Single Stellar Populations in the Near-Infrared - I. Preparation of the IRTF spectral stellar library

We present a detailed study of the stars of the IRTF spectral library to understand its full extent and reliability for use with Stellar Population (SP) modeling. The library consist of 210 stars, with a total of 292 spectra, covering the wavelength range of 0.94 to 2.41 micron at a resolution R = 2000. For every star we infer the effective temperature (Teff), gravity (logg) and metallicity ([Z/Zsun]) using a full-spectrum fitting approach in a section of the K band (2.19 to 2.34 micron) and temperature-NIR colour relations. We test the flux calibration of these stars by calculating their integrated colours and comparing them with the Pickles library colour-temperature relations. We also investigate the NIR colours as a function of the calculated effective temperature and compared them in colour-colour diagrams with the Pickles library. This latter test shows a good broad-band flux calibration, important for the SP models. Finally, we measure the resolution R as a function of wavelength. We find that the resolution increases as a function of lambda from about 6 angstrom in J to 10 angstrom in the red part of the K-band. With these tests we establish that the IRTF library, the largest currently available general library of stars at intermediate resolution in the NIR, is an excellent candidate to be used in stellar population models. We present these models in the next paper of this series.Comment: 17 pages, 19 figures. Accepted for publication in Astronomy and Astrophysic

Dealing with change and uncertainty within the regulatory frameworks for flood defense infrastructure in selected European countries

Whereas existing literature on the interactions between law, adaptive governance and resilience in the water sector often focuses on quality or supply issues, this paper addresses adaptation in national water laws in relation to increasing flood risks. In particular, this paper analyzes the extent to which legal rules governing flood defense infrastructure in a selection of European countries (Sweden, France, England and the Netherlands) allow for response and adaptation to change and uncertainty. While there is evidence that the legal rules on the development of new infrastructure require that changing conditions be considered, the adaptation of existing infrastructure is a more complicated matter. Liability rules fail to adequately address damages resulting from causes external to the action or inaction of owners and managers, in particular extreme events. A trend towards clearer, and in some cases, increased public powers to ensure the safety of flood defense infrastructure is observed. The paper concludes that legal rules should ensure not only that decisions to build flood defenses are based on holistic and future-oriented assessments, but also that this is reflected in the implementation and operation of these structures

The European Union approach to flood risk management and improving societal resilience: lessons from the implementation of the Floods Directive in six European countries

Diversity in flood risk management approaches is often considered to be a strength. However in some national settings, and especially for transboundary rivers, variability and the incompatibility of approaches can reduce the effectiveness of flood risk management. Placed in the context of increasing flood risks, as well as the potential for flooding to undermine the European Union's sustainable development goals, a desire to increase societal resilience to flooding has prompted the introduction of a common European Framework. This paper provides a legal and policy analysis of the implementation of the Floods Directive (2007/60/EC) in six countries; Belgium (Flemish Region), England, France, the Netherlands, Poland and Sweden. Evaluation criteria from existing legal and policy literature frame the study of the Directive and its impact on enhancing or constraining societal resilience by using an adaptive governance approach. These criteria are initially used to analyze the key components of the EU approach, before providing insight of the implementation of the Directive at a national level. Similarities and differences in the legal translation of European goals into existing flood risk management are analyzed alongside their relative influence on policy and practice. The research highlights that the impact of the Floods Directive on increasing societal resilience has been nationally variable, in part due to its focus on procedural obligations, rather than on more substantive requirements. Analysis shows that despite a focus on transboundary river basin management, in some cases existing traditions of flood risk management, have overridden objectives to harmonize flood risk management. This could be strengthened by requiring more stringent cooperation and providing the competent authorities in International River Basins Districts with more power. Despite some shortcomings in directly impacting flood risk outcomes, the Directive has positively stimulated discussion and flood risk management planning in countries that were perhaps lagging behind

Carbon stars in the X-shooter Spectral Library

We provide a new collection of spectra of 35 carbon stars obtained with the ESO/VLT X-shooter instrument as part of the X-shooter Spectral Library project. The spectra extend from 0.3$\mu$m to 2.4$\mu$m with a resolving power above $\sim$ 8000. The sample contains stars with a broad range of (J-K) color and pulsation properties located in the Milky Way and the Magellanic Clouds. We show that the distribution of spectral properties of carbon stars at a given (J-K) color becomes bimodal (in our sample) when (J-K) is larger than about 1.5. We describe the two families of spectra that emerge, characterized by the presence or absence of the absorption feature at 1.53$\mu$m, generally associated with HCN and C$_2$H$_2$. This feature appears essentially only in large-amplitude variables, though not in all observations. Associated spectral signatures that we interpret as the result of veiling by circumstellar matter, indicate that the 1.53$\mu$m feature might point to episodes of dust production in carbon-rich Miras.Comment: 29 pages, 21 figures, 9 tables, Accepted for publication in A&

Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics

There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu complexes with bis(thiosemicarbazone) ligands [Cu(btsc)] exert antibacterial activity against a range of medically significant pathogens. Previous work using Neisseria gonorrhoeae showed that Cu(btsc) complexes may act as inhibitors of respiratory dehydrogenases in the electron transport chain. We now show that these complexes are also toxic against pathogens that lack a respiratory chain. Respiration in Escherichia coli was slightly affected by Cu(btsc) complexes, but our results indicate that, in this model bacterium, the complexes act primarily as agents that deliver toxic Cu ions efficiently into the cytoplasm. Although the chemistry of Cu(btsc) complexes may dictate their mechanism of action, their efficacy depends heavily on bacterial physiology. This is linked to the ability of the target bacterium to tolerate Cu and, additionally, the susceptibility of the respiratory chain to direct inhibition by Cu(btsc) complexes. The physiology of N. gonorrhoeae, including multidrug-resistant strains, makes it highly susceptible to damage by Cu ions and Cu(btsc) complexes, highlighting the potential of Cu(btsc) complexes (and Cu-based therapeutics) as a promising treatment against this important bacterial pathogen

La rentabilidad agrícola como condicionante de la decisión de producción en las empresas de la región centro de Argentina

  The objective of this study is to analyze whether Argentinian farmers from the central region make production decisions considering the calculations of profitability obtained at the time of sowing, or if there are other factors that have an impact such as diversity and alternation of the crops, climate predictions, commercialization problems, expectations of the sectorial policy, technology, and others. The alternatives examined link the production of soy, corn and wheat, which are annual crops, in the provinces of Santa Fe, Córdoba and Buenos Aires, as dependent variable, and the gross margins of soy, corn and wheat in each zone. The period under study covers the years 2011 to 2016. Although profit margins constitute an important element that conditions the production decision, it is clear that other elements are considered at the time of deciding which crop to produce, with the exception of the province of Santa Fe, favored by its lands, climate and logistics, where results evidence a relationship between the crops of higher margin and farmed areas. Future studies can attempt to identify other elements that condition the production and even the degree to which each influences it.El objetivo del trabajo es analizar, si el productor agrícola argentino de la región centro, toma decisiones de producción en virtud de los cálculos de rentabilidad que realiza al momento de sembrar o hay otros factores que influyen como la diversidad y alternancia de los cultivos; pronósticos climáticos, problemas de comercialización, expectativas de la política sectorial, tecnología y otros. Las alternativas examinadas vinculan la producción de soja, maíz y trigo que son cultivos anuales, en las provincias de Santa Fe, Córdoba y Buenos Aires, como variable dependiente y los márgenes brutos de soja, maíz y trigo de cada zona. El período bajo estudio abarca los años 2011 a 2016. Si bien los márgenes de ganancias constituyen un elemento importante que condiciona la decisión de producción, resulta claro que excepto en la provincia de Santa Fe, favorecida por sus tierras, clima y logística, en la que los resultados evidencian una relación entre los cultivos de mayor margen y las áreas sembradas, otros elementos son considerados al momento de decidir el cultivo a producir. Futuras investigaciones pueden intentar identificar otros elementos que condicionan la producción e incluso la medida en que cada uno influye en ésta

Single stellar populations in the near-infrared. II. Synthesis models

We present unresolved single stellar population synthesis models in the near-infrared (NIR) range. The extension to the NIR is important for the study of early-type galaxies, since these galaxies are predominantly old and therefore emit most of their light in this wavelength range. The models are based on a library of empirical stellar spectra, the NASA Infrared Telescope Facility (IRTF) spectral library. Integrating these spectra along theoretical isochrones, while assuming an initial mass function (IMF), we have produced model spectra of single age-metallicity stellar populations at a resolution R ~ 2000. These models can be used to fit observed spectral of globular clusters and galaxies, to derive their age distribution, chemical abundances and IMF. The models have been tested by comparing them to observed colours of elliptical galaxies and clusters in the Magellanic Clouds. Predicted absorption line indices have been compared to published indices of other elliptical galaxies. The comparisons show that our models are well suited for studying stellar populations in unresolved galaxies. They are particularly useful for studying the old and intermediate-age stellar populations in galaxies, relatively free from contamination of young stars and extinction by dust. These models will be indispensable for the study of the upcoming data from JWST and extremely large telescopes, such as the E-ELT. Appendices are available in electronic form at http://www.aanda.orgModel spectra are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/582/A97 and at smg.astro-research.ne

Stellar population models based on the SDSS-IV MaStar library of stellar spectra. I. Intermediate-age/old models

We use the first release of the SDSS/MaStar stellar library comprising ~9000, high S/N spectra, to calculate integrated spectra of stellar population models. The models extend over the wavelength range 0.36-1.03 micron and share the same spectral resolution (R~1800) and flux calibration as the SDSS-IV/MaNGA galaxy data. The parameter space covered by the stellar spectra collected thus far allows the calculation of models with ages and chemical composition in the range t>200 Myr, -2 <=[Z/H]<= + 0.35, which will be extended as MaStar proceeds. Notably, the models include spectra for dwarf Main Sequence stars close to the core H-burning limit, as well as spectra for cold, metal-rich giants. Both stellar types are crucial for modelling lambda>0.7 micron absorption spectra. Moreover, a better parameter coverage at low metallicity allows the calculation of models as young as 500 Myr and the full account of the Blue Horizontal Branch phase of old populations. We present models adopting two independent sets of stellar parameters (T_eff, logg, [Z/H]). In a novel approach, their reliability is tested 'on the fly' using the stellar population models themselves. We perform tests with Milky Way and Magellanic Clouds globular clusters, finding that the new models recover their ages and metallicities remarkably well, with systematics as low as a few per cent for homogeneous calibration sets. We also fit a MaNGA galaxy spectrum, finding residuals of the order of a few per cent comparable to the state-of-art models, but now over a wider wavelength range.Comment: 37 pages, 31 figures, MNRAS in press, models available at http://www.icg.port.ac.uk/masta

Molecular and Structural Discrimination of Proline Racemase and Hydroxyproline-2-Epimerase from Nosocomial and Bacterial Pathogens

The first eukaryotic proline racemase (PRAC), isolated from the human Trypanosoma cruzi pathogen, is a validated therapeutic target against Chagas' disease. This essential enzyme is implicated in parasite life cycle and infectivity and its ability to trigger host B-cell nonspecific hypergammaglobulinemia contributes to parasite evasion and persistence. Using previously identified PRAC signatures and data mining we present the identification and characterization of a novel PRAC and five hydroxyproline epimerases (HyPRE) from pathogenic bacteria. Single-mutation of key HyPRE catalytic cysteine abrogates enzymatic activity supporting the presence of two reaction centers per homodimer. Furthermore, evidences are provided that Brucella abortus PrpA [for ‘proline racemase’ virulence factor A] and homologous proteins from two Brucella spp are bona fide HyPREs and not ‘one way’ directional PRACs as described elsewhere. Although the mechanisms of aminoacid racemization and epimerization are conserved between PRAC and HyPRE, our studies demonstrate that substrate accessibility and specificity partly rely on contraints imposed by aromatic or aliphatic residues distinctively belonging to the catalytic pockets. Analysis of PRAC and HyPRE sequences along with reaction center structural data disclose additional valuable elements for in silico discrimination of the enzymes. Furthermore, similarly to PRAC, the lymphocyte mitogenicity displayed by HyPREs is discussed in the context of bacterial metabolism and pathogenesis. Considering tissue specificity and tropism of infectious pathogens, it would not be surprising if upon infection PRAC and HyPRE play important roles in the regulation of the intracellular and extracellular amino acid pool profiting the microrganism with precursors and enzymatic pathways of the host