Presynaptic control of transmission through group II muscle afferents in the midlumbar and sacral segments of the spinal cord is independent of corticospinal control.

Transmission of information from the terminals group II muscle afferents is subject to potent presynaptic modulation by both segmental group II and cutaneous afferents and by descending monoaminergic systems. Currently it is unknown whether descending corticospinal fibres affect this transmission. Here we have examined whether corticospinal tract activation modulates the size of monosynaptic focal synaptic potentials (FSPs) evoked by group II muscle afferents, and the excitability of intraspinal terminals of group II afferents, both of which are indices used to show presynaptic control. Conditioning stimulation of corticospinal pathways had no effects on the sizes of group II evoked FSPs in the midlumbar or sacral segments at either dorsal horn or intermediate zone locations. These stimuli also had no effect on the excitability of single group II afferent terminals in the dorsal horn of the midlumbar segments. As positive controls, we verified that the corticospinal conditioning stimuli used did effectively depress FSPs evoked from cutaneous afferents recorded at the same spinal locations as the group II field potentials in all experiments. Corticospinal tract conditioning stimuli did not consistently enhance or reduce the depression of group II FSPs that was evoked by stimulation of ipsilateral segmental group II or cutaneous afferents; in the large majority of cases there was no effect. The results reveal that the control of transmission of information from group II afferents in these regions of the spinal cord is independent of direct corticospinal control

Composite patch repair of fatigue-damaged steel members

The use of adhesively bonded composite reinforcements for strengthening metallic structures is a relatively new technique that has been introduced in the past few years. The technique was first applied for crack patching of aircraft components, with the first civil engineering applications on steel bridge members, which have been damaged due to corrosion or fatigue, being more recent. The finite element (FE) method was employed in order to analyse a steel plate containing a crack and reinforced with an adhesively bonded composite patch. The role of parameters such as the crack size and the properties (modulus and thickness) of the patch and the adhesive was examined. Results in tenns of the stress magnification factor at the crack tip and the shear and peel stress distributions at the steel/adhesive interface were obtained. Following this, the FE results were used in order to develop an analytical model for estimating the stress magnification factor (YJ for patched cracks. The effects of patch pre-stressing and thennal loading due to mismatch in thennal expansion coefficients of the materials involved were also examined. Patch debonding was also investigated. Two different cases were considered, namely a patched plate without a crack and a patched plate containing a crack. For the latter, apart from debonding being initiated from the patch extremities (patch end debonding), crack mouth debonding was also considered. The effect of debonding on Yp was determined. Following this, debonding was modelled as a crack located at the steel/adhesive interface and a fracture parameter, namely the energy release rate G, was obtained at the interface crack tip. An analytical model for G pertaining to patch end debonding was also developed. An experimental study was carried out in order to validate the model proposed for Yp' Fatigue tests of patched cracked specimens were performed and crack growth data was obtained and compared with predictions using the analytical model for Yp inside the well known Paris crack growth law. Prior to this, the tensile properties for steel and composite and the fatigue properties of steel were determined from tests. The results indicate that the models obtained can be used for the design of composite patch repairs of steel members. Therefore, they were included in a design methodology, which is also presented. The latter could form the basis of a more ,comprehensive future design guide, or even complete existing guides, such as the CIRIA . guide (Cadei et a1. 2004).EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Serviceability performance of steel-concrete composite beams

YesFor composite beams with low degrees of shear connection, additional deflections occur due to slip in the shear connectors, which can be significant for beams with low degrees of shear connection. A design formula is presented for the effective stiffness of composite beams taking account of the stiffness of the shear connectors, which is compared to measured deflections of 6 symmetric beams and an 11m span composite beam of asymmetric profile. It is shown that the comparison is good when using a shear connector stiffness of 70 kN/mm for single shear connectors and 100 kN/mm for pairs of shear connectors per deck rib. Results of push tests on a range of deck profiles confirm these initial elastic stiffnesses. To ensure that the slip at the serviceability limit state does not lead to permanent deformations of the beam, it is proposed that the minimum degree of shear connection should not fall below 30% for un-propped beams and 40% for propped beams of symmetric cross-section.European Commissio

The impact of tides on the capillary transition zone

The capillary transition zone, also known as the capillary fringe, is a zone where water saturations decrease with height above the water table/oil–water contact as a result of capillary action. In some oil reservoirs, this zone may contain a significant proportion of the oil in place. In groundwater assessments, the capillary fringe can profoundly affect contaminant transport. In this study, we investigated the influence of a tidally induced, semi-diurnal, change in water table depth on the water saturation distribution in the capillary fringe/transition zone. The investigation used a mixture of laboratory experiments, in which the change in saturation with depth was monitored over a period of 90 days, and numerical simulation. We show that tidal changes in water table depth can significantly alter the vertical water saturation profile from what would be predicted using capillary–gravity equilibrium and the drainage or imbibition capillary pressure curves

Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction

Objective To assess the usefulness of in-hospital measurement of C-reactive protein (CRP) concentration in comparison to well-established risk factors as a marker of post-infarct left ventricular systolic dysfunction (LVSD) at discharge. Materials and methods Two hundred and four consecutive patients with ST-segment-elevation myocardial infarction (STEMI) were prospectively enrolled into the study. CRP plasma concentrations were measured before reperfusion, 24 h after admission and at discharge with an ultra-sensitive latex immunoassay. Results CRP concentration increased significantly during the first 24 h of hospitalization (2.4 ± 1.9 vs. 15.7 ± 17.0 mg/L; p\0.001) and persisted elevated at discharge (14.7 ± 14.7 mg/L), mainly in 57 patients with LVSD (2.4 ± 1.8 vs. 25.0 ± 23.4 mg/L; p\0.001; CRP at discharge 21.9 ± 18.6 mg/L). The prevalence of LVSD was significantly increased across increasing tertiles of CRP concentration both at 24 h after admission (13.2 vs. 19.1 vs. 51.5 %; p\0.0001) and at discharge (14.7 vs. 23.5 vs. 45.6 %; p\0.0001). Multivariate analysis demonstrated CRP concentration at discharge to be an independent marker of early LVSD (odds ratio of 1.38 for a 10 mg/L increase, 95 % confidence interval 1.01–1.87; p\0.04). Conclusion Measurement of CRP plasma concentration at discharge may be useful as a marker of early LVSD in patients after a first STEMI

Brain Responses to Violet, Blue, and Green Monochromatic Light Exposures in Humans: Prominent Role of Blue Light and the Brainstem

BACKGROUND: Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by melanopsin-expressing retinal ganglion cells which are more sensitive to blue light than violet or green light. The contribution of the melanopsin system and the brain mechanisms involved in the establishment of such responses to light remain to be established. METHODOLOGY/PRINCIPAL FINDINGS: We exposed 15 participants to short duration (50 s) monochromatic violet (430 nm), blue (473 nm), and green (527 nm) light exposures of equal photon flux (10(13)ph/cm(2)/s) while they were performing a working memory task in fMRI. At light onset, blue light, as compared to green light, increased activity in the left hippocampus, left thalamus, and right amygdala. During the task, blue light, as compared to violet light, increased activity in the left middle frontal gyrus, left thalamus and a bilateral area of the brainstem consistent with activation of the locus coeruleus. CONCLUSION/SIGNIFICANCE: These results support a prominent contribution of melanopsin-expressing retinal ganglion cells to brain responses to light within the very first seconds of an exposure. The results also demonstrate the implication of the brainstem in mediating these responses in humans and speak for a broad involvement of light in the regulation of brain function

Automated office blood pressure measurements in primary care are misleading in more than one third of treated hypertensives: The VALENTINE-Greece Home Blood Pressure Monitoring study

Abstract Background This study assessed the diagnostic reliability of automated office blood pressure (OBP) measurements in treated hypertensive patients in primary care by evaluating the prevalence of white coat hypertension (WCH) and masked uncontrolled hypertension (MUCH) phenomena. Methods Primary care physicians, nationwide in Greece, assessed consecutive hypertensive patients on stable treatment using OBP (1 visit, triplicate measurements) and home blood pressure (HBP) measurements (7 days, duplicate morning and evening measurements). All measurements were performed using validated automated devices with bluetooth capacity (Omron M7 Intelli-IT). Uncontrolled OBP was defined as ≥140/90 mmHg, and uncontrolled HBP was defined as ≥135/85 mmHg. Results A total of 790 patients recruited by 135 doctors were analyzed (age: 64.5 ± 14.4 years, diabetics: 21.4%, smokers: 20.6%, and average number of antihypertensive drugs: 1.6 ± 0.8). OBP (137.5 ± 9.4/84.3 ± 7.7 mmHg, systolic/diastolic) was higher than HBP (130.6 ± 11.2/79.9 ± 8 mmHg; difference 6.9 ± 11.6/4.4 ± 7.6 mmHg, p Conclusions In primary care, automated OBP measurements are misleading in approximately 40% of treated hypertensive patients. HBP monitoring is mandatory to avoid overtreatment of subjects with WCH phenomenon and prevent undertreatment and subsequent excess cardiovascular disease in MUCH