A Low Complexity Space-Time Block Codes Detection for Cell-Free Massive MIMO Systems

The new generation of telecommunication systems must provide acceptable data rates and spectral efficiency for new applications. Recently massive MIMO has been introduced as a key technique for the new generation of telecommunication systems. Cell-free massive MIMO system is not segmented into cells. Each BS antennas are distributed throughout the environment and each user is served by all BSs, simultaneously. In this paper, the performance of the multiuser cell-free massive MIMO-system exploying space-time block codes in the uplink, and with linear decoders is studied. An Inverse matrix approximation using Neumann series is proposed to reduce the computational and hardware complexity of the decoding in the receiver. For this purpose, each user has two antennas, and also for improving the diversity gain performance, space-time block codes are used in the uplink. Then, Neumann series is used to approximate the inverse matrix in ZF and MMSE decoders, and its performance is evaluated in terms of BER and spectral efficiency. In addition, we derive lower bound for throughput of ZF decoder. The simulation results show that performance of the system , in terms of BER and spectral efficiency, is better than the single-antenna users at the same system. Also, the BER performance in a given system with the proposed method will be close to the exact method.Comment: 5 pages, 4 figures, Accepted for ICEE202

SEX-SPECIFIC RESTORATION OF MK-801-INDUCED SENSORIMOTOR GATING DEFICIT BY ENVIRONMENTAL ENRICHMENT

Despite ample evidence of N-methyl-D-aspartate (NMDA) receptor dysfunction in schizophrenia, no study has addressed the effects of enriched environment (EE) on sensorimotor gating deficits induced by postnatal NMDA receptor blockade. We evaluated the effect of EE on sensorimotor gating (measured by prepulse inhibition, PPI), or on sensorimotor gating deficit induced by the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cy clohepten-5,10-imine maleate (MK-801) in both sexes of Wistar rats. Rats were injected with MK-801 (1 mg/kg) on postnatal days (P) 6–10. EE was provided from birth up to the time of experiments on P28–30 or P58–60. PPI data were collected at three prepulse intensities and then averaged to yield global PPI. MK-801 treatment reduced PPI significantly in both sexes. While EE per se had no significant effect on PPI, it restored MK-801-induced PPI deficit only in male rats. An extended period of EE did not influence PPI deficit in female rats. Our results indicate that postnatal exposure to MK-801 may exert long-lasting effects on neuronal circuits underlying sensorimotor gating. Sex-specific modulation of such effects by EE suggests sexually dimorphic mechanisms are involved. � 2015 IBRO. Published by Elsevier Ltd. All rights reserved

Effect of simultaneous exposure to occupational noise and cigarette smoke on binaural hearing impairment

In recent years, it has been postulated that cigarette smoking can aggravate noise-induced hearing loss. In this study, we aimed to assess the effect of concurrent exposure to cigarette smoke and occupational noise on binaural hearing impairment (BHI). In an analytic study on the workers of a large wagon manufacturing company in 2007, 622 male workers (252 smokers and 370 non-smokers, matched for other variables) participated and their BHI was compared. BHI was significantly higher in smokers than in non-smokers (odds ratio= 5.6, P < 0.001, 95 CI =3.4-9.4). Logistic regression confirmed this significant difference as well, and showed a direct relationship between the amount of BHI and pack/years of smoking. Cigarette smoking accompanied by exposure to workplace noise may play a role in causing binaural hearing impairment, so giving up or decreasing the amount of smoking may prevent or at least delay binaural hearing impairment, and eventually reduce its compensation costs

Characteristics of nursing homes and early preventive measures associated with risk of infection from COVID-19 in Lazio region, Italy: a retrospective case-control study

Objectives To understand which organisational-structural characteristics of nursing homes - also referred to as long-term care facilities (LTCFs) - and the preventative measures adopted in response to the pandemic are associated with the risk of a COVID-19 outbreak. Setting LTCFs in Lazio region in Italy. Design The study adopts a case-control design. Participants We included 141 facilities and 100 provided information for the study. Cases were defined as facilities reporting a COVID-19 outbreak (two or more cases) in March-December 2020; controls were defined as LTCFs reporting one case or zero. The exposures include the structural-organisational characteristics of the LTCFs as reported by the facilities, preventative measures employed and relevant external factors. Results Twenty facilities reported an outbreak of COVID-19. In binary logistic regression models, facilities with more than 15 beds were five times more likely to experience an outbreak than facilities with less than 15 beds OR=5.60 (CI 1.61 to 25.12; p value 0.002); admitting new residents to facilities was associated with a substantially higher risk of an outbreak: 6.46 (CI 1.58 to 27.58, p value 0.004). In a multivariable analysis, facility size was the only variable that was significantly associated with a COVID-19 outbreak OR= 5.37 (CI 1.58 to 22.8; p value 0.012) for larger facilities (&gt;15 beds) versus smaller (&lt;15 beds). Other characteristics and measures were not associated with an outbreak. Conclusion There was evidence of a higher risk of COVID-19 in larger facilities and when new patients were admitted during the pandemic. All other structural-organisational characteristics and preventative measures were not associated with an outbreak. This finding calls into question existing policies, especially where there is a risk of harm to residents. One such example is the restriction of visitor access to facilities, resulting in the social isolation of residents

Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3

Myofibrillary myopathies (MFM) are hereditary myopathies histologically characterized by degeneration of myofibrils and aggregation of proteins in striated muscle. Cardiomyopathy is common in MFM but the pathophysiological mechanisms are not well understood. The BAG3-Pro209Leu mutation is associated with early onset MFM and severe restrictive cardiomyopathy (RCM), often necessitating heart transplantation during childhood. We report on a young male patient with a BAG3-Pro209Leu mutation who underwent heart transplantation at eight years of age. Detailed morphological analyses of the explanted heart tissue showed intracytoplasmic inclusions, aggregation of BAG3 and desmin, disintegration of myofibers and Z-disk alterations. The presence of undegraded autophagosomes, seen by electron microscopy, as well as increased levels of p62, LC3-I and WIPI1, detected by immunohistochemistry and western blot analyses, indicated a dysregulation of autophagy. Parkin and PINK1, proteins involved in mitophagy, were slightly increased whereas mitochondrial OXPHOS activities were not altered. These findings indicate that altered autophagy plays a role in the pathogenesis and rapid progression of RCM in MFM caused by the BAG3-Pro209Leu mutation, which could have implications for future therapeutic strategies

Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance

Abstract Background Extensively drug-resistant (XDR) Salmonella enterica serovar Typhi (S. Typhi) poses a grave threat to public health due to increased mortality and morbidity caused by typhoid fever. Honey is a promising antibacterial agent, and we aimed to determine the antibacterial activity of honey against XDR S. Typhi. Methods We isolated 20 clinical isolates of XDR S. Typhi from pediatric septicemic patients and determined the minimum inhibitory concentrations (MICs) of diferent antibiotics against the pathogens using the VITEK 2 Compact system. Antimicrobial-resistant genes carried by the isolates were identifed using PCR. The antibacterial efcacy of fve Pakistani honeys was examined using agar well difusion assay, and their MICs and minimum bactericidal concentrations (MBCs) were determined with the broth microdilution method. Results All 20 isolates were confrmed as S. Typhi. The antibiogram phenotype was confrmed as XDR S. Typhi with resistance to ampicillin (≥32 µg/mL), ciprofoxacin (≥4 µg/mL), and ceftriaxone (≥4 µg/mL) and sensitivity to azithromycin (≤16 µg/mL) and carbapenems (≤1 µg/mL). Molecular conformation revealed the presence of blaTM-1, Sul1, qnrS, gyrA, gyrB, and blaCTX-M-15 genes in all isolates. Among the fve honeys, beri honey had the highest zone of inhibition of 7–15 mm and neem honey had a zone of inhibition of 7–12 mm. The MIC and MBC of beri honey against 3/20 (15%) XDR S. Typhi isolates were 3.125 and 6.25%, respectively, while the MIC and MBC of neem were 3.125 and 6.25%, respectively, against 3/20 (15%) isolates and 6.25 and 12.5%, respectively, against 7/20 (35%) isolates. Conclusion Indigenous honeys have an efective role in combating XDR S. Typhi. They are potential candidates for clinical trials as alternative therapeutic options against XDR S. Typhi isolates. Keywords Antimicrobial resistance, Natural antibiotics, XDR S. Typhi, MIC, Honey, Resistance gene

The minimum-error discrimination via Helstrom family of ensembles and Convex Optimization

Using the convex optimization method and Helstrom family of ensembles introduced in Ref. [1], we have discussed optimal ambiguous discrimination in qubit systems. We have analyzed the problem of the optimal discrimination of N known quantum states and have obtained maximum success probability and optimal measurement for N known quantum states with equiprobable prior probabilities and equidistant from center of the Bloch ball, not all of which are on the one half of the Bloch ball and all of the conjugate states are pure. An exact solution has also been given for arbitrary three known quantum states. The given examples which use our method include: 1. Diagonal N mixed states; 2. N equiprobable states and equidistant from center of the Bloch ball which their corresponding Bloch vectors are inclined at the equal angle from z axis; 3. Three mirror-symmetric states; 4. States that have been prepared with equal prior probabilities on vertices of a Platonic solid. Keywords: minimum-error discrimination, success probability, measurement, POVM elements, Helstrom family of ensembles, convex optimization, conjugate states PACS Nos: 03.67.Hk, 03.65.TaComment: 15 page

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in <em>Trypanosoma brucei</em>

Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans. Despite the presence of the latter, no obvious homologues of known β1–4-galactosyltransferase or β1–2- or β1–6-N-acetylglucosaminyltransferase genes have been found in the parasite genome. However, we previously reported a family of putative UDP-sugar-dependent glycosyltransferases with similarity to the mammalian β1–3-glycosyltransferase family. Here we characterize one of these genes, TbGT11, and show that it encodes a Golgi apparatus resident UDP-GlcNAc:α3-d-mannoside β1–2-N-acetylglucosaminyltransferase I activity (TbGnTI). The bloodstream-form TbGT11 null mutant exhibited significantly modified protein N-glycans but normal growth in vitro and infectivity to rodents. In contrast to multicellular organisms, where the GnTI reaction is essential for biosynthesis of both complex and hybrid N-glycans, T. brucei TbGT11 null mutants expressed atypical “pseudohybrid” glycans, indicating that TbGnTII activity is not dependent on prior TbGnTI action. Using a functional in vitro assay, we showed that TbGnTI transfers UDP-GlcNAc to biantennary Man(3)GlcNAc(2), but not to triantennary Man(5)GlcNAc(2), which is the preferred substrate for metazoan GnTIs. Sequence alignment reveals that the T. brucei enzyme is far removed from the metazoan GnTI family and suggests that the parasite has adapted the β3-glycosyltransferase family to catalyze β1–2 linkages