788 research outputs found
Data Needs of Social Service Agencies: A Case Study of Fort Worth, Texas
There is increasing need for social service agencies and organizations to allocate resources and to plan based on objective needs assessment. This requires greater access and use of data sources. The dual objectives of this paper are to describe and analyze the increased need for data use by social welfare agencies and to present the findings of a data needs assessment study of such organizations in Fort Worth, Texas. The results of this study were used in the planning and development of a series of free data use and data use-applications workshops for social service agency representatives and in the writing of a detailed Resource Manual for agency data users
Preference-for-Solitude and Adjustment Difficulties in Early and Late Adolescence
Social withdrawal has been associated with adjustment difficulties across development. Although much is known about shyness, little is known about preference-for-solitude; even less is known about its relations with adjustment across different periods of adolescence. We examined whether preference-for-solitude might be differentially associated with adjustment difficulties in early and late adolescence. Self- and parent-reports of withdrawal motivations and adjustment were collected from 234 eighth graders (113 boys; M age = 13.43) and 204 twelfth graders (91 boys; M age = 17.25). Results from structural equation modeling demonstrated that above and beyond the effects of shyness, preference-for-solitude was more strongly associated with adjustment difficulties in 8th grade than in 12th grade. Preference-for-solitude was associated with greater anxiety/depression, emotion dysregulation, and lower self-esteem in 8th grade; these relations were not found in 12th grade. Although preference-for-solitude was associated with lower social competence in both 8th and 12th grades, this relation was significantly stronger in 8th grade than in 12th grade. Findings suggest preference-for-solitude has closer ties to maladjustment in early adolescence than in late adolescence. Interventions targeting preferred-solitary youth in early adolescence may be particularly fruitfu
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.
Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual phosphorylation events within the multisite phosphorylation process have never been thoroughly studied. In Saccharomyces cerevisiae, the initiation of S phase is thought to be governed by complexes of Cdk1 and Cln cyclins that phosphorylate six or more sites on the Clb5-Cdk1 inhibitor Sic1, directing it to SCF-mediated destruction. The resulting Sic1-free Clb5-Cdk1 complex triggers S phase. Here, we demonstrate that Sic1 destruction depends on a more complex process in which both Cln2-Cdk1 and Clb5-Cdk1 act in processive multiphosphorylation cascades leading to the phosphorylation of a small number of specific phosphodegrons. The routes of these phosphorylation cascades are shaped by precisely oriented docking interactions mediated by cyclin-specific docking motifs in Sic1 and by Cks1, the phospho-adaptor subunit of Cdk1. Our results indicate that Clb5-Cdk1-dependent phosphorylation generates positive feedback that is required for switch-like Sic1 destruction. Our evidence for a docking network within clusters of phosphorylation sites uncovers a new level of complexity in Cdk1-dependent regulation of cell cycle transitions, and has general implications for the regulation of cellular processes by multisite phosphorylation
Evidence for Cosmic Acceleration is Robust to Observed Correlations Between Type Ia Supernova Luminosity and Stellar Age
Type Ia Supernovae (SNe Ia) are powerful standardizable candles for
constraining cosmological models and provided the first evidence of the
accelerated expansion of the universe. Their precision derives from empirical
correlations, now measured from SNe Ia, between their luminosities,
light-curve shapes, colors and most recently with the stellar mass of their
host galaxy. As mass correlates with other galaxy properties, alternative
parameters have been investigated to improve SN Ia standardization though none
have been shown to significantly alter the determination of cosmological
parameters. We re-examine a recent claim, based on 34 SN Ia in nearby passive
host galaxies, of a 0.05 mag/Gyr dependence of standardized SN Ia luminosity on
host age which if extrapolated to higher redshifts, would be a bias up to 0.25
mag, challenging the inference of dark energy. We reanalyze this sample of
hosts using both the original method and a Bayesian hierarchical model and find
after a fuller accounting of the uncertainties the significance of a dependence
on age to be and after the removal of a single
poorly-sampled SN Ia. To test the claim that a trend seen in old stellar
populations can be applied to younger ages, we extend our analysis to a larger
sample which includes young hosts. We find the residual dependence of host age
(after all standardization typically employed for cosmological measurements) to
be consistent with zero for 254 SNe Ia from the Pantheon sample, ruling out the
large but low significance trend seen in passive hosts.Comment: 9 pages, 3 figures, 3 tables. Accepted for publication in ApJ
Collateral Estoppel
The doctrine of collateral estoppel involves the use of an old judgment in a new action to prevent the relitigation of issues resolved by that old judgment. At common law, use of the doctrine required that the party using collateral estoppel and the party against whom it was used be the same as the parties to the prior judgment. This common law requirement of mutuality has been relaxed and since the United States Supreme Court\u27s 1979 decision in ParklaneHoisery Co. v. Shore, the strict common law requirement of mutuality has all but completely vanished. In Parklane the Court sanctioned the use of collateral estoppel by a plaintiff who was a stranger to the original suit against a defendant who was party to that suit. The courts\u27 search for fair results and judicial economy in the application of the doctrine led to this application of the doctrine in circumstances in which the parties were not mutual. This note traces the un- steady course which the doctrine of collateral estoppel traveled before Parklane. The significance of the Court\u27s decision in Parklane is then analyzed. Finally, post-Parklane applications of collateral estoppel are discussed, including the effect of the use of collateral estoppel on the seventh amendment right to jury trial and its impact on substantive areas of law
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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.
ObjectiveOnset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined miRNAs in ped-MS, but individuals developing MS at an early age may carry a relatively high burden of genetic risk factors, and miRNA dysregulation may therefore play a larger role in the development of ped-MS than in adult-onset MS. This study aimed to look for evidence of miRNA involvement in ped-MS pathogenesis.MethodsGWAS results from 486 ped-MS cases and 1362 controls from the U.S. Pediatric MS Network and Kaiser Permanente Northern California membership were investigated for miRNA-specific signals. First, enrichment of miRNA-target gene network signals was evaluated using MIGWAS software. Second, SNPs in miRNA genes and in target gene binding sites (miR-SNPs) were tested for association with ped-MS, and pathway analysis was performed on associated target genes.ResultsMIGWAS analysis showed that miRNA-target gene signals were enriched in GWAS (P = 0.038) and identified 39 candidate biomarker miRNA-target gene pairs, including immune and neuronal signaling genes. The miR-SNP analysis implicated dysregulation of miRNA binding to target genes in five pathways, mainly involved in immune signaling.InterpretationEvidence from GWAS suggests that miRNAs play a role in ped-MS pathogenesis by affecting immune signaling and other pathways. Candidate biomarker miRNA-target gene pairs should be further studied for diagnostic, prognostic, and/or therapeutic utility
Diffuse Light in Hickson Compact Groups: The Dynamically Young System HCG 44
Compact groups are associations of a few galaxies in which the environment
plays an important role in galaxy evolution. The low group velocity dispersion
favors tidal interactions and mergers, which may bring stars from galaxies to
the diffuse intragroup light. Numerical simulations of galaxy clusters in
hierarchical cosmologies show that the amount of the diffuse light increases
with the dynamical evolution of the cluster. We search for diffuse light in the
galaxy group HCG 44 in order to determine its luminosity and luminosity
fraction. Combining with literature data, we aim to constrain the dynamical
status of Hickson compact groups. We use Intra Group planetary nebulae (IGPNe)
as tracers of diffuse light. These are detected by the so-called on band-off
band technique. We found 12 emission line objects in HCG 44, none of them
associated with the galaxies of the group. 6/12 emission line objects are
consistent with being IGPNe in HCG 44, but are also consistent with being
Ly background galaxies. Thus we derive an upper limit to the diffuse
light fraction in HCG 44 of 4.7%. We find a correlation between the fraction of
elliptical galaxies and the amount of diffuse light in Hickson compact groups.
Those with large fraction of diffuse light are those with large fractions in
number and luminosity of E/S0 galaxies. We propose an evolutionary sequence for
Hickson compact groups in which the amount of diffuse light increases with the
dynamical evolution of the group.Comment: 9 pages, 4 figures, accepted for publication at A&
Ages and Metallicities of Hickson Compact Group Galaxies
Hickson Compact Groups (HCGs) constitute an interesting extreme in the range
of environments in which galaxies are located, as the space density of galaxies
in these small groups are otherwise only found in the centres of much larger
clusters. The work presented here uses Lick indices to make a comparison of
ages and chemical compositions of galaxies in HCGs with those in other
environments (clusters, loose groups and the field). The metallicity and
relative abundance of `-elements' show strong correlations with galaxy
age and central velocity dispersion, with similar trends found in all
environments. However, we show that the previously reported correlation between
-element abundance ratios and velocity dispersion disappears when a
full account is taken of the the abundance ratio pattern in the calibration
stars. This correlation is thus found to be an artifact of incomplete
calibration to the Lick system.
Variations are seen in the ranges and average values of age, metallicity and
-element abundance ratios for galaxies in different environments. Age
distributions support the hierarchical formation prediction that field galaxies
are on average younger than their cluster counterparts. However, the ages of
HCG galaxies are shown to be more similar to those of cluster galaxies than
those in the field, contrary to the expectations of current hierarchical
models. A trend for lower velocity dispersion galaxies to be younger was also
seen. This is again inconsistent with hierarchical collapse models, but is
qualitatively consistent with the latest N-body-SPH models based on monolithic
collapse in which star formation continues for many Gyr in low mass halos.Comment: 18 pages. Submitted for publication in MNRA
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