La superposición entre figuras en el arte parietal paleolítico. Cambios temporales en la región cantábrica.

El fenómeno de la superposición entre figuras en el arte parietal paleolítico ha interesado a los investigadores desde su descubrimiento. Sin embargo, en la actualidad coexisten dos líneas interpretativas antagónicas. Para los primeros investigadores, representados por H. Breuil, las superposiciones constituían auténticas estratigrafías parietales, en las cuales se podía estudiar la evolución estilística del Arte Paleolítico. Para los estructuralistas –encabezados por A. Laming‐Emperaire y A. Leroi‐Gourhan, por el contrario, las superposiciones se explicaban como un recurso de composición sincrónica. En este trabajo queremos proponer una tendencia de cambio temporal en el uso de las superposiciones observable, al menos, en el registro de la región Cantábrica.-------------------------The phenomenon of the overlapping among figures in Palaeolithic rock art has interested the researchers since its discovery. Nevertheless, at present there are still in force two antagonistic interpretative lines. For the first researchers, represented for H. Breuil, the overlappings constituted genuine parietal stratigraphies, where the stylistic evolution of the Palaeolithic Art could be analysed. Structuralists headed for A. Laming‐Emperaire and A. Leroi‐Gourhan, on the other hand, explained the overlappings as a synchronic composition resource. In this paper we want to propose a trend of temporary change in the use of the overlappings. This change is observable, at least, in the record of Cantabrian region

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Painting Altamira Cave ? Shell tools for ochre-processing in the Upper Palaeolithic in northern Iberia

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