1,293 research outputs found
(1,2,3,4-TetraÂhydroÂisoquinoline-2-carboÂdithioÂato-Îș2 S,SâČ)(thioÂcyanato-ÎșN)(triÂphenylÂphosphane)nickel(II)
The NiII atom in the mononuclear title compound, [Ni(C10H10NS2)(NCS)(C18H15P)], exists within a S2PN donor set that defines a distorted square-planar geometry. A significant asymmetry in the NiâS bond lengths support the less effective trans effect of SCNâ over PPh3
Video fire detection - Review
Cataloged from PDF version of article.This is a review article describing the recent developments in Video based Fire Detection (VFD). Video
surveillance cameras and computer vision methods are widely used in many security applications. It is
also possible to use security cameras and special purpose infrared surveillance cameras for fire detection.
This requires intelligent video processing techniques for detection and analysis of uncontrolled fire
behavior. VFD may help reduce the detection time compared to the currently available sensors in both
indoors and outdoors because cameras can monitor âvolumesâ and do not have transport delay that the
traditional âpointâ sensors suffer from. It is possible to cover an area of 100 km2 using a single pan-tiltzoom
camera placed on a hilltop for wildfire detection. Another benefit of the VFD systems is that they
can provide crucial information about the size and growth of the fire, direction of smoke propagation.
© 2013 Elsevier Inc. All rights reserve
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Variable blood processing procedures contribute to plasma proteomic variability
Background
Plasma is a potentially rich source of protein biomarkers for disease progression and drug response. Large multi-center studies are often carried out to increase the number of samples analyzed in a given study. This may increase the chances of variation in blood processing and handling, leading to altered proteomic results. This study evaluates the impact of blood processing variation on LCâMS/MS proteomic analysis of plasma.
Methods
Initially two batches of patient plasma samples (120 and 204 samples, respectively) were analyzed using LCâMS/MS shotgun proteomics. Follow-up experiments were designed and carried out on healthy donor blood in order to examine the effects of different centrifugation conditions, length of delay until first centrifugation, storage temperature and anticoagulant type on results from shotgun proteomics.
Results
Variable levels of intracellular proteins were observed in subsets of patient plasma samples from the initial batches analyzed. This observation correlated strongly with the site of collection, implicating variability in blood processing procedures. Results from the healthy donor blood analysis did not demonstrate a significant impact of centrifugation conditions to plasma proteome variation. The time delay until first centrifugation had a major impact on variability, while storage temperature and anticoagulant showed less pronounced but still significant effects. The intracellular proteins associated with study site effect in patient plasma samples were significantly altered by delayed processing also.
Conclusions
Variable blood processing procedures contribute significantly to plasma proteomic variation and may give rise to increased intracellular proteins in plasma. Accounting for these effects can be important both at study design and data analysis stages. This understanding will be valuable to incorporate in the planning of protein-based biomarker discovery efforts in the future
Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels
Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA gels have significant advantages for controlled delivery applications due to their high capacity to retain water, biocompatibility, and biodegradability. In this study, we demonstrate injectable supramolecular PA nanofiber gels for drug delivery applications. Doxorubicin (Dox), as a widely used chemotherapeutic drug for breast cancer treatment, was encapsulated within the PA gels prepared at different concentrations. Physical and chemical properties of the gels were characterized, and slow release of the Dox molecules through the supramolecular PA nanofiber gels was studied. In addition, the diffusion constants of the drug molecules within the PA nanofiber gels were estimated using fluorescence recovery after the photobleaching (FRAP) method. The PA nanofiber gels did not show any cytotoxicity and the encapsulation strategy enhanced the activity of drug molecules on cellular viability through prolonged release compared to direct administration under in vitro conditions. Moreover, the local in vivo injection of the Dox encapsulated PA nanofiber gels (Dox/PA) to the tumor site demonstrated the lowest tumor growth rate compared to the direct Dox injection and increased the apoptotic cells within the tumor tissue for local drug release through the PA nanofiber gels under in vivo conditions. © The Royal Society of Chemistry 2017
Beautiful Mirrors at the LHC
We explore the "Beautiful Mirrors" model, which aims to explain the measured
value of , discrepant at the level. This scenario
introduces vector-like quarks which mix with the bottom, subtly affecting its
coupling to the . The spectrum of the new particles consists of two
bottom-like quarks and a charge -4/3 quark, all of which have electroweak
interactions with the third generation. We explore the phenomenology and
discovery reach for these new particles at the LHC, exploring single mirror
quark production modes whose rates are proportional to the same mixing
parameters which resolve the anomaly. We find that for mirror quark
masses is required to
reasonably establish the scenario and extract the relevant mixing parameters.Comment: version to be published in JHE
Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease
Background. Antagonists of relevant Gs protein-coupled and agonists of relevant Gi protein-coupled receptors lower renal cAMP and inhibit growth of renal cysts in animal models of human ARPKD (PCK rat) and/or ADPKD (Pkd2â/WS25 mouse). A calcium-sensing receptor (CaR) is expressed in various tubular segments and couples to Gq, thereby activating phospholipase CÎł, InsP3 generation and calcium mobilization from intracellular stores, and Gi proteins. By both mechanisms, CaR activation could lower intracellular cAMP and inhibit renal cyst growth
Search for the Higgs boson in events with missing transverse energy and b quark jets produced in proton-antiproton collisions at s**(1/2)=1.96 TeV
We search for the standard model Higgs boson produced in association with an
electroweak vector boson in events with no identified charged leptons, large
imbalance in transverse momentum, and two jets where at least one contains a
secondary vertex consistent with the decay of b hadrons. We use ~1 fb-1
integrated luminosity of proton-antiproton collisions at s**(1/2)=1.96 TeV
recorded by the CDF II experiment at the Tevatron. We find 268 (16) single
(double) b-tagged candidate events, where 248 +/- 43 (14.4 +/- 2.7) are
expected from standard model background processes. We place 95% confidence
level upper limits on the Higgs boson production cross section for several
Higgs boson masses ranging from 110 GeV/c2 to 140 GeV/c2. For a mass of 115
GeV/c2 the observed (expected) limit is 20.4 (14.2) times the standard model
prediction.Comment: 8 pages, 2 figures, submitted to Phys. Rev. Let
Measurement of the Helicity Fractions of W Bosons from Top Quark Decays Using Fully Reconstructed top-antitop Events with CDF II
We present a measurement of the fractions F_0 and F_+ of longitudinally
polarized and right-handed W bosons in top quark decays using data collected
with the CDF II detector. The data set used in the analysis corresponds to an
integrated luminosity of approximately 318 pb -1. We select ttbar candidate
events with one lepton, at least four jets, and missing transverse energy. Our
helicity measurement uses the decay angle theta*, which is defined as the angle
between the momentum of the charged lepton in the W boson rest frame and the W
momentum in the top quark rest frame. The cos(theta*) distribution in the data
is determined by full kinematic reconstruction of the ttbar candidates. We find
F_0 = 0.85 +0.15 -0.22 (stat) +- 0.06 (syst) and F_+ = 0.05 +0.11 -0.05 (stat)
+- 0.03 (syst), which is consistent with the standard model prediction. We set
an upper limit on the fraction of right-handed W bosons of F_+ < 0.26 at the
95% confidence level.Comment: 11 pages, 2 figures, submitted to Phys. Rev.
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