EGFR inhibitors erlotinib and lapatinib ameliorate epidermal blistering in pemphigus vulgaris in a non-linear, V-shaped relationship

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The response to flexibility: country intervention choices in the first four rounds of the GAVI Health Systems Strengthening applications

Since December 2005 the GAVI Alliance (GAVI) Health Systems Strengthening (HSS) window has offered predictable funding to developing countries, based on a combined population and economic formula. This is intended to assist them to address system constraints to improved immunization coverage and health care delivery, needed to meet the Millennium Development Goals. The application process invites countries to prioritize specific system constraints not adequately addressed by other donors, and allows them to allocate their eligible funds accordingly. This article presents an analysis of the first four rounds of countries' funding applications. These requested funding for a variety of health system initiatives that reflected country-specific requirements, and were not limited to improving immunization coverage. Analyses identified a dominance of operational-level health service provision activities, and an absence of interventions related to demand and financing. While the proposed activities are only now being implemented, the results of this study provide evidence that the open application process employed by the HSS window has led to a shift in analysis and planning—from the programmatic to the systemic—in the countries whose applications have been approved. However, the proposed responses to identified constraints are dominated by short-term operational responses, rather than more complex, longer term approaches to health system strengthenin

Constrained caloric curves and phase transition for hot nuclei

Simulations based on experimental data obtained from multifragmenting quasi-fused nuclei produced in central $^{129}$Xe + $^{nat}$Sn collisions have been used to deduce event by event freeze-out properties in the thermal excitation energy range 4-12 AMeV [Nucl. Phys. A809 (2008) 111]. From these properties and the temperatures deduced from proton transverse momentum fluctuations, constrained caloric curves have been built. At constant average volumes caloric curves exhibit a monotonic behaviour whereas for constrained pressures a backbending is observed. Such results support the existence of a first order phase transition for hot nuclei.Comment: 14 pages, 5 figures, accepted in Physics Letters

The prominent role of the heaviest fragment in multifragmentation and phase transition for hot nuclei

The role played by the heaviest fragment in partitions of multifragmenting hot nuclei is emphasized. Its size/charge distribution (mean value, fluctuations and shape) gives information on properties of fragmenting nuclei and on the associated phase transition.Comment: 11 pages, Proceedings of IWND09, August 23-25, Shanghai (China

Signals of Bose Einstein condensation and Fermi quenching in the decay of hot nuclear systems

We report experimental signals of Bose-Einstein condensation in the decay of hot Ca projectile-like sources produced in mid-peripheral collisions at sub-Fermi energies. The experimental setup, constituted by the coupling of the INDRA 4$\pi$ detector array to the forward angle VAMOS magnetic spectrometer, allowed us to reconstruct the mass, charge and excitation energy of the decaying hot projectile-like sources. Furthermore, by means of quantum fluctuation analysis techniques, temperatures and mean volumes per particle "as seen by" bosons and fermions separately are correlated to the excitation energy of the reconstructed system. The obtained results are consistent with the production of dilute mixed (bosons/fermions) systems, where bosons experience a smaller volume as compared to the surrounding fermionic gas. Our findings recall similar phenomena observed in the study of boson condensates in atomic traps.Comment: Submitted to Phys. Rev. Lett. (december 2014

Charge and current-sensitive preamplifiers for pulse shape discrimination techniques with silicon detectors

New charge and current-sensitive preamplifiers coupled to silicon detectors and devoted to studies in nuclear structure and dynamics have been developed and tested. For the first time shapes of current pulses from light charged particles and carbon ions are presented. Capabilities for pulse shape discrimination techniques are demonstrated.Comment: 14 pages, 12 figures, to be published in Nucl. Inst. Meth.

Estimate of average freeze-out volume in multifragmentation events

An estimate of the average freeze-out volume for multifragmentation events is presented. Values of volumes are obtained by means of a simulation using the experimental charged product partitions measured by the 4pi multidetector INDRA for 129Xe central collisions on Sn at 32 AMeV incident energy. The input parameters of the simulation are tuned by means of the comparison between the experimental and simulated velocity (or energy) spectra of particles and fragments.Comment: To be published in Phys. Lett. B 12 pages, 5 figure

Dynamical effects in multifragmentation at intermediate energies

The fragmentation of the quasi-projectile is studied with the INDRA multidetector for different colliding systems and incident energies in the Fermi energy range. Different experimental observations show that a large part of the fragmentation is not compatible with the statistical fragmentation of a fully equilibrated nucleus. The study of internal correlations is a powerful tool, especially to evidence entrance channel effects. These effects have to be included in the theoretical descriptions of nuclear multifragmentation.Comment: 13 pages, 26 figures, submitted to Physical Review

Projected Quasi-particle Perturbation theory

The BCS and/or HFB theories are extended by treating the effect of four quasi-particle states perturbatively. The approach is tested on the pairing hamiltonian, showing that it combines the advantage of standard perturbation theory valid at low pairing strength and of non-perturbative approaches breaking particle number valid at higher pairing strength. Including the restoration of particle number, further improves the description of pairing correlation. In the presented test, the agreement between the exact solution and the combined perturbative + projection is almost perfect. The proposed method scales friendly when the number of particles increases and provides a simple alternative to other more complicated approaches

Multiplicity correlations of intermediate-mass fragments with pions and fast protons in 12C + 197Au

Low-energy pi+ (E < 35 MeV) from 12C+197Au collisions at incident energies from 300 to 1800 MeV per nucleon were detected with the Si-Si(Li)-CsI(Tl) calibration telescopes of the INDRA multidetector. The inclusive angular distributions are approximately isotropic, consistent with multiple rescattering in the target spectator. The multiplicity correlations of the low-energy pions and of energetic protons (E > 150 MeV) with intermediate-mass fragments were determined from the measured coincidence data. The deduced correlation functions 1 + R \approx 1.3 for inclusive event samples reflect the strong correlations evident from the common impact-parameter dependence of the considered multiplicities. For narrow impact-parameter bins (based on charged-particle multiplicity), the correlation functions are close to unity and do not indicate strong additional correlations. Only for pions at high particle multiplicities (central collisions) a weak anticorrelation is observed, probably due to a limited competition between these emissions. Overall, the results are consistent with the equilibrium assumption made in statistical multifragmentation scenarios. Predictions obtained with intranuclear cascade models coupled to the Statistical Multifragmentation Model are in good agreement with the experimental data.Comment: 9 pages, 11 figures, subm. to EPJ