30 research outputs found

    Functional impairment of systemic scleroderma patients with digital ulcerations: Results from the DUO registry

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    Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

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    OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

    Large-Scale Hydrological Modeling and Decision-Making for Agricultural Water Consumption and Allocation in the Main Stem Tarim River, China

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    A large-scale hydrological model (MIKE HYDRO) was established for the purpose of sustainable agricultural water management in the main stem Tarim River, located in northwest China. In this arid region, agricultural water consumption and allocation management are crucial to address the conflicts among irrigation water users from upstream to downstream. The results of model calibration indicated a close correlation between simulated and observed values. Scenarios with the change on irrigation strategies and land use distributions were investigated. Irrigation scenarios revealed that the available irrigation water has significant and varying effects on the yields of different crops. Irrigation water saving could reach up to 40% in the water-saving irrigation scenario. Land use scenarios illustrated that an increase of farmland area in the lower reach gravely aggravated the water deficit, while a decrease of farmland in the upper reaches resulted in considerable benefits for all sub-catchments. A substitution of crops was also investigated, which demonstrated the potential for saving considerable amounts of irrigation water in upper and middle reaches. Overall, the results of this study provide a scientific basis for decision-making on agricultural water consumption and allocation in the study area

    Scenario development and assessment of the potential impacts of climate and market changes on crops in Europe : Assessing the adaptive capacity of agriculture in the Netherlands to the impacts of climate change under different market and policy scenarios (AgriAdapt project)

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    The Netherlands are an important producer and exporter of agricultural products. Changes in climate, markets and policies may have a large impact on the agricultural sector and farmers will need to adapt to these changes. Sector and policy documents have, so far, insufficiently considered the impacts of climate change and increased climate variability on the sector
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