WHEN IS IT OKAY TO BE HIGH? A GUIDE FOR LAW ENFORCEMENT OFF-DUTY USE OF CANNABIS

This thesis explores policy options for allowing off-duty law enforcement to use cannabis, considering the potential decriminalization and legalization of recreational cannabis use and the high stress levels of first responders. Utilizing Bardach and Patashnik’s eight-step method, this thesis discusses the mental and physical health problems that law enforcement officers face and then provides research on cannabis to determine whether cannabis could be a useful tool in curbing the stress of this occupation. Finally, policies on recreational use for other occupations and a sample from Canada are examined. Research shows that stress levels in the law enforcement occupation cause substantial mental and physical ailments for officers. Moreover, for those retired or outside law enforcement, cannabis has been used as treatment for some of these conditions. This thesis finds that given the potential of federal legalization, fit-for-duty policies that allow recreational, off-duty use are powerful and beneficial tools to mitigate stress-related ailments.Civilian, Prospect Heights Police DepartmentApproved for public release. Distribution is unlimited

Response of different Bt cotton (Gossypium hirsutum L.) hybrids to canopy modification practices

A field investigation was carried out to characterize the growth and development of Bt cotton hybrids by detopping and use of plant growth retardants during the rainy (kharif) season of 2011 and 2012. The experimental site had loamy sand soils with normal in reaction. The experiment (split plot) involved three Bt cotton hybrids (MRC 7017, MRC 7031 and RCH 314) in main plots and growth regulation treatments (Mepiquat chloride (MC) @ 300 ppm, 2, 3, 5-tri iodo benzoic acid (TIBA) @ 100 ppm and Maelic hydrazide (MH) @ 250 ppm) in sub plots with four replications. Hybrid MRC 7017 produced significantly higher (p<0.01) seed cotton yield which was attributed to the maximum number of sympodial branches plant-1, total number of flowers and picked bolls plant-1. Application of MC @ 300 ppm, TIBA @ 100 ppm and MH @ 250 ppm reduced plant height, leaf area index and total dry matter accu-mulation than control. Detopping treatment significantly (p<0.01) reduced plant height than control but attained more plant height than all the PGRs. MC @ 300 ppm, TIBA @ 100 ppm and MH @ 250 ppm at 80 days after sowing had beneficial effect on seed cotton yield. Detopping done at 80 days after sowing failed to influence the seed cotton yield dur-ing both the years. The results revealed that foliar application of MC @ 300 ppm yielded more seed cotton by improv-ing the setting percentage and therefore, increased number of picked (open) bolls plant-1 without exhibiting any ad-verse effect on quality traits

Love and mysticism in the Punjabi qissas of the seventeenth and eighteenth centuries.

This thesis examines the tension between mystical (haqiqi) and romantic (majazi) conceptions of love in the Punjabi qissa tradition before the end of the eighteenth century. All the texts under consideration date from before the third quarter of the eighteenth century and, therefore, both predate and inform the classical qissa tradition of the nineteenth century. The texts narrate three of the most commonly represented love stories in pre-twentieth century Punjab, two of them versions of local folk legends and one an episode from the Quran. A total of six texts are considered in the thesis: Hafiz Barkhurdar's Mirza Sahiba, Siddiq Lali's Yusuf Zulaikha, and the versions of Hir by Ahmad, Muqbil and Varis Shah. The thesis begins with a chapter on the qissa tradition which seeks to situate the qissa in the Punjabi literary tradition and to define the classical qissa based on its formal generic features. The body of the thesis argues that most of the early texts under consideration attempt to subvert the transgressive potential of the love stories they narrate: where Ahmad contains the love story of Hir and Ranjha through narrative compression, for example, Muqbil subtly recasts the story as a mystical allegory. The thesis argues that the image of the slaughter of the Imam Husain underlies the structure of the Mirza Sahiban of Hafiz (as well as the versions of his successors) and that the entire poetic of Siddiq Lali's Yusuf Zulaikha figures the narrative universe as an intersection of the mystical with the worldly. Finally, the thesis argues that Varis Shah's Hir recasts the narrative by introducing a certain sexual component at the same time as it downplays the social and religious transgressiveness present in earlier poems

Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial.

ObjectiveNo evidence of progression or active disease (NEPAD) is a novel combined endpoint defined by the absence of both progression and inflammatory disease activity in primary progressive multiple sclerosis (PPMS). In the placebo-controlled phase III ORATORIO study (NCT01194570), we investigated the effect of ocrelizumab on this comprehensive outcome and its components in a post-hoc analysis.MethodsThe proportion of patients with NEPAD (no evidence of progression [NEP; no 12-week confirmed progression of ≥1/≥0.5 points on the Expanded Disability Status Scale if the baseline score was ≤5.5/>5.5 points, respectively; no 12-week confirmed progression of ≥20% on the Timed 25-Foot Walk test and 9-Hole Peg Test], no brain magnetic resonance imaging activity [no new/enlarging T2 lesions and no T1 gadolinium-enhancing lesions], and no protocol-defined relapse) from baseline to week 120 was determined in ocrelizumab- (600 mg; n = 465) and placebo-treated (n = 234) patients.ResultsThe majority of ORATORIO study patients with PPMS experienced clinical progression or evidence of disease activity. From baseline to week 120, 29.9% and 42.7% ocrelizumab-treated compared to 9.4% and 29.1% placebo-treated patients maintained NEPAD (relative risk [95% confidence interval {CI}], 3.15 [2.07-4.79]; p < 0.001) and NEP (relative risk [95% CI], 1.47 [1.17-1.84]; p < 0.001), respectively. Effects on the individual components of both measures were consistent with the compound outcomes.InterpretationCompared to placebo, ocrelizumab enhanced 3-fold the proportion of PPMS patients with no evidence of either progression or inflammatory disease activity. NEPAD may represent a sensitive and meaningful comprehensive measure of disease control in patients with PPMS. Ann Neurol 2018;84:527-536

Acid/base-triggered switching of circularly polarized luminescence and electronic circular dichroism in organic and organometallic helicenes.

Electronic circular dichroism and circularly polarized luminescence acid/base switching activity has been demonstrated in helicene-bipyridine proligand 1 a and in its “rollover” cycloplatinated derivative 2 a. Whereas proligand 1 a displays a strong bathochromic shift (>160 nm) of the nonpolarized and circularly polarized luminescence upon protonation, complex 2 a displays slightly stronger emission. This strikingly different behavior between singlet emission in the organic helicene and triplet emission in the organometallic derivative has been rationalized by using quantum-chemical calculations. The very large bathochromic shift of the emission observed upon protonation of azahelicene-bipyridine 1 a has been attributed to the decrease in aromaticity (promoting a charge-transfer-type transition rather than a π–π* transition) as well as an increase in the HOMO–LUMO character of the transition and stabilization of the LUMO level upon protonation

Testosterone Fluctuations in Young Men: The Difference Between Interacting With Like and Not-Like Others

The current study investigated young men\u27s testosterone level changes as a result of interacting with other men. Male participants (n = 84) were led to believe that a group they would be interacting with was either similar to them or not similar. The interaction was then one of two types: the other group members were inclusive, or the others excluded the participant during the group interaction. Participants provided saliva samples before and after the interaction. Results suggest that interacting with highly similar men increases circulating testosterone whereas interacting with highly dissimilar men actually lowers testosterone. The nature of the interaction was less important than similarity. Considering that testosterone surges may relate to attempts to gain status within one\u27s group, the results are interpreted as consistent with viewing hormonal changes as a mechanism to alter current behavioral propensities in ways that are likely to be most adaptive. Exploratory analyses suggest a methodologically interesting suppressor effect of the self-report items in predicting testosterone changes

Влияние раскрытия информации о рисках на результаты iPO: данные из Индии

The main aim of the paper is to explore the performance of Indian IPOs in the context of risk disclosures in the offer documents. For the purpose of assessing the impact of risk disclosure factors on initial returns, subsequent returns and post issue risk of IPOs, the study has implemented ordinary least square regression. The study has analysed 109 IPOs that were listed in two main Indian stock exchanges (BSE and NSE) from 2015–2019. Outcomes of the present study are contrary to the previous studies which showed that information disclosure reduces the asymmetry, which is touted as the main reason for underpricing, the present study did not find any association between risk disclosures and underpricing. Quantitative risk measures showed positive association with 1-year returns, but qualitative measures failed to show any association. The post issue risk of the firms showed positive association with external risk factors listed in prospectus and negative association with liquidity. The results of this study are useful for the investors as based on the results they can make decisions about investing in Indian IPOs. Besides, the managers of issuing companies and lead managers of issues can use the results of this study to improve the pricing of issues. To the best of the authors’ knowledge no study has been done before in the Indian context which is specific to risk disclosures (quantitative and qualitative measures) and IPO performance. The present study seeks to fill this gap and contribute to the existing literature.Основная цель данной работы — изучить показатели индийских IPO в контексте раскрытия информации о рисках в эмиссионных документах. Для оценки влияния факторов раскрытия рисков на первоначальную доходность, последующую доходность и риск после выпуска IPO в исследовании использовалась обыкновенная регрессия по методу наименьших квадратов. В ходе исследования проанализировано 109 IPO, которые были осуществлены на двух основных индийских фондовых биржах (NSEI, BSE) в период 2015–2019 гг. Результаты настоящей работы противоречат предыдущим исследованиям, которые показали, что раскрытие информации снижает асимметрию, которая считается основной причиной занижения цен. Однако в настоящем исследовании не было обнаружено никакой связи между раскрытием информации о рисках и недооценкой при IPO. Количественные показатели риска продемонстрировали положительную связь с доходностью за один год, но качественные показатели не зафиксировали никакой связи. Риск фирм после выпуска имеет положительную связь с внешними факторами риска, перечисленными в проспекте эмиссии, и отрицательную связь с ликвидностью. Результаты данного исследования могут быть полезны инвесторам для принятия решений об инвестировании в индийские IPO. Кроме того, менеджеры компанийэмитентов и ведущие менеджеры выпусков могут использовать результаты данного исследования для улучшения ценообразования выпусков. Насколько известно авторам, в индийском контексте не проводилось исследование, посвященное раскрытию информации о рисках (количественные и качественные показатели) и эффективности IPO. Настоящая работа восполняет этот пробел и вносит вклад в существующую литератур

Acid/base-triggered switching of circularly polarized luminescence and electronic circular dichroism in organic and organometallic helicenes

Electronic circular dichroism and circularly polarized luminescence acid/base switching activity has been demonstrated in helicene-bipyridine proligand 1 a and in its “rollover” cycloplatinated derivative 2 a. Whereas proligand 1 a displays a strong bathochromic shift (>160 nm) of the nonpolarized and circularly polarized luminescence upon protonation, complex 2 a displays slightly stronger emission. This strikingly different behavior between singlet emission in the organic helicene and triplet emission in the organometallic derivative has been rationalized by using quantum-chemical calculations. The very large bathochromic shift of the emission observed upon protonation of azahelicene-bipyridine 1 a has been attributed to the decrease in aromaticity (promoting a charge-transfer-type transition rather than a π–π* transition) as well as an increase in the HOMO–LUMO character of the transition and stabilization of the LUMO level upon protonation