654 research outputs found
Nuclear Proliferation: Best Memorials, New England Region, 1977 Philip C. Jessup Moot Court Competition
Geologic and Structural Evolution of the NE Lau Basin, Tonga: Morphotectonic Analysis and Classification of Structures Using Shallow Seismicity
The transition from subduction to transform motion along horizontal terminations of trenches is associated with tearing of the subducting slab and strike-slip tectonics in the overriding plate. One prominent example is the northern Tonga subduction zone, where abundant strike-slip faulting in the NE Lau back-arc basin is associated with transform motion along the northern plate boundary and asymmetric slab rollback. Here, we address the fundamental question: how does this subduction-transform motion influence the structural and magmatic evolution of the back-arc region? To answer this, we undertake the first comprehensive study of the geology and geodynamics of this region through analyses of morphotectonics (remote-predictive geologic mapping) and fault kinematics interpreted from ship-based multibeam bathymetry and Centroid-Moment Tensor data. Our results highlight two unique features of the NE Lau Basin: (1) the occurrence of widely distributed off-axis volcanism, in contrast to typical ridge-centered back-arc volcanism, and (2) fault kinematics dominated by shallow-crustal strike slip-faulting (rather than normal faulting) extending over ~120 km from the transform boundary. The orientations of these strike-slip faults are consistent with reactivation of earlier-formed normal faults in a sinistral megashear zone. Notably, two distinct sets of Riedel megashears are identified, indicating a recent counter-clockwise rotation of part of the stress field in the back-arc region closest to the arc. Importantly, these structures directly control the development of complex volcanic-compositional provinces, which are characterized by variably-oriented spreading centers, off-axis volcanic ridges, extensive lava flows, and point-source rear-arc volcanoes that sample a heterogenous mantle wedge, with sharp gradients and contrasts in composition and magmatic affinity. This study adds to our understanding of the geologic and structural evolution of modern backarc systems, including the association between subduction-transform motions and the siting and style of seafloor volcanism
Transcript-indexed ATAC-seq for precision immune profiling.
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding genes with assay for transposase-accessible chromatin with sequencing (ATAC-seq) analysis at the single-cell level to provide information on the TCR specificity and epigenomic state of individual T cells. By using this approach, termed transcript-indexed ATAC-seq (T-ATAC-seq), we identified epigenomic signatures in immortalized leukemic T cells, primary human T cells from healthy volunteers and primary leukemic T cells from patient samples. In peripheral blood CD4+ T cells from healthy individuals, we identified cis and trans regulators of naive and memory T cell states and found substantial heterogeneity in surface-marker-defined T cell populations. In patients with a leukemic form of cutaneous T cell lymphoma, T-ATAC-seq enabled identification of leukemic and nonleukemic regulatory pathways in T cells from the same individual by allowing separation of the signals that arose from the malignant clone from the background T cell noise. Thus, T-ATAC-seq is a new tool that enables analysis of epigenomic landscapes in clonal T cells and should be valuable for studies of T cell malignancy, immunity and immunotherapy
The most primitive CM chondrites, Asuka 12085, 12169, and 12236, of subtypes 3.0–2.8: Their characteristic features and classification
CM chondrites (CMs) are the most abundant group of carbonaceous chondrites. CMs experienced varying degrees of secondary aqueous alteration and heating that modified or destroyed their primitive features. We have studied three chondrites, Asuka (A) 12085, A 12169, and A 12236. Their modal compositions, chondrule size distributions, and bulk composition indicate that they are CMs. However, the common occurrence of melilite in CAIs and glass in chondrules, abundant Fe–Ni metal, the absence of tochilinite-cronstedtite intergrowths, and almost no phyllosilicates, all suggest that these chondrites, especially A 12169, experienced only minimal aqueous alteration. The textures and compositions of metal and sulfides, the lack of ferroan rims on AOA olivines, the compositional distribution of ferroan olivine, and the Raman spectra of their matrices, indicate that these chondrites experienced neither significant heating nor dehydration. These chondrites, especially A 12169, are the most primitive CMs so far reported. The degree of the alteration increases from A 12169, through A 12236, to A 12085. We propose the criteria for subtypes of 3.0–2.8 for CMs. A 12169, A 12236, and A 12085 are classified as subtype 3.0, 2.9, and 2.8, respectively. The oxygen isotopic composition of the Asuka CMs is consistent with these samples having experienced only a limited degree of aqueous alteration. The CM and CO groups are probably not derived from a single heterogeneous parent body. These chondrites are also of particular significance in view of the imminent return of sample material from the asteroids Ryugu and Bennu
Observers and Locality in Everett Quantum Field Theory
A model for measurement in collapse-free nonrelativistic fermionic quantum
field theory is presented. In addition to local propagation and
effectively-local interactions, the model incorporates explicit representations
of localized observers, thus extending an earlier model of entanglement
generation in Everett quantum field theory [M. A. Rubin, Found. Phys. 32,
1495-1523 (2002)]. Transformations of the field operators from the Heisenberg
picture to the Deutsch-Hayden picture, involving fictitious auxiliary fields,
establish the locality of the model. The model is applied to manifestly-local
calculations of the results of measurements, using a type of sudden
approximation and in the limit of massive systems in narrow-wavepacket states.
Detection of the presence of a spin-1/2 system in a given spin state by a
freely-moving two-state observer illustrates the features of the model and the
nonperturbative computational methodology. With the help of perturbation theory
the model is applied to a calculation of the quintessential "nonlocal" quantum
phenomenon, spin correlations in the Einstein-Podolsky-Rosen-Bohm experiment.Comment: Some changes to introduction and discussion sections, typos
corrected, conclusions unchanged. To appear in Foundations of Physic
Discovery of an intermediate-luminosity red transient in M51 and its likely dust-obscured, infrared-variable progenitor
We present the discovery of an optical transient (OT) in Messier 51,
designated M51 OT2019-1 (also ZTF19aadyppr, AT 2019abn, ATLAS19bzl), by the
Zwicky Transient Facility (ZTF). The OT rose over 15 days to an observed
luminosity of (), in the
luminosity gap between novae and typical supernovae (SNe). Spectra during the
outburst show a red continuum, Balmer emission with a velocity width of
km s, Ca II and [Ca II] emission, and absorption features
characteristic of an F-type supergiant. The spectra and multiband light curves
are similar to the so-called "SN impostors" and intermediate-luminosity red
transients (ILRTs). We directly identify the likely progenitor in archival
Spitzer Space Telescope imaging with a m luminosity of
and a color redder than 0.74 mag, similar
to those of the prototype ILRTs SN 2008S and NGC 300 OT2008-1. Intensive
monitoring of M51 with Spitzer further reveals evidence for variability of the
progenitor candidate at [4.5] in the years before the OT. The progenitor is not
detected in pre-outburst Hubble Space Telescope optical and near-IR images. The
optical colors during outburst combined with spectroscopic temperature
constraints imply a higher reddening of mag and higher
intrinsic luminosity of
() near peak than seen in previous ILRT
candidates. Moreover, the extinction estimate is higher on the rise than on the
plateau, suggestive of an extended phase of circumstellar dust destruction.
These results, enabled by the early discovery of M51 OT2019-1 and extensive
pre-outburst archival coverage, offer new clues about the debated origins of
ILRTs and may challenge the hypothesis that they arise from the
electron-capture induced collapse of extreme asymptotic giant branch stars.Comment: 21 pages, 5 figures, published in ApJ
Planetary nebulae in M33: probes of AGB nucleosynthesis and ISM abundances
We have obtained deep optical spectrophotometry of 16 planetary nebulae in
M33, mostly located in the central two kpc of the galaxy, with the Subaru and
Keck telescopes. We have derived electron temperatures and chemical abundances
from the detection of the [OIII]4363 line for the whole sample. We have found
one object with an extreme nitrogen abundance, 12+log(N/H)=9.20, accompanied by
a large helium content. After combining our data with those available in the
literature for PNe and HII regions, we have examined the behavior of nitrogen,
neon, oxygen and argon in relation to each other, and as a function of
galactocentric distance. We confirm the good correlation between Ne/H and O/H
for PNe in M33. Ar/H is also found to correlate with O/H. This strengthens the
idea that at the metallicity of the bright PNe analyzed in M33, which is
similar to that found in the LMC, these elements have not been significantly
modified during the dredge-up processes that take place during the AGB phase of
their progenitor stars. We find no significant oxygen abundance offset between
PNe and HII regions at any given galactocentric distance, despite the fact that
these objects represent different age groups in the evolution of the galaxy.
Combining the results from PNe and HII regions, we obtain a representative
slope of the ISM alpha-element (O, Ar, Ne) abundance gradient in M33 of -0.025
+/- 0.006 dex/kpc. Both PNe and HII regions display a large abundance
dispersion at any given distance from the galactic center. We find that the N/O
ratio in PNe is enhanced, relative to the HII regions, by approximately 0.8
dex.Comment: 21 pages, 20 figures. Accepted for publication in MNRA
Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C
Since HIV impairs gut barriers to pathogens, HIV-infected adults may be vulnerable to Minimal Hepatic Encephalopathy (MHE) in the absence of cirrhosis
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