Tradeoffs in Model Performance and Effort for Long-Term Phosphorus Leaching Based on In Situ Field Data

Phosphorus and N are critical nutrients for agriculture but are also responsible for surface water enrichment that leads to toxic algal growth. Although P loading to surface waters has traditionally been thought to occur primarily in surface runoff, contributions from subsurface transport can also be significant. The primary objectives of this research were to evaluate several methods of representing macropore flow and transport in a finite element model using plot-scale infiltration and leaching data and to compare several models of various levels of complexity to simulate long-term P leaching. To determine flow and transport parameters, single- and dual-porosity models in HYDRUS-2D were calibrated with infiltration, Cl−, and P data from a 22-h plot-scale leaching experiment on a silt loam mantle with gravel subsoil. Both homogeneous and heterogeneous gravel profiles were simulated. The dual-porosity model with heterogeneous hydraulic conductivity best matched experimental data, with physical nonequilibrium (dual porosity) being more important than two-dimensional (2D) heterogeneity. Long-term (9 yr) P leaching to the water table (3 m below the soil surface) at the field site was simulated with both one-dimensional (1D) and 2D models using the calibrated parameters. There was little difference between analogous 1D and 2D models, suggesting that HYDRUS-1D may be sufficient to model long-term P leaching. Overall, the most important elements for accurately simulating P leaching in this silt loam and gravel soil profile were found to be (i) field-measured hydraulic conductivity of the limiting soil layer, (ii) calibrated dispersivity, and (iii) dual-porosity, in some circumstances

Detailed statistical analysis plan for a cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children

This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: The Healthy Lifestyles Programme (HeLP) trial is being conducted to determine whether a novel school-based intervention is effective and cost-effective in preventing obesity in 9-10 year-old children. This article describes the detailed statistical analysis plan for the HeLP trial, including an amendment (and rationale for amendment) made to originally planned sensitivity analyses. METHODS AND DESIGN: The HeLP trial is a definitive, pragmatic, superiority, cluster randomised controlled trial with two parallel groups and blinded outcome assessment. This update article describes in detail (1) the primary and secondary outcomes, (2) the statistical analysis principles (including which children will be included in each analysis, how the clustered nature of the study design will be accounted for, which covariates will be included in each analysis, how the results will be presented), (3) planned sensitivity analyses, planned subgroup analyses and planned adherence-adjusted analyses for the primary outcome, (4) planned analyses for the secondary outcomes and (e) planned longitudinal analyses. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number (ISRCTN) register: ISRCTN15811706 . Registered on 1 May 2012.The definitive trial of HeLP is funded by the UK National Institute for Health Research (NIHR) Public Health Research Programme (10/3010/01) and a full report will be published on the NIHR website. KW and JL are partially supported by PenCLAHRC, the National Institute for Health Research (NIHR) CLAHRC for the Southwest Peninsul

A randomized phase 2 network trial of tivantinib plus cetuximab versus cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154935/1/cncr32762.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154935/2/cncr32762_am.pd

External fishing effort regulates positive effects of no-take marine protected areas

Marine protected areas (MPAs) have been established across the globe to mitigate the effects of multiple stressors on marine communities. In many locations, MPAs have generated positive effects on fish communities, but the impacts of fishing pressure—the primary stressor MPAs seek to manage—have not been well investigated. We examined changes in fish biomass inside and outside of no-take MPAs over 14 years in central California, USA. Using data from the community-based science program, the California Collaborative Fisheries Research Program, we tested which environmental and human-induced stressors most influence the strength of MPA responses. While temperature and productivity were included in the best fit model, we found that fine-scale fishing effort data, following reserve implementation, best explained the spatial variation in fish community responses to MPAs. Specifically, differences in fish biomass between MPAs and sites open to fishing were larger for reserves near heavily fished locations and these areas exhibited the highest rate of change in fish biomass, indicating strong positive effects of the MPA on the most heavily exploited fish communities. As MPAs continue to be used as a prominent conservation strategy in coastal systems, managers should consider both the suite of human-induced (socio-ecological interactions) and environmental conditions that may alter MPA success as well as establish long-term monitoring programs to fully assess the functionality of marine reserves into the future

Emergent Strain of Human Adenovirus Endemic in Iowa

We evaluated 76 adenovirus type 7 (Ad7) isolates collected in Iowa from 1992 to 2002 and found that genome type Ad7d2 became increasingly prevalent. By 2002, it had supplanted all other Ad7 genome types. The association of Ad7d2 with severe illness and death calls for heightened public health concern

Striking the Right Balance of Intermolecular Coupling for High-Efficiency Singlet Fission

Singlet fission is a process that splits collective excitations, or excitons, into two with unity efficiency. This exciton splitting process, unique to molecular photophysics, has the potential to considerably improve the efficiency of optoelectronic devices through more efficient light harvesting. While the first step of singlet fission has been characterized in great detail, subsequent steps critical to achieving overall highly-efficient singlet-to-triplet conversion are only just beginning to become well understood. One of the most elementary suggestions, which has yet to be tested, is that an appropriately balanced coupling is necessary to ensure overall highly efficient singlet fission; that is, the coupling needs to be strong enough so that the first step is fast and efficient, yet weak enough to ensure the independent behavior of the resultant triplets. In this work, we show how high overall singlet-to-triplet conversion efficiencies can be achieved in singlet fission by ensuring that the triplets comprising the triplet pair behave as independently as possible. We show that side chain sterics govern local packing in amorphous pentacene derivative nanoparticles, and that this in turn controls both the rate at which triplet pairs form and the rate at which they decay. We show how compact side chains and stronger couplings promote a triplet pair that effectively couples to the ground state, whereas bulkier side chains promote a triplet pair that appears more like two independent and long-lived triplet excitations. Our results show that the triplet pair is not emissive, that its decay is best viewed as internal conversion rather than triplet–triplet annihilation, and perhaps most critically that, in contrast to a number of recent suggestions, the triplets comprising the initially formed triplet pair cannot be considered independently. This work represents a significant step toward better understanding intermediates in singlet fission, and how molecular packing and couplings govern overall triplet yields

Terrain trapped airflows and precipitation variability during an atmospheric river event

We examine thermodynamic and kinematic structures of terrain trapped airflows (TTAs) during an atmospheric river (AR) event impacting Northern California 10–11 March 2016 using Alpha Jet Atmospheric eXperiment (AJAX) aircraft data, in situ observations, and Weather and Research Forecasting (WRF) Model simulations. TTAs are identified by locally intensified low-level winds flowing parallel to the coastal ranges and having maxima over the near-coastal waters. Multiple mechanisms can produce TTAs, including terrain blocking and gap flows. The changes in winds can significantly alter the distribution, timing, and intensity of precipitation. We show here how different mechanisms producing TTAs evolve during this event and influence local precipitation variations. Three different periods are identified from the time-varying wind fields. During period 1 (P1), a TTA develops during synoptic-scale onshore flow that backs to southerly flow near the coast. This TTA occurs when the Froude number (Fr) is less than 1, suggesting low-level terrain blocking is the primary mechanism. During period 2 (P2), a Petaluma offshore gap flow develops, with flows turning parallel to the coast offshore and with Fr \u3e 1. Periods P1 and P2 are associated with slightly more coastal than mountain precipitation. In period 3 (P3), the gap flow initiated during P2 merges with a pre-cold-frontal low-level jet (LLJ) and enhanced precipitation shifts to higher mountain regions. Dynamical mixing also becomes more important as the TTA becomes confluent with the approaching LLJ. The different mechanisms producing TTAs and their effects on precipitation pose challenges to observational and modeling systems needed to improve forecasts and early warnings of AR events

The subgiant branch of omega Cen seen through high-resolution spectroscopy. II. The most metal-rich population

We analyze spectra of 18 stars belonging to the faintest subgiant branch in omega Centauri (the SGB-a), obtained with GIRAFFE@VLT at a resolution o R~17000 and a S/N ratio between 25 and 50. We measure abundances of Al, Ba, Ca, Fe, Ni, Si, and Ti and we find that these stars have =-0.73 +/- 0.14 dex, similarly to the corresponding red giant branch population (the RGB-a). We also measure =+0.40 +/- 0.16 dex, and =+0.87 +/- 0.23 dex, in general agreement with past studies. It is very interesting to note that we found a uniform Al abundance, =+0.32 +/- 0.14 dex, for all the 18 SGB-a stars analysed here, thus supporting past evidence that the usual (anti-)correlations are not present in this population, and suggesting a non globular cluster-like origin of this particular population. In the dwarf galaxy hypothesis for the formation of omega Cen, this population might be the best candidate for the field population of its putative parent galaxy, although some of its properties appear contradictory. It has also been suggested that the most metal-rich population in omega Cen is significantly enriched in helium. If this is true, the traditional abundance analysis techniques, based on model atmospheres with normal helium content, might lead to errors. We have computed helium enhanced atmospheres for three stars in our sample and verified that the abundance errors due to the use of non-enhanced atmospheres are negligible. Additional, indirect support to the enhanced helium content of the SGB-a population comes from our Li upper limits.Comment: 11 pages, 5 figures, accepted for publication in A&

Dust-free quasars in the early Universe

The most distant quasars known, at redshifts z=6, generally have properties indistinguishable from those of lower-redshift quasars in the rest-frame ultraviolet/optical and X-ray bands. This puzzling result suggests that these distant quasars are evolved objects even though the Universe was only seven per cent of its current age at these redshifts. Recently one z=6 quasar was shown not to have any detectable emission from hot dust, but it was unclear whether that indicated different hot-dust properties at high redshift or if it is simply an outlier. Here we report the discovery of a second quasar without hot-dust emission in a sample of 21 z=6 quasars. Such apparently hot-dust-free quasars have no counterparts at low redshift. Moreover, we demonstrate that the hot-dust abundance in the 21 quasars builds up in tandem with the growth of the central black hole, whereas at low redshift it is almost independent of the black hole mass. Thus z=6 quasars are indeed at an early evolutionary stage, with rapid mass accretion and dust formation. The two hot-dust-free quasars are likely to be first-generation quasars born in dust-free environments and are too young to have formed a detectable amount of hot dust around them.Comment: To be published in Nature on the 18 March 2010