Possible Applications of Neural Networks in Manufacturing

Summary form only given. An examination is made of the potential of neural networks and the impact of parallel processing in the design and operations of manufacturing systems. After an initial discussion on possible areas of application, an approach that integrates artificial intelligence, operations research, and neural networks for the solution of a scheduling problem is examine

Systems Architecting Heuristics for Systems Engineering Management and Embedded Systems Engineering

Software development for United States Air Force (USAF) weapon systems is a right here, right now prize captured by those who can rapidly develop requirements and deliver a quality product. The Air Logistics Centers (ALCs) located at Tinker Air Force Base (AFB), Oklahoma, Warner-Robins AFB, Georgia, and Hill AFB, Utah develop requirements utilizing 3400 funding to capture this prize. The ALCs identify these requirements as corrective maintenance or perfective and adaptive maintenance. Colleen A. Calimer and John L. BeVier introduce the concept of the Embedded Systems Engineer in their 2004 INCOSE paper Embedded Systems Engineering: Managing Systems Complexity, Change, and Crises . They present the case that insightful management and utilization of the embedded systems engineer is the critical component of successful engineering activity in the dynamic systems environment. This paper applies systems architecting heuristics to systems engineering management to suggest that embedded systems engineering is functionally beneficial to the operational demands of maintaining the capability of the Avionics Flight Software (AFS) of the B-1B strategic bomber weapon system

Implementing an Architectural Framework to Define and Deliver Net-Centric Capability to Legacy Military Air Assets Operating within a System of Systems

The United States Air Force (USAF) is implementing an integrated net-centric system of systems for airborne operations in support of the global war on terror (GWOT). The GWOT demands that a successful architecture framework transforms and delivers net-centric assets to the war-fighter in a timely manner. A critical component of this implementation is the transformation of legacy strategic air platforms into net-centric air power assets operating within a system of systems. The System Architectural (SA) framework, and the Department of Defense Architectural Framework (DoDAF) are ways of managing complexity and organizing information within a system of systems network. This paper will explore and compare these architectural frameworks; show examples used in a system of systems network; and illustrate how the DoDAF can successfully define the transformation of a legacy weapon system into a net-centric asset

Two-Semester Agile Systems Engineering Design Course: Investigation and Exploration of Immersive Training Technologies

The teaching of systems engineering is a daunting task that involves the development of curriculum capable of teaching students the systems engineering process, the design aspects of engineering, and the interdisciplinary knowledge of a variety of fields. Design is widely considered to be the central or the major distinguishing activity of engineering1. Design can be considered as the center of system engineering, in which engineers employ an interdisciplinary approach to design effective solutions to meet social needs. However, systems engineering requires that traditional academic boundaries be crossed and intertwined with other fields of engineering as well as business, socio-political, and other disciplines that clearly interacts with or are directly affected by the system under consideration. Systems engineering requires different design thinking, as it requires in depth knowledge often beyond the traditional engineering classification boundaries. For example, an electrical engineer must also in many cases have knowledge of software engineering, or safety engineering when designing a cell phone circuit

Oral health and related factors in a group of children with cystic fibrosis in Istanbul, Turkey

Background: Cystic fibrosis (CF) patients can be considered as high caries risk patients because they frequently consume sugar.rich food between meals and they have a high intake of sugar containing syrups, aerosols, and salivary flow reducing medication. Variable caries prevalences were reported in CF patients in previous studies. There are no studies related to CF and salivary thromboplastic activity, which can be presented as a marker of wound healing and bleeding tendency of oral cavity.Objective: The aim of this study was to compare oral health status and salivary pH, flow rate, and thromboplastic activity in children with CF and healthy controls.Materials and Methods: Asample of 35 children with CF (23 girls and 12 boys), and 12 healthy control subjects (6 girls and 6 boys) were selected. Caries experience, oral hygiene, and dental erosion were assessed. Salivary flow rate, pH, thromboplastic activity, and total protein content were determined. Differences between the groups were evaluated using Chi.square test with a significance level set at 0.05.Results: The differences between children with CF and healthy controls in tooth brushing frequency, use of fluoride tablets, caries experience, dental erosion index, oral hygiene index, salivary flow rate and total protein levels were not statistically significant (P > 0.05). Salivary thromboplastic activity of the CF group was significantly lower than the healthy controls (P < 0.01).Conclusion: Large population studies may be necessary to establish the role of salivary thromboplastic activity in children with CF considering our findings related to the decreased salivary thromboplastic activity, which  may indicate delayed oral wound healing process.Key words: Caries, children, cystic fibrosis, saliva, salivary thromboplastic activit

Expressão e distribuição da conexina 32 em fígados de ratos com fibrose induzida experimentalmente

The connexin 32 (Cx32) is a protein that forms the channels that promote the gap junction intercellular communication (GJIC) in the liver, allowing the diffusion of small molecules through cytosol from cell-to-cell. Hepatic fibrosis is characterized by a disruption of normal tissue architeture by cellular lesions, and may alter the GJIC. This work aimed to study the expression and distribution of Cx32 in liver fibrosis induced by the oral administration of dimethylnitrosamine in female Wistar rats. The necropsy of the rats was carried out after five weeks of drug administration. They presented a hepatic fibrosis state. Sections from livers with fibrosis and from control livers were submitted to immunohistochemical, Real Time-PCR and Western-Blot analysis to Cx32. In fibrotic livers the Cxs were diffusely scattered in the cytoplasm, contrasting with the control livers, where the Cx32 formed junction plaques at the cell membrane. Also it was found a decrease in the gene expression of Cx32 without reduction in the protein quantity when compared with controls. These results suggest that there the mechanism of intercellular communication between hepatocytes was reduced by the fibrotic process, which may predispose to the occurrence of a neoplastic process, taken in account that connexins are considered tumor suppressing genes.A conexina 32 (Cx32) é uma proteína que constitui os canais que promovem as comunicações intercelulares via junções comunicantes (CIJC) no fígado, permitindo difusão de pequenas moléculas citoplasmáticas de uma célula à outra. A fibrose hepática caracteriza-se pela alteração da arquitetura normal do fígado e podem alterar as CIJCs. O objetivo deste trabalho foi estudar a expressão e distribuição de Cx32 na fibrose hepática. O objetivo do presente trabalho foi estudar a expressão e distribuição da Cx32 em fígados com fibrose induzida pela administração oral de dimetilnitrosamina em fêmeas de ratos Wistar. A necropsia foi realizada após cinco semanas da última administração da droga e observou-se um quadro de fibrose hepática. Amostras dos fígados com fibrose e de animais controle foram submetidas à análise imunoistoquímica, por Real Time-PCR e por Western-Blot verificando-se a presença de Cx32 difusa e dispersa no citoplasma dos fígados com fibrose. No grupo controle a Cx32 localizou-se na membrana citoplasmática com a formação de placas juncionais. O fígado com fibrose também revelou diminuição da expressão gênica de Cx32, embora sem a redução da quantidade do produto protéico, quando comparado ao grupo controle. Estes resultados sugerem que o mecanismo de comunicação intercelular entre os hepatócitos reduziu-se durante o processo fibrótico, o que pode predispor a ocorrência de processos neoplásicos, uma vez que as conexinas são consideradas genes supressores de tumores.FAPESPCNP

European Respiratory Society International Congress 2018: four shades of epidemiology and tobacco control

In this article, early career members and experienced members of the Epidemiology and Environment Assembly of the European Respiratory Society highlight and summarise a selection of six sessions from the Society’s annual congress, which in 2018 was held in Paris, France. The topics covered in these sessions span from cutting-edge molecular epidemiology of lung function to clinical, occupational and environmental epidemiology of respiratory disease, and from emergent tobacco products to tobacco control

A method for determining venous contribution to BOLD contrast sensory activation

While BOLD contrast reflects haemodynamic changes within capillaries serving neural tissue, it also has a venous component. Studies that have determined the relation of large blood vessels to the activation map indicate that veins are the source of the largest response, and the most delayed in time. It would be informative if the location of these large veins could be extracted from the properties of the functional responses, since vessels are not visible in BOLD contrast images. The present study describes a method for investigating whether measures taken from the functional response can reliably predict vein location, or at least be useful in down-weighting the venous contribution to the activation response, and illustrates this method using data from one subject. We combined fMRI at 3 Tesla with high-resolution anatomical imaging and MR venography to test whether the intrinsic properties of activation time courses corresponded to tissue type. Measures were taken from a gamma fit to the functional response. Mean magnitude showed a significant effect of tissue type (P veins ≈ grey matter > white matter. Mean delays displayed the same ranking across tissue types (P grey matter. However, measures for all tissue types were distributed across an overlapping range. A logistic regression model correctly discriminated 72% of the veins from grey matter in the absence of independent information of macroscopic vessels (ROC=0.72). Whilst tissue classification was not perfect for this subject, weighting the T contrast by the predicted probabilities materially reduced the venous component to the activation map