b1-HSOR and the levels of PROG and T reduced metabolites show regional and sex differences in the nervous system and are affected by changing physiological conditions as well as by neurodegenerative and psychiatric disorders. A decrease in their nervous tissue levels may negatively impact the course and outcome of some pathological events. However, in other pathological conditions their increased levels may have a negative impact. Thus, the use of synthetic analogues of these steroids or 5\u3b1-R modulation have been proposed as therapeutic approaches for several nervous system pathologies. However, further research is needed to fully understand the consequences of these manipulations, in particular with 5\u3b1-R inhibitors

Applying an Indigenous methodology to a North–South, cross-cultural collaboration: successes and remaining challenges

This article represents our collective reflexivity in the process of applying an Indigenous methodology in a North–South, cross-cultural collaboration, funded through the British Government’s Global Challenges Research Fund. The projects’ aim was to bring together Bribri and Jakun leaders (from Costa Rica and Malaysia) for constructive dialogues about sustainable development. Specifically, we applied ulàpeitök (traditional form of Bribri collaboration and translates to lend [peitök] a hand), a concept of collaboration that honours family and community; we also used S-kṍpàkö, the Bribri word for conversation, a concept that translates to feeling the space around each other together. We analyse successes and challenges and elaborate on lessons learned including (a) how and why Indigenous collaboration and reciprocity should be understood before a project is planned or financed, (b) why western academic concepts of reciprocity (such as one-to-one exchanges) need to be decolonized to include Indigenous ways of relating to others, and (c) paying special attention to language in the co-writing of publications to avoid cultural misrepresentation. Our research can inform other North/South, Indigenous/non-Indigenous collaborations that aim to contribute to decolonizing research

FUSE Observations of Nebular O VI Emission from NGC 6543

NGC 6543 is one of the few planetary nebulae (PNe) whose X-ray emission has been shown to be extended and originate from hot interior gas. Using FUSE observations we have now detected nebular O VI emission from NGC 6543. Its central star, with an effective temperature of ~50,000 K, is too cool to photoionize O V, so the O VI ions must have been produced by thermal collisions at the interface between the hot interior gas and the cool nebular shell. We modeled the O VI emission incorporating thermal conduction, but find that simplistic assumptions for the AGB and fast wind mass loss rates overproduce X-ray emission and O VI emission. We have therefore adopted the pressure of the interior hot gas for the interface layer and find that expected O VI emission to be comparable to the observations.Comment: 4 pages, 4 figures, 1 table, using emulateapj.cls style. Accepted for publication in ApJ Letter

Sex differences in steroid levels and steroidogenesis in the nervous system : Physiopathological role

The nervous system, in addition to be a target for steroid hormones, is the source of a variety of neuroactive steroids, which are synthesized and metabolized by neurons and glial cells. Recent evidence indicates that the expression of neurosteroidogenic proteins and enzymes and the levels of neuroactive steroids are different in the nervous system of males and females. We here summarized the state of the art of neuroactive steroids, particularly taking in consideration sex differences occurring in the synthesis and levels of these molecules. In addition, we discuss the consequences of sex differences in neurosteroidogenesis for the function of the nervous system under healthy and pathological conditions and the implications of neuroactive steroids and neurosteroidogenesis for the development of sex-specific therapeutic interventions

Reduction of the size of datasets by using evolutionary feature selection: the case of noise in a modern city

Smart city initiatives have emerged to mitigate the negative effects of a very fast growth of urban areas. Most of the population in our cities are exposed to high levels of noise that generate discomfort and different health problems. These issues may be mitigated by applying different smart cities solutions, some of them require high accurate noise information to provide the best quality of serve possible. In this study, we have designed a machine learning approach based on genetic algorithms to analyze noise data captured in the university campus. This method reduces the amount of data required to classify the noise by addressing a feature selection optimization problem. The experimental results have shown that our approach improved the accuracy in 20% (achieving an accuracy of 87% with a reduction of up to 85% on the original dataset).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This research has been partially funded by the Spanish MINECO and FEDER projects TIN2016-81766-REDT (http://cirti.es), and TIN2017-88213-R (http://6city.lcc.uma.es)

A new radiative cooling curve based on an up to date plasma emission code

This work presents a new plasma cooling curve that is calculated using the SPEX package. We compare our cooling rates to those in previous works, and implement the new cooling function in the grid-adaptive framework `AMRVAC'. Contributions to the cooling rate by the individual elements are given, to allow for the creation of cooling curves tailored to specific abundance requirements. In some situations, it is important to be able to include radiative losses in the hydrodynamics. The enhanced compression ratio can trigger instabilities (such as the Vishniac thin-shell instability) that would otherwise be absent. For gas with temperatures below 10,000 K, the cooling time becomes very long and does not affect the gas on the timescales that are generally of interest for hydrodynamical simulations of circumstellar plasmas. However, above this temperature, a significant fraction of the elements is ionised, and the cooling rate increases by a factor 1000 relative to lower temperature plasmas.Comment: 11 pages, 6 figures. Typos fixed to match version on A&A 'forthcoming' website. Tables in text format online available at http://www.phys.uu.nl/~schure/coolin