Diagnòstic i tractament de disfuncions visuals a nens amb problemes d´aprenentatge al CUV

Les habilitats visuals tenen un gran impacte a la vida quotidiana de qualsevol persona ja que té una gran implicació a la lectura, escriptura, conducció, esports etc... Encara, té més repercussió en els nens que es troben en edat d’aprenentatge on obtenen una gran part de la informació mitjançant estímuls visuals. Moltes d’aquestes habilitats es poden millorar a través de la teràpia visual, en aquest treball de fi de grau, podrem trobar un recull d’informació de diferents fonts bibliogràfiques on s’expliquen les relacions existents entre la visió i l’aprenentatge. Posteriorment, hi ha la presentació d’un grup de 10 pacients que són alumnes de primària. Podrem llegir sobre la teràpia visual que se’ls hi aplica al Centre Universitari de la Visió a Terrassa, amb una explicació de tots els exercicis realitzats i els valors optomètrics que van assolint progressivament en cada sessió. Això ens permet veure l’efectivitat d’aquest tractament i com milloren en moltes aptituds relacionades amb la visió i el seu processament.Las habilidades visuales tienen un gran impacto en la vida cotidiana de cualquier persona por su gran implicación en ámbitos como la lectura, escritura, conducción, deportes etc... Todavía, tiene más repercusión en los niños que se encuentran en edad de aprendizaje donde la mayor parte de información del medio externo que obtienen proviene mediante estímulos visuales. Muchas de estas habilidades se pueden mejorar a través de la terapia visual, en este trabajo de fin de grado, podremos encontrar una recopilación de información de diferentes fuentes bibliográficas donde se explican las relaciones existentes entre la visión y el aprendizaje. Posteriormente, se presenta un grupo de 10 pacientes que son alumnos de primaria donde se recogen casos clínicos y se puede leer la terapia visual que se les realiza en el Centro Universitario de la Visión en Terrassa, con una explicación detallada de todos los ejercicios y los valores optométricos que se van obteniendo progresivamente en cada sesión. Esto nos permite ver la efectividad de este tratamiento y cómo mejoran en muchas aptitudes relacionadas con la visión y su procesamiento.Visual skills have a great impact on everyone’s daily life as they are involved in activities such as reading, writing, driving, sports, and so on. They are even more important in children of learning age where visual stimuli are the main source of information. Many of these skills can be improved through visual therapy. In this degree’s final project, we will showcase a collection of information gathered from diverse bibliographic sources that focus on the relationship between vision and learning. That is then rounded up with a presentation on the 10 primary school patients which were given visual therapy at the University Vision Center in Terrassa, and on the exercises they underwent, as well as the optometric results obtained in each successive session. This serves as proof of the effectiveness of this treatment and how it improves many skills related to vision and its processing

Las nuevas tecnologías y su Incidencia en la forma de hacer negocios en El Salvador. una interpretación jurídica ante el derecho internacional: caso UBER 2017-2019

Las nuevas tecnologías y su incidencia en la forma de hacer negocios tanto a nivel internacional como en El Salvador es producto del proceso globalizador y la apertura económica que han tenido los Estados en el sistema internacional. Proceso que se ha venido gestando a lo largo de las diferentes décadas posteriores a la finalización de la Segunda Guerra Mundial. En ese sentido, en el capítulo I se describe la incidencia de las nuevas tecnologías y su impacto económico en los nuevos negocios en El Salvador, a través de la exposición de antecedentes claves y acontecimientos históricos ocurridos después de la Segunda Guerra Mundial desde el año 1950 hasta el año de 2015. En el cual se resalta la importancia de las tecnologías de la información y su impacto en la vida social y económica de los Estados. En armonía con el estudio del Derecho Internacional y como estas nuevas tecnologías sirven de base para los nuevos modelos de negocios. El capítulo II contrasta la evolución de la normativa jurídica salvadoreña, así como también su relación con la normativa internacional en relación con los nuevos modelos de negocio como las plataformas digitales Uber, a través de un estudio de las diferentes leyes y reglamentos que podrían regular este tipo de servicios, ya que dicho negocio no posee una marco jurídico o asidero legal que lo respalde, lo cual ha generado una serie de conflictos tanto con instituciones claves como con la competencia. Finalmente, el capítulo III expone la globalización de las tecnologías con los nuevos modelos de negocios basados en las nuevas tecnologías como Uber, a través del estudio de como la globalización y las nuevas tecnologías tienen un impacto en el Estado y el Derecho, así como también se explica cómo Uber es un agente de cambio para el Estado

Complementary pharmacological and toxicological characterization data on the pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl) acetamide

This text presents complementary data corresponding to pharmacological and toxicological characterization of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled “Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analog of lidocaine” Déciga-Campos M., Navarrete-Vázquez G., López-Muñoz F.J., Librowski T., Sánchez-Recillas A., Yañez-Pérez V., Ortiz-Andrade R. (2016) [1]. Toxicity was predicted through the ACD/ToxSuite software and evaluated in vivo using brine shrimp larvae (Artemia salina L.) and mice. Also, we used the micronucleus assay to determine genotoxicity. We used the platform admetSAR to predict absorption properties of LIA and lidocaine. Keywords: N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, Toxicity, Lidocain

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]11 página

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Estudios actuales de literatura comparada. Teorías de la literatura y diálogos interdisciplinarios

Estos dos volúmenes constituyen una contribución al desarrollo de la comparatística que se realiza, principalmente, desde América Latina. El primer volumen está organizado en tres partes y consta de 22 artículos, mientras que el segundo reúne 24 capítulos.UCR::Vicerrectoría de Docencia::Artes y Letras::Facultad de Letras::Escuela de Filología, Lingüística y LiteraturaUCR::Vicerrectoría de Docencia::Ciencias Básicas::Sistema de Educación General::Escuela de Estudios GeneralesUCR::Vicerrectoría de Investigación::Sistema de Estudios de Posgrado::Artes y Letras::Maestría Académica en Literatura FrancesaUCR::Vicerrectoría de Investigación::Sistema de Estudios de Posgrado::Artes y Letras::Maestría Académica en Literatura LatinoamericanaUCR::Vicerrectoría de Docencia::Artes y Letras::Facultad de Letras::Escuela de Lenguas Moderna

Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population

8Pág. Centro de Investigación en Sanidad Animal (CISA)To evaluate the performance of oral saliva swab (OSS) reverse transcription PCR (RT-PCR) compared with RT-PCR and antigen rapid diagnostic test (Ag-RDT) on nasopharyngeal swabs (NPS) for SARS-CoV-2 in children.The study was funded by: Project PI20/00095, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness) and cofounded by the European Regional Development Fund, by Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and Innovation (FIIB HUIS HHEN), and by SERMAS-Fundación para la Investigación Biomédica del Hospital 12 de Octubre. EC-C is supported by the Spanish Society of Paediatrics (Asociación Española de Pediatría); Grant COVID-19 EPICO-AEP 2020. JMM is funded by SERMAS-Fundación para la Investigación Biomédica del Hospital Infanta Sofía y del Henares and by Universidad Europea de Madrid, Spain. MdlS is funded by Grant Cantera de Investigación Santander, Fundación Universidad Europea de Madrid, Spain. ED is funded by the Juan de la Cierva–Incorporación granted by the Spanish Ministry of Science and Innovation. DB-G is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER by ’Contratos para la intensificación de la actividad investigadora en el Sistema Nacional de Salud, 2020 (INT20/00086)’.Peer reviewe

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe