Modeling Business Negotiations for Electronic Commerce

E-commerce "localizes global markets" by opening remote markets to retail and to small companies. Newly developed E-commerce tools allow individual and organizational buyers to search for suppliers anywhere and make deals electronically. We propose a software agent that interacts with a buyer and elicits information about the criteria, preferences, and limitations, and that conducts business negotiation on behalf of the buyer. The agent has been implemented and tested in Negoplan, a software system that supports the simulation of decision processes. Results of several negotiation simulations are presented

Association of Chromosome 9p21 with Subsequent Coronary Heart Disease events:A GENIUS-CHD study of individual participant data

BACKGROUND:Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS:A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103,357 Europeans with established CHD at baseline from the GENIUS-CHD Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/MI), occurred in 13,040 of the 93,115 participants with available outcome data. Effect estimates were compared to case/control risk obtained from CARDIoGRAMPlusC4D including 47,222 CHD cases and 122,264 controls free of CHD. RESULTS:Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/MI among those with established CHD at baseline (GENIUS-CHD OR 1.02; 95% CI 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D OR 1.20; 95% CI 1.18-1.22; p for interaction Conclusions: In contrast to studies comparing individuals with CHD to disease free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development

Subsequent Event Risk in Individuals with Established Coronary Heart Disease:Design and Rationale of the GENIUS-CHD Consortium

BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators

A formal account of sequential decision-making in a co-operative setting

It is typical for an autonomous agent to make decisions in the presence of other agents who respond, react to his action's and undertake actions independently of the agent's decisions. Also, the decision environment is often dynamic and certain changes cannot be forseen. This requires the agent to have an ability to recognize and interpret the situation he faces. The agent needs additional abilities to evaluate the implemented decisions, assess the actions of the others and determine the representation of his current decision problem. This paper gives a formal account of an agent who has specific cognitive and representational abilities required to make sequential decisions in co-operative settings. The restructurable modelling methodology, presented here, has been implemented in the Negoplan system and applied to the simulation, analysis and support of negotiations, patient diagnosis and treatment, investment scenario development, planning and distributed decision-making

Evaluation of automatic updates of Roget’s Thesaurus

Thesauri and similarly organised resources attract increasing interest of Natural Language Processing researchers. Thesauri age fast, so there is a constant need to update their vocabulary. Since a manual update cycle takes considerable time, automated methods are required. This work presents a tuneable method of measuring semantic relatedness, trained on Roget’s Thesaurus, which generates lists of terms related to words not yet in the Thesaurus. Using these lists of terms, we experiment with three methods of adding words to the Thesaurus. We add, with high confidence, over 5500 and 9600 new word senses to versions of Roget’s Thesaurus from 1911 and 1987 respectively. We evaluate our work both manually and by applying the updated thesauri in three NLP tasks: selection of the best synonym from a set of candidates, pseudo-word-sense disambiguation and SAT-style analogy problems. We find that the newly added words are of high quality. The additions significantly improve the performance of Roget’s-based methods in these NLP tasks. The performance of our system compares favourably with that of WordNet-based methods. Our methods are general enough to work with different versions of Roget’s Thesaurus

Komunikacja człowieka z komputerem w języku naturalnym

Streszczenie referatu zaproszonego na: VI Ogólnopolskie Seminarium Metodyczne Informatyki RYNIA 26-30 maj 1981 r

Toward a Parsing Method for Free Word Order Languages

w: Papers in Computational Linguistics II (red. J. S. Bień