Characteristics of patients operated for primary hyperparathyroidism at university hospitals in Türkiye: Differences among Türkiye's geographical regions

Purpose: The aim of this study was to define the clinical and laboratory characteristics of patients operated on for primary hyperpatathyroidism (PHPT) at university hospitals in Türkiye, and to investigate the differences in the clinical presentations of the disease between different geographical regions. Methods: Patients operated on for PHPT in the university hospitals of Türkiye were included in the study. The demographic, clinical, and laboratory findings and the operational data of the patients were investigated according to the whole country and to different geographical regions. Comparisons were performed according to whole country and regions. Results: A total of 1,162 cases were included in the study from different regions and 20 university hospitals. The mean age of patients was 52.4 ± 0.38 (mean ± standard error) in the general population of Türkiye. The rates of hypertension, urolithiasis, bone disease and 25-hydroxyvitamin D insufficiency were 35%, 18.6%, 67.6%, and 63%, respectively. The median parathormone (PTH), serum total calcium (Ca+2) and phosphorus value were 220 pg/mL (range, 70-2,500 pg/mL), 11.2 mg/dL (range, 9.5-11.2 mg/dL), and 2.4 mg/dL (range, 1-4.7 mg/dL), respectively. The median size of the adenomas resected was 16 mm (range, 4-70 mm). Significant differences were observed in the clinical and laboratory findings of the patients operated on due to PHPT between different geographical regions of Türkiye (P < 0.05). Conclusion: The clinical and laboratory characteristics of the patients with PHPT in different geographical regions of Türkiye differ. Furthermore, the general findings of the cases in Türkiye give us a hint that the severity of the disease here is somewhere between Eastern and Western countries. Copyright © 2016, the Korean Surgical Society

A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk

Background This review provides a reappraisal of the potential effects of dairy foods, including dairy fats, on cardiovascular disease (CVD)/coronary heart disease (CHD) risk. Commodities and foods containing saturated fats are of particular focus as current public dietary recommendations are directed toward reducing the intake of saturated fats as a means to improve the overall health of the population. A conference of scientists from different perspectives of dietary fat and health was convened in order to consider the scientific basis for these recommendations. Aims This review and summary of the conference focus on four key areas related to the biology of dairy foods and fats and their potential impact on human health: (a) the effect of dairy foods on CVD in prospective cohort studies; (b) the impact of dairy fat on plasma lipid risk factors for CVD; (c) the effects of dairy fat on non-lipid risk factors for CVD; and (d) the role of dairy products as essential contributors of micronutrients in reference food patterns for the elderly. Conclusions Despite the contribution of dairy products to the saturated fatty acid composition of the diet, and given the diversity of dairy foods of widely differing composition, there is no clear evidence that dairy food consumption is consistently associated with a higher risk of CVD. Thus, recommendations to reduce dairy food consumption irrespective of the nature of the dairy product should be made with cautionJ. Bruce German, Robert A. Gibson, Ronald M. Krauss, Paul Nestel, Benoît Lamarche, Wija A. van Staveren, Jan M. Steijns, Lisette C. P. G. M. de Groot, Adam L. Lock and Frédéric Destaillat

Spin dependent transport behavior in small world networks

Density functional theory (DFT) combined with the non equilibrium Green’s function formalism (NEGF) is applied to perform spin polarized transport calculations on small world network (SWN) systems consisting of atomic wires. Including the spin property in SWN structures leads to interesting electrical properties. It is revealed that the emerging spin polarization depends mainly on the SWN geometry given by the asymmetric distribution of loops joining the arbitrary atoms on the main chain. The spin-asymmetric behavior which yields the spin polarization is found to be largely determined by those loops which are close to the electrodes. However, spin polarization may vanish for a specific SWN structure due to symmetry

Evaluation of the interactions of the Sunitinib malate with topoisomerase enzymes by in vitro enzyme and molecular docking analyses

Today, we live with the fact that anti-cancer drugs, which are in medical use and have been identified to have many mechanisms of action, only allow the treatment of a certain number of cancer types, and despite the research of many molecules with potential anti-cancer properties, not all types of cancer can be treated. Tyrosine kinase inhibitors (TKIs) mostly destroy certain types of cancer cells and many TKIs are currently being investigated in phase stages. Determining their use for various types of cancer is especially important for cases of acquired resistance in cancer. In our study, we investigated whether Sunitinib malate molecule, a multi-target receptor tyrosine kinase inhibitor, targets the topoisomerase I enzyme in addition to its known targets. In our study, we investigated whether Sunitinib malate molecule, a multi-target receptor tyrosine kinase inhibitor, targets the topoisomerase I enzyme in addition to its known targets. The interactions of Sunitinib malate with topoisomerase enzyme I were evaluated by in vitro enzyme activity tests, and Sunitinib malate was shown to inhibit topoisomerase I enzyme in a concentration-dependent manner, and when used in combination with Camptothecin, the potential for inhibition effects was evaluated by in vitro enzyme assays and molecular docking analysis

Effects of granulocyte-macrophage colony-stimulating factor on incisional wound healing in an experimental diabetic rat model

The exact nature of poor wound healing in diabetes is uncertain. Neutrophils play a critical role in the host defense mechanism, and it is suggested that impaired neutrophil functions cause healing difficulties with or without infections in diabetic patients. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used clinically when given systematically to increase the circulating neutrophils, but its wound-healing effects have not been systematically studied. This study was undertaken to examine the effects of GM-CSF on incisional wound healing in an experimental diabetic rat model. Forty rats were randomly divided into three groups, group I receiving saline as control, diabetes-induced group II receiving saline and diabetes-induced group III receiving GM-CSF. The anesthetized rats in all groups were wounded 21 days after diabetes induction by streptozotocin. Blood neutrophil counts and neutrophil fractions were also determined three days after wounding. Tensile strengths of wounded skin and the hydroxyproline (hyp) level of the wound were determined and wound healing processes were evaluated by light and electron microscopy, fourteen days after wounding. Neutrophil counts and phagocytosis were significantly increased in group III and neutrophil counts decreased in group II (p < 0.05). Although the hydroxyproline level of wound tissue significantly decreased in group II as compared with group III (p < 0.05), there was no differences of tensile strength between group II and III (p < 0.05). Wound score in group II was less than that in groups I and III (p < 0.05). It is concluded that PMN may have a role in modulating wound healing. GM-CSF may be useful for creating better wound healing healing. GM-CSF may be useful for creating better wound healing in risky patients such as diabetics

Effects of kaolin and dicarboxylic acid based stress inhibitors on aroma composition of two table grape cultivars (V. vinifera L.)

In this study, effects of two stress inhibitors (particle film – PF and dicarboxylic acid – DA) on aroma composition of Beauty Seedless and Tekirdag Seedless grape cultivars were investigated. Analysis of the aroma components was carried out using solid-phase microextraction technique with gas chromatography (GC) and mass spectrometry (MS). A total of 36 and 24 aroma compounds were identified in Beauty Seedless and Tekirdag Seedless, respectively. The C6-compounds (hexanal and 2-hexenal) were determined as the most abundant compounds in both grape cultivars and they accounted for 40.1% and 72.3% of total aroma composition in Beauty Seedless and Tekirdag Seedless, respectively. Monoterpenes (geraniol, nerol and neric acid) and sesquiterpenes (α-ylangene and germacrene) had a significant contribution of 35% to the total flavor of Beauty Seedless. Benzophenone, maltol, 6-methyl-5-hepten-2-one, 2-ethyl hexanol, 2-pentyl furan, acetic acid, hexanoic acid were other compounds detected at the highest amount. In Tekirdag Seedless, benzene acetaldehyde, 2-ethyl hexanol, maltol, 4-hexen-1-ol, acetic acid and hexanoic acid were determined as proportionally important compounds. When taken into consideration the use of stress inhibitors becoming an interesting area in viticulture, the effects of treatments in the aromatic composition is limited. In the presented study, proportional levels of any aroma compounds could not be attributed to influence of the stress inhibitors. However, findings presented useful contribution for future studies. On the other hand, this study is the first report on aroma composition of Beauty Seedless and Tekirdag Seedless grape cultivars

The relationship between neutrophils and incisional wound healing

The systemic administration of granulocyte-macrophage colony-stimulating factor (GMCSF) is used clinically to increase circulating neutrophils, but its wound healing effects after intraperitoneal treatment have not been studied yet. We planned to investigate the effect of neutrophils on wound healing under cyclophosphamide and GM-CSF treatment. Forty rats were divided into three groups: control group (group I, n = 12) receiving saline, group II (n = 14) receiving cyclophosphamide and group III (n = 14) receiving GM-CSF. The rats in all groups underwent incisional wounding and were euthanized after 7 days. Blood neutrophil counts and functions, tensile strengths and the hydroxyproline level of skin were determined, and a histopathological evaluation of healing was made. Neutrophil counts and phagocytosis significantly increased in group III and decreased in group II. Although the skin hydroxyproline level did not differ, there was a difference in tensile strength of the wounded skin between group II and group III. The wound score in group II was lower than that in groups III and I. As a result we suggest that systemically given GM-CSF - by increasing the neutrophil count and neutrophil phagocytosis index - can enhance the tensile strength of surgical incisions. Copyright (C) 2001 S. Karger AG, Basel

Efficiency and safety of phenylephrine and tropicamide used in premature retinopathy: A prospective observational study

Background: To determine effects and side effects of topical application of phenylephrine 2.5% and tropicamide 0.5% combination in preterm infants. Methods: In this prospective observational study, 60 infants undergoing retinopathy of prematurity (ROP) screening were prospectively observed. Pupillary diameter, blood pressure, heart rate, and oxygen saturation were monitored before and after up to 24 h during ROP screening examinations. Results: The mean pupillary diameter 1 h after the instillation of drops was 5.58 ± 0.75 mm for both eyes. The mean systolic and diastolic pressure and oxygen saturation of infants did not change statistically until the end of the study. The average heart rate decreased by a mean of 4.96 beats/minute from the baseline following eye drops instillation. General condition deterioration, fall in oxygen saturation and bradycardia were observed in 4 infants that already had respiratory distress syndrome. Conclusion: The phenylephrine 2.5% plus tropicamide 0.5% drop is effective and safe as mydriatic combination for retinopathy of prematurity screening. In infants with an additional systemic disease such as respiratory distress syndrome, the side effects of mydriatic drops may be more common. Such babies should be kept under close observation. Trial registration: The trial was retrospectively registered on 28 February 2018. The ClinicalTrials.gov Identifier is NCT03448640. © 2019 The Author(s)