Exploiting the Synergy Between Gossiping and Structured Overlays

In this position paper we argue for exploiting the synergy between gossip-based algorithms and structured overlay networks (SON). These two strands of research have both aimed at building fault-tolerant, dynamic, self-managing, and large-scale distributed systems. Despite the common goals, the two areas have, however, been relatively isolated. We focus on three problem domains where there is an untapped potential of using gossiping combined with SONs. We argue for applying gossip-based membership for ring-based SONs---such as Chord and Bamboo---to make them handle partition mergers and loopy networks. We argue that small world SONs---such as Accordion and Mercury---are specifically well-suited for gossip-based membership management. The benefits would be better graph-theoretic properties. Finally, we argue that gossip-based algorithms could use the overlay constructed by SONs. For example, many unreliable broadcast algorithms for SONs could be augmented with anti-entropy protocols. Similarly, gossip-based aggregation could be used in SONs for network size estimation and load-balancing purposes

Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study.

Brain network activity associated with altered motor control in individuals with chronic pain is not well understood. Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a debilitating condition in which previous studies have revealed altered resting pelvic floor muscle activity in men with CP/CPPS compared to healthy controls. We hypothesized that the brain networks controlling pelvic floor muscles would also show altered resting state function in men with CP/CPPS. Here we describe the results of the first test of this hypothesis focusing on the motor cortical regions, termed pelvic-motor, that can directly activate pelvic floor muscles. A group of men with CP/CPPS (N = 28), as well as group of age-matched healthy male controls (N = 27), had resting state functional magnetic resonance imaging scans as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network study. Brain maps of the functional connectivity of pelvic-motor were compared between groups. A significant group difference was observed in the functional connectivity between pelvic-motor and the right posterior insula. The effect size of this group difference was among the largest effect sizes in functional connectivity between all pairs of 165 anatomically-defined subregions of the brain. Interestingly, many of the atlas region pairs with large effect sizes also involved other subregions of the insular cortices. We conclude that functional connectivity between motor cortex and the posterior insula may be among the most important markers of altered brain function in men with CP/CPPS, and may represent changes in the integration of viscerosensory and motor processing

Deterministic Sampling and Range Counting in Geometric Data Streams

We present memory-efficient deterministic algorithms for constructing epsilon-nets and epsilon-approximations of streams of geometric data. Unlike probabilistic approaches, these deterministic samples provide guaranteed bounds on their approximation factors. We show how our deterministic samples can be used to answer approximate online iceberg geometric queries on data streams. We use these techniques to approximate several robust statistics of geometric data streams, including Tukey depth, simplicial depth, regression depth, the Thiel-Sen estimator, and the least median of squares. Our algorithms use only a polylogarithmic amount of memory, provided the desired approximation factors are inverse-polylogarithmic. We also include a lower bound for non-iceberg geometric queries.Comment: 12 pages, 1 figur

Virtual Reality in Healthcare – what stops hospitals and patients o adopt the technology?

Virtual Reality (VR) has been used in healthcare for nearly a decade but on it’s infancy in the UK. Innovation adoption is still a struggle based on recent reports, specially adoption of high tech innovation. This study looks into the barriers of adoption of VR in pain management in National Health Services in Dorset. The study investigates this from patient and staff point of view

Symmetry in temporal logic model checking

Temporal logic model checking involves checking the state-space of a model of a system to determine whether errors can occur in the system. Often this involves checking symmetrically equivalent areas of the state-space. The use of symmetry reduction to increase the efficiency of model checking has inspired a wealth of activity in the area of model checking research. We provide a survey of the associated literature

Stable Fe( iii ) phenoxyimines as selective and robust CO2/epoxide coupling catalysts

Three phenoxyimine Fe(III)Cl complexes bearing electronically diverse -Cl, -H or -tBu substituents in the ortho position were synthesised. X-ray crystallographic analysis of the complexes reveals mononuclear structures with pentacoordinate iron centres and trigonal bipyramidal geometries. All three complexes demonstrated excellent catalytic activities towards CO2/epoxide coupling to selectively form cyclic carbonates, with catalyst activity correlating with the electron withdrawing nature of the ortho-substituent (Cl > H > tBu) and thus the Lewis acidity of the metal centre. The chloro-substituted complex displayed remarkable activity in the synthesis of propylene carbonate from propylene oxide and CO2, reaching turnover frequencies (TOF) up to 760 h-1 in the presence of TBABr co-catalyst at 120°C and 20 bars of CO2 pressure. Importantly, the catalyst is also very robust, functioning with high substrate loading, under air or in the presence of water. The substrate scope was successfully extended to other terminal epoxides including epichlorohydrin (TOF = 900 h-1) and to the more challenging internal epoxide, cyclohexene oxide (TOF = 80 h-1). These are amongst the highest TOF values reported for an iron CO2/epoxide coupling catalyst to date

The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection

<p>Abstract</p> <p>Background</p> <p>Alternatively activated macrophages (AAMϕ) play important roles in allergies and responses to parasitic infections. However, whether signaling through toll-like receptors (TLRs) plays any role in AAMϕ induction when young <it>Fasciola hepatica </it>penetrates the liver capsule and migrates through the liver tissue is still unclear.</p> <p>Results</p> <p>The data show that the lack of myeloid differentiation factor 88 (MyD88) has no effect on the AAMϕ derived from the bone marrow (BMMϕ) <it>in vitro </it>and does not impair the mRNA expression of arginase-1, resistin-like molecule (RELMα), and Ym1 in BMMϕs. The Th2 cytokine production bias in splenocytes was not significantly altered in <it>F. hepatica</it>-infected mice in the absence of MyD88 <it>in vitro </it>and in the pleural cavity lavage <it>in vivo</it>. In addition, MyD88-deficiency has no effect on the arginase production of the <it>F. hepatica </it>elicited macrophages (Fe Mϕs), production of RELMα and Ym1 proteins and mRNA expression of Ym1 and RELMα of macrophages in the peritoneal cavity 6 weeks post <it>F. hepatica </it>infection.</p> <p>Conclusions</p> <p>The absence of MyD88 has no effect on presence of AAMϕ 6 weeks post <it>F. hepatica </it>infection.</p