Reliability of Diagnostic Tests for Helicobacter pylori Infection

Introduction. Helicobacter pylori (H. pylori) infection is very common worldwide. A reliable diagnosis is crucial for patients with H. pylori-related diseases. At followup, it is important to confirm that eradication therapy has been successful. There is no established gold standard for the diagnosis of H. pylori infection. Material and Methods. A sample of 304 volunteers from the general population was screened for H. pylori infection with serology, 13C-urea breath test (UBT), rapid urease test (RUT) on fresh biopsy, culture from biopsy, and histological examination. Culture was used as gold standard. Results. The sensitivity was 0.99 for serology, 0.90 for UBT, 0.90 for RUT, and 0.90 for histological examination. Corresponding specificities were 0.82, 0.99, 0.98, and 0.97, respectively. The accuracy was 0.86 for serology, 0.96 for UBT, 0.95 for RUT, 0.93 for culture, and 0.95 for histology. There was a strong correlation between the results of UBT and the histological scores of H. pylori colonisation as well as between the results of UBT and the scores of RUT. Conclusion. There were only minor differences in accuracy between the three invasive tests for H. pylori infection in this population. RUT may be recommended as the first choice since a result is obtained within hours. The accuracy of UBT was comparable to the invasive tests, and it is recommended for situations when endoscopy is not needed

Finite-frequency Rayleigh wave tomography of the western Mediterranean: Mapping its lithospheric structure

We present a 3-D shear wave velocity model for the crust and upper mantle of the western Mediterranean from Rayleigh wave tomography. We analyzed the fundamental mode in the 20¿167 s period band (6.0¿50.0 mHz) from earthquakes recorded by a number of temporary and permanent seismograph arrays. Using the two-plane wave method, we obtained phase velocity dispersion curves that were inverted for an isotropic Vs model that extends from the southern Iberian Massif, across the Gibraltar Arc and the Atlas mountains to the Saharan Craton. The area of the western Mediterranean that we have studied has been the site of complex subduction, slab rollback, and simultaneous compression and extension during African-European convergence since the Oligocene. The shear velocity model shows high velocities beneath the Rif from 65 km depth and beneath the Granada Basin from ¿¿70 km depth that extend beneath the Alboran Domain to more than 250 km depth, which we interpret as a near-vertical slab dangling from beneath the western Alboran Sea. The slab appears to be attached to the crust beneath the Rif and possibly beneath the Granada Basin and Sierra Nevada where low shear velocities (3.8 km/s) are mapped to >55 km depth. The attached slab is pulling down the Gibraltar Arc crust, thickening it, and removing the continental margin lithospheric mantle beneath both Iberia and Morocco as it descends into the deeper mantle. Thin lithosphere is indicated by very low upper mantle velocities beneath the Alboran Sea, above and east of the dangling slab and beneath the Cenozoic volcanics.This research was funded by the U.S. National Science Foundation EAR-0808939. The deployment of the IberArray broadband seismic network is part of the CONSOLIDER CSD2006-00041 (Geosciences in Iberia: Integrated studies on Topography and 4-D Evolution) grant from the Spanish Ministry of Science and Innovation. Additional funding was provided by the Spanish ministry under grants CGL2010-17280 and by Generalitat de Catalunya under grant 2009 SGR 6.Peer Reviewe

Subduction-driven recycling of continental margin lithosphere

Whereas subduction recycling of oceanic lithosphere is one of the central themes of plate tectonics, the recycling of continental lithosphere appears to be far more complicated and less well understood(1). Delamination and convective downwelling are two widely recognized processes invoked to explain the removal of lithospheric mantle under or adjacent to orogenic belts(2-5). Here we relate oceanic plate subduction to removal of adjacent continental lithosphere in certain plate tectonic settings. We have developed teleseismic body wave images from dense broadband seismic experiments that show higher than expected volumes of anomalously fast mantle associated with the subducted Atlantic slab under northeastern South America and the Alboran slab beneath the Gibraltar arc region(6,7); the anomalies are under, and are aligned with, the continental margins at depths greater than 200 kilometres. Rayleigh wave analysis(8,9) finds that the lithospheric mantle under the continental margins is significantly thinner than expected, and that thin lithosphere extends from the orogens adjacent to the subduction zones inland to the edges of nearby cratonic cores. Taking these data together, here we describe a process that can lead to the loss of continental lithosphere adjacent to a subduction zone. Subducting oceanic plates can viscously entrain and remove the bottom of the continental thermal boundary layer lithosphere from adjacent continental margins. This drives surface tectonics and pre-conditions the margins for further deformation by creating topography along the lithosphere-asthenosphere boundary. This can lead to development of secondary downwellings under the continental interior, probably under both South America and the Gibraltar arc(8,10), and to delamination of the entire lithospheric mantle, as around the Gibraltar arc(11). This process reconciles numerous, sometimes mutually exclusive, geodynamic models proposed to explain the complex oceanic-continental tectonics of these subduction zones(12-17)This research was supported by US National Science Foundation grants EAR 0003572, 0607801 and 0808939 (A.L.), EAR 0808931 (E.D.H.), EAR 0809023 and 1054638 (M.S.M.), the Venezuelan National Fund for Science, Technology and Innovation grant G-2002000478 and PDVSA-INTEVEP-FUNVISIS cooperative agreement 2004-141 (M.S.), the Spanish Ministry of Science and Innovation grants CSD2006-00041, CGL2009-09727 and CGL2010-15146 (J.G. and R.C.), and by an A. v. Humboldt Foundation Research Prize (A.L.).Peer Reviewe

Subduction-driven recycling of continental margin lithosphere.

[EN]Whereas subduction recycling of oceanic lithosphere is one of the central themes of plate tectonics, the recycling of continental lithosphere appears to be far more complicated and less well understood1. Delamination and convective downwelling are two widely recognized processes invoked to explain the removal of lithospheric mantle under or adjacent to orogenic belts2,3,4,5. Here we relate oceanic plate subduction to removal of adjacent continental lithosphere in certain plate tectonic settings. We have developed teleseismic body wave images from dense broadband seismic experiments that show higher than expected volumes of anomalously fast mantle associated with the subducted Atlantic slab under northeastern South America and the Alboran slab beneath the Gibraltar arc region6,7; the anomalies are under, and are aligned with, the continental margins at depths greater than 200 kilometres. Rayleigh wave analysis8,9 finds that the lithospheric mantle under the continental margins is significantly thinner than expected, and that thin lithosphere extends from the orogens adjacent to the subduction zones inland to the edges of nearby cratonic cores. Taking these data together, here we describe a process that can lead to the loss of continental lithosphere adjacent to a subduction zone. Subducting oceanic plates can viscously entrain and remove the bottom of the continental thermal boundary layer lithosphere from adjacent continental margins. This drives surface tectonics and pre-conditions the margins for further deformation by creating topography along the lithosphere–asthenosphere boundary. This can lead to development of secondary downwellings under the continental interior, probably under both South America and the Gibraltar arc8,10, and to delamination of the entire lithospheric mantle, as around the Gibraltar arc11. This process reconciles numerous, sometimes mutually exclusive, geodynamic models proposed to explain the complex oceanic-continental tectonics of these subduction zones12,13,14,15,16,17

Field propagation in de Sitter black holes

We present an exhaustive analysis of scalar, electromagnetic and gravitational perturbations in the background of Schwarzchild-de Sitter and Reissner-Nordstrom-de Sitter spacetimes. The field propagation is considered by means of a semi-analytical (WKB) approach and two numerical schemes: the characteristic and general initial value integrations. The results are compared near the extreme cosmological constant regime, where analytical results are presented. A unifying picture is established for the dynamics of different spin fields.Comment: 15 pages, 16 figures, published versio

Friend or foe? The current epidemiologic evidence on selenium and human cancer risk.

Scientific opinion on the relationship between selenium and the risk of cancer has undergone radical change over the years, with selenium first viewed as a possible carcinogen in the 1940s then as a possible cancer preventive agent in the 1960s-2000s. More recently, randomized controlled trials have found no effect on cancer risk but suggest possible low-dose dermatologic and endocrine toxicity, and animal studies indicate both carcinogenic and cancer-preventive effects. A growing body of evidence from human and laboratory studies indicates dramatically different biological effects of the various inorganic and organic chemical forms of selenium, which may explain apparent inconsistencies across studies. These chemical form-specific effects also have important implications for exposure and health risk assessment. Overall, available epidemiologic evidence suggests no cancer preventive effect of increased selenium intake in healthy individuals and possible increased risk of other diseases and disorders

Psychosocial correlates with depressive symptoms six years after a first episode of psychosis as compared with findings from a general population sample

BACKGROUND: Depression is frequently occurring during and after psychosis. The aim of this study was to analyze if the psychosocial characteristics associated with depression/depressive symptoms in the late phase of a first episode psychosis (FEP) population were different compared to persons from the general population. METHODS: A questionnaire was sent out to all individuals six years after their FEP and to a general population sample. Depressive symptoms were recorded using a self-rating scale, the Major Depression Inventory. RESULTS: Formerly FEP persons had a higher representation of depressive symptoms/depression, unemployment, financial problems and insufficient social network. Depressive symptoms/depression were found to be associated with psychosocial problems. An age and gender effect was found in the general population, but not in the FEP sample. When the psychosocial characteristics were taken into account there were no association between having had FEP and depressive symptoms. CONCLUSIONS: The association between having been a FEP patient and depressive symptoms/depression disappeared when negative social aspects were taken into account

Changes in cognitive domains during three years in patients with Alzheimer's disease treated with donepezil

<p>Abstract</p> <p>Background</p> <p>The objective was to identify separate cognitive domains in the standard assessment tools (MMSE, ADAS-Cog) and analyze the process of decline within domains during three years in Alzheimer's disease (AD) patients with donepezil treatment.</p> <p>Method</p> <p>AD patients (n = 421) were recruited from a clinical multi-centre study program in Sweden. Patients were assessed every six months during three years. All patients received donepezil starting directly after study entry. After dropouts, 158 patients remained for analyses over three years. Data for the other patients were analysed until they dropped out (4 groups based on length in study).</p> <p>Results</p> <p>Factor analyses of all items suggested that there were three intercorrelated factors: a General, a Memory and a Spatial factor for which we constructed corresponding domains. Overall there was a cognitive improvement at six months followed by a linear drop over time for the three domains. Some group and domain differences were identified. Patients who remained longer in the study had better initial performance and a slower deterioration rate. The early dropouts showed no improvement at six months and many dropped out due to side effects. The other groups displayed a performance improvement at six months that was less pronounced in the Memory domain. Before dropping out, deterioration accelerated, particularly in the Spatial domain.</p> <p>Conclusion</p> <p>The course of illness in the three domains was heterogeneous among the patients. We were not able to identify any clinically relevant correlates of this heterogeneity. As an aid we constructed three algorithms corresponding to the cognitive domains, which can be used to characterize patients initially, identify rapid decliners and follow the course of the disease.</p