Effect of Acipimox on Plasma Lipids and Glucose/Insulin in Pregnant Rats

To determine how a reduction in maternal hypertriglyceridemia during late pregnancy may affect glucose/insulin relationships, pregnant and virgin rats were orally treated with acipimox, a potent antilipolytic agent. In 20-day pregnant rats receiving 80 mg of acipimox, plasma triglycerides (TG), free fatty acids (FFA), and glycerol decreased more than in virgin rats shortly after the drug (up to 7 hours), when compared with animals treated with distilled water, whereas plasma glucose level was unaffected by the treatment in either group of rats. When acipimox was given every 12 hours from day 17 to day 20 of pregnancy, plasma TG, FFA, and glycerol levels progressively increased, whereas they either decreased or did not change in virgin rats receiving the same treatment, with no effect in plasma glucose levels in either group. Fetal body weight was lower than in controls in 20-day pregnant rats that received acipimox for 3 days. On day 20 of pregnancy, 3 hours after receiving acipimox or distilled water, rats received a 2 g glucose/kg oral load and it was found that the change in plasma glucose was similar in both groups, whereas the increase in plasma insulin was greater in pregnant rats treated with acipimox. However, no difference was found in either variable after the oral glucose load in virgin rats receiving acipimox or distilled water. No differences in plasma glucose levels were found after intravenous (IV) administration of insulin in pregnant rats treated or not treated with acipimox. In conclusion, present results show that administration of acipimox during the last days of gestation inhibited lipolysis and decreased fetal weight. Over a short period of time, in pregnant rats, reductions of plasma FFA and TG after acipimox treatment improved the glucose-induced insulin release, but did not seem to have any effect in peripheral insulin resistance

Ontogenetic changes in DNA and RNA content of laboratory-reared Prochilodus lineatus larvae: use of RNA/DNA ratios as indicators of nutritional condition

The aims of the present study were to describe the ontogenetic performance of DNA and RNA content, as well as to assess the nutritional condition of Prochilodus lineatus larvae reared under different feeding treatments. The experiment consisted of two parts, the first 6-14 days after hatching (DAH) and the second 15-21 DAH. In the first part of the experiment, larvae were kept under one of two feeding treatments: fed or starved. During the second part of the experiment, larvae were kept under one of four treatments: fed, fed until 14 DAH and later starved, starved until 14 DAH and fed later or starved. It is of note that the size and weight reached of larvae that were starved during early development and later received food were higher than those of than larvae in the other feeding treatments. In addition, instantaneous growth rates were higher and nutritional condition was better in larvae that were initially starved and fed later. The availability of food following a period of starvation seems to trigger larval metabolism and cellular division. Consequently, we recommend maintaining appropriate food provision in the aquaculture of P. lineatus larvae, especially in advanced developmental stages. We verified that RNA/DNA ratio is affected by the feeding condition and that it is sensitive enough to promptly reflect changes in feeding conditions of P. lineatus larvae. Thus, the RNA/DNA ratio could be used to assess nutritional condition of both wild and cultured P. lineatus larvae.Fil: Diaz, Marina Vera. Instituto Nacional de Investigaciones y Desarrollo Pesquero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Gómez, M. I.. Dirección de Pesca Continental; ArgentinaFil: Sánchez, S.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias. Instituto de Ictiología del Nordeste; ArgentinaFil: Fuentes, Carlos Mariano. Dirección de Pesca Continental; Argentin

Fallen and Lost into the Abyss? A Mesolithic Human Skull from Sima Hedionda IV (Casares, Málaga, Iberian Peninsula)

The presence of scattered prehistoric human bones in caves and sinkholes is common in many regions of Iberia. These are usually interpreted as erratic elements coming from burial contexts, usually collective associations. These burial contexts are very frequent in karst areas of the Iberian Peninsula since the Early Neolithic, mostly in the Late Neolithic, and Copper Age, while findings from earlier chronologies are much more unusual. In this work, we present partial remains of a human skull from the Mesolithic period, recovered from a cave in the Strait of Gibraltar area. Although there is no conclusive evidence pointing to a dismantled burial context, this constitutes an isolated find, where its final location appears to be consistent with gravitational fall followed by water transportation.We are grateful to members of the caving groups GES Casares (Casares Underground Exploration Group) and SE Mainake (Speleo-Excursionist Society), and the town Council of Casares for their help throughout the work of survey and archaeological research inside Sima Hedionda II/IV. The frontal bone SHII/IV/7001-7 (known as Cecilín) was first located by Carlos Pintos Zanca, Juan Antonio Rodriguez Alarcón, Rafael Beltran, and Pascal Boutery de la SE Mainake. CT scan was carried out in the Clinical Veterinary Hospital of the University of Cordoba. We would like to thank especially Dr Manuel Novales Durán (Department of Animal Medicine and Surgery, UCO) for his help in the scanning process. We would also appreciate the help of Alvaro Perea (Ergonidámica Clínica, Córdoba) in composing Figures 5 and 6 using the OsiriX DICOM Wiever software. Dating Beta-424650 was funded by an internal research grant from La Trobe University. The “Archaeological Survey Project in Sima Hedionda II/IV, Casares (Málaga)” was partly self-financed by the team members themselves, and also partly (Technical equipment, transportation, other datings, maintenance, and accommodation) with the support of the Casares Town Council. Thanks to the efforts of the last institution, this cave is now gated and protected. This work has been carried out in the framework of the Project “Archaeobiology of the Neolithic of the Southern Iberian Peninsula” (NeArqBioSI) A-HUM-460-UGR18 by Consejería de Economía, Conocimiento, Empresas y Universidad. FEDER Programme – Junta de Andalucía-Universidad de Granada. Call 2019. SPG is Juan de la Cierva Incorporación (IJC2019-038830-I) funded by MCIN/AEI/10.13039/501100011033. We would like to thank the anonymous reviewers for their thoughtful comments and efforts in improving our manuscript

Forage Yield and Nutritive Value of 30 Cultivars of Maize for Silage in the Highland Valleys of Central Mexico

In Mexico, the selection of maize cultivars for forage has mainly been based on dry matter (DM) yields, not considering nutritional quality as an important evaluation parameter. The objective of this study was to assess forage yield and nutritive value of Highland and Subtropical maize cultivars for silage in the Highland Valleys of Central México

Social Learning Analytics en la Educación Superior. Una experiencia en el Grado de Educación Primaria

The concept of Learning Analytics, as we understand it today, is relatively new but the practice of evaluating user behavior is not innovative. For years, technological development, along with other educational aspects, have encouraged, developed and facilitated this practice as a way of providing a personalized quality experience to students. The main goal of this study, carried out in the Primary Education Degree of the University of Murcia, was to research, from the perspective of Social Learning Analytics, how students learn and collaborate in online environments, specifically through their use of social media. With the idea of improving and optimizing future teaching experiences, a pilot study was conducted using weblog, Twitter and Facebook to work with different topics on the subject. The method used in this research was a participant observation and the analysis performed was both quantitative, based mainly on the data gathered from the learning analytics, and qualitative (analyzing students’ content from comments). Results show that there was greater interaction on Facebook than weblogs, where students interacted to deal with aspects related to the learning process and the topic of the subject. This exchange of information grew during the development of the experience. In addition, learning analytics shows that there is a relationship between group members and their interaction and behavior in networks.El concepto de Learning Analytics es relativamente nuevo tal como lo entendemos hoy en día, pero la práctica de evaluar el comportamiento del usuario a través de registros previos de actividad no lo es tanto. Con el tiempo, los avances tecnológicos, junto con otros factores educativos han alentado, desarrollado y facilitado esta práctica para proporcionar una experiencia personalizada de calidad al alumnado. El objetivo general de este estudio, realizado en el Grado de Educación Primaria de la Universidad de Murcia, se centra en conocer desde la perspectiva de Social Learning Analytics, cómo aprende y colabora el alumnado en entornos virtuales, específicamente a través de medios sociales. Con la idea de mejorar y optimizar futuras experiencias docentes, se llevó a cabo un estudio piloto en el que se usó Facebook, Twitter y un blog grupal para el desarrollo de las tareas de la asignatura. El método empleado en esta investigación ha sido el de la observación participante y el tipo de análisis realizado ha sido tanto cuantitativo, basado principalmente en los datos obtenidos de las propias analíticas de aprendizaje, como cualitativo (análisis de contenido de las intervenciones y comentarios del alumnado). Los resultados obtenidos muestran que hubo una mayor interacción en Facebook que en el blog grupal, donde los alumnos interaccionaban para tratar aspectos relacionados con el proceso de aprendizaje y la temática de la asignatura. Este intercambio de información fue creciendo durante el desarrollo de la experiencia. Además, las analíticas de aprendizaje muestran que existe una relación en cuanto a los miembros del grupo y sus interacciones y comportamientos en las redes

Root and aerial growth in early-maturing peach trees under two crop load treatments

 The objectives of the paper were to study the pattern of root growth (measured by minirhizotrons) in relation to trunk, fruit and shoot growth and the effects of crop load on tree growth and yield in peach trees. Two crop load (commercial and low) treatments were applied in a mature early-maturing peach tree orchard growing in Mediterranean conditions. Root growth dynamics were measured using minirhizotrons during one growing season. Shoot, trunk and fruit growth were also measured. At harvest, all fruits were weighed, counted and sized. Roots grew throughout the year but at lower rates during the active fruit growth phase. Root growth was asynchronous with shoot growth, while root and trunk growth rates were highest after harvest, when the canopy was big enough to allocate the photo-assimilates to organs that would ensure the following season’s yield. Shoot and fruit growth was greater in the low crop load treatment and was accompanied by a non-significant increase in root growth. High level of fruit thinning decreased the current yield but the fruits were more marketable because of their greater size

Tratamiento quirúrgico en las cifosis congénitas: Revisión de 14 pacientes

Los autores efectúan una revisión de 14 pacientes con cifosis congénita, intervenidos entre los años 1979-1989, con un seguimiento medio de 7 años. La edad media preoperatoria fue de 11 años (todos ellos mayores de 5 años), con una cifosis media de 7 9 . En 6 casos se realizó una artrodesis posterior y en 8 una anterior combinada con una fusión posterior. Inicialmente obtuvieron una corrección media de la curva de 18° con la artrodesis posterior y 20° con la artrodesis combinada. La pérdida postoperatoria final fue de 10° y 8° respectivamente. En un caso, se produjo una pseudoartrosis por fusión corta. Como complicaciones postoperatorias en 5 pacientes, una radiculopatía, una infección superficial y cuatro protusiones de material que requirieron su extracción. Los autores analizan los factores que han podido influir en los resultados obtenidos, comparándolos posteriormente con los conseguidos por otros centros hospitalarios importantes.Fourteen patients with congenital kyphosis treated surgically between 1979- 1989 were reviewed. All had a follow-up of 2 years or more, with an average follow-up of 7 years. The average age at surgery was 11 and the average kyphosis was 79°. Six cases had posterior fusion only and eigth had combined anterior and posterior fusion. The results showed an average correction of the curve at surgery of 18° with posterior arthrodesis and 20° with combined arthrodesis. There was thus an average loss of 10° and 8° respectively from the time of surgery in both types of treatment. Pseudoarthrosis by short fusion ocurred in one case. Other complications after surgery were 1 radiculopathy, one wound infection and four rod protusion (six patients). The factors that have influence in this results were analysed. A comparison from the results of treatment at other medical centers was also carried out

Ethanol toxicity differs depending on the time of day

Ethanol is one of the most commonly abused drugs and consequently its toxic and psychoactive effect has been widely investigated, although little is known about the time-dependent effects of this drug. In the present research zebrafish was used to assess daily rhythms in ethanol toxicity and behavioural effects, as well as the temporal pattern of expression of key genes involved in ethanol detoxification in the liver (adh8a, adh5, aldh2.1 and aldh2.2). Our results showed marked differences in the mortality rate of zebrafish larvae depending on the time of day of the exposure to 5% ethanol for 1h (82% and 6% mortality in the morning and at night, respectively). A significant daily rhythm was detected with the acrophase located at “zeitgeber” time (ZT) = 04:22 h. Behavioural tests exposing zebrafish to 1% ethanol provoked a major decrease in swimming activity (68–84.2% reduction) at ZT2, ZT6 and ZT10. In contrast, exposure at ZT18 stimulated swimming activity (27% increase). During the day fish moved towards the bottom of the tank during ethanol exposure, whereas at night zebrafish increased their activity levels right after the exposure to ethanol. Genes involved in ethanol detoxification failed to show significant daily rhythms in LD, although all of them exhibited circadian regulation in constant darkness (DD) with acrophases in phase and located at the end of the subjective night. Taken altogether, this research revealed the importance of considering the time of day when designing and carrying out toxicological and behavioural tests to investigate the effects of ethanol, as the adverse effects of this drug were more marked when fish were exposed in the morning than at night

Exact solutions for transient mixing of two gases of different densities

This Brief Communication presents a number of exact solutions describing the transient mixing of two gases of different molecular weights. Descriptions are given for both the concentration field and the associated induced motion in one-dimensional spherical, cylindrical, and planar configurations, including mixing layers, pockets, coflow jets, and concentrated mass sources

Rubricas de evaluación en la enseñanza universitaria

[SPA]La evaluación es un elemento esencial del proceso educativo, ya sea por el hecho de que nos permite conocer si los alumnos han conseguido las competencias necesarias para superar una materia o bien porque nos permite valorar la calidad de los procesos de enseñanza-aprendizaje y en función de ello, mejorarlos. Siguiendo con estos patrones y tomando el Espacio Europeo de Educación Superior como referente queremos exponer los resultados de una experiencia de Innovación Docente llevada a cabo el presente curso académico 2010/2011 con alumnos de último curso de Pedagogía. Es una experiencia que incorpora la evaluación continua del alumno haciendo uso del portafolio electrónico y de rúbricas de evaluación. [ENG]Evaluation is one the most important elements in learning processes because it´s useful to know if students have acquired the competence level to pass a subject or because it´s useful to evaluate quality learning processes and to improve them. In relation whith this and having the european convergence as reference, in this paper we explain our experience of educational innovation developed this academic year 2010/2011 with the population of students of last year of Pedagogy. This experience is about continuos assessment using electronic portfolio and evaluation rubrics.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci