Evaluation Nonlinear Soil Response In Situ

Evaluation of nonlinear soil properties is an important concern in geotechnical earthquake engineering. Typically, nonlinear properties are expressed in terms of the nonlinear reduction in shear and constrained moduli with strain and the nonlinear increase in material damping in shear and constrained compression with strain. At this time, there is essentially total dependency on laboratory testing to evaluate nonlinear soil properties. The accuracy and limitations involved in modeling in situ properties with laboratory evaluated properties remains to be studied. In an attempt to evaluate nonlinear soil properties directly in the field, an in situ test method is being developed at the University of Texas that dynamically loads a soil deposit while simultaneously measuring strains, soil properties, and pore water pressures. Initial testing with this method has focused on vertically loading an unsaturated sandy soil, evaluating the magnitude of induced strains, and assessing the variation of constrained modulus (in terms of compression wave velocity, VP) with effective vertical stress and vertical strain. Preliminary results show that the test method can be used to: (1) evaluate the increase in small-strain VP with increasing vertical effective stress, (2) induce nonlinear compressional and shear strains, and (3) evaluate the nonlinear reduction in VP with increasing vertical strain

Evidence-Based Medicine: Acknowledging the Role for Physical Activity

Modern technology and lifestyles have created an environment that predisposes our population to inactivity, resulting in fewer people meeting the Canadian Physical Activity Guidelines. There is a clear link between inactivity and the risk of developing chronic health conditions including hypertension, type 2 diabetes, and cancer; however, exercise prescription and counselling by physicians is lacking. This may in part be attributed to inadequate training of physicians during medical school. In this commentary, we outline the demand for awareness and training of physicians to prepare them to prescribe physical activity, and propose steps to increase exercise prescrip­tion for improved population health.   La technologie moderne ainsi que nos habitudes de vie actuelles nous prédisposent à l’inactivité ce qui mène moins de personnes à respecter les directives canadiennes en matière d’activité physique. Un lien direct existe entre l’inactivité et le risque de développer des problèmes de santé chroniques incluant l’hypertension, le diabète de type 2, et le cancer. Toutefois, l’exercice et le counseling pre­scrits par les médecins sont peu pratiqués par les patients qui pourraient en bénéficier. Dans cet article, nous soulignerons le besoin de formation des médecins afin de mieux les préparer à prescrire de l’activité physique à leur patients et leur proposer des étapes pour améliorer la santé physique de la population

Student Pharmacists and Street Children: A Mutually Beneficial Relationship

The Tumaini Children’s Drop-In Center is a daytime drop-in center for the street children of Eldoret, Kenya. It is part of a partnership between the Purdue University College of Pharmacy, the Academic Model Providing Access to Healthcare program, Eldoret community members, and numerous individuals in both Kenya and the US. Through the efforts of local staff and Purdue student pharmacists, who work at the local hospital on an eight-week clinical rotation, the center has helped a population of nearly 400 local street children by providing a safe haven from life on the streets. Purdue student pharmacists aid the center by applying for grants to fund service-learning projects. These projects, run by the students, help provide the children with basic necessities in addition to screening and education sessions regarding local health issues. In turn, the street children aid the students by providing a break from the stress of the hospital and by providing a broader view of what health care should look like

Comparison of Winter Strawberry Production in a Commercial Heated High Tunnel versus a University Greenhouse

For the past 4 years, the University of Nebraska strawberry team has worked to develop low cost, sustainable methods for farmers and growers to produce strawberries in a double polyethylene greenhouse during the winter. This past year, this growing system was adapted to become a commercial grower’s heated high tunnel for the winter/spring of 2013-14. The idea was to scale up to a farm-size demonstration and compare it to the university greenhouse production system with a goal to expand marketing opportunities for strawberries into the winter season

Making sense of cancer news coverage trends: a comparison of three comprehensive content analyses

Cancer stories (N = 5,327) in the top 50 U.S. newspapers were analyzed by a team of four coders and the results were compared with the earliest analyses of this type (from 1977 and 1980). Using cancer incidence rates as a comparison, three cancers were found to be consistently underreported (male Hodgkin’s, and thyroid) and four cancers were found to be consistently overreported (breast, blood/Leukemia, pancreatic, and bone/muscle). In addition, cancer news coverage consistently has focused on treatment rather than on other aspects of the cancer continuum (e.g., prevention), portrayed lifestyle choices (e.g., diet, smoking) as the most common cancer risk factor, and rarely reported incidence or mortality data. Finally, the data were compatible with the idea that personalization bias (e.g., celebrity profiles, event coverage) may explain some news coverage distortions

A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery [preprint]

Nonsense suppressors (NonSups) treat premature termination codon (PTC) disorders by inducing the selection of near cognate tRNAs at the PTC position, allowing readthrough of the PTC and production of full-length protein. Studies of NonSup-induced readthrough of eukaryotic PTCs have been carried out using animals, cells or crude cell extracts. In these studies, NonSups can promote readthrough directly, by binding to components of the protein synthesis machinery, or indirectly, by inhibiting nonsense-mediated mRNA decay or by other mechanisms. Here we utilize a highly-purified in vitro system (Zhang et al., 2016. eLife 5: e13429) to measure exclusively direct NonSup-induced readthrough. Of 17 previously identified NonSups, 13 display direct effects, apparently via at least two different mechanisms. We can monitor such direct effects by single molecule FRET (smFRET). Future smFRET experiments will permit elucidation of the mechanisms by which NonSups stimulate direct readthrough, aiding ongoing efforts to improve the clinical usefulness of NonSups

Nationwide Acute Care Physical Therapist Practice Analysis Identifies Knowledge, Skills, and Behaviors That Reflect Acute Care Practice

Background and Purpose. Acute care physical therapists have experienced the effects of dramatic changes in health care reimbursement systems and population demographics. Acute care hospitals now serve a patient population of much older, chronically ill patients who are hospitalized for shorter periods of time in a practice environment in which physical therapy staffing resources are often inadequate. The purposes of this study were to document common experiences in the practice of acute care physical therapy and to identify differences in the perceptions of physical therapists with varying levels of experience and in various sizes of acute care facilities. Subjects and Methods. A survey questionnaire was mailed to 500 randomly selected physical therapists employed in acute care facilities. The therapists answered questions regarding the frequency of various physical therapy evaluation and treatment practices, problems encountered in delivering physical therapy services, coordination of the discharge planning process, and perceptions of staffing trends in the acute care setting. The responses of 188 physical therapists who completed the survey were compared by their experience levels and the size of the institutions in which they practiced. Results. Subjects reported that patient factors, such as medical complications and cooperation; organizational factors, such as staffing shortages and large caseloads; and health care system constraints, such as difficulty changing orders and limited time in which to work with the patient interfered with patients reaching physical therapy goals. Conclusion and Discussion. Inadequate skills for successful acute care practice and maladaptive therapist beliefs about acute care career possibilities may adversely affect physical therapist career longevity in the acute care setting

Nationwide Acute Care Physical Therapist Practice Analysis Identifies Knowledge, Skills, and Behaviors That Reflect Acute Care Practice

Background and Purpose. Acute care physical therapists have experienced the effects of dramatic changes in health care reimbursement systems and population demographics. Acute care hospitals now serve a patient population of much older, chronically ill patients who are hospitalized for shorter periods of time in a practice environment in which physical therapy staffing resources are often inadequate. The purposes of this study were to document common experiences in the practice of acute care physical therapy and to identify differences in the perceptions of physical therapists with varying levels of experience and in various sizes of acute care facilities. Subjects and Methods. A survey questionnaire was mailed to 500 randomly selected physical therapists employed in acute care facilities. The therapists answered questions regarding the frequency of various physical therapy evaluation and treatment practices, problems encountered in delivering physical therapy services, coordination of the discharge planning process, and perceptions of staffing trends in the acute care setting. The responses of 188 physical therapists who completed the survey were compared by their experience levels and the size of the institutions in which they practiced. Results. Subjects reported that patient factors, such as medical complications and cooperation; organizational factors, such as staffing shortages and large caseloads; and health care system constraints, such as difficulty changing orders and limited time in which to work with the patient interfered with patients reaching physical therapy goals. Conclusion and Discussion. Inadequate skills for successful acute care practice and maladaptive therapist beliefs about acute care career possibilities may adversely affect physical therapist career longevity in the acute care setting

Aeroallergen sensitisation for detecting asthma in primary care:a diagnostic test accuracy study

peer reviewe