Prognostic models for predicting recurrence and survival in women with endometrial cancer

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: To review all prognostic models that combine two or more clinical, histological or molecular variables, or a combination of these variables, to provide an individualised assessment of risk of recurrence or death from disease and evaluate their performance to predict these outcomes in people undergoing curative treatment for endometrial cancer

Polymicrobial oral biofilm models: simplifying the complex

Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host–pathogen interactions. In vivo animal models provide useful models of some oral diseases; however, these are expensive and carry vast ethical implications. Oral biofilms grown or maintained in vitro offer a useful platform for certain studies and have the advantages of being inexpensive to establish and easy to reproduce and manipulate. In addition, a wide range of variables can be monitored and adjusted to mimic the dynamic environmental changes at different sites in the oral cavity, such as pH, temperature, salivary and gingival crevicular fluid flow rates, or microbial composition. This review provides a detailed insight for early-career oral science researchers into how the biofilm models used in oral research have progressed and improved over the years, their advantages and disadvantages, and how such systems have contributed to our current understanding of oral disease pathogenesis and aetiology

Factors determining ultra-short-term survival and the commencement of active treatment in high-grade serous ovarian cancer: a case comparison study

From Springer Nature via Jisc Publications RouterHistory: received 2020-06-12, accepted 2021-03-10, registration 2021-03-10, pub-electronic 2021-04-08, online 2021-04-08, collection 2021-12Publication status: PublishedFunder: Cancer Research UK; doi: http://dx.doi.org/10.13039/501100000289; Grant(s): 22647Abstract: Background: Despite improvements in median survival some patients with advanced ovarian cancer die within 100 days of diagnosis; the reasons for which remain poorly understood. Here we investigate if ultra short-term survival can be explained by patient characteristics or treatment pathways. Methods: A nested case comparison study was used to examine differences between patients with high grade serous ovarian/fallopian tube cancer who died within 100 days (n = 28) compared to a comparison group of patients matched for histology and including any survival greater than 100 days (n = 134). Results: Cases and comparison patients had similar ages, BMI, ACE-27, deprivation indices, and distribution of disease on CT. There were no significant delays in time to diagnosis or treatment (p = 0.68) between the groups. However, cases had lower serum albumin, haemoglobin and higher platelet counts than matched comparison patients (p < 0.0001) and a worse performance score (P = 0.006). Conclusion: Patients who die rapidly after a diagnosis of ovarian cancer are only slightly older and have similar pre treatment frailty compared to patients whose survival approaches the median. However they do appear to undergo greater physiological compromise as a result of their disease

Australian shellfish ecosystems: past distribution, current status and future direction

We review the status of marine shellfish ecosystems formed primarily by bivalves in Australia, including: identifying ecosystem-forming species, assessing their historical and current extent, causes for decline and past and present management. Fourteen species of bivalves were identified as developing complex, three-dimensional reef or bed ecosystems in intertidal and subtidal areas across tropical, subtropical and temperate Australia. A dramatic decline in the extent and condition of Australia's two most common shellfish ecosystems, developed by Saccostrea glomerata and Ostrea angasi oysters, occurred during the mid-1800s to early 1900s in concurrence with extensive harvesting for food and lime production, ecosystem modification, disease outbreaks and a decline in water quality. Out of 118 historical locations containing O. angasi-developed ecosystems, only one location still contains the ecosystem whilst only six locations are known to still contain S. glomerata-developed ecosystems out of 60 historical locations. Ecosystems developed by the introduced oyster Crasostrea gigas are likely to be increasing in extent, whilst data on the remaining 11 ecosystem-forming species are limited, preventing a detailed assessment of their current ecosystem-forming status. Our analysis identifies that current knowledge on extent, physical characteristics, biodiversity and ecosystem services of Australian shellfish ecosystems is extremely limited. Despite the limited information on shellfish ecosystems, a number of restoration projects have recently been initiated across Australia and we propose a number of existing government policies and conservation mechanisms, if enacted, would readily serve to support the future conservation and recovery of Australia's shellfish ecosystems

A large population of ultra-compact dwarfs and bright intracluster globulars in the Fornax cluster

All the previously cataloged ultracompact dwarf (UCD) galaxies in the Fornax and Virgo clusters have 17.5 < b(J) < 20. Using the 2dF spectrograph on the Anglo-Australian Telescope, we have carried out a search for fainter UCDs in the Fornax Cluster. In the magnitude interval 19.5 < b(J) < 21.5, we have found 54 additional compact cluster members within a projected radius of 0 degrees.9 (320 kpc) of the cluster center, all of which meet our selection and observational criteria to be UCDs. These newly identified objects, however, overlap in luminosity and spatial distribution with objects classified as globular clusters (GCs) belonging to the central cluster galaxy NGC 1399; in fact, about half of the objects in our sample are included in recent catalogs of NGC 1399/Fornax GCs. The numbers, luminosity function, and spatial distributions of our compact object sample are consistent with being the bright tail of the Fornax cluster-wide GC population. Yet, our present larger sample of intergalactic compact objects forms a dynamically distinct population from both the NGC1399 GCs and the nucleated dwarf ellipticals in Fornax. This supports the interpretation that the UCDs, which populate the bright tail of the GC luminosity function, are, in some respects, a separate class of objects, at least to the extent that they have experienced a distinct dynamical history and origin, which differs from the bulk of the NGC1399 GCs. Correcting for our spectroscopic incompleteness, we estimate that there are similar to 105 +/- 13 of these brighter compact cluster objects down to b(J) < 21.5 in the central region of the Fornax, and hence these UCDs/globulars outnumber other galaxy types in this space. The differences in their dynamics and distribution compared to dwarf ellipticals (dEs) may be consistent with a threshing or tidal destruction origin, if they have come from a subpopulation of dE galaxies on initial orbits that rendered them susceptible to such processes

High-resolution large-scale onshore wind energy assessments : A review of potential definitions, methodologies and future research needs

Funding Information: KG, MK, JS, OT and SW gratefully acknowledge support from the European Research Council (’‘reFUEL’’ ERC-2017-STG 758149). JL has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement No. 715132). MJ and IS were funded by the Engineering and Physical Sciences Research Council [ EP/R045518/1 ] through the IDLES programme. JW is funded through an ETH Postdoctoral Fellowship and acknowledges support from the ETH foundation and the Uniscientia foundation. The authors gratefully acknowledge the helpful comments of three anonymous reviewers on an earlier version of this paper.Peer reviewedPublisher PD

The 2dF galaxy redshift survey: clustering properties of radio galaxies

The clustering properties of local, S1.4 GHz≥ 1 mJy, radio sources are investigated for a sample of 820 objects drawn from the joint use of the Faint Images of the Radio Sky at 20 cm (FIRST) and 2dF Galaxy Redshift surveys. To this aim, we present 271 new bJ≤ 19.45 spectroscopic counterparts of FIRST radio sources to be added to those already introduced in our previous paper. The two-point correlation function for the local radio population is found to be entirely consistent with estimates obtained for the whole sample of 2dFGRS galaxies. From measurements of the redshift-space correlation function ξ(s) we derive a redshift-space clustering length s0 = 10.7+0.8 −0.7 Mpc, while from the projected correlation function Ξ(rT) we estimate the parameters of the real-space correlation function ξ(r) = (r/r0) −γ, r0 = 6.7+0.9 −1.1 Mpc and γ= 1.6 ± 0.1, where h = 0.7 is assumed. Different results are instead obtained if we only consider sources that present signatures of active galactic nucleus (AGN) activity in their spectra. These objects are shown to be very strongly correlated, with r0 = 10.9+1.0 −1.2 Mpc and γ= 2 ± 0.1, a steeper slope than has been claimed in other recent works. No difference is found in the clustering properties of radio-AGNs of different radio luminosity. Comparisons with models for ξ(r) show that AGN-fuelled sources reside in dark matter haloes more massive than ∼1013.4 M⊙, higher than the corresponding figure for radio-quiet quasi-stellar objects. This value can be converted into a minimum black hole mass associated with radio-loud, AGN-fuelled objects of MminBH∼ 109 M⊙. The above results then suggest - at least for relatively faint radio objects - the existence of a threshold black hole mass associated with the onset of significant radio activity such as that of radio-loud AGNs; however, once the activity is triggered, there appears to be no evidence for a connection between black hole mass and level of radio outpu

The 2dF Galaxy Redshift Survey: correlation functions, peculiar velocities and the matter density of the Universe

We present a detailed analysis of the two-point correlation function, ξ(σ, π), from the 2dF Galaxy Redshift Survey (2dFGRS). The large size of the catalogue, which contains ∼220 000 redshifts, allows us to make high-precision measurements of various properties of the galaxy clustering pattern. The effective redshift at which our estimates are made is zs≈ 0.15, and similarly the effective luminosity, Ls≈ 1.4L*. We estimate the redshift-space correlation function, ξ(s), from which we measure the redshift-space clustering length, s0= 6.82 ± 0.28 h−1 Mpc. We also estimate the projected correlation function, Ξ(σ), and the real-space correlation function, ξ(r), which can be fit by a power law (r/r0), with r0= 5.05 ± 0.26 h−1 Mpc, γr= 1.67 ± 0.03. For r≳ 20 h−1 Mpc, ξ drops below a power law as, for instance, is expected in the popular Λ cold dark matter model. The ratio of amplitudes of the real- and redshift-space correlation functions on scales of 8-30 h−1 Mpc gives an estimate of the redshift-space distortion parameter β. The quadrupole moment of ξ(σ, π) on scales 30-40 h−1 Mpc provides another estimate of β. We also estimate the distribution function of pairwise peculiar velocities, ƒ(v), including rigorously the significant effect due to the infall velocities, and we find that the distribution is well fit by an exponential form. The accuracy of our ξ(σ, π) measurement is sufficient to constrain a model, which simultaneously fits the shape and amplitude of ξ(r) and the two redshift-space distortion effects parametrized by β and velocity dispersion, a. We find β= 0.49 ± 0.09 and a= 506 ± 52 km s−1, although the best-fitting values are strongly correlated. We measure the variation of the peculiar velocity dispersion with projected separation, a(σ), and find that the shape is consistent with models and simulations. This is the first time that β and ƒ(v) have been estimated from a self-consistent model of galaxy velocities. Using the constraints on bias from recent estimates, and taking account of redshift evolution, we conclude that β (L=L*, z= 0) = 0.47 ± 0.08, and that the present-day matter density of the Universe, Ωm≈ 0.3, consistent with other 2dFGRS estimates and independent analyse

The 2dF Galaxy Redshift Survey: the nature of the relative bias between galaxies of different spectral type

We present an analysis of the relative bias between early- and late-type galaxies in the Two-degree Field Galaxy Redshift Survey (2dFGRS) - as defined by the η parameter of Madgwick et al., which quantifies the spectral type of galaxies in the survey. We calculate counts in cells for flux-limited samples of early- and late-type galaxies, using approximately cubical cells with sides ranging from 7 to 42 h−1 Mpc. We measure the variance of the counts in cells using the method of Efstathiou et al., which we find requires a correction for a finite volume effect equivalent to the integral constraint bias of the autocorrelation function. Using a maximum-likelihood technique we fit lognormal models to the one-point density distribution, and develop methods of dealing with biases in the recovered variances resulting from this technique. We then examine the joint density distribution function, f(δE, δL), and directly fit deterministic bias models to the joint counts in cells. We measure a linear relative bias of ≈1.3, which does not vary significantly with ℓ. A deterministic linear bias model is, however, a poor approximation to the data, especially on small scales (ℓ≤ 28h−1 Mpc) where deterministic linear bias is excluded at high significance. A power-law bias model with index b1≈ 0.75 is a significantly better fit to the data on all scales, although linear bias becomes consistent with the data for ℓ≳ 40h−1 Mp

SNAPSHOT USA 2019 : a coordinated national camera trap survey of the United States

This article is protected by copyright. All rights reserved.With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states during a 14-week period (17 August - 24 November of 2019). We sampled wildlife at 1509 camera trap sites from 110 camera trap arrays covering 12 different ecoregions across four development zones. This effort resulted in 166,036 unique detections of 83 species of mammals and 17 species of birds. All images were processed through the Smithsonian's eMammal camera trap data repository and included an expert review phase to ensure taxonomic accuracy of data, resulting in each picture being reviewed at least twice. The results represent a timely and standardized camera trap survey of the USA. All of the 2019 survey data are made available herein. We are currently repeating surveys in fall 2020, opening up the opportunity to other institutions and cooperators to expand coverage of all the urban-wild gradients and ecophysiographic regions of the country. Future data will be available as the database is updated at eMammal.si.edu/snapshot-usa, as well as future data paper submissions. These data will be useful for local and macroecological research including the examination of community assembly, effects of environmental and anthropogenic landscape variables, effects of fragmentation and extinction debt dynamics, as well as species-specific population dynamics and conservation action plans. There are no copyright restrictions; please cite this paper when using the data for publication.Publisher PDFPeer reviewe