Semiclassical treatment of the Dirac sea contribution for finite nuclei

Dirac sea corrections for bulk properties of finite nuclei are computed within a self-consistent scheme in the $\sigma$-$\omega$ model. The valence part is treated in the Hartree approximation whereas the sea contribution is evaluated semiclassically up to fourth order in $\hbar$. Numerically, we find a quick convergence of the semiclassical expansion; the fourth order contributing much less than one percent to the binding energy per nucleon.Comment: LaTeX, 11 page

The S11−NS_{11}- N(1535) and −N-N(1650) Resonances in Meson-Baryon Unitarized Coupled Channel Chiral Perturbation Theory

The $s-$wave meson-baryon scattering is analyzed for the strangeness S=0 sector in a Bethe-Salpeter coupled channel formalism incorporating Chiral Symmetry. Four channels have been considered: $\pi N$, $\eta N$, $K \Lambda$, $K \Sigma$. The needed two particle irreducible matrix amplitude is taken from lowest order Chiral Perturbation Theory in a relativistic formalism and low energy constants are fitted to the elastic $\pi N$ phase-shifts and the $\pi^- p \to \eta n$ and $\pi^- p \to K^0 \Lambda$ cross section data. The position of the complex poles in the second Riemann sheet of the scattering amplitude determine masses and widths of the $S_{11}-$ $N$(1535) and $-N$(1650) resonances, in reasonable agreement with experiment. A good overall description of data, from $\pi N$ threshold up to 2 GeV, is achieved keeping in mind that the two pion production channel has not been included.Comment: 35 pages, LaTeX + 7 ps-figure files. Some minor mistakes have been corrected for and a new appendix discussing the matching to HBChPT has been also adde

Atomistic Simulations of Grain Boundary Pinning in CuFe Alloys

The authors apply a hybrid Monte Carlo-molecular dynamics code to the study of grain boundary motion upon annealing of pure Cu and Cu with low concentrations of Fe. The hybrid simulations account for segregation and precipitation of the low solubility Fe, together with curvature driven grain boundary motion. Grain boundaries in two different systems, a {Sigma}7+U-shaped half-loop grain and a nanocrystalline sample, were found to be pinned in the presence of Fe concentrations exceeding 3%

S=−1S=-1 Meson-Baryon Unitarized Coupled Channel Chiral Perturbation Theory and the S01−S_{01}- Λ\Lambda(1405) and −Λ- \Lambda(1670) Resonances

The $s-$wave meson-baryon scattering is analyzed for the strangeness $S=-1$ and isospin I=0 sector in a Bethe-Salpeter coupled channel formalism incorporating Chiral Symmetry. Four channels have been considered: $\pi \Sigma$, $\bar K N$, $\eta \Lambda$ and $K \Xi$. The required input to solve the Bethe-Salpeter equation is taken from lowest order Chiral Perturbation Theory in a relativistic formalism. There appear undetermined low energy constants, as a consequence of the renormalization of the amplitudes, which are obtained from fits to the $\pi\Sigma\to\pi\Sigma$ mass-spectrum, to the elastic $\bar K N \to \bar K N$ and $\bar K N\to \pi \Sigma$ $t$--matrices and to the $K^- p \to \eta \Lambda$ cross section data. The position and residues of the complex poles in the second Riemann Sheet of the scattering amplitude determine masses, widths and branching ratios of the $S_{01}-$ $\Lambda$(1405) and $-\Lambda$(1670) resonances, in reasonable agreement with experiment. A good overall description of data, from $\pi \Sigma$ threshold up to 1.75 GeV, is achieved despite the fact that three-body channels have not been explicitly included.Comment: 23 pages, Latex, 10 Figures. In this revised version a new subsection 3.6 on Heavy Baryon Expansion and new references have been adde

Pd-(L)1 inhibitors as monotherapy for the first-line treatment of non-small-cell lung cancer patients with high pd-l1 expression : A network meta-analysis

Altres ajuts: RocheProgrammed cell death-ligand 1 (PD-L1) has emerged as a potential biomarker for selec-tion of patients more likely to respond to immunotherapy and as a prognostic factor in non-small cell lung cancer (NSCLC). In this network meta-analysis, we aimed to evaluate the efficacy of first-line anti-PD-(L)1 monotherapy in advanced NSCLC patients with high PD-L1 expression (≥50%) compared to platinum-based chemotherapy. We also evaluated efficacy outcomes according to tumor mutational burden (TMB). To that end, we conducted a systematic review. Six clinical trials with 2111 patients were included. In head-to-head comparisons, immunotherapy showed a significant improvement in progression-free survival (PFS: HRpooled = 0.69, 95% CI: 0.52-0.90, p = 0.007), overall survival (OS: HRpooled = 0.69, 95% CI: 0.61-0.78; p < 0.001) and overall response rate (ORR) (Risk ratio (RR)pooled = 1.354, 95% CI: 1.04-1.762, p = 0.024). In the assessment of relative efficacy for PFS through indirect comparisons, pembrolizumab (results from KEYNOTE-024) ranked highest followed by cemiplimab and atezolizumab, with statistical significance determined for some of the drugs. In terms of OS, cemiplimab ranked highest followed by atezolizumab and pembrolizumab, although non-significant OS was determined for these drugs. In conclusion, PD-(L)1 inhibitor mon-otherapy improves efficacy outcomes in the first line setting of advanced NSCLC patients with high PD-L1 expression. Evaluations with longer follow up are still needed to determine the superiority of any specific drug

Soluciones y alternativas a las inundaciones periódicas anuales en zonas de alto riesgo en el área metropolitana de Guadalajara, un desafío a los planes de ordenamiento urbano y territorial

The Guadalajara Metropolitan Area has experience accelerated urban growth since 2000, which has led to a change in land use that has caused significant alterations in natural runoff, as well as decrease in infiltration into the land and as a consequence, a considerable increase in points vulnerable to floods. The positive and negative effects are two sides of the same coin; on the one hand, they proclaim excessive policies that seek to privatize water resources and, on the other to provide water in an excessive amount through concessions. The paradigm shift seen from the perspective of watershed management is precisely to solve problems associated with the exploitation of the planet´s natural resources, in addition to associating them with projects of an urban nature, hydraulic infrastructure, transportation or a combination of these and do not present any modification in the rivers and streams. The objective of this work is focused on controlling the annual periodic floods that occur in the lower part of the basin, by means of probabilistic and statistical models, as results present alternative solutions, such as: rectification of channels, catchment works, as well as works to remove dredging in the rainwater channels.El Área Metropolitana de Guadalajara ha experimentado un acelerado crecimiento urbano a partir del año 2000, esto ha propiciado un cambio de uso de suelo que ha originado importantes alteraciones en los escurrimientos naturales, además de una disminución de infiltraciones al subsuelo y como consecuencia un aumento considerable de puntos vulnerables a las inundaciones. Los efectos positivos y negativos son cara de la misma moneda, por un lado, pregonan políticas desmedidas de pretender privatizar el recurso hídrico y por otro de dotar de agua desmedidamente por medio de concesiones. El cambio de paradigma visto desde el manejo de cuencas es precisamente resolver problemas asociados a la explotación de los recursos naturales del planeta, además de asociarlos con proyectos de índole urbano, de infraestructura hidráulica, de transporte o una combinación de estas y que no presenten modificación alguna en los cauces y arroyos. El objetivo de este trabajo se centra en controlar las inundaciones periódicas anuales que se presentan en la parte baja de la cuenca, mediante modelos probabilísticos y estadísticos, como resultados presentar alternativas de solución, tales como: rectificación de cauces, obras de captación, así como obras desazolves en los canales de aguas pluviales

Los Procesos Constructivos de Vivienda Vertical en serie, un desafío a los planes de Desarrollo Urbano y Territorial, en el Área Metropolitana de Guadalajara

The subdivisions in the Metropolitan Area of Guadalajara (AMG) of restricted access have become a model of segregated spaces in the peripheries of the cities. These models of development have undergone significant transformations in the urban basins of the mexican territory, since they are housing developments with greater backwardnees, causing a greater fragmentation of public spaces, favoring the coexistence of a polarized society. The paradigm shift seen from urbanization in high-risk áreas, is to incorporate key elements, such as architectural and technological innovations that are able to reduce or decrease the amount of energy produced by the vast majority in the construction of vertical housing.&nbsp; The goal then is to determine the flooding that occurs in the Lomas of Mirador neighborhood by means of probabilistic and statistical models, as well as to identify by means topographic cartography the flood plains that occur in the hydrographic basin of the valley zone of the municipality of Tlajomulco of Zuñiga, the results obtained were the peak flows for return periods Tr up to 100 years before and after the urbanization, it is concluded that a combination of hydraulic Works presentes na alterntive solution to the problems mentioned above.Los fraccionamientos en el Área Metropolitana de Guadalajara (AMG) de acceso restringido se han convertido en un modelo de espacios segregados en las periferias de las ciudades. Dichos modelos de desarrollo han sufrido grandes transformaciones significativas en las cuecas urbanas del territorio mexicano, ya que se trata de viviendas con mayores rezagos, ocasionando una mayor fragmentación de espacios públicos, propiciando la coexistencia de una sociedad polarizada. El cambio de paradigma visto desde la urbanización en zonas de alto riesgo, es incorporar elementos clave, tales como innovaciones arquitectónicas y tecnológicas que sean capaces de abatir o disminuir la cantidad de energía producidos por la gran mayoría en la construcción de vivienda vertical. El objetivo entonces es determinar la magnitud de los escurrimientos pluviales en la parte baja de la colonia Lomas del Mirador, así como los hidrogramas antes y después de la urbanización mediante modelos probabilísticos y estadísticos que se producen en la cuenca hidrográfica de la zona valles del municipio de Tlajomulco de Zúñiga, los resultados obtenidos fueron los gastos picos para periodos de retorno Tr hasta 100 años antes y después de la urbanización, se concluye que una combinación de obras hidráulicas presenta una alternativa de solución a los problemas antes citados

SOBRINA Spanish study-analysing the frequency, cost and adverse events associated with overuse in primary care: protocol for a retrospective cohort study

Introduction Several institutions and quality national agencies have fostered the creation of recommendations on what not to do to reduce overuse in clinical practice. In primary care, their impact has hardly been studied. The frequency of adverse events (AEs) associated with doing what must not be done has not been analysed, either. The aim of this study is to measure the frequency of overuse and AEs associated with doing what must not be done (commission errors) in primary care and their cost. Methods and analysis A coordinated, multicentric, national project. A retrospective cohort study using computerised databases of primary care medical records from national agencies and regional health services will be conducted to analyse the frequency of the overuse due to ignore the do-not-do recommendations, and immediately afterwards, depending on their frequency, a representative random sample of medical records will be reviewed with algorithms (triggers) that determine the frequency of AEs associated with these recommendations. Cost will determine by summation of the direct costs due to the consultation, pharmacy, laboratory and imaging activities according to the cases. Ethics and dissemination The study protocol has been approved by the Ethics Committee of Primary Care Research of the Valencian Community. We aim to disseminate the findings through international peerreviewed journals and on the website (http://www. nohacer. es/). Outcomes will be used to incorporate algorithms into the electronic history to assist in making clinical decisions