The role of glyclinergic interneurons in the dorsal column nuclei

[Abstract] The aim of this paper is to provide new insights about the circuitry and the role of the dorsal column nuclei (DCN) in processing somatosensory information. The presence of glycinergic cells, a second type of DCN interneurons in addition to well-known GABAergic interneurons, opens the door to more complex interactions between cuneate cells as well as to a new hypothesis about the computational implications of such interactions. The research posed here fits in a broader context in the field of the sensory systems and deals with the general issue on the role of subcortical structures (i.e the thalamus) in processing sensory information

Sleep and wakefulness in the cuneate nucleus: a computational study

We present a computational study about the influence of the sensorimotor cortex on the processing of the cuneate nucleus during sleep as well as wakefulness. Realistic computational models were developed supported by experimental data obtained from intact-brain preparations in cat. Furthermore, a physiologically plausible circuit is proposed and predictions under both different cortical stimulation and synaptic configurations are suggested. The computer simulations show that the CN circuitry (1) under sleep conditions can block the transmission of afferent sensory information, and (2) under awaking conditions can perform operations such as filtering and facilitation

A Computational Model of Cuneothalamic Projection Neurons

[Abstract] The dorsal column nuclei, cuneatus and gracilis, play a fundamental role in the processing and integration of somesthetic ascending information. Intracellular and patch-clamp recordings obtained in cat in vivo have shown that cuneothalamic projection neurons present two modes of activity: oscillatory and tonic (Canedo et al 1998 Neuroscience 84 603–17). The former is the basis of generating, in sleep and anaesthetized states, slow, delta and spindle rhythms under the control of the cerebral cortex (Mari˜no et al 2000 Neuroscience 95 657–73). The latter is needed, during wakefulness, to process somesthetic information in real time. To study this behaviour we have developed the first realistic computational model of the cuneothalamic projection neurons. The modelling was guided by experimental recordings, which suggest the existence of hyperpolarization-activated inward currents, transient low- and high-threshold calcium currents, and calcium-activated potassium currents. The neuronal responses were simulated during (1) sleep, (2) transition from sleep to wakefulness and (3) wakefulness under both excitatory and inhibitory synaptic input. In wakefulness the model predicts a set of synaptically driven firing modes that could be associated with information processing strategies in the middle cuneate nucleus

A realistic computational model of the local circuitry of the cuneate nucleus

Intracellular recordings obtained under cutaneous and lemniscal stimulation show that the afferent fibers can establish excitatory and inhibitory synaptic connections with cuneothalamic neurons [5]. In addition, distinct types of recurrent collaterals with the capability of either exciting or inhibiting both cuneothalamic neurons and interneurons were also discovered [6]. With these data we have generated hypothesis about which circuits are implicated and also developed realistic computational models to test the hypothesis and study the cuneate properties [17,18]. The results show that the cuneate could perform spatial and temporal filtering and therefore detect dynamic edges

Cortical modulation of dorsal column nuclei: a computational study

[Abstract] We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computational models that have been tested with simultaneous electrocorticographic as well as intracellular cuneate recordings performed in anaesthetized cats. The results show that, (1) under sleep conditions, the model can block the transmission of afferent sensory information and, (2) operations expected during wakefulness, such as filtering and facilitation, can be performed if synaptic parameters are appropriately tuned.Argentina. Consejo Interinstitucional de Ciencia y Tecnología; PB01-121212Xunta de Galicia; XU02–211

At the beginnings of the funerary Megalithism in Iberia at Campo de Hockey necropolis

The excavations undertaken at the Campo de Hockey site in 2008 led to the identification of a major Neolithic necropolis in the former Island of San Fernando (Bay of Cádiz). This work presents the results of the latest studies, which indicate that the site stands as one of the oldest megalithic necropolises in the Iberian Peninsula. The main aim of this work is to present with precision the chronology of this necropolis through a Bayesian statistical model that confirms that the necropolis was in use from c. 4300 to 3800 cal BC. The presence of prestige grave goods in the earliest and most monumental graves suggest that the Megalithism phenomenon emerged in relation to maritime routes linked to the distribution of exotic products. We also aim to examine funerary practices in these early megalithic communities, and especially their way of life and the social reproduction system. As such, in addition to the chronological information and the Bayesian statistics, we provide the results of a comprehensive interdisciplinary study, including anthropological, archaeometric and genetic data.State Research Agency (SRA)European Commission HAR2017-87324-P 2014-2020 ERDF Operational ProgrammeDepartment of Economy, Knowledge, Business and University of the Regional Government of Andalusia FEDER-UCA18-106917 CEIMAR CEIJ-015European Social Fund (ESF) D1113102E3Junta de Andaluci

Improving the co and ch4 gas sensor response at room temperature of alpha-fe2o3(0001) epitaxial thin films grown on srtio3(111) incorporating au(111) islands

In this work, the functional character of complex -Fe2O3(0001)/SrTiO3(111) and Au(111) islands/ -Fe2O3(0001)/SrTiO3(111) heterostructures has been proven as gas sensors at room temperature. Epitaxial Au islands and -Fe2O3 thin film are grown by pulsed laser deposition on SrTiO3(111) substrates. Intrinsic parameters such as the composition, particle size and epitaxial character are investigated for their influence on the gas sensing response. Both Au and -Fe2O3 layer show an island-type growth with an average particle size of 40 and 62 nm, respectively. The epitaxial and incommensurate growth is evidenced, confirming a rotation of 30 between the in-plane crystallographic axes of -Fe2O3(0001) structure and those of SrTiO3(111) substrate and between the in-plane crystallographic axes of Au(111) and those of -Fe2O3(0001) structure. -Fe2O3 is the only phase of iron oxide identified before and after its functionalization with Au nanoparticles. In addition, its structural characteristics are also preserved after Au deposition, with minor changes at short-range order. Conductance measurements of Au(111)/ -Fe2O3(0001)/SrTiO3(111) system show that the incorporation of epitaxial Au islands on top of the -Fe2O3(0001) layer induces an enhancement of the gas-sensing activity of around 25% under CO and 35% under CH4 gas exposure, in comparison to a bare -Fe2O3(0001) layer grown on SrTiO3(111) substrates. In addition, the response of the heterostructures to CO gas exposure is around 5–10% higher than to CH4 gas in each case.This work has been supported by the Ministerio Español de Ciencia e Innovación (MICINN) and the Consejo Superior de Investigaciones Cientificas (CSIC) through the projects PIE-2010-OE-013- 200014, PIE 2021-60-E-030 and RTI2018-095303-A-C52. The ESRF, MICINN and CSIC are acknowledged for the provision of synchrotron radiation facilities. A.S. acknowledges financial support from Comunidad de Madrid for an “Atracción de Talento Investigador” Contract (2017-t2/IND5395)

Application of choice models in tourism recommender systems

Choice models (CM) are proposed in the field of tourism recommender systems (TRS)with the aim of providing algorithms with both a theoretical understanding of tour-ist's motivations and a certain degree of transparency. The goal of this work is toovercome some of the limitations of current state-of-art algorithms used in TRSs byproviding: (1) accurate preferences, which are learnt from user choices rather thanfrom ratings, and (2) interpretable coefficients, which are achieved by means of theset of estimated parameters of CM. The study was carried out with a gastronomicdata set generated in an ecological experiment in the tourism domain. The perfor-mance of CM has been compared with a set of baseline algorithms (rating-based andensembles) by using two evaluation metrics: precision and DCG. The CM out-performed the baseline algorithms when the size of the choice set was limited. Thefindings suggest that CM may provide an optimal trade-off between theoreticalsoundness, interpretability and performance in the field of TRSThis research was sponsored by EMALCSA/Coruña Smart City under grant CSC-14-13, the Ministry of Science and Innovation of Spain under grant TIN2014-56633-C3-1-R, the Ministry of Economy and Competitiveness of Spain under grant MTM2013-41383P, the Consellería de Cultura, Educación e Ordenación Universitaria (accreditation 2016-2019, ED431G/08), and the European Regional Development Fund (ERDF)S

Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation

Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by the coordinated proliferation and differentiation of mammary epithelial cells. However, the endogenous molecular factors regulating these developmental dynamics are still poorly defined. Endocannabinoid signaling is known to determine cell fate-related events during the development of different organs in the central nervous system and the periphery. Here, we report that the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) plays a pivotal role in adult mammary gland development. Specifically, it is required for luminal lineage specification in the mammary gland, and it promotes hormone-driven secretory differentiation of mammary epithelial cells by controlling the endogenous levels of anandamide and the subsequent activation of cannabinoid CB1 receptors. Together, our findings shed light on the role of the endocannabinoid system in breast development and point to FAAH as a therapeutic target in milk-production deficitsThis study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI17/00041 and PI20/00590 to CS and EP-G and co-funded by the European Union. IT is the recipient of a PFIS fellowship (from the Spanish Ministry of Economy and Competitiveness

At the beginnings of the funerary Megalithism in Iberia at Campo de Hockey necropolis

[EN] The excavations undertaken at the Campo de Hockey site in 2008 led to the identification of a major Neolithic necropolis in the former Island of San Fernando (Bay of Cadiz). This work presents the results of the latest studies, which indicate that the site stands as one of the oldest megalithic necropolises in the Iberian Peninsula. The main aim of this work is to present with precision the chronology of this necropolis through a Bayesian statistical model that confirms that the necropolis was in use from c. 4300 to 3800 cal BC. The presence of prestige grave goods in the earliest and most monumental graves suggest that the Megalithism phenomenon emerged in relation to maritime routes linked to the distribution of exotic products. We also aim to examine funerary practices in these early megalithic communities, and especially their way of life and the social reproduction system. As such, in addition to the chronological information and the Bayesian statistics, we provide the results of a comprehensive interdisciplinary study, including anthropological, archaeometric and genetic data.We wish to express our gratitude to Antonio Saez Espligares (Historical Museum of San Fernando) and Lourdes Lorenzo (Figlina, s.l.) for their support during the archaeological excavation. This research was conducted in the framework of the following research projects: "Analysis of prehistoric societies from the Middle Palaeolithic to the Late Neolithic at both sides of the Strait of Gibraltar: relations and contacts", funded by the State Research Agency (SRA) and the European Regional Development Fund (ERDF). Ref.: HAR2017-87324-P. (2018-2021). "Analisis interdisciplinar para el conocimiento del poblamiento humano de la Bahia de Cadiz durante la Prehistoria Reciente (VI-II milenios a.n.e.)", funded by 2014-2020 ERDF Operational Programme and the Department of Economy, Knowledge, Business and University of the Regional Government of Andalusia. Ref.: FEDER-UCA18-106917 (2020-2023). "Analisis de los isotopos de oxigeno en conchas y de los isotopos estables de oxigeno y carbono en huesos humanos en el poblado neolitico insular de Campo de Hockey (San Fernando, Cadiz)", authorised and funded by CEIMAR. Ref.: CEIJ-015 (2018-2019). Eduardo Molina Piernas acknowledges co-funding from European Social Fund (D1113102E3) and Junta de Andalucia