125 research outputs found
Effect of polyphenol intake on biomarkers and cardiovascular risk
174 p.[ES] Introducción La enfermedad cardiovascular es la principal causa de muerte en todo el mundo y, a pesar de las estrategias preventivas llevadas a cabo, continúa siendo un problema de salud pública. La dieta mediterránea ha demostrado numerosos beneficios cardiosaludables dada su riqueza en moléculas antioxidantes y antiinflamatorias y, muy especialmente, en polifenoles. Estos compuestos bioactivos han mostrado beneficios a nivel cardiovascular debido a sus propiedades antitrombóticas, antiinflamatorias y antiagregantes. Sin embargo, el estudio de su potencial en humanos es limitado. Dado el gran número de compuestos que existen, y, por ende, sus variadas biodisponibilidades y mecanismos de acción, aún hay muchos puntos que necesitan ser esclarecidos. Por este motivo, el objetivo principal de la presente tesis doctoral es evaluar la asociación entre el consumo de polifenoles, y el riesgo y biomarcadores de riesgo cardiovascular (RCV).
Metodología Se utilizó la información disponible de 6.633 participantes del estudio PREDIMED-Plus, un ensayo clínico aleatorizado multicéntrico, que recopiló información sobre hábitos alimentarios y estilos de vida, así como muestras sanguíneas para análisis bioquímicos. El consumo de polifenoles se estimó utilizando los datos de consumo de alimentos del cuestionario semicuantitativo de frecuencia alimentaria de 143 ítems y el contenido de polifenoles de cada alimento contenido en la base de datos Phenol-Explorer. Los consumos estimados se ajustaron por la ingesta total de energía de acuerdo al método de residuales.
Mediante modelos de regresión lineal multivariante, se evaluó la asociación entre la ingesta de polifenoles y el RCV (estimado mediante ecuaciones de riesgo). Además, se evaluó la asociación entre la ingesta de polifenoles y, el ácido úrico (mediante regresión lineal multivariante) y, mediante modelos de regresión de Cox con un tiempo de seguimiento constante (t=1) se estimó los Prevalence Ratio de la hiperuricemia.
Por otro lado, se establecieron patrones de consumo de polifenoles mediante análisis factorial y análisis clúster, comparando ambos métodos y relacionando la adherencia a cada patrón con el RCV estimado.
Todos los análisis se realizaron para hombres y mujeres por separado, además de en la población total.
Resultados La ingesta total de polifenoles (βQ5vs.Q1= 0,10, IC 95%: 0,04 a 0,17) y flavonoides (βQ5vs.Q1= 0,17, IC 95%: 0,10 a 0,24) se asoció directa y significativamente con una mejor salud cardiovascular óptima (Life’s Simple 7). Se encontraron asociaciones inversas entre el consumo de la clase otros polifenoles y, el RCV estimado mediante Framingham (βQ5vs.Q1= -1,22%, IC 95%: -2,37 a -0,07) y SCORE (βQ5vs.Q1=-0,32, IC 95%: -2,37 a -0,07). En las mujeres, las asociaciones entre el consumo de polifenoles y todas las ecuaciones de riesgo, tienden a ser protectoras.
La ingesta de ácidos fenólicos (βQ5vs.Q1= -0,17, IC 95%: -0,27 a -0,06), ácidos hidroxicinámicos (βQ5vs.Q1= -0,19, IC 95%: -0,3 a -0,09), alquilmetoxifenoles (βQ5vs.Q1= 0,2, IC 95%: -0,31 a -0. 1) y metoxifenoles (βQ5vs.Q1= -0,24, IC 95%: -0,34 a -0,13) -0,24, IC 95%: -0,34 a -0,13) mostró una asociación inversa con los niveles de ácido úrico en suero y, la hiperuricemia (PRQ5vs.Q1=0,82, IC 95%:0,71-0,95; PRQ5vs.Q1=0,82, IC 95%:0,71-0,95; PRQ5vs.Q1=0,80, IC 95%:0,70-0,92 y PR=0,79, IC 95%:0,69-0,91, respectivamente).
Los patrones de polifenoles revelaron diferencias entre hombres y mujeres, así como en su asociación con el RCV. Respecto a aquellos derivados del análisis factorial: para el total de la muestra, y los hombres, el patrón 3 (aceitunas y aceite de oliva) se asoció positivamente con el RCV, también presentaron, mayor prevalencia de diabetes y mayores consumos de sodio. El patrón 4 formado por el café en todos los grupos, también se asoció con mayor RCV. En cuanto al análisis clúster, el clúster 2 en el total y en hombres, caracterizados por consumo de polifenoles del café y las aceitunas y aceite de oliva, también mostraron mayor RCV.
Conclusiones La clase otros polifenoles mostró asociaciones inversas con el riesgo cardiovascular estimado, encontrándose resultados similares con las ecuaciones de Framingham, Framingham-REGICOR y Life’s Simple 7 (después de eliminar el componente de dieta) y diferentes con la SCORE, pero los predictores que se incluyen en esta herramienta son escasos.
Una mayor ingesta subclases de polifenoles presentes en el café: ácidos hidroxicinámicos, alquilmetoxifenoles y metoxifenoles se asoció de forma inversa a los niveles de ácido úrico y la hiperuricemia.
Encontramos diferencias en los patrones de ingesta de polifenoles entre hombres y mujeres, y en sus asociaciones con la RCV. Estas diferencias de sexo pueden explicarse por el hecho de que llevan estilos de vida diferentes, ya que un patrón no se refiere sólo a los hábitos dietéticos.
Además, los sujetos que presentaban un mayor riesgo al inicio del estudio podrían sentirse más motivados para mejorar su hábito dietético (causalidad inversa).
Nuestros hallazgos añaden nuevos conocimientos en el estudio de los compuestos fenólicos, destacando la importancia de analizarlos por sexo y de estudiar los determinantes de las elecciones alimentarias y los patrones dietéticos en relación con la percepción de riesgo y los estilos de vida específicos.[EN] Introduction Cardiovascular disease is the leading cause of death worldwide and, despite preventive strategies, continues to be a public health problem. The Mediterranean diet has demonstrated numerous benefits in this regard given its richness in antioxidant and anti-inflammatory molecules, and most especially, in polyphenols. These bioactive compounds have shown cardiovascular benefits due to their antithrombotic, anti-inflammatory and antiplatelet properties. However, the study of their potential in humans is limited. Given the large number of compounds that exist and, therefore, their varied bioavailability and mechanisms of action, there are still many points that need to be clarified. For this reason, the main objective of this doctoral thesis is to evaluate the association between polyphenol intake and cardiovascular risk (CVR) and biomarkers.
Methods The information available from 6,633 participants in the PREDIMED-Plus study was used, it is a multicenter randomized clinical trial, which collected information on dietary habits and lifestyles, as well as blood samples for biochemical analysis. Polyphenol intakes were estimated using food consumption data from the 143-item semi-quantitative food frequency questionnaire and the polyphenol content of each food contained in the Phenol-Explorer database. Estimated intakes were adjusted for total energy intake according to the residuals method.
The association between polyphenol intake and CVR (estimated using risk equations) was evaluated using multivariate linear regression models. In addition, the association between polyphenol intake and uric acid was evaluated (using multivariate linear regression) and, using Cox regression models with a constant follow-up time (t=1), the prevalence ratio of hyperuricemia was estimated.
On the other hand, polyphenol consumption patterns were established by factor analysis and cluster analysis, comparing both methods and relating adherence to each pattern with the estimated CVR.
All analyses were performed for men and women separately, as well as in the total population.
Results Total polyphenol (βQ5vs.Q1= 0.10, 95% CI: 0.04 to 0.17) and flavonoid (βQ5vs.Q1= 0.17, 95% CI: 0.10 to 0.24) intakes were directly and significantly associated with improved optimal cardiovascular health (Life's Simple 7). Inverse associations were found between other polyphenols class intake and, CVR estimated by Framingham (βQ5vs.Q1= -1.22%, 95% CI: -2.37 to -0.07) and SCORE (βQ5vs.Q1=-0.32, 95% CI: -2.37 to -0.07). In women, the associations between polyphenol intake and all risk equations tended to be protective.
The intake of phenolic acids (βQ5vs.Q1= -0.17, 95% CI: -0.27 to -0.06), hydroxycinnamic acids (βQ5vs.Q1= -0.19, 95% CI: -0.3 to -0.09), alkylmethoxyphenols (βQ5vs.Q1= 0.2, 95% CI: -0.31 to -0. 1) and methoxyphenols (βQ5vs.Q1= -0.24, 95% CI -0.34 to -0.13) showed an inverse association with serum uric acid levels and, hyperuricemia (PRQ5vs.Q1=0.82, 95% CI:0.71-0.95; PRQ5vs.Q1=0.82, 95% CI:0.71-0.95; PRQ5vs.Q1=0.80, 95% CI:0.70-0.92 and PRQ5vs.Q1=0.79, 95% CI:0.69-0.91, respectively).
The polyphenol patterns revealed differences between men and women, as well as, in their association with CVR. Regarding those derived from the factorial analysis: for the total sample and the men, pattern 3 (olives and olive oil poyphenols) was positively associated with CVR, they also had a higher prevalence of diabetes and higher sodium intake. Pattern 4, formed by coffee polyphenols in all groups, was also associated with higher CVR. As for the cluster analysis, cluster 2 in the total and in men, characterized by consumption of coffee polyphenols and olives and olive oil, also showed higher CVR.
Conclusions The other polyphenols class showed inverse associations with estimated cardiovascular risk, finding similar results with the Framingham, Framingham-REGICOR and Life's Simple 7 equations (after eliminating the diet component), and different with the SCORE, but predictors included in this scale are scarce.
Higher intakes of polyphenols present in coffee: hydroxycinnamic acids, alkylmethoxyphenols, and methoxyphenols, were inversely associated with serum uric acid levels and hyperuricemia.
We found differences in polyphenol intake patterns between men and women, and in their associations with CVR. These sex differences may be explained by the fact that they lead different lifestyles, since a pattern does not refer only to dietary habits. Moreover, subjects who were at higher risk at baseline might be more motivated to improve their dietary habit (reverse causality).
Our findings add new insights in the study of phenolic compounds, highlighting the importance of analyzing them by sex and studying the determinants of food choices and dietary patterns in relation to risk perception and specific lifestyles
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk
BACKGROUND: Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge
comes from preclinical studies. The aim of the present study was to assess the association of the intake of different
classes of polyphenols with serum uric acid and hyperuricemia.
METHODS AND RESULTS: This cross-sectional
analysis involved baseline data of 6332 participants. Food polyphenol content
was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer
database.
Multivariable-adjusted
linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol
intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up
time (t=1) were
performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse
association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI,
−0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient,
−0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric
acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71–0.95];
PR, 0.82 [95% CI, 0.71–0.95];
PR, 0.80 [95% CI, 0.70–0.92];
and
PR, 0.79 [95% CI, 0.69–0.91];
respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated
with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02–0.26])
but not with
hyperuricemia. CONCLUSIONS: In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic
acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia.
Nevertheless, our findings warrant further research.European Research Council (ERC)
European Commission 2013-2018
340918official funding agency for biomedical research of the Spanish government
Instituto de Salud Carlos IIIEuropean Commission PI13/00673
PI13/00492
PI13/00272
PI13/01123
PI13/00462
PI13/00233
PI13/02184
PI13/00728
PI13/01090
PI13/01056
PI14/01722
PI14/00636
PI14/00618
PI14/00696
PI14/01206
PI14/01919Especial Action ProjectLa Caixa Foundation 2013ACUP00194Consejo Interinstitucional de Ciencia y Tecnologia (CICYT) AGL2016-75329-RCenter for Forestry Research & Experimentation (CIEF)European Commission PROMETEO/2017/017Generalitat de Catalunya SGR-2019Junta de Andalucia PI0458/2013
PS0358/2016
PI0137/2018SEMERGEN (Sociedad Espanola de Medicos de Atencion Primaria)European Cooperation in Science and Technology (COST)IDISBA (Instituto de Investigacion Sanitaria Islas Baleares)European Commission CIBEROBN CB06/03
CB12/03European Commission
European Commission Joint Research Centre EAT2BENI-CE_H2020_SFS2016Spanish Ministry of Science, Innovation and Universities for the Formacion de Profesorado Universitario FPU17/00785Instituto de Salud Carlos III, through the Fondo de Investigacion para la Salud - European Regional Development Fund PI16/00501
PI16/00533
PI16/00381
PI16/00366
PI16/01522
PI16/01120
PI17/00764
PI17/01183
PI17/00855
PI17/01347
PI17/00525
PI17/01827
PI17/00532
PI17/00215
PI17/01441
PI17/00508
PI17/01732
PI17/00926
PI19/00957
PI16/00473Instituto de Salud Carlos III
European Commission PI14/00853
PI14/01374
PI14/00972
PI19/00386
PI19/00309
PI19/01032
PI19/00576
PI19/00017
PI19/01226
PI19/00781
PI19/01560
PI16/00662
PI16/01873
PI16/01094
PI19/01332
PI14/00728
PI14/0147
Puertas lógicas cuánticas en moléculas magnéticas
El objetivo general de este trabajo de fin de grado es explorar posibilidad de que moléculas formadas por tres iones lantánidos puedan realizar una puerta cuántica condicional C-Phase o C-Z. La idea es lograr que el átomo central actúe como interruptor de la interacción entre los dos extremos. En concreto se ha estudiado el caso de la molécula [CeEr2], compuesta de dos iones erbio que actuarían como qubits de la puerta y un ion central cerio que actuaría como el interruptor. Para ello se han realizado medidas de la imanación, la susceptibilidad magnética, el calor específico molar y el espectro de EPR de esta molécula, así como de otras dos similares ([LaEr2] y [CeLu2]) que permiten estudiar los iones erbio y el ion cerio por separado. Los resultados muestran que cada una de las tierras raras se comporta como un sistema de dos niveles (espín efectivo 1/2) y puede por tanto codificar un qubit, y revelan la presencia de un acoplo entre los iones erbio y el ion cerio. Estos ingredientes confirman que la molécula estudiada proporciona un prototipo para implementar una puerta lógica cuántica
Family history of first degree as a risk factor for colorectal cancer
Objetivo: El objetivo de este estudio es evaluar la asociación entre antecedentes familiares (AF) de primer grado y cáncer colorrectal (CCR).Método: Se incluyeron 2857 controles y 1360 casos de CCR, del estudio MCC-Spain. La odds ratio (OR)y el intervalo de confianza del 95% (IC95%) de los AF de primer grado y el CCR se estimaron mediante regresión logística no condicional según la localización tumoral en los casos. Resultados: Los AF de primer grado duplicaron el riesgo de CCR (OR: 2,19; IC95%: 1,80-2,66), incrementándose en aquellos que presentaban dos o más (OR: 4,22; IC95%: 2,29-7,78) y en aquellos cuyos familiares fueron diagnosticados antes de los 50 años (OR: 3,24; IC95%: 1,52-6,91). Presentar AF se relacionó con estilos de vida como un menor consumo de vegetales. En cuanto a la asociación de los AF con la localización no se observaron diferencias significativas entre colon y recto, pero sí en la relación de estas con la edad de diagnóstico, presentando más AF los diagnosticados antes de los 50 años (OR: 4,79; IC95%:2,65-8,65).Conclusiones: Presentar AF de primer grado de CCR aumenta las probabilidades de desarrollar este cáncer, y también se elevan cuando el familiar es diagnosticado a edad temprana. Por ello, debe ser una población diana sobre la que incrementar las medidas de prevención.Objective
To evaluate the association between first-degree family history and colorectal cancer (CRC).
Method
We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression.
Results
First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80–2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29–7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52–6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65–8.65).
Conclusions
First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures
Women’s occupational health and safety management: An issue for corporate social responsibility
This study measures the extent to which the gender perspective is taken into account in Occupational Health & Safety (OHS) management and proposes an innovative approach for managing it. This work is an exploratory study of the relations between women´s OHS and Corporate Social Responsibility (CSR) through the examination of the main management practices that literature supports in a survey conducted at 117 companies in Spain with different levels of commitment to gender equality. Overall, the practices in question are found to be deployed to a moderate extent and their impact is limited. The most relevant initiatives are those related to the prevention, punishment and eradication of sexual harassment in the workplace and violence against women. Our findings indicate that compliance with the law and the importance of external recognition in CSR are main drivers in promoting the gender perspective in OHS. A coherent framework is suggested for addressing women’s OHS management based on a voluntary, preventive, systematic approach that goes beyond sexual and reproductive issues, namely the CSR.Ministerio de Igualdad (España), Exp.: 175/0
Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences
Objectives: This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold.
Background: CMR is the reference tool for cardiac imaging but is time-consuming.
Methods: A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female). Left ventricular (LV) mass, volumes, and LV and right ventricular (RV) ejection fraction (LVEF, RVEF) were assessed by 3D ESSOS and 2D cine CMR. LGE (% LV) was assessed using 3D and 2D sequences.
Results: Three-dimensional and LGE acquisitions lasted 24 and 22 s, respectively. Three-dimensional and LGE images were of good quality and allowed quantification in all cases. Mean LVEF by 3D and 2D CMR were 51 ± 12% and 52 ± 12%, respectively, with excellent intermethod agreement (intraclass correlation coefficient [ICC]: 0.96; 95% confidence interval [CI]: 0.94 to 0.97) and insignificant bias. Mean RVEF 3D and 2D CMR were 60.4 ± 5.4% and 59.7 ± 5.2%, respectively, with acceptable intermethod agreement (ICC: 0.73; 95% CI: 0.63 to 0.81) and insignificant bias. Both 2D and 3D LGE showed excellent agreement, and intraobserver and interobserver agreement were excellent for 3D LGE.
Conclusions: ESSOS single breath-hold 3D CMR allows accurate assessment of heart anatomy and function. Combining ESSOS with 3D LGE allows complete cardiac examination in less than 1 min of acquisition time. This protocol expands the indication for CMR, reduces costs, and increases patient comfort. (J Am Coll Cardiol Img 2021;14:1742–1754)Funding included Instituto de Salud Carlos III (ISCIII) and the
European Regional Development Fund (ERDF) Grants DTS17/00136 to
Dr. Ibáñez and PI19/01704 to Dr. Fernandez-Jimenez; Spanish Society
of Cardiology Translational Research Grant 2016 to Dr. Ibáñez;
European Research Council ERC-CoG 819775-MATRIX to Dr. Ibáñez;
Comunidad de Madrid S2017/BMD-3867-RENIM-CM to Drs. Desco
and Ibáñez; and Ministerio de Ciencia e Innovación (MICINN)
RETOS2019-107332RB-I00 to Dr. Ibáñez. Dr. Fernandez-Jimenez received funding from the European Union Horizon 2020 research and innovation programme under Marie Sklodowska-Curie Hrant
Agreement No. 707642. The CNIC is supported by the ISCIII, the
MICINN, and the Pro CNIC Foundation. Drs. Fernandez-Jimenez,
Nothnagel, Fuster, Ibáñez, and Javier Sánchez-González are inventors
of a joint patent (Philips/CNIC) for the new cine imaging
method here described and validated/protected under the IP
#2014P00960EP. Drs. Nothnagel, Kouwenhoven, Clemence, and
Javier Sánchez-González are Philips employees. All other authors
have reported that they have no relationships relevant to the contents
of this paper to disclose
Does having women managers lead to increased gender equality practices in corporate social responsibility?
There is increasing interest in determining what impact having women in management positions may have on corporate social responsibility (CSR) initiatives. Various authors suggest that gender equality practices should be factored into the broader framework of CSR. This paper examines how the presence of women on corporate boards, in top and middle management and as heads of CSR departments, influences gender equality practices in the field of CSR. Using information collected from companies that have signed up to Women's Empowerment Principles in Spain, we show that the presence of women in the aforesaid posts has a positive impact on CSR activities with gender equality objectives. We thus supplement the justice, business and moral arguments with further arguments in support of the incorporation of women into not only corporate boards but all management positions. Finally, we provide a view of how gender equality can be included in the broader framework of CSR.This research was funded by the Ministry of Equality of Spain, Exp.:175/09. The authors would like to thank the managers of the companies who participated in this project. Their kind gesture in sharing their time and effort is greatly appreciated
Glycine-Stabilized Zinc Gluconate has similar bioavailability than Zinc Sulfate in a zinc fortified probiotic food
Objective: In this study, we evaluated zinc gluconate stabilized with glycine (GZ) and sulfate (SZ) in fermented milk as vehicle. Zinc bioavailability was evaluated in an animal model (Sprague Dawley rats) for both zinc sources in the vehicle with a probiotic (Lactobacillus casei DN114001). Results: For growth parameters, higher weight gain and femur weight values were observed when probiotic and zinc were provided together, independent of the source (weight gain: SZ 81.4g±4.0g; GZ 81.8g±4.0g and 70.2g±12.5g without the probiotic; femur weight: SZ 0.51g ±0.05g; GZ 0.52g±0.05g and 0.42g±0.03g without the probiotic). Femur zinc content was higher for zinc gluconate stabilized with glycine in the presence of the probiotic (97.04ppm±8.40ppm), and the results were similar for zinc sulfate with or without probiotic (84.51ppm±2.44ppm and 84.94ppm±2.28ppm, respectively). Serum antioxidant capacity and immune cellular response were also evaluated by using free radical scavenging assays and a T cell proliferation assay respectively. The free radical scavenging assay showed a tendency to increase with zinc provision, and the highest proliferation index was observed for glycine-stabilized zinc gluconate and the probiotic. Conclusion: The results indicate that the combination of zinc (as glycine-stabilized zinc gluconate) and a probiotic may be beneficial for the evaluated parameters.Fil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hernández, F.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Torti, Horacio Emilio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Massot, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Huarte, M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Rubín de Celis, E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Weill, R.. Danone Argentina S,a,; ArgentinaFil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Boccio, J.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Salgueiro, María Jimena. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
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